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Relationship between coronary artery calcification and myocardial ischemia on computed tomography myocardial perfusion in patients with stable chest pain.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

El Mahdiui M, Smit JM, van Rosendael AR, Jukema JW, Bax JJ, Scholte AJHA.
PMID: 31529386
J Nucl Cardiol. 2021 Aug;28(4):1707-1714. doi: 10.1007/s12350-019-01869-8. Epub 2019 Sep 16.

BACKGROUND: Coronary artery calcium (CAC) score has shown to provide incremental prognostic information when added to the Framingham risk score. Although the relation between CAC and myocardial ischemia has been evaluated, there has been little evaluation of the relationship...

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El Mahdiui M, Smit JM, van Rosendael AR, et al. Relationship between coronary artery calcification and myocardial ischemia on computed tomography myocardial perfusion in patients with stable chest pain. J Nucl Cardiol. 2019;28(4):1707-1714doi: 10.1007/s12350-019-01869-8.
El Mahdiui, M., Smit, J. M., van Rosendael, A. R., Jukema, J. W., Bax, J. J., & Scholte, A. J. H. A. (2021). Relationship between coronary artery calcification and myocardial ischemia on computed tomography myocardial perfusion in patients with stable chest pain. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 28(4), 1707-1714. https://doi.org/10.1007/s12350-019-01869-8
El Mahdiui, Mohammed, et al. "Relationship between coronary artery calcification and myocardial ischemia on computed tomography myocardial perfusion in patients with stable chest pain." Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology vol. 28,4 (2021): 1707-1714. doi: https://doi.org/10.1007/s12350-019-01869-8
El Mahdiui M, Smit JM, van Rosendael AR, Jukema JW, Bax JJ, Scholte AJHA. Relationship between coronary artery calcification and myocardial ischemia on computed tomography myocardial perfusion in patients with stable chest pain. J Nucl Cardiol. 2021 Aug;28(4):1707-1714. doi: 10.1007/s12350-019-01869-8. Epub 2019 Sep 16. PMID: 31529386; PMCID: PMC8421270.
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Older adults' active involvement in an undergraduate program in gerontology: Motives and meaning.

Gerontology & geriatrics education

Sliepenbeek M, Smits C, Spelt EJ, Jukema JS.
PMID: 31543060
Gerontol Geriatr Educ. 2021 Oct-Dec;42(4):516-527. doi: 10.1080/02701960.2019.1669588. Epub 2019 Sep 23.

Two Dutch undergraduate programs in applied gerontology have teamed up with older volunteers to educate students in collaborating with older adults in the field of age-friendly service development. The research question of this study was: What are the motives...

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Sliepenbeek M, Smits C, Spelt EJ, et al. Older adults' active involvement in an undergraduate program in gerontology: Motives and meaning. Gerontol Geriatr Educ. 2019;42(4):516-527doi: 10.1080/02701960.2019.1669588.
Sliepenbeek, M., Smits, C., Spelt, E. J., & Jukema, J. S. (2021). Older adults' active involvement in an undergraduate program in gerontology: Motives and meaning. Gerontology & geriatrics education, 42(4), 516-527. https://doi.org/10.1080/02701960.2019.1669588
Sliepenbeek, Marjan, et al. "Older adults' active involvement in an undergraduate program in gerontology: Motives and meaning." Gerontology & geriatrics education vol. 42,4 (2021): 516-527. doi: https://doi.org/10.1080/02701960.2019.1669588
Sliepenbeek M, Smits C, Spelt EJ, Jukema JS. Older adults' active involvement in an undergraduate program in gerontology: Motives and meaning. Gerontol Geriatr Educ. 2021 Oct-Dec;42(4):516-527. doi: 10.1080/02701960.2019.1669588. Epub 2019 Sep 23. PMID: 31543060.
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Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.

Hypertension (Dallas, Tex. : 1979)

Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, O'Reilly PF, Cabrera CP, Warren HR, Rose LM, Verwoert GC, Hottenga JJ, Strawbridge RJ, Esko T, Arking DE, Hwang SJ, Guo X, Kutalik Z, Trompet S, Shrine N, Teumer A, Ried JS, Bis JC, Smith AV, Amin N, Nolte IM, Lyytikäinen LP, Mahajan A, Wareham NJ, Hofer E, Joshi PK, Kristiansson K, Traglia M, Havulinna AS, Goel A, Nalls MA, Sõber S, Vuckovic D, Luan J, Del Greco M F, Ayers KL, Marrugat J, Ruggiero D, Lopez LM, Niiranen T, Enroth S, Jackson AU, Nelson CP, Huffman JE, Zhang W, Marten J, Gandin I, Harris SE, Zemunik T, Lu Y, Evangelou E, Shah N, de Borst MH, Mangino M, Prins BP, Campbell A, Li-Gao R, Chauhan G, Oldmeadow C, Abecasis G, Abedi M, Barbieri CM, Barnes MR, Batini C, Beilby J, Blake T, Boehnke M, Bottinger EP, Braund PS, Brown M, Brumat M, Campbell H, Chambers JC, Cocca M, Collins F, Connell J, Cordell HJ, Damman JJ, Davies G, de Geus EJ, de Mutsert R, Deelen J, Demirkale Y, Doney ASF, Dörr M, Farrall M, Ferreira T, Frånberg M, Gao H, Giedraitis V, Gieger C, Giulianini F, Gow AJ, Hamsten A, Harris TB, Hofman A, Holliday EG, Hui J, Jarvelin MR, Johansson Å, Johnson AD, Jousilahti P, Jula A, Kähönen M, Kathiresan S, Khaw KT, Kolcic I, Koskinen S, Langenberg C, Larson M, Launer LJ, Lehne B, Liewald DCM, Lin L, Lind L, Mach F, Mamasoula C, Menni C, Mifsud B, Milaneschi Y, Morgan A, Morris AD, Morrison AC, Munson PJ, Nandakumar P, Nguyen QT, Nutile T, Oldehinkel AJ, Oostra BA, Org E, Padmanabhan S, Palotie A, Paré G, Pattie A, Penninx BWJH, Poulter N, Pramstaller PP, Raitakari OT, Ren M, Rice K, Ridker PM, Riese H, Ripatti S, Robino A, Rotter JI, Rudan I, Saba Y, Saint Pierre A, Sala CF, Sarin AP, Schmidt R, Scott R, Seelen MA, Shields DC, Siscovick D, Sorice R, Stanton A, Stott DJ, Sundström J, Swertz M, Taylor KD, Thom S, Tzoulaki I, Tzourio C, Uitterlinden AG, Völker U, Vollenweider P, Wild S, Willemsen G, Wright AF, Yao J, Thériault S, Conen D, Attia J, Sever P, Debette S, Mook-Kanamori DO, Zeggini E, Spector TD, van der Harst P, Palmer CNA, Vergnaud AC, Loos RJF, Polasek O, Starr JM, Girotto G, Hayward C, Kooner JS, Lindgren CM, Vitart V, Samani NJ, Tuomilehto J, Gyllensten U, Knekt P, Deary IJ, Ciullo M, Elosua R, Keavney BD, Hicks AA, Scott RA, Gasparini P, Laan M, Liu Y, Watkins H, Hartman CA, Salomaa V, Toniolo D, Perola M, Wilson JF, Schmidt H, Zhao JH, Lehtimäki T, van Duijn CM, Gudnason V, Psaty BM, Peters A, Rettig R, James A, Jukema JW, Strachan DP, Palmas W, Metspalu A, Ingelsson E, Boomsma DI, Franco OH, Bochud M, Newton-Cheh C, Munroe PB, Elliott P, Chasman DI, Chakravarti A, Knight J, Morris AP, Levy D, Tobin MD, Snieder H, Caulfield MJ, Ehret GB.
PMID: 28739976
Hypertension. 2017 Jul 24; doi: 10.1161/HYPERTENSIONAHA.117.09438. Epub 2017 Jul 24.

Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel...

Cite
Wain LV, Vaez A, Jansen R, et al. Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Hypertension. 2017;doi: 10.1161/HYPERTENSIONAHA.117.09438.
Wain, L. V., Vaez, A., Jansen, R., Joehanes, R., van der Most, P. J., Erzurumluoglu, A. M., O'Reilly, P. F., Cabrera, C. P., Warren, H. R., Rose, L. M., Verwoert, G. C., Hottenga, J. J., Strawbridge, R. J., Esko, T., Arking, D. E., Hwang, S. J., Guo, X., Kutalik, Z., Trompet, S., Shrine, N., Teumer, A., Ried, J. S., Bis, J. C., Smith, A. V., Amin, N., Nolte, I. M., Lyytikäinen, L. P., Mahajan, A., Wareham, N. J., Hofer, E., Joshi, P. K., Kristiansson, K., Traglia, M., Havulinna, A. S., Goel, A., Nalls, M. A., Sõber, S., Vuckovic, D., Luan, J., Del Greco M, F., Ayers, K. L., Marrugat, J., Ruggiero, D., Lopez, L. M., Niiranen, T., Enroth, S., Jackson, A. U., Nelson, C. P., Huffman, J. E., Zhang, W., Marten, J., Gandin, I., Harris, S. E., Zemunik, T., Lu, Y., Evangelou, E., Shah, N., de Borst, M. H., Mangino, M., Prins, B. P., Campbell, A., Li-Gao, R., Chauhan, G., Oldmeadow, C., Abecasis, G., Abedi, M., Barbieri, C. M., Barnes, M. R., Batini, C., Beilby, J., Blake, T., Boehnke, M., Bottinger, E. P., Braund, P. S., Brown, M., Brumat, M., Campbell, H., Chambers, J. C., Cocca, M., Collins, F., Connell, J., Cordell, H. J., Damman, J. J., Davies, G., de Geus, E. J., de Mutsert, R., Deelen, J., Demirkale, Y., Doney, A. S. F., Dörr, M., Farrall, M., Ferreira, T., Frånberg, M., Gao, H., Giedraitis, V., Gieger, C., Giulianini, F., Gow, A. J., Hamsten, A., Harris, T. B., Hofman, A., Holliday, E. G., Hui, J., Jarvelin, M. R., Johansson, �. �., Johnson, A. D., Jousilahti, P., Jula, A., Kähönen, M., Kathiresan, S., Khaw, K. T., Kolcic, I., Koskinen, S., Langenberg, C., Larson, M., Launer, L. J., Lehne, B., Liewald, D. C. M., Lin, L., Lind, L., Mach, F., Mamasoula, C., Menni, C., Mifsud, B., Milaneschi, Y., Morgan, A., Morris, A. D., Morrison, A. C., Munson, P. J., Nandakumar, P., Nguyen, Q. T., Nutile, T., Oldehinkel, A. J., Oostra, B. A., Org, E., Padmanabhan, S., Palotie, A., Paré, G., Pattie, A., Penninx, B. W. J. H., Poulter, N., Pramstaller, P. P., Raitakari, O. T., Ren, M., Rice, K., Ridker, P. M., Riese, H., Ripatti, S., Robino, A., Rotter, J. I., Rudan, I., Saba, Y., Saint Pierre, A., Sala, C. F., Sarin, A. P., Schmidt, R., Scott, R., Seelen, M. A., Shields, D. C., Siscovick, D., Sorice, R., Stanton, A., Stott, D. J., Sundström, J., Swertz, M., Taylor, K. D., Thom, S., Tzoulaki, I., Tzourio, C., Uitterlinden, A. G., Völker, U., Vollenweider, P., Wild, S., Willemsen, G., Wright, A. F., Yao, J., Thériault, S., Conen, D., Attia, J., Sever, P., Debette, S., Mook-Kanamori, D. O., Zeggini, E., Spector, T. D., van der Harst, P., Palmer, C. N. A., Vergnaud, A. C., Loos, R. J. F., Polasek, O., Starr, J. M., Girotto, G., Hayward, C., Kooner, J. S., Lindgren, C. M., Vitart, V., Samani, N. J., Tuomilehto, J., Gyllensten, U., Knekt, P., Deary, I. J., Ciullo, M., Elosua, R., Keavney, B. D., Hicks, A. A., Scott, R. A., Gasparini, P., Laan, M., Liu, Y., Watkins, H., Hartman, C. A., Salomaa, V., Toniolo, D., Perola, M., Wilson, J. F., Schmidt, H., Zhao, J. H., Lehtimäki, T., van Duijn, C. M., Gudnason, V., Psaty, B. M., Peters, A., Rettig, R., James, A., Jukema, J. W., Strachan, D. P., Palmas, W., Metspalu, A., Ingelsson, E., Boomsma, D. I., Franco, O. H., Bochud, M., Newton-Cheh, C., Munroe, P. B., Elliott, P., Chasman, D. I., Chakravarti, A., Knight, J., Morris, A. P., Levy, D., Tobin, M. D., Snieder, H., Caulfield, M. J., & Ehret, G. B. (2017). Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Hypertension (Dallas, Tex. : 1979), . https://doi.org/10.1161/HYPERTENSIONAHA.117.09438
Wain, Louise V, et al. "Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney." Hypertension (Dallas, Tex. : 1979) vol. (2017). doi: https://doi.org/10.1161/HYPERTENSIONAHA.117.09438
Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, O'Reilly PF, Cabrera CP, Warren HR, Rose LM, Verwoert GC, Hottenga JJ, Strawbridge RJ, Esko T, Arking DE, Hwang SJ, Guo X, Kutalik Z, Trompet S, Shrine N, Teumer A, Ried JS, Bis JC, Smith AV, Amin N, Nolte IM, Lyytikäinen LP, Mahajan A, Wareham NJ, Hofer E, Joshi PK, Kristiansson K, Traglia M, Havulinna AS, Goel A, Nalls MA, Sõber S, Vuckovic D, Luan J, Del Greco M F, Ayers KL, Marrugat J, Ruggiero D, Lopez LM, Niiranen T, Enroth S, Jackson AU, Nelson CP, Huffman JE, Zhang W, Marten J, Gandin I, Harris SE, Zemunik T, Lu Y, Evangelou E, Shah N, de Borst MH, Mangino M, Prins BP, Campbell A, Li-Gao R, Chauhan G, Oldmeadow C, Abecasis G, Abedi M, Barbieri CM, Barnes MR, Batini C, Beilby J, Blake T, Boehnke M, Bottinger EP, Braund PS, Brown M, Brumat M, Campbell H, Chambers JC, Cocca M, Collins F, Connell J, Cordell HJ, Damman JJ, Davies G, de Geus EJ, de Mutsert R, Deelen J, Demirkale Y, Doney ASF, Dörr M, Farrall M, Ferreira T, Frånberg M, Gao H, Giedraitis V, Gieger C, Giulianini F, Gow AJ, Hamsten A, Harris TB, Hofman A, Holliday EG, Hui J, Jarvelin MR, Johansson Å, Johnson AD, Jousilahti P, Jula A, Kähönen M, Kathiresan S, Khaw KT, Kolcic I, Koskinen S, Langenberg C, Larson M, Launer LJ, Lehne B, Liewald DCM, Lin L, Lind L, Mach F, Mamasoula C, Menni C, Mifsud B, Milaneschi Y, Morgan A, Morris AD, Morrison AC, Munson PJ, Nandakumar P, Nguyen QT, Nutile T, Oldehinkel AJ, Oostra BA, Org E, Padmanabhan S, Palotie A, Paré G, Pattie A, Penninx BWJH, Poulter N, Pramstaller PP, Raitakari OT, Ren M, Rice K, Ridker PM, Riese H, Ripatti S, Robino A, Rotter JI, Rudan I, Saba Y, Saint Pierre A, Sala CF, Sarin AP, Schmidt R, Scott R, Seelen MA, Shields DC, Siscovick D, Sorice R, Stanton A, Stott DJ, Sundström J, Swertz M, Taylor KD, Thom S, Tzoulaki I, Tzourio C, Uitterlinden AG, Völker U, Vollenweider P, Wild S, Willemsen G, Wright AF, Yao J, Thériault S, Conen D, Attia J, Sever P, Debette S, Mook-Kanamori DO, Zeggini E, Spector TD, van der Harst P, Palmer CNA, Vergnaud AC, Loos RJF, Polasek O, Starr JM, Girotto G, Hayward C, Kooner JS, Lindgren CM, Vitart V, Samani NJ, Tuomilehto J, Gyllensten U, Knekt P, Deary IJ, Ciullo M, Elosua R, Keavney BD, Hicks AA, Scott RA, Gasparini P, Laan M, Liu Y, Watkins H, Hartman CA, Salomaa V, Toniolo D, Perola M, Wilson JF, Schmidt H, Zhao JH, Lehtimäki T, van Duijn CM, Gudnason V, Psaty BM, Peters A, Rettig R, James A, Jukema JW, Strachan DP, Palmas W, Metspalu A, Ingelsson E, Boomsma DI, Franco OH, Bochud M, Newton-Cheh C, Munroe PB, Elliott P, Chasman DI, Chakravarti A, Knight J, Morris AP, Levy D, Tobin MD, Snieder H, Caulfield MJ, Ehret GB. Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Hypertension. 2017 Jul 24; doi: 10.1161/HYPERTENSIONAHA.117.09438. Epub 2017 Jul 24. PMID: 28739976; PMCID: PMC5783787.
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Appropriate use criteria for optical coherence tomography guidance in percutaneous coronary interventions : Recommendations of the working group of interventional cardiology of the Netherlands Society of Cardiology.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

IJsselmuiden AJJ, Zwaan EM, Oemrawsingh RM, Bom MJ, Dankers FJWM, de Boer MJ, Camaro C, van Geuns RJM, Daemen J, van der Heijden DJ, Jukema JW, Kraaijeveld AO, Meuwissen M, Schölzel BE, Pundziute G, van der Harst P, van Ramshorst J, Dirksen MT, Zivelonghi C, Agostoni P, van der Heyden JAS, Wykrzykowska JJ, Scholte MJ, Nef HM, Kofflard MJM, van Royen N, Alings M, Kedhi E.
PMID: 30171434
Neth Heart J. 2018 Oct;26(10):473-483. doi: 10.1007/s12471-018-1143-z.

INTRODUCTION: Optical coherence tomography (OCT) enables detailed imaging of the coronary wall, lumen and intracoronary implanted devices. Responding to the lack of specific appropriate use criteria (AUC) for this technique, we conducted a literature review and a procedure for...

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IJsselmuiden AJJ, Zwaan EM, Oemrawsingh RM, et al. Appropriate use criteria for optical coherence tomography guidance in percutaneous coronary interventions : Recommendations of the working group of interventional cardiology of the Netherlands Society of Cardiology. Neth Heart J. 2018;26(10):473-483doi: 10.1007/s12471-018-1143-z.
IJsselmuiden, A. J. J., Zwaan, E. M., Oemrawsingh, R. M., Bom, M. J., Dankers, F. J. W. M., de Boer, M. J., Camaro, C., van Geuns, R. J. M., Daemen, J., van der Heijden, D. J., Jukema, J. W., Kraaijeveld, A. O., Meuwissen, M., Schölzel, B. E., Pundziute, G., van der Harst, P., van Ramshorst, J., Dirksen, M. T., Zivelonghi, C., Agostoni, P., van der Heyden, J. A. S., Wykrzykowska, J. J., Scholte, M. J., Nef, H. M., Kofflard, M. J. M., van Royen, N., Alings, M., & Kedhi, E. (2018). Appropriate use criteria for optical coherence tomography guidance in percutaneous coronary interventions : Recommendations of the working group of interventional cardiology of the Netherlands Society of Cardiology. Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 26(10), 473-483. https://doi.org/10.1007/s12471-018-1143-z
IJsselmuiden, A J J, et al. "Appropriate use criteria for optical coherence tomography guidance in percutaneous coronary interventions : Recommendations of the working group of interventional cardiology of the Netherlands Society of Cardiology." Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation vol. 26,10 (2018): 473-483. doi: https://doi.org/10.1007/s12471-018-1143-z
IJsselmuiden AJJ, Zwaan EM, Oemrawsingh RM, Bom MJ, Dankers FJWM, de Boer MJ, Camaro C, van Geuns RJM, Daemen J, van der Heijden DJ, Jukema JW, Kraaijeveld AO, Meuwissen M, Schölzel BE, Pundziute G, van der Harst P, van Ramshorst J, Dirksen MT, Zivelonghi C, Agostoni P, van der Heyden JAS, Wykrzykowska JJ, Scholte MJ, Nef HM, Kofflard MJM, van Royen N, Alings M, Kedhi E. Appropriate use criteria for optical coherence tomography guidance in percutaneous coronary interventions : Recommendations of the working group of interventional cardiology of the Netherlands Society of Cardiology. Neth Heart J. 2018 Oct;26(10):473-483. doi: 10.1007/s12471-018-1143-z. PMID: 30171434; PMCID: PMC6150879.
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Metabolomic Consequences of Genetic Inhibition of PCSK9 Compared With Statin Treatment.

Circulation

Sliz E, Kettunen J, Holmes MV, Williams CO, Boachie C, Wang Q, Männikkö M, Sebert S, Walters R, Lin K, Millwood LY, Clarke R, Li L, Rankin N, Welsh P, Delles C, Jukema JW, Trompet S, Ford I, Perola M, Salomaa V, Järvelin MR, Chen Z, Lawlor DA, Ala-Korpela M, Danesh J, Smith GD, Sattar N, Butterworth A, Würtz P.
PMID: 30525347
Circulation. 2018 Nov 27;138(22):2499–2512. doi: 10.1161/CIRCULATIONAHA.118.034942.

BACKGROUND: Both statins and proprotein convertase subtilisin/ kexin type 9 (PCSK9) inhibitors lower blood low-density lipoprotein cholesterol levels to reduce risk of cardiovascular events. To assess potential differences between metabolic effects of these 2 lipid-lowering therapies, we performed detailed...

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Sliz E, Kettunen J, Holmes MV, et al. Metabolomic Consequences of Genetic Inhibition of PCSK9 Compared With Statin Treatment. Circulation. 2018;138(22):2499–2512doi: 10.1161/CIRCULATIONAHA.118.034942.
Sliz, E., Kettunen, J., Holmes, M. V., Williams, C. O., Boachie, C., Wang, Q., Männikkö, M., Sebert, S., Walters, R., Lin, K., Millwood, L. Y., Clarke, R., Li, L., Rankin, N., Welsh, P., Delles, C., Jukema, J. W., Trompet, S., Ford, I., Perola, M., Salomaa, V., Järvelin, M. R., Chen, Z., Lawlor, D. A., Ala-Korpela, M., Danesh, J., Smith, G. D., Sattar, N., Butterworth, A., & Würtz, P. (2018). Metabolomic Consequences of Genetic Inhibition of PCSK9 Compared With Statin Treatment. Circulation, 138(22), 2499–2512. https://doi.org/10.1161/CIRCULATIONAHA.118.034942
Sliz, Eeva, et al. "Metabolomic Consequences of Genetic Inhibition of PCSK9 Compared With Statin Treatment." Circulation vol. 138,22 (2018): 2499–2512. doi: https://doi.org/10.1161/CIRCULATIONAHA.118.034942
Sliz E, Kettunen J, Holmes MV, Williams CO, Boachie C, Wang Q, Männikkö M, Sebert S, Walters R, Lin K, Millwood LY, Clarke R, Li L, Rankin N, Welsh P, Delles C, Jukema JW, Trompet S, Ford I, Perola M, Salomaa V, Järvelin MR, Chen Z, Lawlor DA, Ala-Korpela M, Danesh J, Smith GD, Sattar N, Butterworth A, Würtz P. Metabolomic Consequences of Genetic Inhibition of PCSK9 Compared With Statin Treatment. Circulation. 2018 Nov 27;138(22):2499–2512. doi: 10.1161/CIRCULATIONAHA.118.034942. PMID: 30525347; PMCID: PMC6254781.
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EU-Wide Cross-Sectional Observational Study of Lipid-Modifying Therapy Use in Secondary and Primary Care: the DA VINCI study.

European journal of preventive cardiology

Ray KK, Molemans B, Schoonen WM, Giovas P, Bray S, Kiru G, Murphy J, Banach M, De Servi S, Gaita D, Gouni-Berthold I, Hovingh GK, Jozwiak JJ, Jukema JW, Kiss RG, Kownator S, Iversen HK, Maher V, Masana L, Parkhomenko A, Peeters A, Clifford P, Raslova K, Siostrzonek P, Romeo S, Tousoulis D, Vlachopoulos C, Vrablik M, Catapano AL, Poulter NR.
PMID: 33580789
Eur J Prev Cardiol. 2021 Sep 20;28(11):1279-1289. doi: 10.1093/eurjpc/zwaa047.

AIMS: To provide contemporary data on the implementation of European guideline recommendations for lipid-lowering therapies (LLTs) across different settings and populations and how this impacts low-density lipoprotein cholesterol (LDL-C) goal achievement.METHODS AND RESULTS: An 18 country, cross-sectional, observational study...

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Ray KK, Molemans B, Schoonen WM, et al. EU-Wide Cross-Sectional Observational Study of Lipid-Modifying Therapy Use in Secondary and Primary Care: the DA VINCI study. Eur J Prev Cardiol. 2021;28(11):1279-1289doi: 10.1093/eurjpc/zwaa047.
Ray, K. K., Molemans, B., Schoonen, W. M., Giovas, P., Bray, S., Kiru, G., Murphy, J., Banach, M., De Servi, S., Gaita, D., Gouni-Berthold, I., Hovingh, G. K., Jozwiak, J. J., Jukema, J. W., Kiss, R. G., Kownator, S., Iversen, H. K., Maher, V., Masana, L., Parkhomenko, A., Peeters, A., Clifford, P., Raslova, K., Siostrzonek, P., Romeo, S., Tousoulis, D., Vlachopoulos, C., Vrablik, M., Catapano, A. L., Poulter, N. R. (2021). EU-Wide Cross-Sectional Observational Study of Lipid-Modifying Therapy Use in Secondary and Primary Care: the DA VINCI study. European journal of preventive cardiology, 28(11), 1279-1289. https://doi.org/10.1093/eurjpc/zwaa047
Ray, Kausik K, et al. "EU-Wide Cross-Sectional Observational Study of Lipid-Modifying Therapy Use in Secondary and Primary Care: the DA VINCI study." European journal of preventive cardiology vol. 28,11 (2021): 1279-1289. doi: https://doi.org/10.1093/eurjpc/zwaa047
Ray KK, Molemans B, Schoonen WM, Giovas P, Bray S, Kiru G, Murphy J, Banach M, De Servi S, Gaita D, Gouni-Berthold I, Hovingh GK, Jozwiak JJ, Jukema JW, Kiss RG, Kownator S, Iversen HK, Maher V, Masana L, Parkhomenko A, Peeters A, Clifford P, Raslova K, Siostrzonek P, Romeo S, Tousoulis D, Vlachopoulos C, Vrablik M, Catapano AL, Poulter NR. EU-Wide Cross-Sectional Observational Study of Lipid-Modifying Therapy Use in Secondary and Primary Care: the DA VINCI study. Eur J Prev Cardiol. 2021 Sep 20;28(11):1279-1289. doi: 10.1093/eurjpc/zwaa047. PMID: 33580789.
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The genomics of heart failure: design and rationale of the HERMES consortium.

ESC heart failure

Lumbers RT, Shah S, Lin H, Czuba T, Henry A, Swerdlow DI, Mälarstig A, Andersson C, Verweij N, Holmes MV, Ärnlöv J, Svensson P, Hemingway H, Sallah N, Almgren P, Aragam KG, Asselin G, Backman JD, Biggs ML, Bloom HL, Boersma E, Brandimarto J, Brown MR, Brunner-La Rocca HP, Carey DJ, Chaffin MD, Chasman DI, Chazara O, Chen X, Chen X, Chung JH, Chutkow W, Cleland JGF, Cook JP, de Denus S, Dehghan A, Delgado GE, Denaxas S, Doney AS, Dörr M, Dudley SC, Engström G, Esko T, Fatemifar G, Felix SB, Finan C, Ford I, Fougerousse F, Fouodjio R, Ghanbari M, Ghasemi S, Giedraitis V, Giulianini F, Gottdiener JS, Gross S, Guðbjartsson DF, Gui H, Gutmann R, Haggerty CM, van der Harst P, Hedman ÅK, Helgadottir A, Hillege H, Hyde CL, Jacob J, Jukema JW, Kamanu F, Kardys I, Kavousi M, Khaw KT, Kleber ME, Køber L, Koekemoer A, Kraus B, Kuchenbaecker K, Langenberg C, Lind L, Lindgren CM, London B, Lotta LA, Lovering RC, Luan J, Magnusson P, Mahajan A, Mann D, Margulies KB, Marston NA, März W, McMurray JJV, Melander O, Melloni G, Mordi IR, Morley MP, Morris AD, Morris AP, Morrison AC, Nagle MW, Nelson CP, Newton-Cheh C, Niessner A, Niiranen T, Nowak C, O'Donoghue ML, Owens AT, Palmer CNA, Paré G, Perola M, Perreault LL, Portilla-Fernandez E, Psaty BM, Rice KM, Ridker PM, Romaine SPR, Roselli C, Rotter JI, Ruff CT, Sabatine MS, Salo P, Salomaa V, van Setten J, Shalaby AA, Smelser DT, Smith NL, Stefansson K, Stender S, Stott DJ, Sveinbjörnsson G, Tammesoo ML, Tardif JC, Taylor KD, Teder-Laving M, Teumer A, Thorgeirsson G, Thorsteinsdottir U, Torp-Pedersen C, Trompet S, Tuckwell D, Tyl B, Uitterlinden AG, Vaura F, Veluchamy A, Visscher PM, Völker U, Voors AA, Wang X, Wareham NJ, Weeke PE, Weiss R, White HD, Wiggins KL, Xing H, Yang J, Yang Y, Yerges-Armstrong LM, Yu B, Zannad F, Zhao F, Wilk JB, Holm H, Sattar N, Lubitz SA, Lanfear DE, Shah S, Dunn ME, Wells QS, Asselbergs FW, Hingorani AD, Dubé MP, Samani NJ, Lang CC, Cappola TP, Ellinor PT, Vasan RS, Smith JG.
PMID: 34480422
ESC Heart Fail. 2021 Sep 03; doi: 10.1002/ehf2.13517. Epub 2021 Sep 03.

AIMS: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure.METHODS AND RESULTS: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases...

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Lumbers RT, Shah S, Lin H, et al. The genomics of heart failure: design and rationale of the HERMES consortium. ESC Heart Fail. 2021;doi: 10.1002/ehf2.13517.
Lumbers, R. T., Shah, S., Lin, H., Czuba, T., Henry, A., Swerdlow, D. I., Mälarstig, A., Andersson, C., Verweij, N., Holmes, M. V., Ärnlöv, J., Svensson, P., Hemingway, H., Sallah, N., Almgren, P., Aragam, K. G., Asselin, G., Backman, J. D., Biggs, M. L., Bloom, H. L., Boersma, E., Brandimarto, J., Brown, M. R., Brunner-La Rocca, H. P., Carey, D. J., Chaffin, M. D., Chasman, D. I., Chazara, O., Chen, X., Chen, X., Chung, J. H., Chutkow, W., Cleland, J. G. F., Cook, J. P., de Denus, S., Dehghan, A., Delgado, G. E., Denaxas, S., Doney, A. S., Dörr, M., Dudley, S. C., Engström, G., Esko, T., Fatemifar, G., Felix, S. B., Finan, C., Ford, I., Fougerousse, F., Fouodjio, R., Ghanbari, M., Ghasemi, S., Giedraitis, V., Giulianini, F., Gottdiener, J. S., Gross, S., Guðbjartsson, D. F., Gui, H., Gutmann, R., Haggerty, C. M., van der Harst, P., Hedman, �. �. K., Helgadottir, A., Hillege, H., Hyde, C. L., Jacob, J., Jukema, J. W., Kamanu, F., Kardys, I., Kavousi, M., Khaw, K. T., Kleber, M. E., Køber, L., Koekemoer, A., Kraus, B., Kuchenbaecker, K., Langenberg, C., Lind, L., Lindgren, C. M., London, B., Lotta, L. A., Lovering, R. C., Luan, J., Magnusson, P., Mahajan, A., Mann, D., Margulies, K. B., Marston, N. A., März, W., McMurray, J. J. V., Melander, O., Melloni, G., Mordi, I. R., Morley, M. P., Morris, A. D., Morris, A. P., Morrison, A. C., Nagle, M. W., Nelson, C. P., Newton-Cheh, C., Niessner, A., Niiranen, T., Nowak, C., O'Donoghue, M. L., Owens, A. T., Palmer, C. N. A., Paré, G., Perola, M., Perreault, L. L., Portilla-Fernandez, E., Psaty, B. M., Rice, K. M., Ridker, P. M., Romaine, S. P. R., Roselli, C., Rotter, J. I., Ruff, C. T., Sabatine, M. S., Salo, P., Salomaa, V., van Setten, J., Shalaby, A. A., Smelser, D. T., Smith, N. L., Stefansson, K., Stender, S., Stott, D. J., Sveinbjörnsson, G., Tammesoo, M. L., Tardif, J. C., Taylor, K. D., Teder-Laving, M., Teumer, A., Thorgeirsson, G., Thorsteinsdottir, U., Torp-Pedersen, C., Trompet, S., Tuckwell, D., Tyl, B., Uitterlinden, A. G., Vaura, F., Veluchamy, A., Visscher, P. M., Völker, U., Voors, A. A., Wang, X., Wareham, N. J., Weeke, P. E., Weiss, R., White, H. D., Wiggins, K. L., Xing, H., Yang, J., Yang, Y., Yerges-Armstrong, L. M., Yu, B., Zannad, F., Zhao, F., Wilk, J. B., Holm, H., Sattar, N., Lubitz, S. A., Lanfear, D. E., Shah, S., Dunn, M. E., Wells, Q. S., Asselbergs, F. W., Hingorani, A. D., Dubé, M. P., Samani, N. J., Lang, C. C., Cappola, T. P., Ellinor, P. T., Vasan, R. S., & Smith, J. G. (2021). The genomics of heart failure: design and rationale of the HERMES consortium. ESC heart failure, . https://doi.org/10.1002/ehf2.13517
Lumbers, R Thomas, et al. "The genomics of heart failure: design and rationale of the HERMES consortium." ESC heart failure vol. (2021). doi: https://doi.org/10.1002/ehf2.13517
Lumbers RT, Shah S, Lin H, Czuba T, Henry A, Swerdlow DI, Mälarstig A, Andersson C, Verweij N, Holmes MV, Ärnlöv J, Svensson P, Hemingway H, Sallah N, Almgren P, Aragam KG, Asselin G, Backman JD, Biggs ML, Bloom HL, Boersma E, Brandimarto J, Brown MR, Brunner-La Rocca HP, Carey DJ, Chaffin MD, Chasman DI, Chazara O, Chen X, Chen X, Chung JH, Chutkow W, Cleland JGF, Cook JP, de Denus S, Dehghan A, Delgado GE, Denaxas S, Doney AS, Dörr M, Dudley SC, Engström G, Esko T, Fatemifar G, Felix SB, Finan C, Ford I, Fougerousse F, Fouodjio R, Ghanbari M, Ghasemi S, Giedraitis V, Giulianini F, Gottdiener JS, Gross S, Guðbjartsson DF, Gui H, Gutmann R, Haggerty CM, van der Harst P, Hedman ÅK, Helgadottir A, Hillege H, Hyde CL, Jacob J, Jukema JW, Kamanu F, Kardys I, Kavousi M, Khaw KT, Kleber ME, Køber L, Koekemoer A, Kraus B, Kuchenbaecker K, Langenberg C, Lind L, Lindgren CM, London B, Lotta LA, Lovering RC, Luan J, Magnusson P, Mahajan A, Mann D, Margulies KB, Marston NA, März W, McMurray JJV, Melander O, Melloni G, Mordi IR, Morley MP, Morris AD, Morris AP, Morrison AC, Nagle MW, Nelson CP, Newton-Cheh C, Niessner A, Niiranen T, Nowak C, O'Donoghue ML, Owens AT, Palmer CNA, Paré G, Perola M, Perreault LL, Portilla-Fernandez E, Psaty BM, Rice KM, Ridker PM, Romaine SPR, Roselli C, Rotter JI, Ruff CT, Sabatine MS, Salo P, Salomaa V, van Setten J, Shalaby AA, Smelser DT, Smith NL, Stefansson K, Stender S, Stott DJ, Sveinbjörnsson G, Tammesoo ML, Tardif JC, Taylor KD, Teder-Laving M, Teumer A, Thorgeirsson G, Thorsteinsdottir U, Torp-Pedersen C, Trompet S, Tuckwell D, Tyl B, Uitterlinden AG, Vaura F, Veluchamy A, Visscher PM, Völker U, Voors AA, Wang X, Wareham NJ, Weeke PE, Weiss R, White HD, Wiggins KL, Xing H, Yang J, Yang Y, Yerges-Armstrong LM, Yu B, Zannad F, Zhao F, Wilk JB, Holm H, Sattar N, Lubitz SA, Lanfear DE, Shah S, Dunn ME, Wells QS, Asselbergs FW, Hingorani AD, Dubé MP, Samani NJ, Lang CC, Cappola TP, Ellinor PT, Vasan RS, Smith JG. The genomics of heart failure: design and rationale of the HERMES consortium. ESC Heart Fail. 2021 Sep 03; doi: 10.1002/ehf2.13517. Epub 2021 Sep 03. PMID: 34480422.
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Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multiethnic Population and Causal Associations With Atrial Fibrillation.

Circulation. Genomic and precision medicine

Yang Y, Bartz TM, Brown MR, Guo X, Zilhao NR, Trompet S, Weiss S, Yao J, Brody JA, Defilippi CR, Hoogeveen RC, Lin HJ, Gudnason V, Ballantyne CM, Dorr M, Jukema JW, Petersmann A, Psaty BM, Rotter JI, Boerwinkle E, Fornage M, Jun G, Yu B, Toprak M.
PMID: 34732054
Circ Genom Precis Med. 2021 Nov 04;CIRCGEN121003460. doi: 10.1161/CIRCGEN.121.003460. Epub 2021 Nov 04.

BACKGROUND: Elevated cardiac troponin levels in blood are associated with increased risk of cardiovascular diseases and mortality. Cardiac troponin levels are heritable, but their genetic architecture remains elusive.METHODS: We conducted a transethnic genome-wide association analysis on high-sensitivity cTnT (cardiac...

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Yang Y, Bartz TM, Brown MR, et al. Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multiethnic Population and Causal Associations With Atrial Fibrillation. Circ Genom Precis Med. 2021;CIRCGEN121003460doi: 10.1161/CIRCGEN.121.003460.
Yang, Y., Bartz, T. M., Brown, M. R., Guo, X., Zilhao, N. R., Trompet, S., Weiss, S., Yao, J., Brody, J. A., Defilippi, C. R., Hoogeveen, R. C., Lin, H. J., Gudnason, V., Ballantyne, C. M., Dorr, M., Jukema, J. W., Petersmann, A., Psaty, B. M., Rotter, J. I., Boerwinkle, E., Fornage, M., Jun, G., Yu, B., & Toprak, M. (2021). Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multiethnic Population and Causal Associations With Atrial Fibrillation. Circulation. Genomic and precision medicine, CIRCGEN121003460. https://doi.org/10.1161/CIRCGEN.121.003460
Yang, Yunju, et al. "Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multiethnic Population and Causal Associations With Atrial Fibrillation." Circulation. Genomic and precision medicine vol. (2021): CIRCGEN121003460. doi: https://doi.org/10.1161/CIRCGEN.121.003460
Yang Y, Bartz TM, Brown MR, Guo X, Zilhao NR, Trompet S, Weiss S, Yao J, Brody JA, Defilippi CR, Hoogeveen RC, Lin HJ, Gudnason V, Ballantyne CM, Dorr M, Jukema JW, Petersmann A, Psaty BM, Rotter JI, Boerwinkle E, Fornage M, Jun G, Yu B, Toprak M. Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multiethnic Population and Causal Associations With Atrial Fibrillation. Circ Genom Precis Med. 2021 Nov 04;CIRCGEN121003460. doi: 10.1161/CIRCGEN.121.003460. Epub 2021 Nov 04. PMID: 34732054.
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Association of cognitive function with increased risk of cancer death and all-cause mortality: Longitudinal analysis, systematic review, and meta-analysis of prospective observational studies.

PloS one

Rostamian S, le Cessie S, Marijt KA, Jukema JW, Mooijaart SP, van Buchem MA, van Hall T, Gussekloo J, Trompet S.
PMID: 34995287
PLoS One. 2022 Jan 07;17(1):e0261826. doi: 10.1371/journal.pone.0261826. eCollection 2022.

BACKGROUND: Disturbed cognitive function is associated with several causes of mortality; however, the association between cognitive function and the risk of cancer death has not been extensively investigated yet. We aimed to evaluate the association of cognitive function with...

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Rostamian S, le Cessie S, Marijt KA, et al. Association of cognitive function with increased risk of cancer death and all-cause mortality: Longitudinal analysis, systematic review, and meta-analysis of prospective observational studies. PLoS One. 2022;17(1):e0261826doi: 10.1371/journal.pone.0261826.
Rostamian, S., le Cessie, S., Marijt, K. A., Jukema, J. W., Mooijaart, S. P., van Buchem, M. A., van Hall, T., Gussekloo, J., & Trompet, S. (2022). Association of cognitive function with increased risk of cancer death and all-cause mortality: Longitudinal analysis, systematic review, and meta-analysis of prospective observational studies. PloS one, 17(1), e0261826. https://doi.org/10.1371/journal.pone.0261826
Rostamian, Somayeh, et al. "Association of cognitive function with increased risk of cancer death and all-cause mortality: Longitudinal analysis, systematic review, and meta-analysis of prospective observational studies." PloS one vol. 17,1 (2022): e0261826. doi: https://doi.org/10.1371/journal.pone.0261826
Rostamian S, le Cessie S, Marijt KA, Jukema JW, Mooijaart SP, van Buchem MA, van Hall T, Gussekloo J, Trompet S. Association of cognitive function with increased risk of cancer death and all-cause mortality: Longitudinal analysis, systematic review, and meta-analysis of prospective observational studies. PLoS One. 2022 Jan 07;17(1):e0261826. doi: 10.1371/journal.pone.0261826. eCollection 2022. PMID: 34995287; PMCID: PMC8741047.
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Role of Adenylate Cyclase 9 in the Pharmacogenomic Response to Dalcetrapib: Clinical Paradigm and Molecular Mechanisms in Precision Cardiovascular Medicine.

Circulation. Genomic and precision medicine

Rhainds D, Packard CJ, Brodeur MR, Niesor EJ, Sacks FM, Jukema JW, Wright RS, Waters DD, Heinonen T, Black DM, Laghrissi-Thode F, Dubé MP, Pfeffer MA, Tardif JC.
PMID: 33794646
Circ Genom Precis Med. 2021 Apr;14(2):e003219. doi: 10.1161/CIRCGEN.121.003219. Epub 2021 Apr 02.

Following the neutral results of the dal-OUTCOMES trial, a genome-wide study identified the rs1967309 variant in the adenylate cyclase type 9 (

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Rhainds D, Packard CJ, Brodeur MR, et al. Role of Adenylate Cyclase 9 in the Pharmacogenomic Response to Dalcetrapib: Clinical Paradigm and Molecular Mechanisms in Precision Cardiovascular Medicine. Circ Genom Precis Med. 2021;14(2):e003219doi: 10.1161/CIRCGEN.121.003219.
Rhainds, D., Packard, C. J., Brodeur, M. R., Niesor, E. J., Sacks, F. M., Jukema, J. W., Wright, R. S., Waters, D. D., Heinonen, T., Black, D. M., Laghrissi-Thode, F., Dubé, M. P., Pfeffer, M. A., & Tardif, J. C. (2021). Role of Adenylate Cyclase 9 in the Pharmacogenomic Response to Dalcetrapib: Clinical Paradigm and Molecular Mechanisms in Precision Cardiovascular Medicine. Circulation. Genomic and precision medicine, 14(2), e003219. https://doi.org/10.1161/CIRCGEN.121.003219
Rhainds, David, et al. "Role of Adenylate Cyclase 9 in the Pharmacogenomic Response to Dalcetrapib: Clinical Paradigm and Molecular Mechanisms in Precision Cardiovascular Medicine." Circulation. Genomic and precision medicine vol. 14,2 (2021): e003219. doi: https://doi.org/10.1161/CIRCGEN.121.003219
Rhainds D, Packard CJ, Brodeur MR, Niesor EJ, Sacks FM, Jukema JW, Wright RS, Waters DD, Heinonen T, Black DM, Laghrissi-Thode F, Dubé MP, Pfeffer MA, Tardif JC. Role of Adenylate Cyclase 9 in the Pharmacogenomic Response to Dalcetrapib: Clinical Paradigm and Molecular Mechanisms in Precision Cardiovascular Medicine. Circ Genom Precis Med. 2021 Apr;14(2):e003219. doi: 10.1161/CIRCGEN.121.003219. Epub 2021 Apr 02. PMID: 33794646; PMCID: PMC8284386.
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Cold-Inducible RNA-Binding Protein but Not Its Antisense lncRNA Is a Direct Negative Regulator of Angiogenesis In Vitro and In Vivo via Regulation of the 14q32 angiomiRs-microRNA-329-3p and microRNA-495-3p.

International journal of molecular sciences

Goossens EAC, Zhang L, de Vries MR, Jukema JW, Quax PHA, Nossent AY.
PMID: 34884485
Int J Mol Sci. 2021 Nov 24;22(23). doi: 10.3390/ijms222312678.

Inhibition of the 14q32 microRNAs, miR-329-3p and miR-495-3p, improves post-ischemic neovascularization. Cold-inducible RNA-binding protein (

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Goossens EAC, Zhang L, de Vries MR, et al. Cold-Inducible RNA-Binding Protein but Not Its Antisense lncRNA Is a Direct Negative Regulator of Angiogenesis In Vitro and In Vivo via Regulation of the 14q32 angiomiRs-microRNA-329-3p and microRNA-495-3p. Int J Mol Sci. 2021;22(23)doi: 10.3390/ijms222312678.
Goossens, E. A. C., Zhang, L., de Vries, M. R., Jukema, J. W., Quax, P. H. A., & Nossent, A. Y. (2021). Cold-Inducible RNA-Binding Protein but Not Its Antisense lncRNA Is a Direct Negative Regulator of Angiogenesis In Vitro and In Vivo via Regulation of the 14q32 angiomiRs-microRNA-329-3p and microRNA-495-3p. International journal of molecular sciences, 22(23), . https://doi.org/10.3390/ijms222312678
Goossens, Eveline A C, et al. "Cold-Inducible RNA-Binding Protein but Not Its Antisense lncRNA Is a Direct Negative Regulator of Angiogenesis In Vitro and In Vivo via Regulation of the 14q32 angiomiRs-microRNA-329-3p and microRNA-495-3p." International journal of molecular sciences vol. 22,23 (2021). doi: https://doi.org/10.3390/ijms222312678
Goossens EAC, Zhang L, de Vries MR, Jukema JW, Quax PHA, Nossent AY. Cold-Inducible RNA-Binding Protein but Not Its Antisense lncRNA Is a Direct Negative Regulator of Angiogenesis In Vitro and In Vivo via Regulation of the 14q32 angiomiRs-microRNA-329-3p and microRNA-495-3p. Int J Mol Sci. 2021 Nov 24;22(23). doi: 10.3390/ijms222312678. PMID: 34884485.
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Levothyroxine Treatment and Cardiovascular Outcomes in Older People With Subclinical Hypothyroidism: Pooled Individual Results of Two Randomised Controlled Trials.

Frontiers in endocrinology

Zijlstra LE, Jukema JW, Westendorp RGJ, Du Puy RS, Poortvliet RKE, Kearney PM, O'Keeffe L, Dekkers OM, Blum MR, Rodondi N, Collet TH, Quinn TJ, Sattar N, Stott DJ, Trompet S, den Elzen WPJ, Gussekloo J, Mooijaart SP.
PMID: 34093444
Front Endocrinol (Lausanne). 2021 May 20;12:674841. doi: 10.3389/fendo.2021.674841. eCollection 2021.

BACKGROUND: The cardiovascular effects of treating older adults with subclinical hypothyroidism (SCH) are uncertain. Although concerns have been raised regarding a potential increase in cardiovascular side effects from thyroid hormone replacement, undertreatment may also increase the risk of cardiovascular...

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Zijlstra LE, Jukema JW, Westendorp RGJ, et al. Levothyroxine Treatment and Cardiovascular Outcomes in Older People With Subclinical Hypothyroidism: Pooled Individual Results of Two Randomised Controlled Trials. Front Endocrinol (Lausanne). 2021;12:674841doi: 10.3389/fendo.2021.674841.
Zijlstra, L. E., Jukema, J. W., Westendorp, R. G. J., Du Puy, R. S., Poortvliet, R. K. E., Kearney, P. M., O'Keeffe, L., Dekkers, O. M., Blum, M. R., Rodondi, N., Collet, T. H., Quinn, T. J., Sattar, N., Stott, D. J., Trompet, S., den Elzen, W. P. J., Gussekloo, J., & Mooijaart, S. P. (2021). Levothyroxine Treatment and Cardiovascular Outcomes in Older People With Subclinical Hypothyroidism: Pooled Individual Results of Two Randomised Controlled Trials. Frontiers in endocrinology, 12674841. https://doi.org/10.3389/fendo.2021.674841
Zijlstra, Laurien E, et al. "Levothyroxine Treatment and Cardiovascular Outcomes in Older People With Subclinical Hypothyroidism: Pooled Individual Results of Two Randomised Controlled Trials." Frontiers in endocrinology vol. 12 (2021): 674841. doi: https://doi.org/10.3389/fendo.2021.674841
Zijlstra LE, Jukema JW, Westendorp RGJ, Du Puy RS, Poortvliet RKE, Kearney PM, O'Keeffe L, Dekkers OM, Blum MR, Rodondi N, Collet TH, Quinn TJ, Sattar N, Stott DJ, Trompet S, den Elzen WPJ, Gussekloo J, Mooijaart SP. Levothyroxine Treatment and Cardiovascular Outcomes in Older People With Subclinical Hypothyroidism: Pooled Individual Results of Two Randomised Controlled Trials. Front Endocrinol (Lausanne). 2021 May 20;12:674841. doi: 10.3389/fendo.2021.674841. eCollection 2021. PMID: 34093444; PMCID: PMC8173189.
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