Display options
Cite
, Allende A, Koutsoumanis K, et al. Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed.
Part 2: . EFSA J. 2021;19(10):e06853doi: 10.2903/j.efsa.2021.6853.
, Allende, A., Koutsoumanis, K., Allende, A., Alvarez-Ordóñez, A., Bolton, D., Bover-Cid, S., Chemaly, M., Davies, R., De Cesare, A., Herman, L., Hilbert, F., Lindqvist, R., Nauta, M., Ru, G., Simmons, M., Skandamis, P., Suffredini, E., Andersson, D. I., Bampidis, V., Bengtsson-Palme, J., Bouchard, D., Ferran, A., Kouba, M., López Puente, S., López-Alonso, M., Nielsen, S. S., Pechová, A., Petkova, M., Girault, S., Broglia, A., Guerra, B., Innocenti, M. L., Liébana, E., López-Gálvez, G., Manini, P., Stella, P., & Peixe, L. (2021). Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed.
Part 2: . EFSA journal. European Food Safety Authority, 19(10), e06853. https://doi.org/10.2903/j.efsa.2021.6853
, et al. "Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed.
Part 2: ." EFSA journal. European Food Safety Authority vol. 19,10 (2021): e06853. doi: https://doi.org/10.2903/j.efsa.2021.6853
, Allende A, Koutsoumanis K, Allende A, Alvarez-Ordóñez A, Bolton D, Bover-Cid S, Chemaly M, Davies R, De Cesare A, Herman L, Hilbert F, Lindqvist R, Nauta M, Ru G, Simmons M, Skandamis P, Suffredini E, Andersson DI, Bampidis V, Bengtsson-Palme J, Bouchard D, Ferran A, Kouba M, López Puente S, López-Alonso M, Nielsen SS, Pechová A, Petkova M, Girault S, Broglia A, Guerra B, Innocenti ML, Liébana E, López-Gálvez G, Manini P, Stella P, Peixe L. Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed.
Part 2: . EFSA J. 2021 Oct 26;19(10):e06853. doi: 10.2903/j.efsa.2021.6853. eCollection 2021 Oct. PMID: 34729082; PMCID: PMC8546520.
Copy Download .nbib Format: NLM
Share it on

EFSA J. 2021 Oct 26;19(10):e06853. doi: 10.2903/j.efsa.2021.6853. eCollection 2021 Oct.

Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed.
Part 2: .

EFSA journal. European Food Safety Authority

Ana Allende, Konstantinos Koutsoumanis, Ana Allende, Avelino Alvarez-Ordóñez, Declan Bolton, Sara Bover-Cid, Marianne Chemaly, Robert Davies, Alessandra De Cesare, Lieve Herman, Friederike Hilbert, Roland Lindqvist, Maarten Nauta, Giuseppe Ru, Marion Simmons, Panagiotis Skandamis, Elisabetta Suffredini, Dan I Andersson, Vasileios Bampidis, Johan Bengtsson-Palme, Damien Bouchard, Aude Ferran, Maryline Kouba, Secundino López Puente, Marta López-Alonso, Søren Saxmose Nielsen, Alena Pechová, Mariana Petkova, Sebastien Girault, Alessandro Broglia, Beatriz Guerra, Matteo Lorenzo Innocenti, Ernesto Liébana, Gloria López-Gálvez, Paola Manini, Pietro Stella, Luisa Peixe

PMID: 34729082 PMCID: PMC8546520 DOI: 10.2903/j.efsa.2021.6853

Abstract

The specific concentrations of apramycin, paromomycin, neomycin and spectinomycin in non-target feed for food-producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield, were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC for these antimicrobials, it was not possible to conclude the assessment until further experimental data become available. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels in feed that showed to have an effect on growth promotion/increased yield were reported for apramycin and neomycin, whilst for paromomycin and spectinomycin, no suitable data for the assessment were available. It was recommended to carry out studies to generate the data that are required to fill the gaps which prevented the calculation of the FARSC for these four antimicrobials.

© 2021 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.

Keywords: antimicrobial resistance; apramycin; food‐producing animals; growth promotion; neomycin; paromomycin; spectinomycin

References

  1. J Anim Sci. 1987 Nov;65(5):1243-8 - PubMed
  2. Vet Parasitol. 2009 Nov 12;165(3-4):248-55 - PubMed
  3. J Hyg (Lond). 1984 Aug;93(1):27-34 - PubMed
  4. J Anim Sci. 2012 Nov;90(11):3858-66 - PubMed
  5. J Bacteriol. 1992 Dec;174(24):7896-901 - PubMed
  6. Anim Sci J. 2016 Oct;87(10):1258-1266 - PubMed
  7. Asian-Australas J Anim Sci. 2014 Jan;27(1):93-100 - PubMed
  8. Trends Microbiol. 1997 Jun;5(6):234-40 - PubMed
  9. Res Vet Sci. 2001 Jun;70(3):287-93 - PubMed
  10. Can Vet J. 1973 May;14(5):110-3 - PubMed
  11. Microb Pathog. 2020 Sep;146:104249 - PubMed
  12. Front Microbiol. 2019 Apr 11;10:599 - PubMed
  13. J Am Vet Med Assoc. 2002 Jun 1;220(11):1690-5 - PubMed
  14. J Anim Sci. 2006 Jun;84(6):1422-8 - PubMed
  15. J Dairy Sci. 2005 Jun;88(6):2166-77 - PubMed
  16. Anim Sci J. 2015 Aug;86(8):790-9 - PubMed
  17. Antimicrob Agents Chemother. 2015 Aug;59(8):4714-8 - PubMed
  18. J Anim Sci. 2003 Oct;81(10):2482-7 - PubMed
  19. Antimicrob Agents Chemother. 1972 Mar;1(3):252-8 - PubMed
  20. Epidemiol Infect. 1995 Feb;114(1):105-12 - PubMed
  21. Clin Infect Dis. 1997 Jan;24 Suppl 1:S46-62 - PubMed
  22. Poult Sci. 2004 Feb;83(2):175-82 - PubMed
  23. J Anim Sci. 2008 Jul;86(7):1562-72 - PubMed
  24. J Anim Sci. 2012 Apr;90(4):1118-25 - PubMed
  25. Poult Sci. 1977 Mar;56(2):452-8 - PubMed
  26. Vet Parasitol. 2004 May 26;121(3-4):233-8 - PubMed
  27. Future Microbiol. 2019 Apr;14:533-552 - PubMed
  28. Anim Sci J. 2010 Apr;81(2):205-14 - PubMed
  29. Poult Sci. 1969 Sep;48(5):1703-8 - PubMed
  30. Avian Dis. 1998 Oct-Dec;42(4):738-45 - PubMed
  31. Asian-Australas J Anim Sci. 2013 May;26(5):683-90 - PubMed
  32. Avian Dis. 1982 Apr-Jun;26(2):227-33 - PubMed
  33. J Vet Pharmacol Ther. 1986 Sep;9(3):273-9 - PubMed
  34. J Parasitol. 1993 Oct;79(5):771-4 - PubMed
  35. PLoS One. 2015 Jan 24;10(1):e0116635 - PubMed
  36. Poult Sci. 1971 Jan;50(1):151-5 - PubMed
  37. Biochemistry. 1985 Jan 15;24(2):442-52 - PubMed
  38. Microbiol Rev. 1993 Mar;57(1):138-63 - PubMed
  39. Infect Dis Clin North Am. 2016 Jun;30(2):523-537 - PubMed
  40. J Antimicrob Chemother. 2005 Jul;56(1):20-51 - PubMed
  41. Asian-Australas J Anim Sci. 2014 Aug;27(8):1131-40 - PubMed
  42. Environ Int. 2016 Jan;86:140-9 - PubMed
  43. Front Microbiol. 2018 Mar 19;9:427 - PubMed
  44. Biol Lett. 2006 Sep 22;2(3):463-5 - PubMed
  45. J Dairy Sci. 2003 Dec;86(12):4064-9 - PubMed
  46. Poult Sci. 2000 Jan;79(1):12-7 - PubMed
  47. J Vet Pharmacol Ther. 1985 Mar;8(1):95-104 - PubMed
  48. J Antimicrob Chemother. 1986 Mar;17(3):333-9 - PubMed
  49. Antimicrob Agents Chemother. 1983 Jun;23(6):835-45 - PubMed
  50. Asian-Australas J Anim Sci. 2012 Oct;25(10):1451-6 - PubMed
  51. Front Microbiol. 2017 Oct 26;8:2088 - PubMed
  52. J Anim Sci. 1980 Jul;51(1):121-6 - PubMed
  53. Can J Comp Med. 1974 Jan;38(1):1-6 - PubMed
  54. Res Vet Sci. 1997 May-Jun;62(3):249-52 - PubMed
  55. mBio. 2014 Oct 07;5(5):e01918-14 - PubMed
  56. Antimicrob Agents Chemother. 1979 Jan;15(1):7-13 - PubMed
  57. Cold Spring Harb Perspect Med. 2016 Jun 01;6(6): - PubMed
  58. Arch Anim Nutr. 2010 Feb;64(1):77-84 - PubMed
  59. Intern Med J. 2011 Jun;41(6):441-9 - PubMed
  60. J Anim Sci Technol. 2015 Jan 24;57:4 - PubMed
  61. J Bacteriol. 1999 Feb;181(3):1043-4 - PubMed
  62. Vet Rec. 2000 Jan 15;146(3):61-5 - PubMed
  63. J Anim Sci. 2014 Dec;92(12):5551-9 - PubMed
  64. Avian Dis. 1995 Oct-Dec;39(4):830-6 - PubMed
  65. J Vet Pharmacol Ther. 2007 Apr;30(2):139-44 - PubMed
  66. J Dairy Sci. 2002 Apr;85(4):947-50 - PubMed
  67. Vet Q. 1988 Jul;10(3):191-7 - PubMed
  68. Antimicrob Agents Chemother. 1974 Oct;6(4):415-7 - PubMed
  69. Antimicrob Agents Chemother. 1999 Apr;43(4):727-37 - PubMed
  70. Avian Dis. 1976 Jan-Mar;20(1):118-25 - PubMed
  71. Foodborne Pathog Dis. 2005 Winter;2(4):304-16 - PubMed
  72. J Mol Biol. 2002 Jan 25;315(4):513-27 - PubMed
  73. Microbiome. 2020 Mar 20;8(1):41 - PubMed
  74. ISME J. 2019 Dec;13(12):2927-2937 - PubMed
  75. J Dairy Sci. 2019 Mar;102(3):2094-2102 - PubMed
  76. J Dairy Sci. 1997 Aug;80(8):1751-4 - PubMed
  77. J Sci Food Agric. 2013 Feb;93(3):587-92 - PubMed
  78. PLoS One. 2014 Feb 26;9(2):e88599 - PubMed
  79. Poult Sci. 1985 Aug;64(8):1455-7 - PubMed
  80. Int J Antimicrob Agents. 1999 Aug;12(3):229-37 - PubMed
  81. PLoS Pathog. 2011 Jul;7(7):e1002158 - PubMed
  82. Br Poult Sci. 2009 May;50(3):298-306 - PubMed
  83. J Anim Sci. 1986 Mar;62(3):830-43 - PubMed
  84. FEMS Microbiol Lett. 1989 Oct 15;52(3):261-5 - PubMed
  85. Poult Sci. 2016 Jul 1;95(7):1543-1554 - PubMed
  86. J Bacteriol. 1997 Apr;179(7):2274-80 - PubMed
  87. J Anim Sci. 1988 Jun;66(6):1325-34 - PubMed
  88. J Gen Microbiol. 1992 Mar;138(3):551-61 - PubMed
  89. Clin Orthop Relat Res. 2005 Aug;(437):3-6 - PubMed
  90. PLoS One. 2017 Apr 20;12(4):e0176149 - PubMed
  91. Avian Dis. 1979 Jul-Sep;23(3):670-81 - PubMed
  92. J Anim Physiol Anim Nutr (Berl). 2019 Jan;103(1):72-86 - PubMed
  93. J Vet Pharmacol Ther. 1989 Sep;12(3):296-301 - PubMed
  94. J Anim Sci. 1986 Mar;62(3):844-56 - PubMed
  95. J Antibiot (Tokyo). 1997 Jun;50(6):514-21 - PubMed
  96. J Dairy Sci. 2009 Sep;92(9):4707-14 - PubMed
  97. J Vet Pharmacol Ther. 1994 Feb;17(1):5-11 - PubMed
  98. J Anim Sci. 1997 Jan;75(1):170-5 - PubMed
  99. Parasitol Res. 2014 May;113(5):1875-81 - PubMed
  100. Poult Sci. 1974 Nov;53(6):2059-65 - PubMed
  101. J Anim Sci. 2012 Mar;90(3):833-9 - PubMed

Publication Types