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Showing 13 to 24 of 84 entries
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Molecular autopsy and subsequent functional analysis reveal de novo DSG2 mutation as cause of sudden death.

European journal of medical genetics

Simons E, Labro A, Saenen J, Nijak A, Sieliwonczyk E, Vandendriessche B, Dąbrowska M, Van Craenenbroeck EM, Schepers D, Van Laer L, Loeys BL, Alaerts M.
PMID: 34438094
Eur J Med Genet. 2021 Nov;64(11):104322. doi: 10.1016/j.ejmg.2021.104322. Epub 2021 Aug 23.

Sudden cardiac death (SCD) is a common cause of death in young adults. In up to 80% of cases a genetic cause is suspected. Next-generation sequencing of candidate genes can reveal the cause of SCD, provide prognostic management, and...

Pik3c3 deficiency in myeloid cells imparts partial resistance to experimental autoimmune encephalomyelitis associated with reduced IL-1β production.

Cellular & molecular immunology

Yang G, Song W, Xu J, Postoak JL, Cheng F, Martinez J, Zhang J, Wu L, Van Kaer L.
PMID: 33235386
Cell Mol Immunol. 2021 Aug;18(8):2024-2039. doi: 10.1038/s41423-020-00589-1. Epub 2020 Nov 24.

The PIK3C3/VPS34 subunit of the class III phosphatidylinositol 3-kinase (PtdIns3K) complex plays a role in both canonical and noncanonical autophagy, key processes that control immune-cell responsiveness to a variety of stimuli. Our previous studies found that PIK3C3 is a...

The influence of COVID-19 on routine hematological parameters of hospitalized patients.

Acta clinica Belgica

Blomme S, Smets L, Van Ranst M, Boeckx N, Van Laer C.
PMID: 32886893
Acta Clin Belg. 2020 Sep 04;1-6. doi: 10.1080/17843286.2020.1814649. Epub 2020 Sep 04.

OBJECTIVES: Coronavirus disease 2019 (COVID-19) was first discovered in Wuhan, China, in December 2019, and soon spread around the entire world. As no effective treatment is known, prediction of disease severity is very important in order to estimate a...

Dendritic cell PIK3C3/VPS34 controls the pathogenicity of CNS autoimmunity independently of LC3-associated phagocytosis.

Autophagy

Yang G, Postoak JL, Song W, Martinez J, Zhang J, Wu L, Van Kaer L.
PMID: 33960279
Autophagy. 2021 May 07;1-10. doi: 10.1080/15548627.2021.1922051. Epub 2021 May 07.

PIK3C3/VPS34 is a key player in macroautophagy/autophagy and MAP1LC3/LC3-associated phagocytosis (LAP), which play critical roles in dendritic cell (DC) function. In this study, we assessed the contribution of PIK3C3 to DC function during experimental autoimmune encephalomyelitis (EAE), an animal...

Profiling of three H3F3A-mutated and denosumab-treated giant cell tumors of bone points to diverging pathways during progression and malignant transformation.

Scientific reports

Hasenfratz M, Mellert K, Marienfeld R, von Baer A, Schultheiss M, Roitman PD, Aponte-Tinao LA, Lehner B, Möller P, Mechtersheimer G, Barth TFE.
PMID: 33707617
Sci Rep. 2021 Mar 11;11(1):5709. doi: 10.1038/s41598-021-85319-x.

Giant cell tumor of bone (GCTB) is a locally aggressive lesion of intermediate malignancy. Malignant transformation of GCTB is a rare event. In 2013, the humanized monoclonal antibody against receptor activator of nuclear factor-κb-Ligand (RANKL) denosumab was approved for...

Characterization of Immune Responses to SARS-CoV-2 and Other Human Pathogenic Coronaviruses Using a Multiplex Bead-Based Immunoassay.

Vaccines

Borena W, Kimpel J, Gierer M, Rössler A, Riepler L, Oehler S, von Laer D, Miholits M.
PMID: 34200301
Vaccines (Basel). 2021 Jun 07;9(6). doi: 10.3390/vaccines9060611.

Serological assays that simultaneously detect antibodies to multiple targets of SARS-CoV-2 and to other structurally related coronaviruses provide a holistic picture of antibody response patterns. Well-validated multiplex immunoassays are scarce. Here, we evaluated the performance of an 11-plex serological...

Cardiogeneticsbank@UZA: A Collection of DNA, Tissues, and Cell Lines as a Translational Tool.

Frontiers in medicine

Alaerts M, van de Beek G, Luyckx I, Meester J, Schepers D, Verstraeten A, Saenen J, Van Craenenbroeck E, Goovaerts I, Rodrigus I, Laga S, Hendriks J, Goethals S, De Wilde A, Smits E, Jorens P, Huizing M, Van Laer L, Loeys B.
PMID: 31555651
Front Med (Lausanne). 2019 Sep 06;6:198. doi: 10.3389/fmed.2019.00198. eCollection 2019.

Cardiogeneticsbank@UZA is an academic hospital integrated biobank that collects aortic tissue, blood, cell lines (fibroblasts, vascular smooth muscle cells, peripheral blood mononuclear cells, and induced pluripotent stem cells), and DNA from patients with cardiogenetic disorders, for both diagnostic and...

The Role of HPV and Non-HPV Sexually Transmitted Infections in Patients with Oropharyngeal Carcinoma: A Case Control Study.

Cancers

Kofler B, Laimer J, Bruckmoser E, Steinbichler TB, Runge A, Schartinger VH, von Laer D, Borena W.
PMID: 32397254
Cancers (Basel). 2020 May 08;12(5). doi: 10.3390/cancers12051192.

No abstract available.

Nanoparticle-Formulated Curcumin Prevents Posttherapeutic Disease Reactivation and Reinfection with .

Frontiers in immunology

Tousif S, Singh DK, Mukherjee S, Ahmad S, Arya R, Nanda R, Ranganathan A, Bhattacharyya M, Van Kaer L, Kar SK, Das G.
PMID: 28713372
Front Immunol. 2017 Jun 30;8:739. doi: 10.3389/fimmu.2017.00739. eCollection 2017.

Curcumin, the bioactive component of turmeric also known as "Indian Yellow Gold," exhibits therapeutic efficacy against several chronic inflammatory and infectious diseases. Even though considered as a wonder drug pertaining to a myriad of reported benefits, the translational potential...

Analysis of the CDK4/6 Cell Cycle Pathway in Leiomyosarcomas as a Potential Target for Inhibition by Palbociclib.

Sarcoma

Böhm MJ, Marienfeld R, Jäger D, Mellert K, von Witzleben A, Brüderlein S, Wittau M, von Baer A, Schultheiss M, Mayer-Steinacker R, Rücker FG, Möller P, Bullinger L, Barth TFE.
PMID: 30804704
Sarcoma. 2019 Jan 21;2019:3914232. doi: 10.1155/2019/3914232. eCollection 2019.

Leiomyosarcoma (LMS) is characterized by high genomic complexity, and to date, no specific targeted therapy is available. In a genome-wide approach, we profiled genomic aberrations in a small cohort of eight primary tumours, two relapses, and eight metastases across...

Drug-Drug Interaction of Ergotamine with a Combination of Darunavir, Abacavir, and Lamivudine Causing a Fatal Vasospastic Ischemia.

Case reports in emergency medicine

Petit E, Schoonheydt K, Meert P, Van Laer M.
PMID: 30662776
Case Rep Emerg Med. 2018 Dec 19;2018:4107450. doi: 10.1155/2018/4107450. eCollection 2018.

Ergotamine toxicity has become a rare condition which can be caused by, among others, drug-drug interaction. In this work we report a case with vasospastic ischemia induced by the wrongful combination of ergotamine with recently started Antiretroviral Therapy. Clinicians...

Ectopic expression of transcription factor BATF3 induces B-cell lymphomas in a murine B-cell transplantation model.

Oncotarget

Weiser C, Petkova MV, Rengstl B, Döring C, von Laer D, Hartmann S, Küppers R, Hansmann ML, Newrzela S.
PMID: 29662618
Oncotarget. 2018 Mar 23;9(22):15942-15951. doi: 10.18632/oncotarget.24639. eCollection 2018 Mar 23.

The mechanisms involved in malignant transformation of mature B and T lymphocytes are still poorly understood. In a previous study, we compared gene expression profiles of the tumor cells of Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL)...

Showing 13 to 24 of 84 entries