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Li C, Wu M, Gu L, et al. α- MSH plays anti-inflammatory and anti-fungal role in . Curr Eye Res. 2021;doi: 10.1080/02713683.2021.2006235.
Li, C., Wu, M., Gu, L., Yin, M., Li, H., Yuan, W., Lin, J., Wang, Q., Xu, Q., Jiang, N., & Zhao, G. (2021). α- MSH plays anti-inflammatory and anti-fungal role in . Current eye research, . https://doi.org/10.1080/02713683.2021.2006235
Li, Cui, et al. "α- MSH plays anti-inflammatory and anti-fungal role in ." Current eye research vol. (2021). doi: https://doi.org/10.1080/02713683.2021.2006235
Li C, Wu M, Gu L, Yin M, Li H, Yuan W, Lin J, Wang Q, Xu Q, Jiang N, Zhao G. α- MSH plays anti-inflammatory and anti-fungal role in . Curr Eye Res. 2021 Nov 12; doi: 10.1080/02713683.2021.2006235. Epub 2021 Nov 12. PMID: 34766863.
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Curr Eye Res. 2021 Nov 12; doi: 10.1080/02713683.2021.2006235. Epub 2021 Nov 12.

α- MSH plays anti-inflammatory and anti-fungal role in .

Current eye research

Cui Li, Mengqi Wu, Lingwen Gu, Min Yin, Hui Li, Wu Yuan, Jing Lin, Qian Wang, Qiang Xu, Nan Jiang, Guiqiu Zhao

Affiliations

  1. Department of Ophthalmology The Affiliated Hospital of Qingdao University Qingdao, China, 266003.

PMID: 34766863 DOI: 10.1080/02713683.2021.2006235

Abstract

PURPOSE: To investigate the anti-inflammatory and anti-fungal role of α-melanocyte stimulating hormone (α-MSH) in

METHOD: Corneas of C57BL/6 mice were infected with

RESULTS: Compared with PBS control group, α-MSH treatment alleviated disease response and decreased clinical score at 3 days p.i. HE staining showed less infiltration in corneal tissue after α-MSH treatment. Plate counting experiment showed that number of viable fungus in corneas of α-MSH treated group was less than control group. mRNA levels of IL-1β, TNF-α, IL-6, MIP-2, LOX-1, Dectin-1 and iNOS were decreased. Protein levels of IL-1β, TNF-α, IL-6 and Dectin-1 were decreased. α-MSH treatment also decreased the infiltrating neutrophils and macrophages. The levels of pro-inflammatory cytokines, Dectin-1 and LOX-1 stimulated by

CONCLUSION: α-MSH alleviates the severity and decreases fungal load of

Keywords: Aspergillus fumigates; inflammation; macrophages; neutrophils; α-MSH

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