Display options
Cite
Cao L, Huang C, Cui Zhou D, et al. Proteogenomic characterization of pancreatic ductal adenocarcinoma. Cell. 2021;184(19):5031-5052.e26doi: 10.1016/j.cell.2021.08.023.
Cao, L., Huang, C., Cui Zhou, D., Hu, Y., Lih, T. M., Savage, S. R., Krug, K., Clark, D. J., Schnaubelt, M., Chen, L., da Veiga Leprevost, F., Eguez, R. V., Yang, W., Pan, J., Wen, B., Dou, Y., Jiang, W., Liao, Y., Shi, Z., Terekhanova, N. V., Cao, S., Lu, R. J., Li, Y., Liu, R., Zhu, H., Ronning, P., Wu, Y., Wyczalkowski, M. A., Easwaran, H., Danilova, L., Mer, A. S., Yoo, S., Wang, J. M., Liu, W., Haibe-Kains, B., Thiagarajan, M., Jewell, S. D., Hostetter, G., Newton, C. J., Li, Q. K., Roehrl, M. H., Fenyö, D., Wang, P., Nesvizhskii, A. I., Mani, D. R., Omenn, G. S., Boja, E. S., Mesri, M., Robles, A. I., Rodriguez, H., Bathe, O. F., Chan, D. W., Hruban, R. H., Ding, L., Zhang, B., Zhang, H. (2021). Proteogenomic characterization of pancreatic ductal adenocarcinoma. Cell, 184(19), 5031-5052.e26. https://doi.org/10.1016/j.cell.2021.08.023
Cao, Liwei, et al. "Proteogenomic characterization of pancreatic ductal adenocarcinoma." Cell vol. 184,19 (2021): 5031-5052.e26. doi: https://doi.org/10.1016/j.cell.2021.08.023
Cao L, Huang C, Cui Zhou D, Hu Y, Lih TM, Savage SR, Krug K, Clark DJ, Schnaubelt M, Chen L, da Veiga Leprevost F, Eguez RV, Yang W, Pan J, Wen B, Dou Y, Jiang W, Liao Y, Shi Z, Terekhanova NV, Cao S, Lu RJ, Li Y, Liu R, Zhu H, Ronning P, Wu Y, Wyczalkowski MA, Easwaran H, Danilova L, Mer AS, Yoo S, Wang JM, Liu W, Haibe-Kains B, Thiagarajan M, Jewell SD, Hostetter G, Newton CJ, Li QK, Roehrl MH, Fenyö D, Wang P, Nesvizhskii AI, Mani DR, Omenn GS, Boja ES, Mesri M, Robles AI, Rodriguez H, Bathe OF, Chan DW, Hruban RH, Ding L, Zhang B, Zhang H. Proteogenomic characterization of pancreatic ductal adenocarcinoma. Cell. 2021 Sep 16;184(19):5031-5052.e26. doi: 10.1016/j.cell.2021.08.023. PMID: 34534465; PMCID: PMC8654574.
Copy Download .nbib Format: NLM
Share it on

Cell. 2021 Sep 16;184(19):5031-5052.e26. doi: 10.1016/j.cell.2021.08.023.

Proteogenomic characterization of pancreatic ductal adenocarcinoma.

Cell

Liwei Cao, Chen Huang, Daniel Cui Zhou, Yingwei Hu, T Mamie Lih, Sara R Savage, Karsten Krug, David J Clark, Michael Schnaubelt, Lijun Chen, Felipe da Veiga Leprevost, Rodrigo Vargas Eguez, Weiming Yang, Jianbo Pan, Bo Wen, Yongchao Dou, Wen Jiang, Yuxing Liao, Zhiao Shi, Nadezhda V Terekhanova, Song Cao, Rita Jui-Hsien Lu, Yize Li, Ruiyang Liu, Houxiang Zhu, Peter Ronning, Yige Wu, Matthew A Wyczalkowski, Hariharan Easwaran, Ludmila Danilova, Arvind Singh Mer, Seungyeul Yoo, Joshua M Wang, Wenke Liu, Benjamin Haibe-Kains, Mathangi Thiagarajan, Scott D Jewell, Galen Hostetter, Chelsea J Newton, Qing Kay Li, Michael H Roehrl, David Fenyö, Pei Wang, Alexey I Nesvizhskii, D R Mani, Gilbert S Omenn, Emily S Boja, Mehdi Mesri, Ana I Robles, Henry Rodriguez, Oliver F Bathe, Daniel W Chan, Ralph H Hruban, Li Ding, Bing Zhang, Hui Zhang,

Affiliations

  1. Department of Pathology, Johns Hopkins University, Baltimore, MD 21231, USA.
  2. Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
  3. Department of Medicine, Washington University in St. Louis, St. Louis, MO 631110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA.
  4. Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
  5. Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
  6. The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA.
  7. Department of Oncology, Johns Hopkins University, Baltimore, MD 21205, USA.
  8. Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
  9. Sema4, a Mount Sinai venture, Stamford, CT 06902, USA.
  10. Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA.
  11. Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.
  12. Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
  13. Van Andel Research Institute, Grand Rapids, MI 49503, USA.
  14. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  15. Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
  16. Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, MD 20892, USA.
  17. Departments of Surgery and Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  18. Department of Pathology, Johns Hopkins University, Baltimore, MD 21231, USA; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA.
  19. Department of Pathology, Johns Hopkins University, Baltimore, MD 21231, USA; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA; The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD 21231, USA.
  20. Department of Medicine, Washington University in St. Louis, St. Louis, MO 631110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA. Electronic address: [email protected].
  21. Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: [email protected].
  22. Department of Pathology, Johns Hopkins University, Baltimore, MD 21231, USA; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA. Electronic address: [email protected].

PMID: 34534465 PMCID: PMC8654574 DOI: 10.1016/j.cell.2021.08.023

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor patient survival. Toward understanding the underlying molecular alterations that drive PDAC oncogenesis, we conducted comprehensive proteogenomic analysis of 140 pancreatic cancers, 67 normal adjacent tissues, and 9 normal pancreatic ductal tissues. Proteomic, phosphoproteomic, and glycoproteomic analyses were used to characterize proteins and their modifications. In addition, whole-genome sequencing, whole-exome sequencing, methylation, RNA sequencing (RNA-seq), and microRNA sequencing (miRNA-seq) were performed on the same tissues to facilitate an integrated proteogenomic analysis and determine the impact of genomic alterations on protein expression, signaling pathways, and post-translational modifications. To ensure robust downstream analyses, tumor neoplastic cellularity was assessed via multiple orthogonal strategies using molecular features and verified via pathological estimation of tumor cellularity based on histological review. This integrated proteogenomic characterization of PDAC will serve as a valuable resource for the community, paving the way for early detection and identification of novel therapeutic targets.

Copyright © 2021 Elsevier Inc. All rights reserved.

Keywords: CPTAC; KRAS; endothelial cell; glycoproteins; immune-cold tumors; kinase inhibitors; neoplastic cellularity; pancreatic ductal adenocarcinoma; proteogenomics; tumor subtyping

Conflict of interest statement

Declaration of interests R.H.H. has the potential of receiving royalty payments from Thrive Earlier Diagnosis for the GNAS invention in a relationship overseen by Johns Hopkins University. The remaini

References

  1. Nat Methods. 2020 Sep;17(9):869-870 - PubMed
  2. Cancer Med. 2016 Sep;5(9):2649-56 - PubMed
  3. Nat Methods. 2017 May;14(5):513-520 - PubMed
  4. Cancer Cell. 2009 Jun 2;15(6):489-500 - PubMed
  5. Cell Rep. 2018 Apr 3;23(1):227-238.e3 - PubMed
  6. Cell. 2014 Oct 23;159(3):676-90 - PubMed
  7. Gastroenterology. 2019 May;156(7):2024-2040 - PubMed
  8. Cancer Immunol Immunother. 2005 Apr;54(4):315-27 - PubMed
  9. Oncogene. 2006 May 4;25(19):2773-84 - PubMed
  10. Nat Rev Gastroenterol Hepatol. 2019 Apr;16(4):207-220 - PubMed
  11. Bioinformatics. 2015 Sep 15;31(18):3069-71 - PubMed
  12. Semin Oncol. 2019 Feb;46(1):28-38 - PubMed
  13. Cancer Cell. 2006 Sep;10(3):203-14 - PubMed
  14. Mol Syst Biol. 2018 Nov 20;14(11):e8486 - PubMed
  15. BMC Cancer. 2016 Jan 16;16:24 - PubMed
  16. Science. 2015 Jan 23;347(6220):1260419 - PubMed
  17. Genome Biol. 2019 Oct 21;20(1):213 - PubMed
  18. Nucleic Acids Res. 2010 Jan;38(Database issue):D497-501 - PubMed
  19. J Pathol. 2019 Jun;248(2):131-141 - PubMed
  20. Mol Cell Proteomics. 2019 Mar;18(3):576-593 - PubMed
  21. Nat Biotechnol. 2003 Jun;21(6):660-6 - PubMed
  22. Sci Transl Med. 2017 Jul 12;9(398): - PubMed
  23. Genome Res. 2016 Jan;26(1):108-18 - PubMed
  24. Sci Rep. 2019 Dec 4;9(1):18347 - PubMed
  25. J Proteome Res. 2013 Mar 1;12(3):1377-86 - PubMed
  26. Nat Genet. 1994 Sep;8(1):27-32 - PubMed
  27. Nat Commun. 2020 Aug 13;11(1):4065 - PubMed
  28. Nat Rev Cancer. 2011 Oct 24;11(11):775-91 - PubMed
  29. Nucleic Acids Res. 2015 Jan;43(Database issue):D531-5 - PubMed
  30. Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4164-9 - PubMed
  31. Genome Biol. 2011;12(4):R41 - PubMed
  32. Pathol Int. 2019 Aug;69(8):441-449 - PubMed
  33. World J Gastroenterol. 2014 Aug 28;20(32):11182-98 - PubMed
  34. Cell. 2018 Apr 5;173(2):371-385.e18 - PubMed
  35. Oncotarget. 2017 Jan 31;8(5):7691-7709 - PubMed
  36. Oncogenesis. 2020 Jul 2;9(7):62 - PubMed
  37. Int J Oncol. 2001 May;18(5):1085-91 - PubMed
  38. Nucleic Acids Res. 2016 Jan 4;44(D1):D548-54 - PubMed
  39. Front Oncol. 2019 Nov 01;9:1143 - PubMed
  40. Anal Chem. 2002 Oct 15;74(20):5383-92 - PubMed
  41. Cancer Med. 2019 Nov;8(16):7032-7043 - PubMed
  42. Nucleic Acids Res. 2015 Jan;43(Database issue):D512-20 - PubMed
  43. Sci Transl Med. 2017 Apr 12;9(385): - PubMed
  44. Nucleic Acids Res. 2016 Jul 27;44(13):6274-86 - PubMed
  45. Nat Biotechnol. 2013 Mar;31(3):213-9 - PubMed
  46. Cancers (Basel). 2019 Jan 23;11(2): - PubMed
  47. Bioinformatics. 2017 Jul 15;33(14):2131-2139 - PubMed
  48. Bioinformatics. 2010 Jun 15;26(12):1572-3 - PubMed
  49. Cancer Cell. 2021 Apr 12;39(4):509-528.e20 - PubMed
  50. Nucleic Acids Res. 2019 Jul 2;47(W1):W199-W205 - PubMed
  51. Cell. 2018 Jan 25;172(3):578-589.e17 - PubMed
  52. Nat Methods. 2015 Mar;12(3):258-64, 7 p following 264 - PubMed
  53. Expert Opin Emerg Drugs. 2017 Mar;22(1):77-86 - PubMed
  54. Nature. 2011 Jun 29;474(7353):609-15 - PubMed
  55. Cell Mol Life Sci. 2019 Jul;76(13):2571-2592 - PubMed
  56. Oncotarget. 2016 Apr 5;7(14):17737-50 - PubMed
  57. Genome Res. 2010 Sep;20(9):1297-303 - PubMed
  58. Nature. 2014 Jul 31;511(7511):543-50 - PubMed
  59. Nature. 2020 May;581(7809):434-443 - PubMed
  60. J Cancer. 2019 Aug 28;10(21):5162-5172 - PubMed
  61. Hypoxia (Auckl). 2014 Jul 16;2:91-106 - PubMed
  62. Gastroenterology. 2018 Dec;155(6):1999-2013.e3 - PubMed
  63. Clin Cancer Res. 2020 Sep 15;26(18):4901-4910 - PubMed
  64. Cell. 2017 Jun 15;169(7):1327-1341.e23 - PubMed
  65. Biomedicines. 2017 Nov 18;5(4): - PubMed
  66. Cancer Discov. 2019 Aug;9(8):1102-1123 - PubMed
  67. Nat Genet. 2020 Feb;52(2):231-240 - PubMed
  68. Nucleic Acids Res. 2011 Jan;39(Database issue):D373-6 - PubMed
  69. Cancer Metastasis Rev. 2013 Dec;32(3-4):643-71 - PubMed
  70. J Med Chem. 2008 Sep 25;51(18):5522-32 - PubMed
  71. N Engl J Med. 2011 Aug 25;365(8):768-9; author reply 769 - PubMed
  72. BMB Rep. 2019 Jul;52(7):415-423 - PubMed
  73. Nature. 2012 Oct 4;490(7418):61-70 - PubMed
  74. Anal Chem. 2020 Mar 17;92(6):4217-4225 - PubMed
  75. Pharmacol Res Perspect. 2019 Sep 06;7(5):e00518 - PubMed
  76. Histochem Cell Biol. 2020 Jul;154(1):97-105 - PubMed
  77. Cancer Res. 2020 Oct 15;80(20):4324-4334 - PubMed
  78. Nucleic Acids Res. 2015 Apr 20;43(7):e47 - PubMed
  79. Lancet Gastroenterol Hepatol. 2020 Jul;5(7):698-710 - PubMed
  80. Acta Physiol (Oxf). 2018 Jan;222(1): - PubMed
  81. Anticancer Res. 2019 Jul;39(7):3405-3412 - PubMed
  82. Nature. 2016 Mar 3;531(7592):47-52 - PubMed
  83. J Biol Chem. 2014 Dec 19;289(51):35149-58 - PubMed
  84. Nat Commun. 2015 Apr 09;6:6744 - PubMed
  85. Bioinformatics. 2019 Mar 1;35(5):865-867 - PubMed
  86. J Biol Chem. 2011 Apr 15;286(15):13603-11 - PubMed
  87. Science. 2017 May 26;356(6340): - PubMed
  88. PLoS One. 2014 Dec 26;9(12):e115517 - PubMed
  89. BMC Bioinformatics. 2010 Jul 02;11:367 - PubMed
  90. Br J Cancer. 2014 Aug 26;111(5):817-22 - PubMed
  91. Cell Physiol Biochem. 2015;37(2):707-18 - PubMed
  92. Bioessays. 2011 Aug;33(8):582-7 - PubMed
  93. RNA Biol. 2016;13(4):466-72 - PubMed
  94. Clin Cancer Res. 2017 Jun 15;23(12):3129-3138 - PubMed
  95. Anal Chem. 2018 Jul 3;90(13):8065-8071 - PubMed
  96. Cell. 2016 Jul 28;166(3):755-765 - PubMed
  97. Bioinformatics. 2007 Jun 15;23(12):1495-502 - PubMed
  98. Oncotarget. 2017 Nov 14;8(62):105905-105914 - PubMed
  99. J Cancer. 2018 Oct 31;9(23):4449-4462 - PubMed
  100. Nat Rev Cancer. 2004 Jan;4(1):45-60 - PubMed
  101. Cancer Biol Ther. 2014 Aug;15(8):963-7 - PubMed
  102. Biochem Soc Trans. 2017 Feb 8;45(1):79-88 - PubMed
  103. Sci Rep. 2015 Dec 03;5:17663 - PubMed
  104. Cancer Metastasis Rev. 2020 Sep;39(3):805-823 - PubMed
  105. EMBO J. 1998 Jun 1;17(11):3091-100 - PubMed
  106. Cancer Res. 2014 Jun 1;74(11):2913-21 - PubMed
  107. Small GTPases. 2020 May;11(3):155-159 - PubMed
  108. Nucleic Acids Res. 2017 Jan 4;45(D1):D158-D169 - PubMed
  109. Clin Chem. 2005 Dec;51(12):2229-35 - PubMed
  110. PLoS Med. 2009 Apr 7;6(4):e1000046 - PubMed
  111. Proteomics. 2011 Sep;11(18):3665-74 - PubMed
  112. Cancer Cell. 2021 Mar 8;39(3):361-379.e16 - PubMed
  113. Clin Cancer Res. 2018 May 1;24(9):2171-2181 - PubMed
  114. Mol Cell Proteomics. 2013 Oct;12(10):2820-32 - PubMed
  115. Cold Spring Harb Perspect Biol. 2015 Jan 05;7(1):a020412 - PubMed
  116. Cell Logist. 2012 Apr 1;2(2):105-116 - PubMed
  117. Nat Genet. 2015 Oct;47(10):1168-78 - PubMed
  118. Ann Gastroenterol Surg. 2020 Feb 18;4(2):100-108 - PubMed
  119. Cancer Discov. 2020 Jan;10(1):104-123 - PubMed
  120. Dig Dis Sci. 2014 Nov;59(11):2714-20 - PubMed
  121. Eur J Cancer. 2018 Jan;89:19-26 - PubMed
  122. Physiol Rev. 2020 Oct 1;100(4):1707-1751 - PubMed
  123. Cell Rep. 2016 Nov 15;17(8):2075-2086 - PubMed
  124. Semin Oncol. 2005 Dec;32(6 Suppl 7):S9-15 - PubMed
  125. Cell Syst. 2015 Dec 23;1(6):417-425 - PubMed
  126. Cell. 2019 Oct 31;179(4):964-983.e31 - PubMed
  127. Cell. 2020 Feb 20;180(4):729-748.e26 - PubMed
  128. Gastroenterology. 2019 May;156(7):2056-2072 - PubMed
  129. Cell. 2002 Jul 12;110(1):19-32 - PubMed
  130. Genome Biol. 2016 Oct 20;17(1):218 - PubMed
  131. F1000Res. 2020 Feb 21;9: - PubMed
  132. Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50 - PubMed
  133. J Clin Oncol. 2015 Jan 20;33(3):244-50 - PubMed
  134. Nature. 2009 Nov 5;462(7269):108-12 - PubMed
  135. Science. 2019 Jun 21;364(6446):1156-1162 - PubMed
  136. Cell. 2018 Apr 5;173(2):355-370.e14 - PubMed
  137. Semin Cancer Biol. 2019 Feb;54:40-49 - PubMed
  138. J Biol Chem. 2011 May 20;286(20):17934-44 - PubMed
  139. N Engl J Med. 2019 Jul 25;381(4):317-327 - PubMed
  140. Mod Pathol. 2020 Dec;33(12):2544-2563 - PubMed
  141. J Proteome Res. 2018 Jun 1;17(6):2205-2215 - PubMed
  142. Nat Commun. 2018 Jan 2;9(1):20 - PubMed
  143. Am J Pathol. 1998 Jun;152(6):1501-7 - PubMed
  144. World J Gastroenterol. 2018 May 28;24(20):2137-2151 - PubMed
  145. Nat Med. 2011 Apr;17(4):500-3 - PubMed
  146. J Pathol. 2009 Jul;218(3):380-90 - PubMed
  147. Nucleic Acids Res. 2016 Apr 7;44(6):2859-72 - PubMed
  148. Sci Rep. 2016 Nov 21;6:37189 - PubMed
  149. Nat Rev Clin Oncol. 2020 Sep;17(9):527-540 - PubMed
  150. Nature. 2015 Oct 1;526(7571):68-74 - PubMed
  151. Cancer Biol Ther. 2008 Oct;7(10):1593-601 - PubMed
  152. BMC Bioinformatics. 2013 Jan 16;14:7 - PubMed
  153. Cancer Res. 2004 Feb 1;64(3):871-5 - PubMed
  154. Oncogenesis. 2018 Jan 24;7(1):10 - PubMed
  155. Bioinformatics. 2009 Nov 1;25(21):2865-71 - PubMed
  156. Cancer Res. 2005 Oct 1;65(19):8809-17 - PubMed
  157. Cancer Cell. 2017 Aug 14;32(2):185-203.e13 - PubMed
  158. Mol Cell Proteomics. 2020 Apr;19(4):608-623 - PubMed
  159. Nat Genet. 2013 Oct;45(10):1113-20 - PubMed
  160. J Comput Biol. 2020 Nov;27(11):1595-1609 - PubMed
  161. Oncogene. 2006 Aug 7;25(34):4633-46 - PubMed
  162. Nat Protoc. 2018 Jul;13(7):1632-1661 - PubMed
  163. Anal Chem. 2003 Sep 1;75(17):4646-58 - PubMed
  164. Cell Death Dis. 2018 Oct 30;9(11):1102 - PubMed
  165. Genome Biol. 2011;12(1):R1 - PubMed
  166. Nat Methods. 2018 Aug;15(8):591-594 - PubMed
  167. Front Oncol. 2018 Sep 10;8:367 - PubMed
  168. Clin Cancer Res. 2009 Oct 1;15(19):6052-61 - PubMed
  169. J Intern Med. 2020 Aug;288(2):183-191 - PubMed
  170. Nat Protoc. 2020 Aug;15(8):2589-2610 - PubMed
  171. Mol Biol Cell. 2001 Oct;12(10):3282-94 - PubMed
  172. J Neurosci. 2014 Aug 13;34(33):10924-36 - PubMed
  173. Oncol Lett. 2019 Aug;18(2):983-989 - PubMed
  174. Nucleic Acids Res. 2018 Jan 4;46(D1):D649-D655 - PubMed
  175. J Urol. 2008 Aug;180(2):539-43; discussion 543 - PubMed
  176. Nat Methods. 2015 Feb;12(2):115-21 - PubMed
  177. Nature. 2012 Sep 27;489(7417):519-25 - PubMed
  178. Comput Struct Biotechnol J. 2020 Apr 09;18:1000-1011 - PubMed
  179. Proteome Sci. 2007 Jan 16;5:3 - PubMed
  180. Cell. 2019 May 2;177(4):1035-1049.e19 - PubMed
  181. J Proteome Res. 2019 Dec 6;18(12):4262-4272 - PubMed
  182. Int J Mol Sci. 2020 May 03;21(9): - PubMed
  183. Genome Res. 2012 Mar;22(3):568-76 - PubMed
  184. Bioinformatics. 2009 Aug 15;25(16):2078-9 - PubMed
  185. J Biol Chem. 2006 Apr 14;281(15):10281-90 - PubMed
  186. Am J Transl Res. 2020 Feb 15;12(2):612-617 - PubMed
  187. Cell. 2010 Nov 24;143(5):672-6 - PubMed
  188. Nat Commun. 2020 Apr 7;11(1):1723 - PubMed
  189. Nat Commun. 2013;4:2612 - PubMed
  190. Acta Oncol. 2018 Dec;57(12):1655-1662 - PubMed
  191. Cancer Treat Rev. 2020 Sep;89:102070 - PubMed
  192. Gut. 2019 Jun;68(6):1034-1043 - PubMed
  193. Nat Commun. 2020 Jul 8;11(1):3409 - PubMed
  194. Clin Proteomics. 2019 Sep 7;16:35 - PubMed
  195. Adv Neurobiol. 2014;9:47-70 - PubMed
  196. Genome Biol. 2017 Nov 15;18(1):220 - PubMed
  197. J Clin Invest. 2015 Sep;125(9):3335-7 - PubMed
  198. Nat Rev Drug Discov. 2004 May;3(5):391-400 - PubMed
  199. Nat Protoc. 2018 Jun;13(6):1196-1212 - PubMed
  200. Presse Med. 2019 Mar;48(3 Pt 2):e159-e174 - PubMed
  201. Science. 2008 Sep 26;321(5897):1801-6 - PubMed
  202. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082 - PubMed
  203. Cancer Res. 2019 Sep 1;79(17):4539-4550 - PubMed
  204. Cell Rep. 2020 Jun 16;31(11):107764 - PubMed
  205. Anal Chem. 2018 Dec 18;90(24):14294-14302 - PubMed
  206. J Pathol. 2014 Dec;234(4):502-13 - PubMed
  207. N Engl J Med. 2013 Oct 31;369(18):1691-703 - PubMed
  208. Nat Methods. 2016 Nov 29;13(12):966-967 - PubMed
  209. Cell. 2020 Jul 9;182(1):200-225.e35 - PubMed
  210. Bioinformatics. 2012 Dec 15;28(24):3232-9 - PubMed
  211. Cell Death Dis. 2018 Jan 25;9(2):115 - PubMed
  212. Cell. 2020 Nov 25;183(5):1436-1456.e31 - PubMed
  213. Cell. 2016 Jul 28;166(3):740-754 - PubMed
  214. Pathol Oncol Res. 2016 Jul;22(3):443-7 - PubMed
  215. PLoS One. 2016 Jul 12;11(7):e0159102 - PubMed
  216. J Cell Sci. 2012 Mar 1;125(Pt 5):1073-9 - PubMed
  217. Glycobiology. 2017 Jan;27(1):3-49 - PubMed

Publication Types

Grant support