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Showing 13 to 24 of 3819 entries
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Liposomal Formulations in Clinical Use: An Updated Review.

Pharmaceutics

Bulbake U, Doppalapudi S, Kommineni N, Khan W.
PMID: 28346375
Pharmaceutics. 2017 Mar 27;9(2). doi: 10.3390/pharmaceutics9020012.

Liposomes are the first nano drug delivery systems that have been successfully translated into real-time clinical applications. These closed bilayer phospholipid vesicles have witnessed many technical advances in recent years since their first development in 1965. Delivery of therapeutics...

Development of tea tree oil-loaded liposomal formulation using response surface methodology.

Journal of liposome research

Ge Y, Ge M.
PMID: 25799232
J Liposome Res. 2015 Sep;25(3):222-231. doi: 10.3109/08982104.2014.987786. Epub 2015 Mar 23.

The aim of this study is to prepare tea tree oil liposome (TTOL) and optimize the preparation condition by single factor experiment and statistical design. TTOL was prepared using a thin-film hydration with the combination of sonication method and...

Liposomal delivery of a phosphodiesterase 3 inhibitor rescues low oxygen-induced ATP release from erythrocytes of humans with type 2 diabetes.

Biochemistry and biophysics reports

Dergunov SA, Bowles EA, Gordon W, Green M, Bierman A, Ellsworth ML, Pinkhassik E, Sprague RS.
PMID: 29124155
Biochem Biophys Rep. 2015 May 30;2:137-142. doi: 10.1016/j.bbrep.2015.05.011. eCollection 2015 Jul.

ATP release from erythrocytes in response to low oxygen tension requires an increase in cAMP, the level of which is regulated by phosphodiesterase 3 (PDE3). Such release is defective in erythrocytes of humans with type 2 diabetes (DM2). This...

Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes.

Royal Society open science

Miyazawa T, Kamiyoshihara R, Shimizu N, Harigae T, Otoki Y, Ito J, Kato S, Miyazawa T, Nakagawa K.
PMID: 29515844
R Soc Open Sci. 2018 Feb 14;5(2):171249. doi: 10.1098/rsos.171249. eCollection 2018 Feb.

Liposomes consisting of 100% phosphatidylcholine exhibit poor membrane fusion, cellular uptake and selective targeting capacities. To overcome these limitations, we used Amadori-glycated phosphatidylethanolamine, which is universally present in animals and commonly consumed in foods. We found that liposomes containing...

A Novel Approach on Drug Delivery: Investigation of A New Nano-Formulation of Liposomal Doxorubicin and Biological Evaluation of Entrapped Doxorubicin on Various Osteosarcoma Cell Lines.

Cell journal

Haghiralsadat F, Amoabediny G, Sheikhha MH, Forouzanfar T, Helder MN, Zandieh-Doulabi B.
PMID: 28580308
Cell J. 2017;19:55-65. doi: 10.22074/cellj.2017.4502. Epub 2017 May 17.

OBJECTIVE: In this study we prepared a novel formulation of liposomal doxorubicin (L- DOX). The drug dose was optimized by analyses of cellular uptake and cell viability of osteosarcoma (OS) cell lines upon exposure to nanoliposomes that contained varying...

Ultrasound-triggered local anaesthesia.

Nature biomedical engineering

Rwei AY, Paris JL, Wang B, Wang W, Axon CD, Vallet-Regí M, Langer R, Kohane DS.
PMID: 29152410
Nat Biomed Eng. 2017;1:644-653. doi: 10.1038/s41551-017-0117-6. Epub 2017 Aug 09.

On-demand relief of local pain would allow patients to control the timing, intensity and duration of nerve block in a safe and non-invasive manner. Ultrasound would be a suitable trigger for such a system, as it is in common...

Binding Protein-Dependent Uptake of Maltose into Cells via an ATP-Binding Cassette Transporter.

EcoSal Plus

Davidson AL, Alvarez FJ.
PMID: 26443785
EcoSal Plus. 2010 Sep;4(1). doi: 10.1128/ecosalplus.3.3.3.

Maltose and maltodextrins are actively transported across the cytoplasmic membrane of Escherichia coli and Salmonella by a periplasmic binding protein (BP)- dependent transport system. Since 1996, there have been many advances in the understanding of the structure and mechanism...

Anti-tumor effect of RGD modified PTX loaded liposome on prostatic cancer.

International journal of clinical and experimental medicine

Cao Y, Zhou Y, Zhuang Q, Cui L, Xu X, Xu R, He X.
PMID: 26550128
Int J Clin Exp Med. 2015 Aug 15;8(8):12182-91. eCollection 2015.

In this study, we report an active targeting liposomal formulation directed by a novel peptide (RGD) that specifically binds to the integrins receptors overexpressed on prostatic cancer cells. The objectives of this study were to evaluate the in vitro...

Lipid-based nano-delivery systems for skin delivery of drugs and bioactives.

Frontiers in pharmacology

Hua S.
PMID: 26483690
Front Pharmacol. 2015 Sep 30;6:219. doi: 10.3389/fphar.2015.00219. eCollection 2015.

No abstract available.

Drug Delivery via Cell Membrane Fusion Using Lipopeptide Modified Liposomes.

ACS central science

Yang J, Bahreman A, Daudey G, Bussmann J, Olsthoorn RC, Kros A.
PMID: 27725960
ACS Cent Sci. 2016 Sep 28;2(9):621-630. doi: 10.1021/acscentsci.6b00172. Epub 2016 Aug 22.

Efficient delivery of drugs to living cells is still a major challenge. Currently, most methods rely on the endocytotic pathway resulting in low delivery efficiency due to limited endosomal escape and/or degradation in lysosomes. Here, we report a new...

pH-Responsive Micelle-Based Cytoplasmic Delivery System for Induction of Cellular Immunity.

Vaccines

Yuba E, Sakaguchi N, Kanda Y, Miyazaki M, Koiwai K.
PMID: 29113042
Vaccines (Basel). 2017 Nov 04;5(4). doi: 10.3390/vaccines5040041.

(1) Background: Cytoplasmic delivery of antigens is crucial for the induction of cellular immunity, which is an important immune response for the treatment of cancer and infectious diseases. To date, fusogenic protein-incorporated liposomes and pH-responsive polymer-modified liposomes have been...

Translational nanoparticle engineering for cancer vaccines.

Oncoimmunology

Grippin AJ, Sayour EJ, Mitchell DA.
PMID: 29123947
Oncoimmunology. 2017 Feb 22;6(10):e1290036. doi: 10.1080/2162402X.2017.1290036. eCollection 2017.

Conventional cancer treatments remain insufficient to treat many therapy-resistant tumors.

Showing 13 to 24 of 3819 entries