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Xu J, Zhou M, Luo P, et al. Plasma Metabolomic Profiling of Patients Recovered From Coronavirus Disease 2019 (COVID-19) With Pulmonary Sequelae 3 Months After Discharge. Clin Infect Dis. 2021;73(12):2228-2239doi: 10.1093/cid/ciab147.
Xu, J., Zhou, M., Luo, P., Yin, Z., Wang, S., Liao, T., Yang, F., Wang, Z., Yang, D., Peng, Y., Geng, W., Li, Y., Zhang, H., & Jin, Y. (2021). Plasma Metabolomic Profiling of Patients Recovered From Coronavirus Disease 2019 (COVID-19) With Pulmonary Sequelae 3 Months After Discharge. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 73(12), 2228-2239. https://doi.org/10.1093/cid/ciab147
Xu, Juanjuan, et al. "Plasma Metabolomic Profiling of Patients Recovered From Coronavirus Disease 2019 (COVID-19) With Pulmonary Sequelae 3 Months After Discharge." Clinical infectious diseases : an official publication of the Infectious Diseases Society of America vol. 73,12 (2021): 2228-2239. doi: https://doi.org/10.1093/cid/ciab147
Xu J, Zhou M, Luo P, Yin Z, Wang S, Liao T, Yang F, Wang Z, Yang D, Peng Y, Geng W, Li Y, Zhang H, Jin Y. Plasma Metabolomic Profiling of Patients Recovered From Coronavirus Disease 2019 (COVID-19) With Pulmonary Sequelae 3 Months After Discharge. Clin Infect Dis. 2021 Dec 16;73(12):2228-2239. doi: 10.1093/cid/ciab147. PMID: 33596592; PMCID: PMC7929060.
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Clin Infect Dis. 2021 Dec 16;73(12):2228-2239. doi: 10.1093/cid/ciab147.

Plasma Metabolomic Profiling of Patients Recovered From Coronavirus Disease 2019 (COVID-19) With Pulmonary Sequelae 3 Months After Discharge.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Juanjuan Xu, Mei Zhou, Ping Luo, Zhengrong Yin, Sufei Wang, Tingting Liao, Fan Yang, Zhen Wang, Dan Yang, Yi Peng, Wei Geng, Yunyun Li, Hui Zhang, Yang Jin

Affiliations

  1. Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Pulmonary Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
  2. Department of Translational Medicine Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
  3. Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

PMID: 33596592 PMCID: PMC7929060 DOI: 10.1093/cid/ciab147

Abstract

BACKGROUND: Elucidation of the molecular mechanisms involved in the pathogenesis of coronavirus disease 2019 (COVID-19) may help to discover therapeutic targets.

METHODS: To determine the metabolomic profile of circulating plasma from COVID-19 survivors with pulmonary sequelae 3 months after discharge, a random, outcome-stratified case-control sample was analyzed. We enrolled 103 recovered COVID-19 patients as well as 27 healthy donors, and performed pulmonary function tests, computerized tomography (CT) scans, laboratory examinations, and liquid chromatography-mass spectrometry.

RESULTS: Plasma metabolite profiles of COVID-19 survivors with abnormal pulmonary function were different from those of healthy donors or subjects with normal pulmonary function. These alterations were associated with disease severity and mainly involved amino acid and glycerophospholipid metabolic pathways. Furthermore, increased levels of triacylglycerols, phosphatidylcholines, prostaglandin E2, arginine, and decreased levels of betain and adenosine were associated with pulmonary CO diffusing capacity and total lung capacity. The global plasma metabolomic profile differed between subjects with abnormal and normal pulmonary function.

CONCLUSIONS: Further metabolite-based analysis may help to identify the mechanisms underlying pulmonary dysfunction in COVID-19 survivors, and provide potential therapeutic targets in the future.

© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.

Keywords: COVID-19; lipidomics; metabolomics; pulmonary function

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