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McCormick DW, Richardson LC, Young PR, et al. Deaths in Children and Adolescents Associated With COVID-19 and MIS-C in the United States. Pediatrics. 2021;148(5)doi: 10.1542/peds.2021-052273.
McCormick, D. W., Richardson, L. C., Young, P. R., Viens, L. J., Gould, C. V., Kimball, A., Pindyck, T., Rosenblum, H. G., Siegel, D. A., Vu, Q. M., Komatsu, K., Venkat, H., Openshaw, J. J., Kawasaki, B., Siniscalchi, A. J., Gumke, M., Leapley, A., Tobin-D'Angelo, M., Kauerauf, J., Reid, H., White, K., Ahmed, F. S., Richardson, G., Hand, J., Kirkey, K., Larson, L., Byers, P., Garcia, A., Ojo, M., Zamcheck, A., Lash, M. K., Lee, E. H., Reilly, K. H., Wilson, E., de Fijter, S., Naqvi, O. H., Harduar-Morano, L., Burch, A. K., Lewis, A., Kolsin, J., Pont, S. J., Barbeau, B., Bixler, D., Reagan-Steiner, S., Koumans, E. H. (2021). Deaths in Children and Adolescents Associated With COVID-19 and MIS-C in the United States. Pediatrics, 148(5), . https://doi.org/10.1542/peds.2021-052273
McCormick, David W, et al. "Deaths in Children and Adolescents Associated With COVID-19 and MIS-C in the United States." Pediatrics vol. 148,5 (2021). doi: https://doi.org/10.1542/peds.2021-052273
McCormick DW, Richardson LC, Young PR, Viens LJ, Gould CV, Kimball A, Pindyck T, Rosenblum HG, Siegel DA, Vu QM, Komatsu K, Venkat H, Openshaw JJ, Kawasaki B, Siniscalchi AJ, Gumke M, Leapley A, Tobin-D'Angelo M, Kauerauf J, Reid H, White K, Ahmed FS, Richardson G, Hand J, Kirkey K, Larson L, Byers P, Garcia A, Ojo M, Zamcheck A, Lash MK, Lee EH, Reilly KH, Wilson E, de Fijter S, Naqvi OH, Harduar-Morano L, Burch AK, Lewis A, Kolsin J, Pont SJ, Barbeau B, Bixler D, Reagan-Steiner S, Koumans EH. Deaths in Children and Adolescents Associated With COVID-19 and MIS-C in the United States. Pediatrics. 2021 Nov;148(5). doi: 10.1542/peds.2021-052273. Epub 2021 Aug 12. PMID: 34385349.
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Pediatrics. 2021 Nov;148(5). doi: 10.1542/peds.2021-052273. Epub 2021 Aug 12.

Deaths in Children and Adolescents Associated With COVID-19 and MIS-C in the United States.

Pediatrics

David W McCormick, LaTonia Clay Richardson, Paul R Young, Laura J Viens, Carolyn V Gould, Anne Kimball, Talia Pindyck, Hannah G Rosenblum, David A Siegel, Quan M Vu, Ken Komatsu, Heather Venkat, John J Openshaw, Breanna Kawasaki, Alan J Siniscalchi, Megan Gumke, Andrea Leapley, Melissa Tobin-D'Angelo, Judy Kauerauf, Heather Reid, Kelly White, Farah S Ahmed, Gillian Richardson, Julie Hand, Kim Kirkey, Linnea Larson, Paul Byers, Ali Garcia, Mojisola Ojo, Ariela Zamcheck, Maura K Lash, Ellen H Lee, Kathleen H Reilly, Erica Wilson, Sietske de Fijter, Ozair H Naqvi, Laurel Harduar-Morano, Anna-Kathryn Burch, Adele Lewis, Jonathan Kolsin, Stephen J Pont, Bree Barbeau, Danae Bixler, Sarah Reagan-Steiner, Emilia H Koumans,

Affiliations

  1. Coronavirus Disease 2019 Response Team [email protected].
  2. Epidemic Intelligence Service.
  3. Coronavirus Disease 2019 Response Team.
  4. Arizona Department of Health Services, Phoenix, Arizona.
  5. Career Epidemiology Field Officer Program, Centers for Disease Control and Prevention, Atlanta, Georgia.
  6. California Department of Public Health, Sacramento, California.
  7. Colorado Department of Public Health and Environment, Denver, Colorado.
  8. State of Connecticut Department of Public Health, Hartford, Connecticut.
  9. Florida Department of Health, Tallahassee, Florida.
  10. Georgia Department of Public Health, Atlanta, Georgia.
  11. Illinois Department of Public Health, Springfield, Illinois.
  12. Indiana Department of Health, Indianapolis, Indiana.
  13. Kansas Department of Health and Environment, Topeka, Kansas.
  14. Louisiana Department of Health, Baton Rouge, Louisiana.
  15. Michigan Department of Health and Human Services, Lansing, Michigan.
  16. Minnesota Department of Health, Saint Paul, Minnesota.
  17. Mississippi State Department of Health, Jackson, Mississippi.
  18. Nevada Department of Health and Human Services, Carson City, Nevada.
  19. New Jersey Department of Health, Trenton, New Jersey.
  20. New York State Department of Health, Albany, New York.
  21. New York City Department of Health and Mental Hygiene, New York City, New York.
  22. North Carolina Department of Health and Human Services, Raleigh, North Carolina.
  23. Ohio Department of Health, Columbus, Ohio.
  24. Oklahoma State Department of Health, Oklahoma City, Oklahoma.
  25. Pennsylvania Department of Health, Harrisburg, Pennsylvania.
  26. South Carolina Department of Health and Environmental Control, Columbia, South Carolina.
  27. Tennessee Department of Health, Nashville, Tennessee.
  28. Texas Department of State Health Services, Austin, Texas.
  29. Utah Department of Health, Salt Lake City, Utah.

PMID: 34385349 DOI: 10.1542/peds.2021-052273

Abstract

OBJECTIVES: To describe the demographics, clinical characteristics, and hospital course among persons <21 years of age with a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated death.

METHODS: We conducted a retrospective case series of suspected SARS-CoV-2-associated deaths in the United States in persons <21 years of age during February 12 to July 31, 2020. All states and territories were invited to participate. We abstracted demographic and clinical data, including laboratory and treatment details, from medical records.

RESULTS: We included 112 SARS-CoV-2-associated deaths from 25 participating jurisdictions. The median age was 17 years (IQR 8.5-19 years). Most decedents were male (71, 63%), 31 (28%) were Black (non-Hispanic) persons, and 52 (46%) were Hispanic persons. Ninety-six decedents (86%) had at least 1 underlying condition; obesity (42%), asthma (29%), and developmental disorders (22%) were most commonly documented. Among 69 hospitalized decedents, common complications included mechanical ventilation (75%) and acute respiratory failure (82%). The sixteen (14%) decedents who met multisystem inflammatory syndrome in children (MIS-C) criteria were similar in age, sex, and race and/or ethnicity to decedents without MIS-C; 11 of 16 (69%) had at least 1 underlying condition.

CONCLUSIONS: SARS-CoV-2-associated deaths among persons <21 years of age occurred predominantly among Black (non-Hispanic) and Hispanic persons, male patients, and older adolescents. The most commonly reported underlying conditions were obesity, asthma, and developmental disorders. Decedents with coronavirus disease 2019 were more likely than those with MIS-C to have underlying medical conditions.

Copyright © 2021 by the American Academy of Pediatrics.

Conflict of interest statement

POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.

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