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Botti-Lodovico Y, Nair P, Nosamiefan D, et al. The Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Response. Viruses. 2021;13(8)doi: 10.3390/v13081605.
Botti-Lodovico, Y., Nair, P., Nosamiefan, D., Stremlau, M., Schaffner, S., Agignoae, S. V., Aiyepada, J. O., Ajogbasile, F. V., Akpede, G. O., Alhasan, F., Andersen, K. G., Asogun, D. A., Ayodeji, O. O., Badiane, A. S., Barnes, K., Bauer, M. R., Bell-Kareem, A., Benard, M. E., Benevolence, E. O., Blessing, O., Boehm, C. K., Boisen, M. L., Bond, N. G., Branco, L. M., Butts, M. J., Carter, A., Colubri, A., Deme, A. B., DeRuff, K. C., Diédhiou, Y., Edamhande, A. P., Elhamoumi, S., Engel, E. J., Eromon, P., Fallah, M., Folarin, O. A., Fry, B., Garry, R., Gaye, A., Gbakie, M., Gevao, S. M., Gionet, G., Gladden-Young, A., Goba, A., Gomis, J. F., Happi, A. N., Houghton, M., Ihekwuazu, C., Iruolagbe, C. O., Jackson, J., Jalloh, S., Johnson, J., Kanneh, L., Kayode, A., Kemball, M., Kingsley, O. C., Koroma, V., Kotliar, D., Mehta, S., Metsky, H. C., Michael, A., Mirhashemi, M. E., Modjarrad, K., Momoh, M., Myhrvold, C. A., Naregose, O. G., Ndiaye, T., Ndiaye, M., Ndiaye, A., Normandin, E., Odia, I., Oguzie, J. U., Okogbenin, S. A., Okokhere, P. O., Okolie, J., Olawoye, I. B., Olumade, T. J., Oluniyi, P. E., Omoregie, O., Park, D. J., Paye, M. F., Petros, B., Philippakis, A. A., Priscilla, A., Ricks, A., Rimoin, A., Sandi, J. D., Schieffelin, J. S., Schreiber, M., Seck, M. C., Siddiqui, S., Siddle, K., Smither, A. R., Sy, M., Sy, N., Tomkins-Tinch, C. H., Tomori, O., Ugwu, C., Uwanibe, J. N., Uyigue, E. A., Victoria, D. I., Vinzé, A., Vodzak, M. E., Welch, N., Wurie, H. I., Zoumarou, D., Grant, D. S., Ndiaye, D., MacInnis, B., Sabeti, P. C., & Happi, C. (2021). The Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Response. Viruses, 13(8), . https://doi.org/10.3390/v13081605
Botti-Lodovico, Yolanda, et al. "The Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Response." Viruses vol. 13,8 (2021). doi: https://doi.org/10.3390/v13081605
Botti-Lodovico Y, Nair P, Nosamiefan D, Stremlau M, Schaffner S, Agignoae SV, Aiyepada JO, Ajogbasile FV, Akpede GO, Alhasan F, Andersen KG, Asogun DA, Ayodeji OO, Badiane AS, Barnes K, Bauer MR, Bell-Kareem A, Benard ME, Benevolence EO, Blessing O, Boehm CK, Boisen ML, Bond NG, Branco LM, Butts MJ, Carter A, Colubri A, Deme AB, DeRuff KC, Diédhiou Y, Edamhande AP, Elhamoumi S, Engel EJ, Eromon P, Fallah M, Folarin OA, Fry B, Garry R, Gaye A, Gbakie M, Gevao SM, Gionet G, Gladden-Young A, Goba A, Gomis JF, Happi AN, Houghton M, Ihekwuazu C, Iruolagbe CO, Jackson J, Jalloh S, Johnson J, Kanneh L, Kayode A, Kemball M, Kingsley OC, Koroma V, Kotliar D, Mehta S, Metsky HC, Michael A, Mirhashemi ME, Modjarrad K, Momoh M, Myhrvold CA, Naregose OG, Ndiaye T, Ndiaye M, Ndiaye A, Normandin E, Odia I, Oguzie JU, Okogbenin SA, Okokhere PO, Okolie J, Olawoye IB, Olumade TJ, Oluniyi PE, Omoregie O, Park DJ, Paye MF, Petros B, Philippakis AA, Priscilla A, Ricks A, Rimoin A, Sandi JD, Schieffelin JS, Schreiber M, Seck MC, Siddiqui S, Siddle K, Smither AR, Sy M, Sy N, Tomkins-Tinch CH, Tomori O, Ugwu C, Uwanibe JN, Uyigue EA, Victoria DI, Vinzé A, Vodzak ME, Welch N, Wurie HI, Zoumarou D, Grant DS, Ndiaye D, MacInnis B, Sabeti PC, Happi C. The Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Response. Viruses. 2021 Aug 13;13(8). doi: 10.3390/v13081605. PMID: 34452470; PMCID: PMC8402630.
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Viruses. 2021 Aug 13;13(8). doi: 10.3390/v13081605.

The Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Response.

Viruses

Yolanda Botti-Lodovico, Parvathy Nair, Dolo Nosamiefan, Matthew Stremlau, Stephen Schaffner, Sebastian V Agignoae, John Oke Aiyepada, Fehintola V Ajogbasile, George O Akpede, Foday Alhasan, Kristian G Andersen, Danny A Asogun, Oladele Oluwafemi Ayodeji, Aida S Badiane, Kayla Barnes, Matthew R Bauer, Antoinette Bell-Kareem, Muoebonam Ekene Benard, Ebo Ohomoime Benevolence, Osiemi Blessing, Chloe K Boehm, Matthew L Boisen, Nell G Bond, Luis M Branco, Michael J Butts, Amber Carter, Andres Colubri, Awa B Deme, Katherine C DeRuff, Younousse Diédhiou, Akhilomen Patience Edamhande, Siham Elhamoumi, Emily J Engel, Philomena Eromon, Mosoka Fallah, Onikepe A Folarin, Ben Fry, Robert Garry, Amy Gaye, Michael Gbakie, Sahr M Gevao, Gabrielle Gionet, Adrianne Gladden-Young, Augustine Goba, Jules Francois Gomis, Anise N Happi, Mary Houghton, Chikwe Ihekwuazu, Christopher Ojemiega Iruolagbe, Jonathan Jackson, Simbirie Jalloh, Jeremy Johnson, Lansana Kanneh, Adeyemi Kayode, Molly Kemball, Ojide Chiedozie Kingsley, Veronica Koroma, Dylan Kotliar, Samar Mehta, Hayden C Metsky, Airende Michael, Marzieh Ezzaty Mirhashemi, Kayvon Modjarrad, Mambu Momoh, Cameron A Myhrvold, Okonofua Grace Naregose, Tolla Ndiaye, Mouhamadou Ndiaye, Aliou Ndiaye, Erica Normandin, Ikponmwosa Odia, Judith Uche Oguzie, Sylvanus A Okogbenin, Peter O Okokhere, Johnson Okolie, Idowu B Olawoye, Testimony J Olumade, Paul E Oluniyi, Omigie Omoregie, Daniel J Park, Mariétou Faye Paye, Brittany Petros, Anthony A Philippakis, Abechi Priscilla, Alan Ricks, Anne Rimoin, John Demby Sandi, John S Schieffelin, Monica Schreiber, Mame Cheikh Seck, Sameed Siddiqui, Katherine Siddle, Allison R Smither, Mouhamad Sy, Ngayo Sy, Christopher H Tomkins-Tinch, Oyewale Tomori, Chinedu Ugwu, Jessica N Uwanibe, Eghosasere Anthonia Uyigue, Dada Ireti Victoria, Anika Vinzé, Megan E Vodzak, Nicole Welch, Haja Isatta Wurie, Daba Zoumarou, Donald S Grant, Daouda Ndiaye, Bronwyn MacInnis, Pardis C Sabeti, Christian Happi

Affiliations

  1. Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
  2. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
  3. African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede, Osun State, Nigeria.
  4. Equator Labs Incorporated, Washington, DC 20011, USA.
  5. Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
  6. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.
  7. Harvard Kennedy School, Cambridge, MA 02138, USA.
  8. Institute of Lassa Fever, Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
  9. Department of Biological Sciences, Redeemer's University, Ede, Osun State, Nigeria.
  10. Department of Medicine, Faculty of Clinical Sciences, College of Medicine, Ambrose Alli University, Ekpoma, Edo State, Nigeria.
  11. Viral Hemorrhagic Fever Program, Kenema Government Hospital, Ministry of Health and Sanitation, Kenema, Sierra Leone.
  12. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  13. Scripps Research Translational Institute, La Jolla, CA 92037, USA.
  14. Ambrose Alli University, Ekpoma, Edo State, Nigeria.
  15. Federal Medical Centre, Owo, Ondo State, Nigeria.
  16. Université Cheikh Anta Diop, BP 5005, Dakar, Senegal.
  17. Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA.
  18. Tulane University Medical Center, New Orleans, LA 70112, USA.
  19. Department of Molecular Biology, Princeton University, Princeton, NJ 08540, USA.
  20. Zalgen Labs, Germantown, MD 20876, USA.
  21. University of Massachusetts Medical School, Worcester, MA 01605, USA.
  22. Refuge Place International, Bassa Town, Lower Johnsonville, Liberia.
  23. Fathom Information Design, Boston, MA 02114, USA.
  24. University of Sierra Leone, Freetown, Sierra Leone.
  25. College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone.
  26. Department of Internal Medicine, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
  27. Dimagi, Inc., Cambridge, MA 02139, USA.
  28. Department of Medical Microbiology, Alex-Ekwueme Federal University Teaching Hospital Abakaliki, Abakaliki, Ebonyi, Nigeria.
  29. Department of Critical Care Medicine, University of Maryland Medical Center, Baltimore, MA 21201, USA.
  30. Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  31. Eastern Polytechnic College, Kenema, Sierra Leone.
  32. Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  33. Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
  34. West African Examinations Council, Yaba, Lagos State, Nigeria.
  35. Harvard-MIT Health Sciences and Technology, Cambridge, MA 02139, USA.
  36. Harvard/MIT MD-PhD Program, Boston, MA 02115, USA.
  37. MASS Design Group, Boston, MA 02116, USA.
  38. Yale School of Architecture, New Haven, CT 06511, USA.
  39. Department of Epidemiology, Jonathan and Karing Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA.
  40. Section of Infectious Disease, Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA.
  41. Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  42. Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
  43. Ikorodu General Hospital, Ikorodu, Lagos State, Nigeria.
  44. Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.
  45. Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA.

PMID: 34452470 PMCID: PMC8402630 DOI: 10.3390/v13081605

Abstract

While investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in Lassa virus binding and entry. This led us to pursue field work to test our hypothesis that natural selection acting on LARGE-detected in the Yoruba population of Nigeria-conferred resistance to Lassa Fever in some West African populations. As we delved further, we conjectured that the "emerging" nature of recently discovered diseases like Lassa fever is related to a newfound capacity for detection, rather than a novel viral presence, and that humans have in fact been exposed to the viruses that cause such diseases for much longer than previously suspected. Dr. Stefan Kunz's critical efforts not only laid the groundwork for this discovery, but also inspired and catalyzed a series of events that birthed Sentinel, an ambitious and large-scale pandemic prevention effort in West Africa. Sentinel aims to detect and characterize deadly pathogens before they spread across the globe, through implementation of its three fundamental pillars: Detect, Connect, and Empower. More specifically, Sentinel is designed to detect known and novel infections rapidly, connect and share information in real time to identify emerging threats, and empower the public health community to improve pandemic preparedness and response anywhere in the world. We are proud to dedicate this work to Stefan Kunz, and eagerly invite new collaborators, experts, and others to join us in our efforts.

Keywords: Ebola; LARGE; Lassa fever; Lassa virus; bioinformatics; diagnostic tools; genomic surveillance; infectious disease; pandemic preemption; pandemic response

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