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Sanderson M, Pal T, Beeghly-Fadiel A, et al. A Pooled Case-only Analysis of Reproductive Risk Factors and Breast Cancer Subtype Among Black Women in the Southeastern United States. Cancer Epidemiol Biomarkers Prev. 2021;30(7):1416-1423doi: 10.1158/1055-9965.EPI-20-1784.
Sanderson, M., Pal, T., Beeghly-Fadiel, A., Fadden, M. K., Dujon, S. A., Clinton, C., Jimenez, C., Davis, J., Fortune, M., Thompson, J., Benson, K., Conley, N., Reid, S., Tezak, A., Shu, X. O., Zheng, W., Blot, W. J., & Lipworth, L. (2021). A Pooled Case-only Analysis of Reproductive Risk Factors and Breast Cancer Subtype Among Black Women in the Southeastern United States. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 30(7), 1416-1423. https://doi.org/10.1158/1055-9965.EPI-20-1784
Sanderson, Maureen, et al. "A Pooled Case-only Analysis of Reproductive Risk Factors and Breast Cancer Subtype Among Black Women in the Southeastern United States." Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology vol. 30,7 (2021): 1416-1423. doi: https://doi.org/10.1158/1055-9965.EPI-20-1784
Sanderson M, Pal T, Beeghly-Fadiel A, Fadden MK, Dujon SA, Clinton C, Jimenez C, Davis J, Fortune M, Thompson J, Benson K, Conley N, Reid S, Tezak A, Shu XO, Zheng W, Blot WJ, Lipworth L. A Pooled Case-only Analysis of Reproductive Risk Factors and Breast Cancer Subtype Among Black Women in the Southeastern United States. Cancer Epidemiol Biomarkers Prev. 2021 Jul;30(7):1416-1423. doi: 10.1158/1055-9965.EPI-20-1784. Epub 2021 May 04. PMID: 33947654; PMCID: PMC8254754.
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Cancer Epidemiol Biomarkers Prev. 2021 Jul;30(7):1416-1423. doi: 10.1158/1055-9965.EPI-20-1784. Epub 2021 May 04.

A Pooled Case-only Analysis of Reproductive Risk Factors and Breast Cancer Subtype Among Black Women in the Southeastern United States.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Maureen Sanderson, Tuya Pal, Alicia Beeghly-Fadiel, Mary Kay Fadden, Steffie-Ann Dujon, Chrystina Clinton, Cecilia Jimenez, Jennifer Davis, Mieke Fortune, Jasmine Thompson, Kiera Benson, Nicholas Conley, Sonya Reid, Ann Tezak, Xiao-Ou Shu, Wei Zheng, William J Blot, Loren Lipworth

Affiliations

  1. Department of Family and Community Medicine, Meharry Medical College, Nashville, Tennessee. [email protected].
  2. Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
  3. Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
  4. Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
  5. Department of Family and Community Medicine, Meharry Medical College, Nashville, Tennessee.
  6. Department of Psychiatry, Vanderbilt University Medical Center, Nashville, Tennessee.

PMID: 33947654 PMCID: PMC8254754 DOI: 10.1158/1055-9965.EPI-20-1784

Abstract

BACKGROUND: We investigated the association between reproductive risk factors and breast cancer subtype in Black women. On the basis of the previous literature, we hypothesized that the relative prevalence of specific breast cancer subtypes might differ according to reproductive factors.

METHODS: We conducted a pooled analysis of 2,188 (591 premenopausal, 1,597 postmenopausal) Black women with a primary diagnosis of breast cancer from four studies in the southeastern United States. Breast cancers were classified by clinical subtype. Case-only polytomous logistic regression models were used to estimate ORs and 95% confidence intervals (CI) for HER2

RESULTS: Relative to women who had ER

CONCLUSIONS: This large pooled study of Black women with breast cancer revealed etiologic heterogeneity among breast cancer subtypes.

IMPACT: Black parous women who do not breastfeed are more likely to be diagnosed with TNBC, which has a worse prognosis, than with ER

©2021 American Association for Cancer Research.

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