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Quinn MCJ, McCue K, Shi W, et al. Identification of a Locus Near . Cancer Epidemiol Biomarkers Prev. 2021;30(9):1669-1680doi: 10.1158/1055-9965.EPI-20-1817.
Quinn, M. C. J., McCue, K., Shi, W., Johnatty, S. E., Beesley, J., Civitarese, A., O'Mara, T. A., Glubb, D. M., Tyrer, J. P., Armasu, S. M., Ong, J. S., Gharahkhani, P., Lu, Y., Gao, B., Patch, A. M., Fasching, P. A., Beckmann, M. W., Lambrechts, D., Vergote, I., Velez Edwards, D. R., Beeghly-Fadiel, A., Benitez, J., Garcia, M. J., Goodman, M. T., Dörk, T., Dürst, M., Modugno, F., Moysich, K., du Bois, A., Pfisterer, J., Bauman, K., Karlan, B. Y., Lester, J., Cunningham, J. M., Larson, M. C., McCauley, B. M., Kjaer, S. K., Jensen, A., Hogdall, C. K., Hogdall, E., Schildkraut, J. M., Riggan, M. J., Berchuck, A., Cramer, D. W., Terry, K. L., Bjorge, L., Webb, P. M., Friedlander, M., Pejovic, T., Moffitt, M., Glasspool, R., May, T., Ene, G. E. V., Huntsman, D. G., Woo, M., Carney, M. E., Hinsley, S., Heitz, F., Fereday, S., Kennedy, C. J., Edwards, S. L., Winham, S. J., deFazio, A., Pharoah, P. D. P., Goode, E. L., MacGregor, S., Chenevix-Trench, G. (2021). Identification of a Locus Near . Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 30(9), 1669-1680. https://doi.org/10.1158/1055-9965.EPI-20-1817
Quinn, Michael C J, et al. "Identification of a Locus Near ." Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology vol. 30,9 (2021): 1669-1680. doi: https://doi.org/10.1158/1055-9965.EPI-20-1817
Quinn MCJ, McCue K, Shi W, Johnatty SE, Beesley J, Civitarese A, O'Mara TA, Glubb DM, Tyrer JP, Armasu SM, Ong JS, Gharahkhani P, Lu Y, Gao B, Patch AM, Fasching PA, Beckmann MW, Lambrechts D, Vergote I, Velez Edwards DR, Beeghly-Fadiel A, Benitez J, Garcia MJ, Goodman MT, Dörk T, Dürst M, Modugno F, Moysich K, du Bois A, Pfisterer J, Bauman K, Karlan BY, Lester J, Cunningham JM, Larson MC, McCauley BM, Kjaer SK, Jensen A, Hogdall CK, Hogdall E, Schildkraut JM, Riggan MJ, Berchuck A, Cramer DW, Terry KL, Bjorge L, Webb PM, Friedlander M, Pejovic T, Moffitt M, Glasspool R, May T, Ene GEV, Huntsman DG, Woo M, Carney ME, Hinsley S, Heitz F, Fereday S, Kennedy CJ, Edwards SL, Winham SJ, deFazio A, Pharoah PDP, Goode EL, MacGregor S, Chenevix-Trench G. Identification of a Locus Near . Cancer Epidemiol Biomarkers Prev. 2021 Sep;30(9):1669-1680. doi: 10.1158/1055-9965.EPI-20-1817. Epub 2021 Jun 23. PMID: 34162658; PMCID: PMC8419101.
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Cancer Epidemiol Biomarkers Prev. 2021 Sep;30(9):1669-1680. doi: 10.1158/1055-9965.EPI-20-1817. Epub 2021 Jun 23.

Identification of a Locus Near .

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Michael C J Quinn, Karen McCue, Wei Shi, Sharon E Johnatty, Jonathan Beesley, Andrew Civitarese, Tracy A O'Mara, Dylan M Glubb, Jonathan P Tyrer, Sebastian M Armasu, Jue-Sheng Ong, Puya Gharahkhani, Yi Lu, Bo Gao, Ann-Marie Patch, Peter A Fasching, Matthias W Beckmann, Diether Lambrechts, Ignace Vergote, Digna R Velez Edwards, Alicia Beeghly-Fadiel, Javier Benitez, Maria J Garcia, Marc T Goodman, Thilo Dörk, Matthias Dürst, Francesmary Modugno, Kirsten Moysich, Andreas du Bois, Jacobus Pfisterer, Klaus Bauman, Beth Y Karlan, Jenny Lester, Julie M Cunningham, Melissa C Larson, Bryan M McCauley, Susanne K Kjaer, Allan Jensen, Claus K Hogdall, Estrid Hogdall, Joellen M Schildkraut, Marjorie J Riggan, Andrew Berchuck, Daniel W Cramer, Kathryn L Terry, Line Bjorge, Penelope M Webb, Michael Friedlander, Tanja Pejovic, Melissa Moffitt, Rosalind Glasspool, Taymaa May, Gabrielle E V Ene, David G Huntsman, Michelle Woo, Michael E Carney, Samantha Hinsley, Florian Heitz, Sian Fereday, Catherine J Kennedy, Stacey L Edwards, Stacey J Winham, Anna deFazio, Paul D P Pharoah, Ellen L Goode, Stuart MacGregor, Georgia Chenevix-Trench,

Affiliations

  1. Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  2. Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom.
  3. Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota.
  4. Crown Princess Mary Cancer Care Centre, Westmead Hospital, Sydney, New South Wales, Australia.
  5. Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, New South Wales, Australia.
  6. Division of Hematology and Oncology, Department of Medicine, University of California at Los Angeles, David Geffen School of Medicine, Los Angeles, California.
  7. Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
  8. VIB Center for Cancer Biology, VIB, Leuven, Belgium.
  9. Laboratory for Translational Genetics, Department of Human Genetics, University of Leuven, Leuven, Belgium.
  10. Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
  11. Department of Obstetrics and Gynecology, Vanderbilt Epidemiology Center, Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, Tennessee.
  12. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
  13. Human Genetics Group, Spanish National Cancer Centre (CNIO), and Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain.
  14. Computational Oncology Group, Spanish National Cancer Centre (CNIO), Madrid, Spain.
  15. Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
  16. Department of Biomedical Sciences, Community and Population Health Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
  17. Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
  18. Department of Gynecology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany.
  19. Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  20. Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania.
  21. Womens Cancer Research Center, Magee-Womens Research Institute and Hillman Cancer Center, Pittsburgh, Pennsylvania.
  22. Division of Cancer Prevention and Population Sciences, Cancer Pathology & Prevention, Roswell Park Cancer Institute, Buffalo, New York.
  23. Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany.
  24. Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany.
  25. Gynecologic Oncology Center, Kiel, Germany.
  26. Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California.
  27. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
  28. Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  29. Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
  30. Department of Lifestyle, Reproduction and Cancer, Danish Cancer Society Research Center, Copenhagen, Denmark.
  31. Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
  32. Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina.
  33. Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
  34. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts.
  35. Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
  36. Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.
  37. Prince of Wales Clinical School, University of New South Wales, Sydney, Australia.
  38. Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon.
  39. Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.
  40. Beatson West of Scotland Cancer Centre and University of Glasgow, Glasgow, United Kingdom.
  41. Division of Gynecologic Oncology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.
  42. British Columbia's Ovarian Cancer Research (OVCARE) Program, Vancouver General Hospital, BC Cancer Agency and University of British Columbia, British Columbia, Canada.
  43. Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.
  44. Department of Obstetrics and Gynaecology, The University of British Columbia, Vancouver, British Columbia, Canada.
  45. Department of Molecular Oncology, The University of British Columbia, Vancouver, British Columbia, Canada.
  46. British Columbia's Ovarian Cancer Research (OVCARE) Program, Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada.
  47. Department of Obstetrics and Gynecology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii.
  48. Cancer Research UK Glasgow Clinical Trials Unit, University of Glasgow, Glasgow, United Kingdom.
  49. Department for Gynecology with the Center for Oncologic Surgery Charité Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
  50. Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
  51. Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.
  52. Strangeways Research Laboratory, Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Worts Causeway, Cambridge, United Kingdom.
  53. Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. [email protected].

PMID: 34162658 PMCID: PMC8419101 DOI: 10.1158/1055-9965.EPI-20-1817

Abstract

BACKGROUND: Many loci have been found to be associated with risk of epithelial ovarian cancer (EOC). However, although there is considerable variation in progression-free survival (PFS), no loci have been found to be associated with outcome at genome-wide levels of significance.

METHODS: We carried out a genome-wide association study (GWAS) of PFS in 2,352 women with EOC who had undergone cytoreductive surgery and standard carboplatin/paclitaxel chemotherapy.

RESULTS: We found seven SNPs at 12q24.33 associated with PFS (

CONCLUSIONS: The locus at 12q24.33 represents one of the first genome-wide significant loci for survival for any cancer.

IMPACT: This finding provides insight into genetic markers associated with EOC outcome and potential treatment options.

©2021 American Association for Cancer Research.

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