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Science. 2021 Dec 10;374(6573):1343-1353. doi: 10.1126/science.abl8912. Epub 2021 Oct 21.

Protection against SARS-CoV-2 Beta variant in mRNA-1273 vaccine-boosted nonhuman primates.

Science (New York, N.Y.)

Kizzmekia S Corbett, Matthew Gagne, Danielle A Wagner, Sarah O' Connell, Sandeep R Narpala, Dillon R Flebbe, Shayne F Andrew, Rachel L Davis, Barbara Flynn, Timothy S Johnston, Christopher D Stringham, Lilin Lai, Daniel Valentin, Alex Van Ry, Zackery Flinchbaugh, Anne P Werner, Juan I Moliva, Manjari Sriparna, Sijy O'Dell, Stephen D Schmidt, Courtney Tucker, Angela Choi, Matthew Koch, Kevin W Bock, Mahnaz Minai, Bianca M Nagata, Gabriela S Alvarado, Amy R Henry, Farida Laboune, Chaim A Schramm, Yi Zhang, Eun Sung Yang, Lingshu Wang, Misook Choe, Seyhan Boyoglu-Barnum, Shi Wei, Evan Lamb, Saule T Nurmukhambetova, Samantha J Provost, Mitzi M Donaldson, Josue Marquez, John-Paul M Todd, Anthony Cook, Alan Dodson, Andrew Pekosz, Eli Boritz, Aurélie Ploquin, Nicole Doria-Rose, Laurent Pessaint, Hanne Andersen, Kathryn E Foulds, John Misasi, Kai Wu, Andrea Carfi, Martha C Nason, John Mascola, Ian N Moore, Darin K Edwards, Mark G Lewis, Mehul S Suthar, Mario Roederer, Adrian McDermott, Daniel C Douek, Nancy J Sullivan, Barney S Graham, Robert A Seder

Affiliations

  1. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  2. Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Department of Microbiology and Immunology, Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA.
  3. BIOQUAL Inc., Rockville, MD 20850, USA.
  4. Moderna Inc., Cambridge, MA 02139, USA.
  5. Infectious Disease Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  6. Department of Microbiology and Immunology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA.
  7. Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

PMID: 34672695 DOI: 10.1126/science.abl8912

Abstract

[Figure: see text].

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