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Showing 25 to 36 of 1448 entries
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Endovascular intracranial treatment of acute ischemic strokes.

The Journal of cardiovascular surgery

Rangel-Castilla L, Snyder KV, Siddiqui AH, Levy EI, Hopkins LN.
PMID: 26683822
J Cardiovasc Surg (Torino). 2015 Dec 18; Epub 2015 Dec 18.

Acute ischemic stroke (AIS) is the leading cause of long-term disability and the second cause of death worldwide. Intravenous (IV) tissue plasminogen activator (tPA) remains the only FDA-approved treatment for AIS. The use of IV tPA in AIS related...

A Rare Case of Acute Pulmonary Embolism after Coronary Angiography due to Sand Bag Compression.

The International journal of angiology : official publication of the International College of Angiology, Inc

Kivrak T, Durmus E, Atas H, Sunbul M, Sari I.
PMID: 24436623
Int J Angiol. 2013 Dec;22(4):255-8. doi: 10.1055/s-0033-1347933.

Pulmonary embolism (PE) is very rare after coronary angiography. We present here a case of acute PE after coronary angiography due to sand bag compression which has not been reported previously. After the femoral sheath removal, patient was immobilized...

Antithrombotic Effects of Five Organic Extracts of Bangladeshi Plants In Vitro and Mechanisms in In Silico Models.

Evidence-based complementary and alternative medicine : eCAM

Mahmud S, Akhter S, Rahman MA, Aklima J, Akhter S, Merry SR, Jubair SM, Dash R, Emran TB.
PMID: 26075001
Evid Based Complement Alternat Med. 2015;2015:782742. doi: 10.1155/2015/782742. Epub 2015 May 17.

This research was carried out to investigate the thrombolytic effects of the methanolic extracts of five Bangladeshi plants. Phytochemical metabolites of those plants have been identified to elucidate whether the plant-derived metabolites are linked with the thrombolytic effects. Potential...

Reperfusion therapy for acute stroke improves outcome by decreasing neuroinflammation.

Translational stroke research

Montaner J, Salat D, García-Berrocoso T, Molina CA, Chacón P, Ribó M, Alvarez-Sabín J, Rosell A.
PMID: 24323553
Transl Stroke Res. 2010 Dec;1(4):261-7. doi: 10.1007/s12975-010-0038-0. Epub 2010 Aug 28.

Inflammation is a major step in the ischemic cascade, and proinflammatory cytokines, adhesion molecules and chemokines have been related to brain injury after stroke. To investigate if tissue plasminogen activator (tPA) treatment decreases the deleterious neuroinflammatory response that follows...

Early and intermediate prognosis of intravenous thrombolytic therapy in acute ischemic stroke subtypes according to the causative classification of stroke system.

Pakistan journal of medical sciences

Pashapour A, Atalu A, Farhoudi M, Taheraghdam AA, Sadeghi Hokmabadi E, Sharifipour E, Najafineshli M.
PMID: 24353536
Pak J Med Sci. 2013 Jan;29(1):181-6. doi: 10.12669/pjms.291.2897.

OBJECTIVES: Intravenous thrombolytic therapy has established acceptable results in treating ischemic stroke. However, there is little information on treatment outcome especially in different subtypes. The aim of current study was to evaluate early and intermediate prognosis in intravenous thrombolytic...

Endovascular Therapy in Strokes with ASPECTS 5-7 May Result in Smaller Infarcts and Better Outcomes as Compared to Medical Treatment Alone.

Interventional neurology

Noorian AR, Rangaraju S, Sun CH, Owada K, Nahab F, Belagaje SR, Anderson AM, Frankel MR, Nogueira RG.
PMID: 26600794
Interv Neurol. 2015 Oct;4(1):30-7. doi: 10.1159/000438775. Epub 2015 Sep 18.

INTRODUCTION: Intra-arterial therapy (IAT) for large vessel occlusion strokes (LVOS) has been increasingly utilized. The benefit of IAT in patients with midrange Alberta Stroke Program Early Computed Tomography Score (ASPECTS) remains to be established.MATERIALS AND METHODS: This was a...

Imaging of experimental stroke models.

Translational stroke research

Fisher M, Bråtane BT.
PMID: 24323752
Transl Stroke Res. 2012 Mar;3(1):16-21. doi: 10.1007/s12975-011-0113-1. Epub 2011 Nov 15.

The ischemic penumbra is the target of acute stroke therapy. It can be approximated on diffusion/perfusion MRI as the ischemic region with abnormal perfusion and normal diffusion imaging. Using arterial spin labeling perfusion MRI and diffusion MRI, our group...

Cooperation between CD4+ T Cells and Humoral Immunity Is Critical for Protection against Dengue Using a DNA Vaccine Based on the NS1 Antigen.

PLoS neglected tropical diseases

Gonçalves AJ, Oliveira ER, Costa SM, Paes MV, Silva JF, Azevedo AS, Mantuano-Barradas M, Nogueira AC, Almeida CJ, Alves AM.
PMID: 26650916
PLoS Negl Trop Dis. 2015 Dec 09;9(12):e0004277. doi: 10.1371/journal.pntd.0004277. eCollection 2015 Dec.

Dengue virus (DENV) is spread through most tropical and subtropical areas of the world and represents a serious public health problem. At present, the control of dengue disease is mainly hampered by the absence of antivirals or a vaccine,...

Acute Intravenous Calcium Antagonist for Suspected Hemiplegic Migraine - A Case Story.

Case reports in neurology

Rath CL, He J, Nordling MM, Wienecke T.
PMID: 28559833
Case Rep Neurol. 2017 May 05;9(1):98-105. doi: 10.1159/000474934. eCollection 2017.

Stroke mimics, like attacks of hemiplegic migraine, are challenging in acute stroke evaluation. We present a 28-year-old woman with a suspected hemiplegic migraine attack with left-sided hemiparalysis. Brain CT with perfusion imaging 1 h 54 min after symptom onset...

Endovascular Stroke Therapy Focused on Stent Retriever Thrombectomy and Direct Clot Aspiration: Historical Review and Modern Application.

Journal of Korean Neurosurgical Society

Kang DH, Park J.
PMID: 28490161
J Korean Neurosurg Soc. 2017 May;60(3):335-347. doi: 10.3340/jkns.2016.0809.005. Epub 2017 May 01.

Intravenous recombinant tissue plasminogen activator had been the only approved treatment for acute ischemic stroke since its approval in 1995. However, the restrictive time window, numerous contraindications, and its low recanalization rate were all limitations of this modality. Under...

Development of Genetically Modified Chinese Hamster Ovary Host Cells for the Enhancement of Recombinant Tissue Plasminogen Activator Expression.

The Malaysian journal of medical sciences : MJMS

Rahimpour A, Ahani R, Najaei A, Adeli A, Barkhordari F, Mahboudi F.
PMID: 27547109
Malays J Med Sci. 2016 Mar;23(2):6-13.

BACKGROUND: Chinese hamster ovary (CHO) cells are the most commonly used host system for the expression of high quality recombinant proteins. However, the development of stable, high-yielding CHO cell lines is a major bottleneck in the industrial manufacturing of...

Middle Cerebral Artery Occlusion Model of Stroke in Rodents: A Step-by-Step Approach.

Journal of vascular and interventional neurology

Shahjouei S, Cai PY, Ansari S, Sharififar S, Azari H, Ganji S, Zand R.
PMID: 26958146
J Vasc Interv Neurol. 2016 Jan;8(5):1-8.

Stroke is one of the leading causes of morbidity and mortality in developed countries and an immense amount of medical care resources are devoted to combat the poststroke debilitating consequences. The key to develop effective and clinically applicable treatment...

Showing 25 to 36 of 1448 entries