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Showing 1 to 12 of 406 entries
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Treatment with a High Dose Combination of PMSG/hCG Preparation of Mares Clinically Diagnosed with Ovarian Quiescence during the Breeding Season (Investigation from 1975 to 2000).

Journal of equine science

Tsukada T, Sato K, Moriyoshi M, Koyago M, Sawamukai Y.
PMID: 24833954
J Equine Sci. 2008;19(2):35-8. doi: 10.1294/jes.19.35. Epub 2008 Jul 09.

A total of 88 thoroughbred mares were diagnosed with clinical ovarian quiescence and subjected to four treatment regimens. Using PMSG, hCG or combinations of both. A high dose combination of 5,000IU PMSG with 5,000IU hCG showed significantly higher rates...

Overexpression of REIC/Dkk-3 suppresses the expression of CD147 and inhibits the proliferation of human bladder cancer cells.

Oncology letters

Horikawa Y, Watanabe M, Sadahira T, Ariyoshi Y, Kobayashi Y, Araki M, Wada K, Ochiai K, Li SA, Nasu Y.
PMID: 28927069
Oncol Lett. 2017 Sep;14(3):3223-3228. doi: 10.3892/ol.2017.6548. Epub 2017 Jul 08.

Our group previously developed an adenoviral vector encoding the REIC/Dkk-3 gene (Ad-REIC), a tumor suppressor, for cancer gene therapy. The Ad-REIC agent induces apoptosis and inhibits invasion in a number of cancer cell lines; however, the molecular mechanisms underlying...

Bone morphogenetic protein-4 modulates proliferation and terminal differentiation of fetal hepatic stem/progenitor cells.

Hepatology research : the official journal of the Japan Society of Hepatology

Goto F, Kakinuma S, Miyoshi M, Tsunoda T, Kaneko S, Sato A, Asano Y, Otani S, Azuma S, Nagata H, Kawai-Kitahata F, Murakawa M, Nitta S, Itsui Y, Nakagawa M, Asahina Y, Watanabe M.
PMID: 27670640
Hepatol Res. 2017 Aug;47(9):941-952. doi: 10.1111/hepr.12823. Epub 2016 Oct 31.

Fetal hepatic stem/progenitor cells, called hepatoblasts, play central roles in liver organogenesis; however, molecular mechanisms regulating proliferation and terminal differentiation of such cells have not been completely elucidated. Bone morphogenetic protein-4 (BMP-4) is essential for the development of stem...

Ultrasound analysis of gray-scale median value of carotid plaques is a useful reference index for cerebro-cardiovascular events in patients with type 2 diabetes.

Journal of diabetes investigation

Ariyoshi K, Okuya S, Kunitsugu I, Matsunaga K, Nagao Y, Nomiyama R, Takeda K, Tanizawa Y.
PMID: 25621138
J Diabetes Investig. 2015 Jan;6(1):91-7. doi: 10.1111/jdi.12242. Epub 2014 Jun 10.

AIMS/INTRODUCTION: Measurements of plaque echogenicity, the gray-scale median (GSM), were shown to correlate inversely with risk factors for cerebro-cardiovascular disease (CVD). The eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio is a potential predictor of CVD risk. In the present study,...

Aggressive gastrointestinal food allergy in neonates and its possible relationship to necrotizing enterocolitis.

International journal of surgery case reports

Suda K, Yanai T, Toma M, Aiyoshi T, Sasaki T, Muraji T.
PMID: 28601030
Int J Surg Case Rep. 2017;36:175-178. doi: 10.1016/j.ijscr.2017.05.038. Epub 2017 Jun 02.

INTRODUCTION: The incidence of gastrointestinal food allergy (FA) in neonates is increasing. Despite this, cases of patients with gastrointestinal FA who develop necrotizing enterocolitis (NEC) requiring laparotomy are extremely rare.PRESENTATION OF CASE: We describe two cases that presented with...

Concomitant fat embolism syndrome and pulmonary embolism in a patient with a femoral shaft fracture.

Acute medicine & surgery

Ebina M, Inoue A, Atsumi T, Ariyoshi K.
PMID: 29123766
Acute Med Surg. 2015 Jul 03;3(2):135-138. doi: 10.1002/ams2.127. eCollection 2016 Apr.

CASE: A 22-year-old man was injured in a traffic accident and developed respiratory distress on his first day of admission. On postadmission day 3, he developed serious respiratory distress with a suddenly altered mental status. Chest computed tomography revealed...

Androgen receptor overexpression is neuroprotective in experimental stroke.

Translational stroke research

Ayala P, Uchida M, Akiyoshi K, Cheng J, Hashimoto J, Jia T, Ronnekleiv OK, Murphy SJ, Wiren KM, Hurn PD.
PMID: 24323653
Transl Stroke Res. 2011 Sep;2(3):346-57. doi: 10.1007/s12975-011-0079-z. Epub 2011 Apr 15.

Male sex is a known risk factor in human stroke. However, the role of the cognate receptor for androgens-the androgen receptor (AR)-in stroke outcome remains unclear. Here, we found that AR mRNA is downregulated in the peri-infarct tissue of...

Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity.

Frontiers in pharmacology

Nishimura Y, Sasagawa S, Ariyoshi M, Ichikawa S, Shimada Y, Kawaguchi K, Kawase R, Yamamoto R, Uehara T, Yanai T, Takata R, Tanaka T.
PMID: 26441656
Front Pharmacol. 2015 Sep 15;6:199. doi: 10.3389/fphar.2015.00199. eCollection 2015.

Both caloric restriction (CR) and resveratrol (RSV) have beneficial effects on obesity. However, the biochemical pathways that mediate these beneficial effects might be complex and interconnected and have not been fully elucidated. To reveal the common therapeutic mechanism of...

Reactions of community members regarding community health workers' activities as a measure of the impact of a training program in Amazonas, Brazil.

Journal of rural medicine : JRM

Kawasaki R, Sadamori T, Ferreira de Almeida T, Akiyoshi M, Nishihara M, Yoshimura T, Ohnishi M.
PMID: 26380586
J Rural Med. 2015;10(1):7-19. doi: 10.2185/jrm.2890. Epub 2014 Dec 06.

OBJECTIVES: The aim of this study was to evaluate the impact of community health worker (CHW) training on recognition and satisfaction regarding the performance of CHWs among members of the community in Amazonas, Brazil, which is a resource-poor area...

Molecular Epidemiology of Rubella Virus Strains Detected Around the Time of the 2012-2013 Epidemic in Japan.

Frontiers in microbiology

Mori Y, Miyoshi M, Kikuchi M, Sekine M, Umezawa M, Saikusa M, Matsushima Y, Itamochi M, Yasui Y, Kanbayashi D, Miyoshi T, Akiyoshi K, Tatsumi C, Zaitsu S, Kadoguchi M, Otsuki N, Okamoto K, Sakata M, Komase K, Takeda M.
PMID: 28848523
Front Microbiol. 2017 Aug 09;8:1513. doi: 10.3389/fmicb.2017.01513. eCollection 2017.

A nationwide rubella epidemic occurred from 2012 to 2013 in Japan, resulting in around 17,000 rubella cases and the birth of 45 infants with congenital rubella syndrome. The aim of this study was to genetically characterize the rubella viruses...

Reduction in gastrointestinal bleeding by development and implementation of a protocol for stress ulcer prophylaxis: a before-after study.

Journal of pharmaceutical health care and sciences

Ikemura M, Nakasako S, Seo R, Atsumi T, Ariyoshi K, Hashida T.
PMID: 26819744
J Pharm Health Care Sci. 2015 Dec 15;1:33. doi: 10.1186/s40780-015-0034-3. eCollection 2015.

BACKGROUND: The implementation of a protocol has been associated with improvements in the processes of care in clinical settings. Although stress ulcer prophylaxis is recommended for critically ill patients at high risk, there is currently no consensus on its...

Computer-Aided Reaction Design. Development of a New Facile Procedure to Synthesize 2-Mercapto-3-alkoxycarboxylate on the Basis of ab Initio Molecular Orbital Calculations.

The Journal of organic chemistry

Fukuda S, Akiyoshi Y, Hori K.
PMID: 11674550
J Org Chem. 1999 Jun 25;64(13):4768-4774. doi: 10.1021/jo990055n.

This paper describes a new facial procedure to substitute a tosyloxy group in 2-(tosyloxy)alkanoate with SH(-) to yield 2-mercaptoalkanoate on the basis of ab initio MO calculations. Combination of substrate and solvent effects can control both reactivity and selectivity...

Showing 1 to 12 of 406 entries