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Yang B, Hong Z, Luse DC, et al. The Diagnostic Role of Neurophysiological Tests for Premature Ejaculation: A Prospective Multicenter Study. J Urol. 2021;207(1):172-182doi: 10.1097/JU.0000000000002198.
Yang, B., Hong, Z., Luse, D. C., Han, Y., Sun, G., Feng, Y., Zhang, C., Sun, C., Xu, Z., Chen, H., Yao, B., Liu, K., Zhu, W., Chen, Y., Wang, R., Dai, Y., & Xia, J. (2022). The Diagnostic Role of Neurophysiological Tests for Premature Ejaculation: A Prospective Multicenter Study. The Journal of urology, 207(1), 172-182. https://doi.org/10.1097/JU.0000000000002198
Yang, Baibing, et al. "The Diagnostic Role of Neurophysiological Tests for Premature Ejaculation: A Prospective Multicenter Study." The Journal of urology vol. 207,1 (2022): 172-182. doi: https://doi.org/10.1097/JU.0000000000002198
Yang B, Hong Z, Luse DC, Han Y, Sun G, Feng Y, Zhang C, Sun C, Xu Z, Chen H, Yao B, Liu K, Zhu W, Chen Y, Wang R, Dai Y, Xia J. The Diagnostic Role of Neurophysiological Tests for Premature Ejaculation: A Prospective Multicenter Study. J Urol. 2022 Jan;207(1):172-182. doi: 10.1097/JU.0000000000002198. Epub 2021 Aug 30. PMID: 34455861.
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J Urol. 2022 Jan;207(1):172-182. doi: 10.1097/JU.0000000000002198. Epub 2021 Aug 30.

The Diagnostic Role of Neurophysiological Tests for Premature Ejaculation: A Prospective Multicenter Study.

The Journal of urology

Baibing Yang, Zhiwei Hong, Dustin C Luse, Youfeng Han, Guohai Sun, Yuming Feng, Chenwang Zhang, Chao Sun, Zhipeng Xu, Hai Chen, Bing Yao, Kaifeng Liu, Weidong Zhu, Yun Chen, Run Wang, Yutian Dai, Jiadong Xia

Affiliations

  1. Department of Andrology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
  2. Division of Urology, Department of Surgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas.
  3. Department of Urology, Fujian Provincial Hospital, Fuzhou, China.
  4. Center of Reproductive Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
  5. Department of Urology, Northern Jiangsu People's Hospital, Yangzhou, China.
  6. Department of Urology, Zhongda Hospital, Southeast University, Nanjing, China.
  7. Department of Andrology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
  8. Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

PMID: 34455861 DOI: 10.1097/JU.0000000000002198

Abstract

PURPOSE: Premature ejaculation (PE) is one of the most common male sexual dysfunctions. Local anesthetics (LAs) and dapoxetine are frequently used to treat PE; however, previous studies show variable efficacy. This study aims to determine the efficacy of LAs and dapoxetine using a novel classification based on neurophysiological tests.

MATERIALS AND METHODS: This multicenter cohort study enrolled adult men (568) with an intravaginal ejaculatory latency time (IELT) ≤2 minutes. Patients were divided into 4 groups according to the results of neurophysiological tests and assigned different treatments for 12 weeks: 1) penile sensory hyperexcitability type (Sens)-LAs; 2) penile sympathetic hyperexcitability type (Symp)-dapoxetine; 3) mixed type (Mixed)-both LAs and dapoxetine; 4) normal type (Norm)-both LAs and dapoxetine. Self-estimated IELT and patient-reported outcomes were recorded.

RESULTS: The total percentage of men achieving IELT >2 minutes and ≥5 minutes after treatment were 82.7% and 76.7%, respectively. For men with abnormal results of neurophysiological tests, 401 (86.6%) had improved IELT >2 minutes after the 12-week treatment course, in which 375 (81.0%) achieved IELT ≥5 minutes. All patient-reported outcome measures improved in each group after 12 weeks of treatment, with greater improvements among those with abnormal neurophysiological tests.

CONCLUSIONS: The efficacy of LAs and dapoxetine increased in PE patients with abnormal results of neurophysiological tests. This novel classification of PE using neurophysiological tests could help guide and improve efficacy of PE therapies.

Keywords: anesthetics, local; neurophysiological monitoring; premature ejaculation; serotonin uptake inhibitors

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