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Showing 13 to 24 of 197 entries
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A Proton-Ionizable Ester Crown of 3,5-Disubstituted 1H-Pyrazole Able To Form Stable Dinuclear Complexes with Lipophilic Phenethylamines.

The Journal of organic chemistry

Campayo L, Bueno JM, Navarro P, Ochoa C, Jimenez-Barbero J, Pèpe G, Samat A.
PMID: 11671626
J Org Chem. 1997 May 02;62(9):2684-2693. doi: 10.1021/jo9623651.

A convenient synthesis of the proton-ionizable crown 3 is reported that uses dibutyltin oxide. In acetonitrile, the reaction of 3 (LH(2)) with phenethylamine and homoveratrylamine (molar ratio 1:2) affords solid dinuclear complexes [LH(2)]2RNH(2) (4a,b), which spectroscopic (FAB-MS, IR, (1)H...

Baylis-Hillman adducts in rhodium-catalyzed 1,4-additions: unusual reactivity.

Chemical communications (Cambridge, England)

Navarre L, Darses S, Genet JP.
PMID: 15116208
Chem Commun (Camb). 2004 May 07;(9):1108-9. doi: 10.1039/b402928c. Epub 2004 Apr 05.

In the presence of a rhodium catalyst, unactivated Baylis-Hillman adducts reacted with arylboronic acids to afford trisubstituted alkenes with good yields. This highly efficient reaction (aerobic conditions, low temperature) is believed to proceeds via an unexpected mechanism involving 1,4-addition/beta-hydroxy...

A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa.

Nature communications

Chung JJ, Navarro B, Krapivinsky G, Krapivinsky L, Clapham DE.
PMID: 21224844
Nat Commun. 2011 Jan 11;2:153. doi: 10.1038/ncomms1153.

Calcium signalling is critical for successful fertilization. In spermatozoa, capacitation, hyperactivation of motility and the acrosome reaction are all mediated by increases in intracellular Ca(2+). Cation channels of sperm proteins (CATSPERS1-4) form an alkalinization-activated Ca(2+)-selective channel required for the...

Excited-state dynamics and two-photon absorption cross sections of fluorescent diphenyl-tin(IV) derivatives with schiff bases: a comparative study of the effect of chelation from the ultrafast to the steady-state time scale.

The journal of physical chemistry. A

Zugazagoitia JS, Maya M, Damián-Zea C, Navarro P, Beltrán HI, Peon J.
PMID: 20038153
J Phys Chem A. 2010 Jan 21;114(2):704-14. doi: 10.1021/jp904784b.

Schiff bases bearing an intramolecular hydrogen bond are known to undergo excited-state intramolecular proton transfer and E-Z isomerization, which are related to their thermochromism and solvatochromism properties. In this study, we explored these ultrafast photoinduced processes for two doubly...

Global Decrease of Histone H3K27 Acetylation in ZEB1-Induced Epithelial to Mesenchymal Transition in Lung Cancer Cells.

Cancers

Roche J, Nasarre P, Gemmill R, Baldys A, Pontis J, Korch C, Guilhot J, Ait-Si-Ali S, Drabkin H.
PMID: 24216980
Cancers (Basel). 2013 Apr 03;5(2):334-56. doi: 10.3390/cancers5020334.

The epithelial to mesenchymal transition (EMT) enables epithelial cells with a migratory mesenchymal phenotype. It is activated in cancer cells and is involved in invasion, metastasis and stem-like properties. ZEB1, an E-box binding transcription factor, is a major suppressor...

Aspirin inhibits cancer stem cells properties and growth of glioblastoma multiforme through Rb1 pathway modulation.

Journal of cellular physiology

Pozzoli G, Marei HE, Althani A, Boninsegna A, Casalbore P, Marlier LNJL, Lanzilli G, Zonfrillo M, Petrucci G, Rocca B, Navarra P, Sgambato A, Cenciarelli C.
PMID: 30701538
J Cell Physiol. 2019 Jan 30; doi: 10.1002/jcp.28194. Epub 2019 Jan 30.

Several clinical studies indicated that the daily use of aspirin or acetylsalicylic acid reduces the cancer risk via cyclooxygenases (Cox-1 and Cox-2) inhibition. In addition, aspirin-induced Cox-dependent and -independent antitumor effects have also been described. Here we report, for...

Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism.

Wellcome open research

Clarke TK, Zeng Y, Navrady L, Xia C, Haley C, Campbell A, Navarro P, Amador C, Adams MJ, Howard DM, Soler A, Hayward C, Thomson PA, Smith BH, Padmanabhan S, Hocking LJ, Hall LS, Porteous DJ, Deary IJ, McIntosh AM.
PMID: 30756089
Wellcome Open Res. 2019 Jan 14;3:11. doi: 10.12688/wellcomeopenres.13893.2. eCollection 2018.

No abstract available.

Boron Nitride as a Novel Support for Highly Stable Palladium Nanocatalysts by Atomic Layer Deposition.

Nanomaterials (Basel, Switzerland)

Weber M, Lamboux C, Navarra B, Miele P, Zanna S, Dufond ME, Santinacci L, Bechelany M.
PMID: 30340372
Nanomaterials (Basel). 2018 Oct 18;8(10). doi: 10.3390/nano8100849.

The ability to prepare controllable nanocatalysts is of great interest for many chemical industries. Atomic layer deposition (ALD) is a vapor phase technique enabling the synthesis of conformal thin films and nanoparticles (NPs) on high surface area supports and...

Immune Evasion in Pancreatic Cancer: From Mechanisms to Therapy.

Cancers

Martinez-Bosch N, Vinaixa J, Navarro P.
PMID: 29301364
Cancers (Basel). 2018 Jan 03;10(1). doi: 10.3390/cancers10010006.

Pancreatic ductal adenocarcinoma (PDA), the most frequent type of pancreatic cancer, remains one of the most challenging problems for the biomedical and clinical fields, with abysmal survival rates and poor therapy efficiency. Desmoplasia, which is abundant in PDA, can...

Correction: Pedigree- and SNP-Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation.

PLoS genetics

Xia C, Amador C, Huffman J, Trochet H, Campbell A, Porteous D, Scotland G, Hastie ND, Hayward C, Vitart V, Navarro P, Haley CS.
PMID: 28196069
PLoS Genet. 2017 Feb 14;13(2):e1006608. doi: 10.1371/journal.pgen.1006608. eCollection 2017 Feb.

[This corrects the article DOI: 10.1371/journal.pgen.1005804.].

Fine mapping the .

NPJ aging and mechanisms of disease

van Leeuwen EM, Huffman JE, Bis JC, Isaacs A, Mulder M, Sabo A, Smith AV, Demissie S, Manichaikul A, Brody JA, Feitosa MF, Duan Q, Schraut KE, Navarro P, van Vliet-Ostaptchouk JV, Zhu G, Mbarek H, Trompet S, Verweij N, Lyytikäinen LP, Deelen J, Nolte IM, van der Laan SW, Davies G, Vermeij-Verdoold AJ, van Oosterhout AA, Vergeer-Drop JM, Arking DE, Trochet H, Medina-Gomez C, Rivadeneira F, Uitterlinden AG, Dehghan A, Franco OH, Sijbrands EJ, Hofman A, White CC, Mychaleckyj JC, Peloso GM, Swertz MA, Willemsen G, de Geus EJ, Milaneschi Y, Penninx BW, Ford I, Buckley BM, de Craen AJ, Starr JM, Deary IJ, Pasterkamp G, Oldehinkel AJ, Snieder H, Slagboom PE, Nikus K, Kähönen M, Lehtimäki T, Viikari JS, Raitakari OT, van der Harst P, Jukema JW, Hottenga JJ, Boomsma DI, Whitfield JB, Montgomery G, Martin NG, Polasek O, Vitart V, Hayward C, Kolcic I, Wright AF, Rudan I, Joshi PK, Wilson JF, Lange LA, Wilson JG, Gudnason V, Harris TB, Morrison AC, Borecki IB, Rich SS, Padmanabhan S, Psaty BM, Rotter JI, Smith BH, Boerwinkle E, Cupples LA, van Duijn C.
PMID: 28721259
NPJ Aging Mech Dis. 2015 Nov 12;1:15011. doi: 10.1038/npjamd.2015.11. eCollection 2015.

BACKGROUND: Individuals with exceptional longevity and their offspring have significantly larger high-density lipoprotein concentrations (HDL-C) particle sizes due to the increased homozygosity for the I405V variant in the cholesteryl ester transfer protein (METHODS: We performed a meta-analysis of HDL-C...

Exploring Mental Health Professionals' Perspectives of Text-Based Online Counseling Effectiveness With Young People: Mixed Methods Pilot Study.

JMIR mental health

Navarro P, Sheffield J, Edirippulige S, Bambling M.
PMID: 32012097
JMIR Ment Health. 2020 Jan 29;7(1):e15564. doi: 10.2196/15564.

BACKGROUND: Population-based studies show that the risk of mental ill health is highest among young people aged 10 to 24 years, who are also the least likely to seek professional treatment because of a number of barriers. Electronic mental...

Showing 13 to 24 of 197 entries