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Showing 13 to 24 of 140 entries
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Bayesian Inference for Integrating .

ACS synthetic biology

McNaughton AD, Bredeweg EL, Manzer J, Zucker J, Munoz Munoz N, Burnet MC, Nakayasu ES, Pomraning KR, Merkley ED, Dai Z, Chrisler WB, Baker SE, St John PC, Kumar N.
PMID: 34636549
ACS Synth Biol. 2021 Nov 19;10(11):2968-2981. doi: 10.1021/acssynbio.1c00267. Epub 2021 Oct 12.

Optimizing the metabolism of microbial cell factories for yields and titers is a critical step for economically viable production of bioproducts and biofuels. In this process, tuning the expression of individual enzymes to obtain the desired pathway flux is...

White Matter Disruption in Pediatric Traumatic Brain Injury: Results from ENIGMA Pediatric Moderate to Severe Traumatic Brain Injury.

Neurology

Dennis EL, Caeyenberghs K, Hoskinson KR, Merkley TL, Suskauer SJ, Asarnow RF, Babikian T, Bartnik-Olson B, Bickart K, Bigler ED, Ewing-Cobbs L, Figaji A, Giza CC, Goodrich-Hunsaker NJ, Hodges CB, Hovenden Aa ES, Irimia A, Königs M, Levin HS, Lindsey HM, Max JE, Newsome MR, Olsen A, Ryan NP, Schmidt AT, Spruiell MS, Wade BS, Ware AL, Watson CG, Wheeler AL, Yeates KO, Zielinski BA, Kochunov P, Jahanshad N, Thompson PM, Tate DF, Wilde EA.
PMID: 34050006
Neurology. 2021 May 28; doi: 10.1212/WNL.0000000000012222. Epub 2021 May 28.

OBJECTIVE: Our study addressed aims: (1) test the hypothesis that moderate-severe TBI in pediatric patients is associated with widespread white matter (WM) disruption; (2) test the hypothesis that age and sex impact WM organization after injury; and (3) examine...

Immunization needs a technology boost.

Nature

Berkley S.
PMID: 32080552
Nature. 2017 Nov;551(7680):273. doi: 10.1038/d41586-017-05923-8.

No abstract available.

Application of Impedance-Based Techniques in Hepatology Research.

Journal of clinical medicine

Morgan K, Gamal W, Samuel K, Morley SD, Hayes PC, Bagnaninchi P, Plevris JN.
PMID: 31878354
J Clin Med. 2019 Dec 24;9(1). doi: 10.3390/jcm9010050.

There are a variety of end-point assays and techniques available to monitor hepatic cell cultures and study toxicity within in vitro models. These commonly focus on one aspect of cell metabolism and are often destructive to cells. Impedance-based cellular...

Investigating the visual number form area: a replication study.

Royal Society open science

Merkley R, Conrad B, Price G, Ansari D.
PMID: 31824678
R Soc Open Sci. 2019 Oct 30;6(10):182067. doi: 10.1098/rsos.182067. eCollection 2019 Oct.

The influential triple-code model of number representation proposed that there are three distinct brain regions for three different numerical representations: verbal words, visual digits and abstract magnitudes. It was hypothesized that the region for visual digits, known as the...

Tauopathy induces degeneration and impairs regeneration of sensory nerves in the cornea.

Experimental eye research

Li S, Shi S, Luo B, Xia F, Ha Y, Merkley KH, Motamedi M, Zhang W, Liu H.
PMID: 34929160
Exp Eye Res. 2021 Dec 18;215:108900. doi: 10.1016/j.exer.2021.108900. Epub 2021 Dec 18.

The cornea is transparent and innervated by a dense collection of sensory nerves originating from the ocular branch of the trigeminal nerve. This study was designed to comprehensively analyze alterations of corneal sub-basal nerve plexus in a mouse model...

Fundamental mechanistic insights from rare but paradigmatic neuroimmunological diseases.

Nature reviews. Neurology

Wiendl H, Gross CC, Bauer J, Merkler D, Prat A, Liblau R.
PMID: 34050331
Nat Rev Neurol. 2021 Jul;17(7):433-447. doi: 10.1038/s41582-021-00496-7. Epub 2021 May 28.

The pathophysiology of complex neuroimmunological diseases, such as multiple sclerosis and autoimmune encephalitis, remains puzzling - various mechanisms that are difficult to dissect seem to contribute, hampering the understanding of the processes involved. Some rare neuroimmunological diseases are easier...

Diffusion-Weighted Imaging in Mild Traumatic Brain Injury: A Systematic Review of the Literature.

Neuropsychology review

Lindsey HM, Hodges CB, Greer KM, Wilde EA, Merkley TL.
PMID: 33721207
Neuropsychol Rev. 2021 Mar 15; doi: 10.1007/s11065-021-09485-5. Epub 2021 Mar 15.

There is evidence that diffusion-weighted imaging (DWI) is able to detect tissue alterations following mild traumatic brain injury (mTBI) that may not be observed on conventional neuroimaging; however, findings are often inconsistent between studies. This systematic review assesses patterns...

Balancing Resiliency and New Accountabilities: Insights from Chief Nurse Executives amid the COVID-19 Pandemic.

Nursing leadership (Toronto, Ont.)

Jeffs L, Merkley J, Canzian S, Taggart R, Andress I, Harris A.
PMID: 33616521
Nurs Leadersh (Tor Ont). 2020 Dec;33(4):7-19. doi: 10.12927/cjnl.2021.26425.

This article outlines how chief nurse executives (CNEs) in an urban regional hospital network are navigating the balancing act of organizational (internal) and system-level (regional and/or provincial) accountabilities amid the coronavirus disease 2019 (COVID-19) pandemic. Key to their leadership...

Tauopathy induces degeneration and impairs regeneration of sensory nerves in the cornea.

Experimental eye research

Li S, Shi S, Luo B, Xia F, Ha Y, Merkley KH, Motamedi M, Zhang W, Liu H.
PMID: 34929160
Exp Eye Res. 2021 Dec 18;215:108900. doi: 10.1016/j.exer.2021.108900. Epub 2021 Dec 18.

The cornea is transparent and innervated by a dense collection of sensory nerves originating from the ocular branch of the trigeminal nerve. This study was designed to comprehensively analyze alterations of corneal sub-basal nerve plexus in a mouse model...

Tauopathy induces degeneration and impairs regeneration of sensory nerves in the cornea.

Experimental eye research

Li S, Shi S, Luo B, Xia F, Ha Y, Merkley KH, Motamedi M, Zhang W, Liu H.
PMID: 34929160
Exp Eye Res. 2021 Dec 18;215:108900. doi: 10.1016/j.exer.2021.108900. Epub 2021 Dec 18.

The cornea is transparent and innervated by a dense collection of sensory nerves originating from the ocular branch of the trigeminal nerve. This study was designed to comprehensively analyze alterations of corneal sub-basal nerve plexus in a mouse model...

White Matter Disruption in Pediatric Traumatic Brain Injury: Results from ENIGMA Pediatric Moderate to Severe Traumatic Brain Injury.

Neurology

Dennis EL, Caeyenberghs K, Hoskinson KR, Merkley TL, Suskauer SJ, Asarnow RF, Babikian T, Bartnik-Olson B, Bickart K, Bigler ED, Ewing-Cobbs L, Figaji A, Giza CC, Goodrich-Hunsaker NJ, Hodges CB, Hovenden Aa ES, Irimia A, Königs M, Levin HS, Lindsey HM, Max JE, Newsome MR, Olsen A, Ryan NP, Schmidt AT, Spruiell MS, Wade BS, Ware AL, Watson CG, Wheeler AL, Yeates KO, Zielinski BA, Kochunov P, Jahanshad N, Thompson PM, Tate DF, Wilde EA.
PMID: 34050006
Neurology. 2021 May 28; doi: 10.1212/WNL.0000000000012222. Epub 2021 May 28.

OBJECTIVE: Our study addressed aims: (1) test the hypothesis that moderate-severe TBI in pediatric patients is associated with widespread white matter (WM) disruption; (2) test the hypothesis that age and sex impact WM organization after injury; and (3) examine...

Showing 13 to 24 of 140 entries