Display options
Cite
Chen T, Huang J, Yu Y, et al. Sound-Evoked Responses in the Vestibulo-Ocular Reflex Pathways of Rats. Front Neurosci. 2021;15:741571doi: 10.3389/fnins.2021.741571.
Chen, T., Huang, J., Yu, Y., Tang, X., Zhang, C., Xu, Y., Arteaga, A., Allison, J., Mustain, W., Donald, M. C., Rappai, T., Zhang, M., Zhou, W., & Zhu, H. (2021). Sound-Evoked Responses in the Vestibulo-Ocular Reflex Pathways of Rats. Frontiers in neuroscience, 15741571. https://doi.org/10.3389/fnins.2021.741571
Chen, Tianwen, et al. "Sound-Evoked Responses in the Vestibulo-Ocular Reflex Pathways of Rats." Frontiers in neuroscience vol. 15 (2021): 741571. doi: https://doi.org/10.3389/fnins.2021.741571
Chen T, Huang J, Yu Y, Tang X, Zhang C, Xu Y, Arteaga A, Allison J, Mustain W, Donald MC, Rappai T, Zhang M, Zhou W, Zhu H. Sound-Evoked Responses in the Vestibulo-Ocular Reflex Pathways of Rats. Front Neurosci. 2021 Oct 14;15:741571. doi: 10.3389/fnins.2021.741571. eCollection 2021. PMID: 34720863; PMCID: PMC8551456.
Copy Download .nbib Format: NLM
Share it on

Front Neurosci. 2021 Oct 14;15:741571. doi: 10.3389/fnins.2021.741571. eCollection 2021.

Sound-Evoked Responses in the Vestibulo-Ocular Reflex Pathways of Rats.

Frontiers in neuroscience

Tianwen Chen, Jun Huang, Yue Yu, Xuehui Tang, Chunming Zhang, Youguo Xu, Alberto Arteaga, Jerome Allison, William Mustain, Matthew C Donald, Tracy Rappai, Michael Zhang, Wu Zhou, Hong Zhu

Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, Jackson, MS, United States.
  2. Department of Otolaryngology, First Affiliated Hospital, Shanxi Medical University, Taiyuan, China.
  3. Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS, United States.
  4. School of Medicine, University of Mississippi Medical Center, Jackson, MS, United States.
  5. Summer Undergraduate Research Program, University of Mississippi Medical Center, Jackson, MS, United States.
  6. Department of Neurology, University of Mississippi Medical Center, Jackson, MS, United States.

PMID: 34720863 PMCID: PMC8551456 DOI: 10.3389/fnins.2021.741571

Abstract

Vestibular evoked myogenic potentials (VEMP) have been used to assess otolith function in clinics worldwide. However, there are accumulating evidence suggesting that the clinically used sound stimuli activate not only the otolith afferents, but also the canal afferents, indicating canal contributions to the VEMPs. To better understand the neural mechanisms underlying the VEMPs and develop discriminative VEMP protocols, we further examined sound-evoked responses of the vestibular nucleus neurons and the abducens neurons, which have the interneurons and motoneurons of the vestibulo-ocular reflex (VOR) pathways. Air-conducted clicks (50-80 dB SL re ABR threshold, 0.1 ms duration) or tone bursts (60-80 dB SL, 125-4,000 Hz, 8 ms plateau, 1 ms rise/fall) were delivered to the ears of Sprague-Dawley or Long-Evans rats. Among 425 vestibular nucleus neurons recorded in anesthetized rats and 18 abducens neurons recorded in awake rats, sound activated 35.9% of the vestibular neurons that increased discharge rates for ipsilateral head rotation (Type I neuron), 15.7% of the vestibular neurons that increased discharge rates for contralateral head rotation (Type II neuron), 57.2% of the vestibular neurons that did not change discharge rates during head rotation (non-canal neuron), and 38.9% of the abducens neurons. Sound sensitive vestibular nucleus neurons and abducens neurons exhibited characteristic tuning curves that reflected convergence of canal and otolith inputs in the VOR pathways. Tone bursts also evoked well-defined eye movements that increased with tone intensity and duration and exhibited peak frequency of ∼1,500 Hz. For the left eye, tone bursts evoked upward/rightward eye movements for ipsilateral stimulation, and downward/leftward eye movements for contralateral stimulation. These results demonstrate that sound stimulation results in activation of the canal and otolith VOR pathways that can be measured by eye tracking devices to develop discriminative tests of vestibular function in animal models and in humans.

Copyright © 2021 Chen, Huang, Yu, Tang, Zhang, Xu, Arteaga, Allison, Mustain, Donald, Rappai, Zhang, Zhou and Zhu.

Keywords: abducens nucleus; canal; eye movement; otolith; single unit recording; vestibular-evoked myogenic potential (VEMP); vestibulo ocular reflex

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

  1. Exp Brain Res. 2005 Jul;164(3):271-85 - PubMed
  2. J Assoc Res Otolaryngol. 2008 Sep;9(3):334-48 - PubMed
  3. J Assoc Res Otolaryngol. 2009 Dec;10(4):569-77 - PubMed
  4. Exp Brain Res. 2004 May;156(2):129-34 - PubMed
  5. Acta Otolaryngol. 1977 Nov-Dec;84(5-6):352-60 - PubMed
  6. Arch Otolaryngol Head Neck Surg. 1998 Mar;124(3):249-58 - PubMed
  7. Brain Res. 1989 May 22;487(2):278-87 - PubMed
  8. Hear Res. 2016 May;335:118-127 - PubMed
  9. Neurology. 1992 Aug;42(8):1635-6 - PubMed
  10. J Neurophysiol. 1996 Sep;76(3):1896-903 - PubMed
  11. Acta Otolaryngol. 1997 Jan;117(1):66-72 - PubMed
  12. J Neurosci Methods. 1998 Apr 30;80(2):201-8 - PubMed
  13. J Neurophysiol. 1975 Sep;38(5):1232-49 - PubMed
  14. J Comp Neurol. 1987 Oct 22;264(4):547-70 - PubMed
  15. Exp Brain Res. 1996 Sep;111(1):149-52 - PubMed
  16. Exp Brain Res. 1999 Dec;129(4):483-93 - PubMed
  17. J Neurophysiol. 1992 Nov;68(5):1906-9 - PubMed
  18. Neurosci Res. 2011 Dec;71(4):315-27 - PubMed
  19. Otol Neurotol. 2004 May;25(3):345-52 - PubMed
  20. J Neurophysiol. 2011 Aug;106(2):754-63 - PubMed
  21. J Neurophysiol. 1992 Jul;68(1):244-64 - PubMed
  22. Neurology. 2006 Apr 11;66(7):1079-87 - PubMed
  23. J Neurophysiol. 1978 Nov;41(6):1647-61 - PubMed
  24. Exp Brain Res. 1995;103(1):174-8 - PubMed
  25. J Neurophysiol. 2007 Apr;97(4):2780-9 - PubMed
  26. J Neurophysiol. 1995 Dec;74(6):2445-59 - PubMed
  27. Brain Res. 1987 Dec 1;435(1-2):48-56 - PubMed
  28. Clin Neurophysiol. 2010 May;121(5):636-51 - PubMed
  29. J Comp Neurol. 1987 Oct 22;264(4):571-94 - PubMed
  30. Curr Opin Otolaryngol Head Neck Surg. 2006 Oct;14(5):299-304 - PubMed
  31. Brain Res. 1985 Nov 25;348(1):28-35 - PubMed
  32. J Assoc Res Otolaryngol. 2014 Feb;15(1):73-86 - PubMed

Publication Types