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Sci Signal. 2021 Nov 09;14(708):eabe5380. doi: 10.1126/scisignal.abe5380. Epub 2021 Nov 09.

Dynamic variability in SHP-1 abundance determines natural killer cell responsiveness.

Science signaling

Zeguang Wu, Soo Park, Colleen M Lau, Yi Zhong, Sam Sheppard, Joseph C Sun, Jayajit Das, Grégoire Altan-Bonnet, Katharine C Hsu

Affiliations

  1. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  2. Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  3. Department of Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, NY 10065, USA.
  4. Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  5. Battelle Center for Mathematical Medicine, Research Institute at the Nationwide Children's Hospital, Columbus, OH 43205, USA.
  6. Department of Pediatrics, Pelotonia Institute of ImmunoOncology, Wexner College of Medicine, Ohio State University, Columbus, OH 43210, USA.
  7. Department of Biomedical Informatics, Ohio State University, Columbus, OH 43210, USA.
  8. Biophysics Graduate Program, Ohio State University, Columbus, OH 43210, USA.
  9. Immunodynamics Group, Cancer and Inflammation Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20814, USA.
  10. Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
  11. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

PMID: 34752140 DOI: 10.1126/scisignal.abe5380

Abstract

[Figure: see text].

Publication Types

Grant support