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Bjornsson TD, Shand DG. Estimation of kinetic parameters from a two-point determination of the drug cumulation factor. Clin Pharmacol Ther. 1979;26(5):540-7doi: 10.1002/cpt1979265540.
Bjornsson, T. D., & Shand, D. G. (1979). Estimation of kinetic parameters from a two-point determination of the drug cumulation factor. Clinical pharmacology and therapeutics, 26(5), 540-7. https://doi.org/10.1002/cpt1979265540
Bjornsson, T D, and Shand, D G. "Estimation of kinetic parameters from a two-point determination of the drug cumulation factor." Clinical pharmacology and therapeutics vol. 26,5 (1979): 540-7. doi: https://doi.org/10.1002/cpt1979265540
Bjornsson TD, Shand DG. Estimation of kinetic parameters from a two-point determination of the drug cumulation factor. Clin Pharmacol Ther. 1979 Nov;26(5):540-7. doi: 10.1002/cpt1979265540. PMID: 498694.
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Clin Pharmacol Ther. 1979 Nov;26(5):540-7. doi: 10.1002/cpt1979265540.

Estimation of kinetic parameters from a two-point determination of the drug cumulation factor.

Clinical pharmacology and therapeutics

T D Bjornsson, D G Shand

PMID: 498694 DOI: 10.1002/cpt1979265540

Abstract

A method is described which allows the calculation of kinetic parameters of drugs from two data points, involving a set of simple algebraic equations. This method is based on cumulation characteristics of drugs during multiple dosing. The necessary two blood samples are collected at the end of the first dosing interval and before a succeeding dose after steady state has been reached. The method is applicable for drugs which exhibit linear kinetic characteristics not subject to concentration or time-dependent phenomena. The estimates of the kinetic parameters are associated with different ranges of possible errors, with total clearance being the most reliable estimate. The potential clinical utility of this method is discussed.

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