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Adv Opt Mater. 2019 Aug 05;7(15). doi: 10.1002/adom.201900229. Epub 2019 May 06.

Quaternary Ammonium Salt Based NIR-II Probes for .

Advanced optical materials

Chunrong Qu, Yuling Xiao, Hui Zhou, Bingbing Ding, Anguo Li, Jiacheng Lin, Xiaodong Zeng, Hao Chen, Kun Qian, Xiao Zhang, Wei Fang, Junzhu Wu, Zixin Deng, Zhen Cheng, Xuechuan Hong

Affiliations

  1. State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China; Molecular Imaging Program at Stanford (MIPS), Bio-X Program, and Department of Radiology, Canary Center at Stanford for Cancer Early Detection, Stanford University, California 94305-5344, USA.
  2. State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China.
  3. State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China; Shenzhen Institute of Wuhan University, Shenzhen, 518057, China.
  4. State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China; Molecular Imaging Program at Stanford (MIPS), Bio-X Program, and Department of Radiology, Canary Center at Stanford for Cancer Early Detection, Stanford University, California 94305-5344, USA; Shenzhen Institute of Wuhan University, Shenzhen, 518057, China.
  5. Molecular Imaging Program at Stanford (MIPS), Bio-X Program, and Department of Radiology, Canary Center at Stanford for Cancer Early Detection, Stanford University, California 94305-5344, USA.
  6. Hubei Provincial Key Laboratory of Developmentally Originated Disease, Center for Experimental Basic Medical Education, Wuhan University, Wuhan 430071, China.

PMID: 32983835 PMCID: PMC7517706 DOI: 10.1002/adom.201900229

Abstract

Traditional luminescent materials including fluorescent probes suffer from notorious aggregation-caused quenching (ACQ) in aqueous solutions. Although several approaches such as the aggregation-induced emission (AIE) effect have been developed, it remains a significant challenge to identify an effective and efficient strategy to resolve this issue. Herein, quaternary ammonium salts

Keywords: NIR-II fluorescence imaging; organic small-molecule probe; tumor imaging; twisted intramolecular charge transfer

Conflict of interest statement

Conflict of Interest The authors declare no conflict of interest.

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