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Mao C, Liu X, Zhang Y, et al. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature. 2021;593(7860):586-590doi: 10.1038/s41586-021-03539-7.
Mao, C., Liu, X., Zhang, Y., Lei, G., Yan, Y., Lee, H., Koppula, P., Wu, S., Zhuang, L., Fang, B., Poyurovsky, M. V., Olszewski, K., & Gan, B. (2021). DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature, 593(7860), 586-590. https://doi.org/10.1038/s41586-021-03539-7
Mao, Chao, et al. "DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer." Nature vol. 593,7860 (2021): 586-590. doi: https://doi.org/10.1038/s41586-021-03539-7
Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, Koppula P, Wu S, Zhuang L, Fang B, Poyurovsky MV, Olszewski K, Gan B. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature. 2021 May;593(7860):586-590. doi: 10.1038/s41586-021-03539-7. Epub 2021 May 12. PMID: 33981038.
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Nature. 2021 May;593(7860):586-590. doi: 10.1038/s41586-021-03539-7. Epub 2021 May 12.

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer.

Nature

Chao Mao, Xiaoguang Liu, Yilei Zhang, Guang Lei, Yuelong Yan, Hyemin Lee, Pranavi Koppula, Shiqi Wu, Li Zhuang, Bingliang Fang, Masha V Poyurovsky, Kellen Olszewski, Boyi Gan

Affiliations

  1. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  2. The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.
  3. Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  4. Kadmon Corporation, LLC, New York, NY, USA.
  5. Kadmon Corporation, LLC, New York, NY, USA. [email protected].
  6. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [email protected].
  7. The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. [email protected].

PMID: 33981038 DOI: 10.1038/s41586-021-03539-7

Abstract

Ferroptosis, a form of regulated cell death that is induced by excessive lipid peroxidation, is a key tumour suppression mechanism

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