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Zhao X, Zhang H, Gao Y, et al. A Simple Injectable Moldable Hydrogel Assembled from Natural Glycyrrhizic Acid with Inherent Antibacterial Activity. ACS Appl Bio Mater. 2020;3(1):648-653doi: 10.1021/acsabm.9b01007.
Zhao, X., Zhang, H., Gao, Y., Lin, Y., & Hu, J. (2020). A Simple Injectable Moldable Hydrogel Assembled from Natural Glycyrrhizic Acid with Inherent Antibacterial Activity. ACS applied bio materials, 3(1), 648-653. https://doi.org/10.1021/acsabm.9b01007
Zhao, Xia, et al. "A Simple Injectable Moldable Hydrogel Assembled from Natural Glycyrrhizic Acid with Inherent Antibacterial Activity." ACS applied bio materials vol. 3,1 (2020): 648-653. doi: https://doi.org/10.1021/acsabm.9b01007
Zhao X, Zhang H, Gao Y, Lin Y, Hu J. A Simple Injectable Moldable Hydrogel Assembled from Natural Glycyrrhizic Acid with Inherent Antibacterial Activity. ACS Appl Bio Mater. 2020 Jan 21;3(1):648-653. doi: 10.1021/acsabm.9b01007. Epub 2020 Jan 07. PMID: 35019409.
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ACS Appl Bio Mater. 2020 Jan 21;3(1):648-653. doi: 10.1021/acsabm.9b01007. Epub 2020 Jan 07.

A Simple Injectable Moldable Hydrogel Assembled from Natural Glycyrrhizic Acid with Inherent Antibacterial Activity.

ACS applied bio materials

Xia Zhao, Hao Zhang, Yuxia Gao, Yuan Lin, Jun Hu

Affiliations

  1. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
  2. Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
  3. Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.

PMID: 35019409 DOI: 10.1021/acsabm.9b01007

Abstract

Injectable low-molecular-weight hydrogels (LMWHs) from biocompatible materials have attracted much attention in biomedical applications because they can adapt any desired sizes and cavity shapes. Searching for simple, biocompatible injectable LMWHs owning inherent antibacterial activity without complicated chemical modification remains an open question to avoid the tedious synthesis/purification process and the easy bacterial infection of hydrogels in a moist environment. In this work, glycyrrhizic acid (GL), a naturally occurring compound, was found to form a stable transparent LMWH at 37 °C in physiological phosphate buffered saline (PBS) with nanoclusters as the microstructures. Moreover, this hydrogel exhibited great injectable and moldable properties. The antibacterial study showed that the growth of Gram-positive

Keywords: antibacterial activity; glycyrrhizic acid; injectability; low-molecular-weight hydrogel; natural product

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