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Petersen MJ, Liang C, Kjaerulff L, et al. Serrulatane diterpenoids from the leaves of Eremophila glabra and their potential as antihyperglycemic drug leads. Phytochemistry. 2021;196:113072doi: 10.1016/j.phytochem.2021.113072.
Petersen, M. J., Liang, C., Kjaerulff, L., Ndi, C., Semple, S., Buirchell, B., Coriani, S., Møller, B. L., & Staerk, D. (2021). Serrulatane diterpenoids from the leaves of Eremophila glabra and their potential as antihyperglycemic drug leads. Phytochemistry, 196113072. https://doi.org/10.1016/j.phytochem.2021.113072
Petersen, Malene J, et al. "Serrulatane diterpenoids from the leaves of Eremophila glabra and their potential as antihyperglycemic drug leads." Phytochemistry vol. 196 (2021): 113072. doi: https://doi.org/10.1016/j.phytochem.2021.113072
Petersen MJ, Liang C, Kjaerulff L, Ndi C, Semple S, Buirchell B, Coriani S, Møller BL, Staerk D. Serrulatane diterpenoids from the leaves of Eremophila glabra and their potential as antihyperglycemic drug leads. Phytochemistry. 2021 Dec 29;196:113072. doi: 10.1016/j.phytochem.2021.113072. Epub 2021 Dec 29. PMID: 34973506.
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Phytochemistry. 2021 Dec 29;196:113072. doi: 10.1016/j.phytochem.2021.113072. Epub 2021 Dec 29.

Serrulatane diterpenoids from the leaves of Eremophila glabra and their potential as antihyperglycemic drug leads.

Phytochemistry

Malene J Petersen, Chao Liang, Louise Kjaerulff, Chi Ndi, Susan Semple, Bevan Buirchell, Sonia Coriani, Birger Lindberg Møller, Dan Staerk

Affiliations

  1. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen, Denmark.
  2. Quality Use of Medicines and Pharmacy Research Centre, Clinical and Health Sciences, University of South Australia, Frome Road, Adelaide, 5000, Australia.
  3. Wise Owl Consulting, Como, Western Australia, 6152, Australia.
  4. Department of Chemistry, Technical University of Denmark, Kemitorvet Building 207, DK-2800, Kongens Lyngby, Denmark.
  5. Plant Biochemistry Laboratory, Department of Plant and Environment Sciences, University of Copenhagen, Thorvaldsensvej 40, DK-1871, Frederiksberg C, Denmark.
  6. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen, Denmark. Electronic address: [email protected].

PMID: 34973506 DOI: 10.1016/j.phytochem.2021.113072

Abstract

Eremophila (Scrophulariaceae) is a genus of Australian desert plants, which have been used by Australian Aboriginal people for various medicinal purposes. Crude extracts of the leaf resin of Eremophila glabra (R.Br.) Ostenf. showed α-glucosidase and protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with IC

Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Keywords: Eremophila glabra; Flavonoids; High-resolution inhibition profiling; Protein-tyrosine phosphatase 1B; Scrophulariaceae; Serrulatane diterpenoids; α-Glucosidase

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