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Showing 6769 to 6779 of 6779 entries
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Comparison of Successful and Unsuccessful Cases of New Drug Approvals Based on the International Council on Harmonization E5 Guidelines in Japan.

Clinical pharmacology in drug development

Asada R, Shimizu S, Nakamura H, Ono S, Yamaguchi T.
PMID: 33787062
Clin Pharmacol Drug Dev. 2021 May;10(5):434-439. doi: 10.1002/cpdd.942. Epub 2021 Mar 30.

No abstract available.

Adsorption Forms of NO on Iridium-Doped Rhodium Clusters in the Gas Phase Revealed by Infrared Multiple Photon Dissociation Spectroscopy.

The journal of physical chemistry. A

Zhang Y, Yamaguchi M, Kawada K, Kudoh S, Lushchikova OV, Bakker JM, Mafuné F.
PMID: 34978823
J Phys Chem A. 2022 Jan 13;126(1):36-43. doi: 10.1021/acs.jpca.1c08628. Epub 2022 Jan 03.

The adsorption of an NO molecule on a cationic iridium-doped rhodium cluster, Rh

Association between glucose intolerance and chemotherapy-induced lung injury in patients with lung cancer and interstitial lung disease.

Cancer chemotherapy and pharmacology

Otani T, Yamaguchi K, Nakao S, Sakamoto S, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Iwamoto H, Fujitaka K, Hamada H, Hattori N.
PMID: 34350479
Cancer Chemother Pharmacol. 2021 Nov;88(5):857-865. doi: 10.1007/s00280-021-04341-y. Epub 2021 Aug 04.

PURPOSE: Cytotoxic chemotherapy-induced lung injury is a fatal complication in patients with lung cancer and interstitial lung disease (ILD). We aimed to evaluate the association between hyperglycemia and this form of lung injury in patients with lung cancer concomitant...

Reliability of IDH1-R132H and ATRX and/or p53 immunohistochemistry for molecular subclassification of Grade 2/3 gliomas.

Brain tumor pathology

Nishikawa T, Watanabe R, Kitano Y, Yamamichi A, Motomura K, Ohka F, Aoki K, Hirano M, Kato A, Yamaguchi J, Maeda S, Kibe Y, Saito R, Wakabayashi T, Kato Y, Sato S, Ogino T, Natsume A, Ito I.
PMID: 34826036
Brain Tumor Pathol. 2022 Jan;39(1):14-24. doi: 10.1007/s10014-021-00418-x. Epub 2021 Nov 26.

Since the World Health Organization 2016 classification (2016 WHO), genetic status has been incorporated into the diagnosis of Grade 2/3 gliomas (lower-grade gliomas). Therefore, immunohistochemistry (IHC) of IDH1-R132H, ATRX, and p53 have been used in place of genetic status....

Cardiac Pressure Overload Decreases ETV1 Expression in the Left Atrium, Contributing to Atrial Electrical and Structural Remodeling.

Circulation

Yamaguchi N, Xiao J, Narke D, Shaheen D, Lin X, Offerman E, Khodadadi-Jamayran A, Shekhar A, Choy A, Wass SY, Van Wagoner DR, Chung MK, Park DS.
PMID: 33225722
Circulation. 2021 Feb 23;143(8):805-820. doi: 10.1161/CIRCULATIONAHA.120.048121. Epub 2020 Nov 23.

BACKGROUND: Elevated intracardiac pressure attributable to heart failure induces electrical and structural remodeling in the left atrium (LA) that begets atrial myopathy and arrhythmias. The underlying molecular pathways that drive atrial remodeling during cardiac pressure overload are poorly defined....

The effect of simple heat treatment on apatite formation on grit-blasted/acid-etched dental Ti implants already in clinical use.

Journal of biomedical materials research. Part B, Applied biomaterials

Ogura A, Yamaguchi S, Le PTM, Yamamoto K, Omori M, Inoue K, Kato-Kogoe N, Nakajima Y, Nakano H, Ueno T, Yamada T, Mori Y.
PMID: 34323348
J Biomed Mater Res B Appl Biomater. 2021 Jul 29; doi: 10.1002/jbm.b.34915. Epub 2021 Jul 29.

Grit-blasted/acid-etched titanium dental implants have a moderately roughened surface that is suitable for cell adhesion and exhibits faster osseointegration. However, the roughened surface does not always maintain stable fixation over a long period. In this study, a simple heat...

Accelerated decline in lung function in adults with a history of remitted childhood asthma.

The European respiratory journal

Miura S, Iwamoto H, Omori K, Yamaguchi K, Sakamoto S, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Fujitaka K, Hamada H, Yokoyama A, Hattori N.
PMID: 34588191
Eur Respir J. 2022 Jan 13;59(1). doi: 10.1183/13993003.00305-2021. Print 2022 Jan.

BACKGROUND: A significant number of children with asthma show remission in adulthood. Although these adults are often diagnosed with COPD in later life, the effect of clinically remitted childhood asthma on the decline in lung function during adulthood is...

Geriatric nutritional risk index as a prognostic indicator in elderly patients with early colorectal cancer undergoing endoscopic submucosal dissection.

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

Kato M, Hayashi Y, Fukuda H, Yamaguchi S, Inoue T, Ogiyama H, Kitamura S, Komori M, Yamamoto K, Yamamoto M, Nagai K, Nakahara M, Egawa S, Yamada T, Sasakawa A, Kizu T, Nishiyama O, Shichijo S, Yoshii S, Tsujii Y, Shinzaki S, Iijima H, Takehara T.
PMID: 34297872
Dig Endosc. 2021 Jul 23; doi: 10.1111/den.14090. Epub 2021 Jul 23.

OBJECTIVES: Data on the long-term outcomes of endoscopic submucosal dissection (ESD) performed in elderly patients with early colorectal cancer (CRC) are limited. We analyzed the prognosis of elderly CRC patients, not only from the viewpoint of treatment curability but...

Characteristics of Household Transmission of COVID-19 during Its Outbreak in Okinawa, Japan from February to May 2020.

Japanese journal of infectious diseases

Kuba Y, Shingaki A, Nidaira M, Kakita T, Maeshiro N, Oyama M, Kudeken T, Miyagi A, Yamauchi M, Kyan H.
PMID: 33952770
Jpn J Infect Dis. 2021 Nov 22;74(6):579-583. doi: 10.7883/yoken.JJID.2020.943. Epub 2021 Apr 30.

The Okinawa prefecture confirmed 142 cases of coronavirus disease from February 14 to May 2020. Among them, 78 were the first cases of a household with 174 household contacts. Of the 174 contacts, 21 contracted the disease, indicating a...

Direct platelet adhesion potentiates group 2 innate lymphoid cell functions.

Allergy

Orimo K, Tamari M, Takeda T, Kubo T, Rückert B, Motomura K, Sugiyama H, Yamada A, Saito K, Arae K, Kuriyama M, Hara M, Soyka MB, Ikutani M, Yamaguchi S, Morimoto N, Nakabayashi K, Hata K, Matsuda A, Akdis CA, Sudo K, Saito H, Nakae S, Tamaoki J, Tagaya E, Matsumoto K, Morita H.
PMID: 34402091
Allergy. 2021 Aug 17; doi: 10.1111/all.15057. Epub 2021 Aug 17.

BACKGROUND: Platelets are thought to be involved in the pathophysiology of asthma, presumably through direct adhesion to inflammatory cells, including group 2 innate lymphoid cells (ILC2s). Here, we tried to elucidate the effects of platelet adhesion to ILC2s in...

Dual Antiplatelet Therapy Using Cilostazol in Patients With Stroke and Intracranial Arterial Stenosis.

Journal of the American Heart Association

Uchiyama S, Toyoda K, Omae K, Saita R, Kimura K, Hoshino H, Sakai N, Okada Y, Tanaka K, Origasa H, Naritomi H, Houkin K, Yamaguchi K, Isobe M, Minematsu K, Matsumoto M, Tominaga T, Tomimoto H, Terayama Y, Yasuda S, Yamaguchi T.
PMID: 34622679
J Am Heart Assoc. 2021 Oct 19;10(20):e022575. doi: 10.1161/JAHA.121.022575. Epub 2021 Oct 08.

Background Long-term benefit of dual antiplatelet therapy (DAPT) over single antiplatelet therapy (SAPT) for the prevention of recurrent stroke has not been established in patients with intracranial arterial stenosis. We compared the efficacy and safety of DAPT with cilostazol...

Showing 6769 to 6779 of 6779 entries