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Suda A, Takahashi J, Beltrame JF, et al. International prospective cohort study of microvascular angina - Rationale and design. Int J Cardiol Heart Vasc. 2020;31:100630doi: 10.1016/j.ijcha.2020.100630.
Suda, A., Takahashi, J., Beltrame, J. F., Berry, C., Camici, P. G., Crea, F., Escaned, J., Ford, T., Carlos Kaski, J., Kiyooka, T., Metha, P. K., Ong, P., Ozaki, Y., Pepine, C., Rimoldi, O., Safdar, B., Sechtem, U., Tsujita, K., Yii, E., Noel Bairey Merz, C., Shimokawa, H. (2020). International prospective cohort study of microvascular angina - Rationale and design. International journal of cardiology. Heart & vasculature, 31100630. https://doi.org/10.1016/j.ijcha.2020.100630
Suda, Akira, et al. "International prospective cohort study of microvascular angina - Rationale and design." International journal of cardiology. Heart & vasculature vol. 31 (2020): 100630. doi: https://doi.org/10.1016/j.ijcha.2020.100630
Suda A, Takahashi J, Beltrame JF, Berry C, Camici PG, Crea F, Escaned J, Ford T, Carlos Kaski J, Kiyooka T, Metha PK, Ong P, Ozaki Y, Pepine C, Rimoldi O, Safdar B, Sechtem U, Tsujita K, Yii E, Noel Bairey Merz C, Shimokawa H. International prospective cohort study of microvascular angina - Rationale and design. Int J Cardiol Heart Vasc. 2020 Sep 11;31:100630. doi: 10.1016/j.ijcha.2020.100630. eCollection 2020 Dec. PMID: 32984497; PMCID: PMC7494778.
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Int J Cardiol Heart Vasc. 2020 Sep 11;31:100630. doi: 10.1016/j.ijcha.2020.100630. eCollection 2020 Dec.

International prospective cohort study of microvascular angina - Rationale and design.

International journal of cardiology. Heart & vasculature

Akira Suda, Jun Takahashi, John F Beltrame, Colin Berry, Paolo G Camici, Filippo Crea, Javier Escaned, Tom Ford, Juan Carlos Kaski, Takahiko Kiyooka, Puja K Metha, Peter Ong, Yukio Ozaki, Carl Pepine, Ornella Rimoldi, Basmah Safdar, Udo Sechtem, Kenichi Tsujita, Eric Yii, C Noel Bairey Merz, Hiroaki Shimokawa,

Affiliations

  1. Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
  2. The Discipline of Medicine, University of Adelaide, Basil Hetzel Institute, Central Adelaide Local Health Network, Adelaide, South Australia, Australia.
  3. British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom.
  4. Vita Salute University and San Raffaele Hospital, Milan, Italy.
  5. Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy.
  6. Department of Cardiology, Hospital Clínico San Carlos IDISSC and Universidad Complutense de Madrid, Madrid, Spain.
  7. Cardiovascular and Cell Sciences Research Institute, St George's, University of London, UK.
  8. Department of Cardiology, Tokai University Oiso Hospital, Oiso, Japan.
  9. Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA, USA.
  10. Department of Cardiology, Robert-Bosch-Krankenhaus, Stuttgart, Germany.
  11. Department of Cardiology, Fujita Medical University, Toyonaka, Aichi, Japan.
  12. Division of Cardiovascular Medicine, University of Florida, College of Medicine, Gainesville, FL, USA.
  13. Institute of Molecular Bioimaging and Physiology, Consiglio Nazionale delle Ricerche, Segrate, Italy.
  14. Department of Emergency Medicine, Yale University, New Haven, CT, USA.
  15. Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
  16. Barbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  17. International University of Health and Welfare, Narita, Japan.

PMID: 32984497 PMCID: PMC7494778 DOI: 10.1016/j.ijcha.2020.100630

Abstract

BACKGROUND: Patients with signs and symptoms of myocardial ischemia and non-obstructive coronary artery disease (CAD) frequently have coronary functional abnormalities, including coronary microvascular dysfunction. Those with the latter are grouped under the term "microvascular angina" (MVA). Although diagnostic criteria exist for MVA, as recently proposed by our COVADIS (COronary VAsomotor Disorders International Study) group and the condition has been increasingly recognized in clinical practice, the clinical characteristics and long-term prognosis of MVA patients in the current era remain to be fully elucidated.

AIMS: In the present study, we aimed to prospectively assess the clinical characteristics and long-term prognosis of MVA subjects in the current era in an international, multicenter, observational, and prospective registry study.

METHODS: A total of 15 medical centers across 7 countries (USA, UK, Germany, Spain, Italy, Australia, and Japan) enrolled subjects fulfilling the COVADIS diagnostic criteria for MVA as follows; (1) signs and/or symptoms of myocardial ischemia, (2) absence of obstructive CAD, and (3) objective evidence of myocardial ischemia and/or coronary microvascular dysfunction. The primary endpoint was the composite of major cardiovascular events (MACE), including cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, hospitalization due to heart failure or unstable angina. Between July 2015 and December 2018, a total of 706 subjects with MVA (M/F 256/450, 61.1 ± 11.8 [SD] yrs.) were registered. Subjects will be followed for at least 1 year.

SUMMARY: The present study will provide important information regarding the clinical characteristics, management, and long-term prognosis of MVA patients in the current era.

© 2020 The Authors.

Keywords: Coronary microvascular dysfunction; Microvascular angina

Conflict of interest statement

F.C. reports speaker fees from AstraZeneca, Amgen and Servier and institutional agreements between his employ-er, the Catholic University, and Biotronik, Boheringer Ingelheim. C.N.B.M. reports lecture

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