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El Manaa W, Duplan E, Goiran T, et al. Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology. Autophagy. 2021;17(12):4363-4385doi: 10.1080/15548627.2021.1917129.
El Manaa, W., Duplan, E., Goiran, T., Lauritzen, I., Vaillant Beuchot, L., Lacas-Gervais, S., Morais, V. A., You, H., Qi, L., Salazar, M., Ozcan, U., Chami, M., Checler, F., & Alves da Costa, C. (2021). Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology. Autophagy, 17(12), 4363-4385. https://doi.org/10.1080/15548627.2021.1917129
El Manaa, Wejdane, et al. "Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology." Autophagy vol. 17,12 (2021): 4363-4385. doi: https://doi.org/10.1080/15548627.2021.1917129
El Manaa W, Duplan E, Goiran T, Lauritzen I, Vaillant Beuchot L, Lacas-Gervais S, Morais VA, You H, Qi L, Salazar M, Ozcan U, Chami M, Checler F, Alves da Costa C. Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology. Autophagy. 2021 Dec;17(12):4363-4385. doi: 10.1080/15548627.2021.1917129. Epub 2021 May 24. PMID: 34030589; PMCID: PMC8726674.
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Autophagy. 2021 Dec;17(12):4363-4385. doi: 10.1080/15548627.2021.1917129. Epub 2021 May 24.

Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology.

Autophagy

Wejdane El Manaa, Eric Duplan, Thomas Goiran, Inger Lauritzen, Loan Vaillant Beuchot, Sandra Lacas-Gervais, Vanessa Alexandra Morais, Han You, Ling Qi, Mario Salazar, Umut Ozcan, Mounia Chami, Frédéric Checler, Cristine Alves da Costa

Affiliations

  1. INSERM, CNRS, IPMC, Team Labeled "Laboratory of Excellence (LABEX) Distalz", Sophia-Antipolis, Université Côte d'Azur, Valbonne, France.
  2. Centre Commun de Microscopie Appliquée, Université Côte d'Azur, Nice, France.
  3. Instituto de Medicina Molecular - João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
  4. State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.
  5. Division of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, NY, USA.
  6. Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

PMID: 34030589 PMCID: PMC8726674 DOI: 10.1080/15548627.2021.1917129

Abstract

Parkinson disease (PD)-affected brains show consistent endoplasmic reticulum (ER) stress and mitophagic dysfunctions. The mechanisms underlying these perturbations and how they are directly linked remain a matter of questions. XBP1 is a transcription factor activated upon ER stress after unconventional splicing by the nuclease ERN1/IREα thereby yielding XBP1s, whereas PINK1 is a kinase considered as the sensor of mitochondrial physiology and a master gatekeeper of mitophagy process. We showed that XBP1s transactivates

Keywords: Mitophagy; PINK1; Parkinson disease; XBP1; phosphorylation; transcription; unfolded protein response

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