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Reglero-Real N, Pérez-Gutiérrez L, Nourshargh S. Endothelial cell autophagy keeps neutrophil trafficking under control. Autophagy. 2021;1-3doi: 10.1080/15548627.2021.1987675.
Reglero-Real, N., Pérez-Gutiérrez, L., & Nourshargh, S. (2021). Endothelial cell autophagy keeps neutrophil trafficking under control. Autophagy, 1-3. https://doi.org/10.1080/15548627.2021.1987675
Reglero-Real, Natalia, et al. "Endothelial cell autophagy keeps neutrophil trafficking under control." Autophagy vol. (2021): 1-3. doi: https://doi.org/10.1080/15548627.2021.1987675
Reglero-Real N, Pérez-Gutiérrez L, Nourshargh S. Endothelial cell autophagy keeps neutrophil trafficking under control. Autophagy. 2021 Oct 31;1-3. doi: 10.1080/15548627.2021.1987675. Epub 2021 Oct 31. PMID: 34720030.
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Autophagy. 2021 Oct 31;1-3. doi: 10.1080/15548627.2021.1987675. Epub 2021 Oct 31.

Endothelial cell autophagy keeps neutrophil trafficking under control.

Autophagy

Natalia Reglero-Real, Lorena Pérez-Gutiérrez, Sussan Nourshargh

Affiliations

  1. Centre for Microvascular Research, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  2. Centre for Inflammation and Therapeutic Innovation, Queen Mary University of London, London, UK.

PMID: 34720030 DOI: 10.1080/15548627.2021.1987675

Abstract

A defining feature of an inflammatory reaction is infiltration of neutrophils into tissues, a response that requires breaching of endothelial cells (ECs) that line the lumenal aspect of blood vessels. Dysregulated neutrophil trafficking is a hallmark of pathology, but details of the molecular mechanisms that terminate neutrophil breaching of venular walls remain unclear. In this work, we have identified EC autophagy as a negative regulator of neutrophil diapedesis in acute physiological inflammation. Specifically,

Keywords: ATG16L1; ATG5; endothelium; inflammation; junctions; neutrophils

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