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Are antimicrobial stewardship interventions effective and safe in long-term care facilities? A systematic review and meta-analysis.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

Crespo-Rivas JC, Guisado-Gil AB, Peñalva G, Rodríguez-Villodres Á, Martín-Gandul C, Pachón-Ibáñez ME, Lepe JA, Cisneros JM.
PMID: 34118423
Clin Microbiol Infect. 2021 Oct;27(10):1431-1438. doi: 10.1016/j.cmi.2021.06.003. Epub 2021 Jun 10.

BACKGROUND: Long-term care facilities (LTCFs) are health-care settings with high antimicrobial consumption and hence need to develop effective antimicrobial stewardship programmes (ASPs).OBJECTIVE: To assess the effects of ASPs on care-related, clinical and ecological outcomes in LTCFs.METHODS: Data sources were...

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Crespo-Rivas JC, Guisado-Gil AB, Peñalva G, et al. Are antimicrobial stewardship interventions effective and safe in long-term care facilities? A systematic review and meta-analysis. Clin Microbiol Infect. 2021;27(10):1431-1438doi: 10.1016/j.cmi.2021.06.003.
Crespo-Rivas, J. C., Guisado-Gil, A. B., Peñalva, G., Rodríguez-Villodres, �. �., Martín-Gandul, C., Pachón-Ibáñez, M. E., Lepe, J. A., & Cisneros, J. M. (2021). Are antimicrobial stewardship interventions effective and safe in long-term care facilities? A systematic review and meta-analysis. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 27(10), 1431-1438. https://doi.org/10.1016/j.cmi.2021.06.003
Crespo-Rivas, Juan Carlos, et al. "Are antimicrobial stewardship interventions effective and safe in long-term care facilities? A systematic review and meta-analysis." Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases vol. 27,10 (2021): 1431-1438. doi: https://doi.org/10.1016/j.cmi.2021.06.003
Crespo-Rivas JC, Guisado-Gil AB, Peñalva G, Rodríguez-Villodres Á, Martín-Gandul C, Pachón-Ibáñez ME, Lepe JA, Cisneros JM. Are antimicrobial stewardship interventions effective and safe in long-term care facilities? A systematic review and meta-analysis. Clin Microbiol Infect. 2021 Oct;27(10):1431-1438. doi: 10.1016/j.cmi.2021.06.003. Epub 2021 Jun 10. PMID: 34118423.
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Consumer demand for novel fruit and vegetable products with extended shelf lives in East Africa: a multinational multi-product analysis.

Public health nutrition

Tepe J, Benali M, Lemken D.
PMID: 34889175
Public Health Nutr. 2021 Dec 10;1-11. doi: 10.1017/S136898002100478X. Epub 2021 Dec 10.

OBJECTIVE: To evaluate the potential of products made out of underutilised fruits and vegetables for closing seasonal nutritional gaps among rural and urban consumers in East Africa.DESIGN: The multinational analysis combines sensory testing and experimental auctions to assess consumers'...

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Tepe J, Benali M, Lemken D. Consumer demand for novel fruit and vegetable products with extended shelf lives in East Africa: a multinational multi-product analysis. Public Health Nutr. 2021;1-11doi: 10.1017/S136898002100478X.
Tepe, J., Benali, M., & Lemken, D. (2021). Consumer demand for novel fruit and vegetable products with extended shelf lives in East Africa: a multinational multi-product analysis. Public health nutrition, 1-11. https://doi.org/10.1017/S136898002100478X
Tepe, Johanna, et al. "Consumer demand for novel fruit and vegetable products with extended shelf lives in East Africa: a multinational multi-product analysis." Public health nutrition vol. (2021): 1-11. doi: https://doi.org/10.1017/S136898002100478X
Tepe J, Benali M, Lemken D. Consumer demand for novel fruit and vegetable products with extended shelf lives in East Africa: a multinational multi-product analysis. Public Health Nutr. 2021 Dec 10;1-11. doi: 10.1017/S136898002100478X. Epub 2021 Dec 10. PMID: 34889175.
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Advances in Proteasome Enhancement by Small Molecules.

Biomolecules

George DE, Tepe JJ.
PMID: 34944433
Biomolecules. 2021 Nov 30;11(12). doi: 10.3390/biom11121789.

The proteasome system is a large and complex molecular machinery responsible for the degradation of misfolded, damaged, and redundant cellular proteins. When proteasome function is impaired, unwanted proteins accumulate, which can lead to several diseases including age-related and neurodegenerative...

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George DE, Tepe JJ. Advances in Proteasome Enhancement by Small Molecules. Biomolecules. 2021;11(12)doi: 10.3390/biom11121789.
George, D. E., & Tepe, J. J. (2021). Advances in Proteasome Enhancement by Small Molecules. Biomolecules, 11(12), . https://doi.org/10.3390/biom11121789
George, Dare E, and Tepe, Jetze J. "Advances in Proteasome Enhancement by Small Molecules." Biomolecules vol. 11,12 (2021). doi: https://doi.org/10.3390/biom11121789
George DE, Tepe JJ. Advances in Proteasome Enhancement by Small Molecules. Biomolecules. 2021 Nov 30;11(12). doi: 10.3390/biom11121789. PMID: 34944433; PMCID: PMC8699248.
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Phytochemistry reflects different evolutionary history in traditional classes versus specialized structural motifs.

Scientific reports

Uckele KA, Jahner JP, Tepe EJ, Richards LA, Dyer LA, Ochsenrider KM, Philbin CS, Kato MJ, Yamaguchi LF, Forister ML, Smilanich AM, Dodson CD, Jeffrey CS, Parchman TL.
PMID: 34446754
Sci Rep. 2021 Aug 26;11(1):17247. doi: 10.1038/s41598-021-96431-3.

Foundational hypotheses addressing plant-insect codiversification and plant defense theory typically assume a macroevolutionary pattern whereby closely related plants have similar chemical profiles. However, numerous studies have documented variation in the degree of phytochemical trait lability, raising the possibility that...

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Uckele KA, Jahner JP, Tepe EJ, et al. Phytochemistry reflects different evolutionary history in traditional classes versus specialized structural motifs. Sci Rep. 2021;11(1):17247doi: 10.1038/s41598-021-96431-3.
Uckele, K. A., Jahner, J. P., Tepe, E. J., Richards, L. A., Dyer, L. A., Ochsenrider, K. M., Philbin, C. S., Kato, M. J., Yamaguchi, L. F., Forister, M. L., Smilanich, A. M., Dodson, C. D., Jeffrey, C. S., & Parchman, T. L. (2021). Phytochemistry reflects different evolutionary history in traditional classes versus specialized structural motifs. Scientific reports, 11(1), 17247. https://doi.org/10.1038/s41598-021-96431-3
Uckele, Kathryn A, et al. "Phytochemistry reflects different evolutionary history in traditional classes versus specialized structural motifs." Scientific reports vol. 11,1 (2021): 17247. doi: https://doi.org/10.1038/s41598-021-96431-3
Uckele KA, Jahner JP, Tepe EJ, Richards LA, Dyer LA, Ochsenrider KM, Philbin CS, Kato MJ, Yamaguchi LF, Forister ML, Smilanich AM, Dodson CD, Jeffrey CS, Parchman TL. Phytochemistry reflects different evolutionary history in traditional classes versus specialized structural motifs. Sci Rep. 2021 Aug 26;11(1):17247. doi: 10.1038/s41598-021-96431-3. PMID: 34446754; PMCID: PMC8390663.
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Optimization and adaptation of the diagnostic capacity for the performance of large volumes of SARS-CoV-2 RT-PCR.

Enfermedades infecciosas y microbiologia clinica (English ed.)

Camacho-Martínez P, Martin-Gutiérrez G, Peñalva G, Merino-Díaz L, Lepe JA.
PMID: 33712264
Enferm Infecc Microbiol Clin (Engl Ed). 2021 Feb 11; doi: 10.1016/j.eimc.2021.01.014. Epub 2021 Feb 11.

INTRODUCTION: In the present manuscript we describe the planning carried out in our hospital to adapt our diagnostic capability to perform large numbers of SARS-CoV-2 RT-PCR.METHODS: The analysis and prediction of workflow included the number of RT-PCR per week...

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Camacho-Martínez P, Martin-Gutiérrez G, Peñalva G, et al. Optimización y adecuación de la capacidad diagnóstica para la realización de grandes volúmenes de RT-PCR de SARS-CoV-2. Optimization and adaptation of the diagnostic capacity for the performance of large volumes of SARS-CoV-2 RT-PCR. Enferm Infecc Microbiol Clin (Engl Ed). 2021;doi: 10.1016/j.eimc.2021.01.014.
Camacho-Martínez, P., Martin-Gutiérrez, G., Peñalva, G., Merino-Díaz, L., & Lepe, J. A. (2021). Optimización y adecuación de la capacidad diagnóstica para la realización de grandes volúmenes de RT-PCR de SARS-CoV-2. Optimization and adaptation of the diagnostic capacity for the performance of large volumes of SARS-CoV-2 RT-PCR. Enfermedades infecciosas y microbiologia clinica (English ed.), . https://doi.org/10.1016/j.eimc.2021.01.014
Camacho-Martínez, Pedro, et al. "Optimización y adecuación de la capacidad diagnóstica para la realización de grandes volúmenes de RT-PCR de SARS-CoV-2." Optimization and adaptation of the diagnostic capacity for the performance of large volumes of SARS-CoV-2 RT-PCR. Enfermedades infecciosas y microbiologia clinica (English ed.) vol. (2021). doi: https://doi.org/10.1016/j.eimc.2021.01.014
Camacho-Martínez P, Martin-Gutiérrez G, Peñalva G, Merino-Díaz L, Lepe JA. Optimización y adecuación de la capacidad diagnóstica para la realización de grandes volúmenes de RT-PCR de SARS-CoV-2. Optimization and adaptation of the diagnostic capacity for the performance of large volumes of SARS-CoV-2 RT-PCR. Enferm Infecc Microbiol Clin (Engl Ed). 2021 Feb 11; doi: 10.1016/j.eimc.2021.01.014. Epub 2021 Feb 11. Spanish. PMID: 33712264; PMCID: PMC7877244.
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Pseudomonas monteilii nosocomial meningitis in a patient with an intraventricular catheter.

Enfermedades infecciosas y microbiologia clinica (English ed.)

Toledo H, Martín-Gutiérrez G, Lepe JA.
PMID: 34893456
Enferm Infecc Microbiol Clin (Engl Ed). 2021 Dec 07; doi: 10.1016/j.eimce.2021.11.004. Epub 2021 Dec 07.

No abstract available.

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Toledo H, Martín-Gutiérrez G, Lepe JA. Pseudomonas monteilii nosocomial meningitis in a patient with an intraventricular catheter. Enferm Infecc Microbiol Clin (Engl Ed). 2021;doi: 10.1016/j.eimce.2021.11.004.
Toledo, H., Martín-Gutiérrez, G., & Lepe, J. A. (2021). Pseudomonas monteilii nosocomial meningitis in a patient with an intraventricular catheter. Enfermedades infecciosas y microbiologia clinica (English ed.), . https://doi.org/10.1016/j.eimce.2021.11.004
Toledo, Héctor, et al. "Pseudomonas monteilii nosocomial meningitis in a patient with an intraventricular catheter." Enfermedades infecciosas y microbiologia clinica (English ed.) vol. (2021). doi: https://doi.org/10.1016/j.eimce.2021.11.004
Toledo H, Martín-Gutiérrez G, Lepe JA. Pseudomonas monteilii nosocomial meningitis in a patient with an intraventricular catheter. Enferm Infecc Microbiol Clin (Engl Ed). 2021 Dec 07; doi: 10.1016/j.eimce.2021.11.004. Epub 2021 Dec 07. PMID: 34893456.
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Highly accurate whole-genome imputation of SARS-CoV-2 from partial or low-quality sequences.

GigaScience

Ortuño FM, Loucera C, Casimiro-Soriguer CS, Lepe JA, Camacho Martinez P, Merino Diaz L, de Salazar A, Chueca N, García F, Perez-Florido J, Dopazo J.
PMID: 34865008
Gigascience. 2021 Dec 02;10(12). doi: 10.1093/gigascience/giab078.

BACKGROUND: The current SARS-CoV-2 pandemic has emphasized the utility of viral whole-genome sequencing in the surveillance and control of the pathogen. An unprecedented ongoing global initiative is producing hundreds of thousands of sequences worldwide. However, the complex circumstances in...

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Ortuño FM, Loucera C, Casimiro-Soriguer CS, et al. Highly accurate whole-genome imputation of SARS-CoV-2 from partial or low-quality sequences. Gigascience. 2021;10(12)doi: 10.1093/gigascience/giab078.
Ortuño, F. M., Loucera, C., Casimiro-Soriguer, C. S., Lepe, J. A., Camacho Martinez, P., Merino Diaz, L., de Salazar, A., Chueca, N., García, F., Perez-Florido, J., & Dopazo, J. (2021). Highly accurate whole-genome imputation of SARS-CoV-2 from partial or low-quality sequences. GigaScience, 10(12), . https://doi.org/10.1093/gigascience/giab078
Ortuño, Francisco M, et al. "Highly accurate whole-genome imputation of SARS-CoV-2 from partial or low-quality sequences." GigaScience vol. 10,12 (2021). doi: https://doi.org/10.1093/gigascience/giab078
Ortuño FM, Loucera C, Casimiro-Soriguer CS, Lepe JA, Camacho Martinez P, Merino Diaz L, de Salazar A, Chueca N, García F, Perez-Florido J, Dopazo J. Highly accurate whole-genome imputation of SARS-CoV-2 from partial or low-quality sequences. Gigascience. 2021 Dec 02;10(12). doi: 10.1093/gigascience/giab078. PMID: 34865008; PMCID: PMC8643610.
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Prevalence and Risk Factors for Multidrug-Resistant Organisms Colonization in Long-Term Care Facilities Around the World: A Review.

Antibiotics (Basel, Switzerland)

Rodríguez-Villodres Á, Martín-Gandul C, Peñalva G, Guisado-Gil AB, Crespo-Rivas JC, Pachón-Ibáñez ME, Lepe JA, Cisneros JM.
PMID: 34200238
Antibiotics (Basel). 2021 Jun 07;10(6). doi: 10.3390/antibiotics10060680.

Elderly people confined to chronic care facilities face an increased risk of acquiring infections by multidrug-resistant organisms (MDROs). This review presents the current knowledge of the prevalence and risk factors for colonization by MDROs in long-term care facilities (LTCF),...

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Rodríguez-Villodres Á, Martín-Gandul C, Peñalva G, et al. Prevalence and Risk Factors for Multidrug-Resistant Organisms Colonization in Long-Term Care Facilities Around the World: A Review. Antibiotics (Basel). 2021;10(6)doi: 10.3390/antibiotics10060680.
Rodríguez-Villodres, �. �., Martín-Gandul, C., Peñalva, G., Guisado-Gil, A. B., Crespo-Rivas, J. C., Pachón-Ibáñez, M. E., Lepe, J. A., & Cisneros, J. M. (2021). Prevalence and Risk Factors for Multidrug-Resistant Organisms Colonization in Long-Term Care Facilities Around the World: A Review. Antibiotics (Basel, Switzerland), 10(6), . https://doi.org/10.3390/antibiotics10060680
Rodríguez-Villodres, Ángel, et al. "Prevalence and Risk Factors for Multidrug-Resistant Organisms Colonization in Long-Term Care Facilities Around the World: A Review." Antibiotics (Basel, Switzerland) vol. 10,6 (2021). doi: https://doi.org/10.3390/antibiotics10060680
Rodríguez-Villodres Á, Martín-Gandul C, Peñalva G, Guisado-Gil AB, Crespo-Rivas JC, Pachón-Ibáñez ME, Lepe JA, Cisneros JM. Prevalence and Risk Factors for Multidrug-Resistant Organisms Colonization in Long-Term Care Facilities Around the World: A Review. Antibiotics (Basel). 2021 Jun 07;10(6). doi: 10.3390/antibiotics10060680. PMID: 34200238; PMCID: PMC8228357.
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Overview of Traumatic Brain Injury in American Football Athletes.

Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine

Canseco JA, Franks RR, Karamian BA, Divi SN, Reyes AA, Mao JZ, Al Saiegh F, Donnally CJ, Schroeder GD, Harrop JS, Pepe MD, Vaccaro AR.
PMID: 33797476
Clin J Sport Med. 2021 Mar 24; doi: 10.1097/JSM.0000000000000918. Epub 2021 Mar 24.

OBJECTIVE: The aim of this review is to provide a summary of the epidemiology, clinical presentation, pathophysiology, and treatment of traumatic brain injury in collision athletes, particularly those participating in American football.DATA SOURCES: A literature search was conducted using...

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Canseco JA, Franks RR, Karamian BA, et al. Overview of Traumatic Brain Injury in American Football Athletes. Clin J Sport Med. 2021;doi: 10.1097/JSM.0000000000000918.
Canseco, J. A., Franks, R. R., Karamian, B. A., Divi, S. N., Reyes, A. A., Mao, J. Z., Al Saiegh, F., Donnally, C. J., Schroeder, G. D., Harrop, J. S., Pepe, M. D., & Vaccaro, A. R. (2021). Overview of Traumatic Brain Injury in American Football Athletes. Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine, . https://doi.org/10.1097/JSM.0000000000000918
Canseco, Jose A, et al. "Overview of Traumatic Brain Injury in American Football Athletes." Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine vol. (2021). doi: https://doi.org/10.1097/JSM.0000000000000918
Canseco JA, Franks RR, Karamian BA, Divi SN, Reyes AA, Mao JZ, Al Saiegh F, Donnally CJ, Schroeder GD, Harrop JS, Pepe MD, Vaccaro AR. Overview of Traumatic Brain Injury in American Football Athletes. Clin J Sport Med. 2021 Mar 24; doi: 10.1097/JSM.0000000000000918. Epub 2021 Mar 24. PMID: 33797476.
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Impact of Pharmacist Intervention on Electrocardiogram Monitoring of Pediatric Patients on Multiple QTc Interval-Prolonging Medications.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

Hutchins LM, Temple JD, Hilmas E.
PMID: 29290739
J Pediatr Pharmacol Ther. 2017 Nov-Dec;22(6):399-405. doi: 10.5863/1551-6776-22.6.399.

OBJECTIVES: To determine whether dedicated pharmacy services improve the rate of electrocardiogram (ECG) monitoring in patients at risk for medication-induced QTc interval prolongation. In addition, determine how pediatric institutions currently monitor patients at risk for medication-induced QTc interval prolongation.METHODS:...

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Hutchins LM, Temple JD, Hilmas E. Impact of Pharmacist Intervention on Electrocardiogram Monitoring of Pediatric Patients on Multiple QTc Interval-Prolonging Medications. J Pediatr Pharmacol Ther. 2017;22(6):399-405doi: 10.5863/1551-6776-22.6.399.
Hutchins, L. M., Temple, J. D., & Hilmas, E. (2017). Impact of Pharmacist Intervention on Electrocardiogram Monitoring of Pediatric Patients on Multiple QTc Interval-Prolonging Medications. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 22(6), 399-405. https://doi.org/10.5863/1551-6776-22.6.399
Hutchins, Lisa M, et al. "Impact of Pharmacist Intervention on Electrocardiogram Monitoring of Pediatric Patients on Multiple QTc Interval-Prolonging Medications." The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG vol. 22,6 (2017): 399-405. doi: https://doi.org/10.5863/1551-6776-22.6.399
Hutchins LM, Temple JD, Hilmas E. Impact of Pharmacist Intervention on Electrocardiogram Monitoring of Pediatric Patients on Multiple QTc Interval-Prolonging Medications. J Pediatr Pharmacol Ther. 2017 Nov-Dec;22(6):399-405. doi: 10.5863/1551-6776-22.6.399. PMID: 29290739; PMCID: PMC5736251.
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Piper kelleyi, a hotspot of ecological interactions and a new species from Ecuador and Peru.

PhytoKeys

Tepe EJ, Rodríguez-Castañeda G, Glassmire AE, Dyer LA.
PMID: 24596490
PhytoKeys. 2014 Feb 07;(34):19-32. doi: 10.3897/phytokeys.34.6376. eCollection 2014.

We describe Piper kelleyi sp. nov., a new species from the eastern Andes of Ecuador and Peru, named in honor of Dr. Walter Almond Kelley. Piper kelleyi is a member of the Macrostachys clade of the genus Piper and...

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Tepe EJ, Rodríguez-Castañeda G, Glassmire AE, et al. Piper kelleyi, a hotspot of ecological interactions and a new species from Ecuador and Peru. PhytoKeys. 2014;(34):19-32doi: 10.3897/phytokeys.34.6376.
Tepe, E. J., Rodríguez-Castañeda, G., Glassmire, A. E., & Dyer, L. A. (2014). Piper kelleyi, a hotspot of ecological interactions and a new species from Ecuador and Peru. PhytoKeys, (34), 19-32. https://doi.org/10.3897/phytokeys.34.6376
Tepe, Eric J, et al. "Piper kelleyi, a hotspot of ecological interactions and a new species from Ecuador and Peru." PhytoKeys vol. ,34 (2014): 19-32. doi: https://doi.org/10.3897/phytokeys.34.6376
Tepe EJ, Rodríguez-Castañeda G, Glassmire AE, Dyer LA. Piper kelleyi, a hotspot of ecological interactions and a new species from Ecuador and Peru. PhytoKeys. 2014 Feb 07;(34):19-32. doi: 10.3897/phytokeys.34.6376. eCollection 2014. PMID: 24596490; PMCID: PMC3941067.
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Azomethine ylide mediated inversion of configuration of quaternary imidazoline carbon: converting trans- to its cis- imidazolines.

Tetrahedron letters

Qu K, Fisk JS, Tepe JJ.
PMID: 21857756
Tetrahedron Lett. 2011 Sep 21;52(38):4840-4842. doi: 10.1016/j.tetlet.2011.07.022.

An efficient synthetic methodology of converting trans-4,5-diaryl-2-imidazolines to the corresponding cis-4,5-diaryl-2-imidazolines has been developed. This methodology features mild reaction conditions and a simple one-pot two-step procedure.

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Qu K, Fisk JS, Tepe JJ. Azomethine ylide mediated inversion of configuration of quaternary imidazoline carbon: converting trans- to its cis- imidazolines. Tetrahedron Lett. 2011;52(38):4840-4842doi: 10.1016/j.tetlet.2011.07.022.
Qu, K., Fisk, J. S., & Tepe, J. J. (2011). Azomethine ylide mediated inversion of configuration of quaternary imidazoline carbon: converting trans- to its cis- imidazolines. Tetrahedron letters, 52(38), 4840-4842. https://doi.org/10.1016/j.tetlet.2011.07.022
Qu, Ke, et al. "Azomethine ylide mediated inversion of configuration of quaternary imidazoline carbon: converting trans- to its cis- imidazolines." Tetrahedron letters vol. 52,38 (2011): 4840-4842. doi: https://doi.org/10.1016/j.tetlet.2011.07.022
Qu K, Fisk JS, Tepe JJ. Azomethine ylide mediated inversion of configuration of quaternary imidazoline carbon: converting trans- to its cis- imidazolines. Tetrahedron Lett. 2011 Sep 21;52(38):4840-4842. doi: 10.1016/j.tetlet.2011.07.022. PMID: 21857756; PMCID: PMC3157035.
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