Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 25 to 36 of 20009 entries
Sorted by: Best Match Show Resources per page
Cutaneous leukocytoclastic vasculitis: the role of lymphocytes and related immune markers.

Postepy dermatologii i alergologii

Gambichler T, Kulik MA, Skrygan M, Rooms I, Höxtermann S.
PMID: 28951703
Postepy Dermatol Alergol. 2017 Aug;34(4):299-305. doi: 10.5114/ada.2017.69307. Epub 2017 Aug 01.

INTRODUCTION: Apart from neutrophils, other immune cells may play a significant pathogenetic role in cutaneous leukocytoclastic vasculitis (CLV).AIM: To investigate lymphocytes and related immunological factors in patients with CLV requiring systemic glucocorticosteroid treatment.MATERIAL AND METHODS: Fourteen patients with severe...

Triptolide Promotes Senescence of Prostate Cancer Cells Through Histone Methylation and Heterochromatin Formation.

Asian Pacific journal of cancer prevention : APJCP

Tamgue O, Lei M.
PMID: 28952292
Asian Pac J Cancer Prev. 2017 Sep 27;18(9):2519-2526. doi: 10.22034/APJCP.2017.18.9.2519.

Background: Triptolide is a medicinal herb-derived diterpene triepoxide with potent anti-tumor activity, mainly ,correlated with its ability to inhibit and inactivate subunits of RNA polymerase II, thereby suppressing global gene transcription. Epigenetic imbalance including histone methylation are well known...

Integration of known DNA, RNA and protein biomarkers provides prediction of anti-TNF response in rheumatoid arthritis: results from the COMBINE study.

Molecular medicine (Cambridge, Mass.)

Folkersen L, Brynedal B, Diaz-Gallo LM, Ramsköld D, Shchetynsky K, Westerlind H, Sundström Y, Schepis D, Hensvold A, Vivar N, Eloranta ML, Rönnblom L, Brunak S, Malmström V, Catrina A, Moerch UG, Klareskog L, Padyukov L, Berg L.
PMID: 27532898
Mol Med. 2016 Sep;22:322-328. doi: 10.2119/molmed.2016.00078. Epub 2016 Aug 15.

OBJECTIVE: In rheumatoid arthritis (RA) several recent efforts have sought to discover means of predicting which patients would benefit from treatment. However, results have been discrepant with few successful replications. Our objective was to build a biobank with DNA,...

Isolation and detection of circulating tumour cells from metastatic melanoma patients using a slanted spiral microfluidic device.

Oncotarget

Aya-Bonilla CA, Marsavela G, Freeman JB, Lomma C, Frank MH, Khattak MA, Meniawy TM, Millward M, Warkiani ME, Gray ES, Ziman M.
PMID: 28978038
Oncotarget. 2017 Jun 27;8(40):67355-67368. doi: 10.18632/oncotarget.18641. eCollection 2017 Sep 15.

Circulating Tumour Cells (CTCs) are promising cancer biomarkers. Several methods have been developed to isolate CTCs from blood samples. However, the isolation of melanoma CTCs is very challenging as a result of their extraordinary heterogeneity, which has hindered their...

Endoplasmic Reticulum Stress PERK-ATF4-CHOP Pathway Is Associated with Hypothalamic Neuronal Injury in Different Durations of Stress in Rats.

Frontiers in neuroscience

Yi S, Shi W, Wang H, Ma C, Zhang X, Wang S, Cong B, Li Y.
PMID: 28392758
Front Neurosci. 2017 Mar 24;11:152. doi: 10.3389/fnins.2017.00152. eCollection 2017.

The hypothalamus, which is the initial part of the hypothalamic-pituitary-adrenal (HPA) axis, plays a critical role in regulating stress in the central nervous system. The present study aimed to determine whether endoplasmic reticulum stress in hypothalamic neurons is differentially...

Peripheral blood Th9 cells reconstitution and its relationship with acute graft-versus-host disease after matched-sibling peripheral blood hematopoietic stem cell transplantation.

American journal of translational research

Pang N, Xu J, Qu J, Duan X, Yuan H, Chen G, Jiang M, Ding J.
PMID: 28861153
Am J Transl Res. 2017 Aug 15;9(8):3623-3632. eCollection 2017.

T helper type 9 (Th9) cells have recently been identified as a new effector T cell subset. This study is to analyze the reconstitution of Th9 cell after matched sibling peripheral blood hematopoietic stem cell transplantation (MS-PBSCT) and the...

Evaluation of spermatozoal function-useful tools or just science.

Reproduction in domestic animals = Zuchthygiene

Niżański W, Partyka A, Prochowska S.
PMID: 27670939
Reprod Domest Anim. 2016 Sep;51:37-45. doi: 10.1111/rda.12786.

Conventional microscopic semen analysis does not provide precise information on the fertilizing potential of a male. The traditional basis for semen evaluation is that male fertility is dependent on production of a "proper" concentration/number of motile, morphologically normal spermatozoa...

Unraveling Macrophage Heterogeneity in Erythroblastic Islands.

Frontiers in immunology

Seu KG, Papoin J, Fessler R, Hom J, Huang G, Mohandas N, Blanc L, Kalfa TA.
PMID: 28979259
Front Immunol. 2017 Sep 20;8:1140. doi: 10.3389/fimmu.2017.01140. eCollection 2017.

Mammalian erythropoiesis occurs within erythroblastic islands (EBIs), niches where maturing erythroblasts interact closely with a central macrophage. While it is generally accepted that EBI macrophages play an important role in erythropoiesis, thorough investigation of the mechanisms by which they...

Screening glioma stem cells in U251 cells based on the P1 promoter of the CD133 gene.

Oncology letters

Wang X, Chen L, Xiao Z, Wang Y, Liu T, Zhang T, Zhang Y.
PMID: 27698813
Oncol Lett. 2016 Oct;12(4):2457-2462. doi: 10.3892/ol.2016.4966. Epub 2016 Aug 05.

Cluster of differentiation (CD)133 is an important cell surface marker of glioma stem cells (GSCs). The transcription of the CD133 gene is controlled by five alternative promoters (P1, P2, P3, P4 and P5), which are expressed in a tissue-specific...

NIMA-related kinase 2 regulates hepatocellular carcinoma cell growth and proliferation.

Oncology letters

Lai XB, Nie YQ, Huang HL, Li YF, Cao CY, Yang H, Shen B, Feng ZQ.
PMID: 28454295
Oncol Lett. 2017 Mar;13(3):1587-1594. doi: 10.3892/ol.2017.5618. Epub 2017 Jan 18.

NIMA-related kinase 2 (Nek2) is often upregulated in human cancer and is important in regulating the cell cycle and gene expression, and maintaining centrosomal structure and function. The present study aimed to investigate the expression pattern, clinical significance, and...

miR-455-5p functions as a potential oncogene by targeting galectin-9 in colon cancer.

Oncology letters

Yang Q, Hou C, Huang D, Zhuang C, Jiang W, Geng Z, Wang X, Hu L.
PMID: 28454350
Oncol Lett. 2017 Mar;13(3):1958-1964. doi: 10.3892/ol.2017.5608. Epub 2017 Jan 17.

Although there is evidence that galectin-9 is a critical factor in health and disease, the upstream regulatory microRNA (miRNA or miR) of the protein remains poorly defined. miR-455-5p is characterized as a tumor-associated miRNA in cancer research. However, the...

Induced Pluripotent Stem Cells derived Muscle Progenitors Effectively Mitigate Muscular Dystrophy through Restoring the Dystrophin Distribution.

Journal of stem cell research & therapy

Cai WF, Huang W, Wang L, Wang JP, Zhang L, Ashraf M, Wu S, Wang Y.
PMID: 28979820
J Stem Cell Res Ther. 2016;6(10). doi: 10.4172/2157-7633.1000361. Epub 2016 Sep 26.

BACKGROUND: Duchenne Muscular Dystrophy (DMD) is a recessive form of muscular disorder, resulting from the dystrophin gene mutations in X-chromosome. Application of embryonic stem cells or adult stem cells has demonstrated the therapeutic effects on DMD through both cell-based...

Showing 25 to 36 of 20009 entries