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Molecular Genetic Testing in Pain and Addiction: Facts, Fiction and Clinical Utility.

Addiction genetics

Blum K, Hauser M, Fratantonio J, Badgaiyan RD.
PMID: 26807291
Addict Genet. 2015 Jul 01;2(1):1-5. doi: 10.1515/addge-2015-0001. Epub 2015 Aug 28.

The Brain Reward Cascade (BRC) is an interaction of neurotransmitters and their respective genes to control the amount of dopamine released within the brain. Any variations within this pathway, whether genetic or environmental (epigenetic), may result in addictive behaviors...

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Blum K, Hauser M, Fratantonio J, et al. Molecular Genetic Testing in Pain and Addiction: Facts, Fiction and Clinical Utility. Addict Genet. 2015;2(1):1-5doi: 10.1515/addge-2015-0001.
Blum, K., Hauser, M., Fratantonio, J., & Badgaiyan, R. D. (2015). Molecular Genetic Testing in Pain and Addiction: Facts, Fiction and Clinical Utility. Addiction genetics, 2(1), 1-5. https://doi.org/10.1515/addge-2015-0001
Blum, Kenneth, et al. "Molecular Genetic Testing in Pain and Addiction: Facts, Fiction and Clinical Utility." Addiction genetics vol. 2,1 (2015): 1-5. doi: https://doi.org/10.1515/addge-2015-0001
Blum K, Hauser M, Fratantonio J, Badgaiyan RD. Molecular Genetic Testing in Pain and Addiction: Facts, Fiction and Clinical Utility. Addict Genet. 2015 Jul 01;2(1):1-5. doi: 10.1515/addge-2015-0001. Epub 2015 Aug 28. PMID: 26807291; PMCID: PMC4720149.
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Nonconscious processing and a novel target for schizophrenia research.

Open journal of psychiatry

Badgaiyan RD.
PMID: 24404419
Open J Psychiatr. 2012 Nov 01;2(4). doi: 10.4236/ojpsych.2012.224047.

Analysis of the pattern of altered cognition observed in schizophrenia provides better insight into neurocognitive deficits. It reveals a potential novel target for schizophrenia research. To understand this target we reviewed the findings of neuroimaging studies on implicit [nonconscious]...

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Badgaiyan RD. Nonconscious processing and a novel target for schizophrenia research. Open J Psychiatr. 2012;2(4)doi: 10.4236/ojpsych.2012.224047.
Badgaiyan, R. D. (2012). Nonconscious processing and a novel target for schizophrenia research. Open journal of psychiatry, 2(4), . https://doi.org/10.4236/ojpsych.2012.224047
Badgaiyan, Rajendra D. "Nonconscious processing and a novel target for schizophrenia research." Open journal of psychiatry vol. 2,4 (2012). doi: https://doi.org/10.4236/ojpsych.2012.224047
Badgaiyan RD. Nonconscious processing and a novel target for schizophrenia research. Open J Psychiatr. 2012 Nov 01;2(4). doi: 10.4236/ojpsych.2012.224047. PMID: 24404419; PMCID: PMC3882161.
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"Pro-dopamine regulation (KB220Z™)" as a long-term therapeutic modality to overcome reduced resting state dopamine tone in opiate/opioid epidemic in America.

Journal of systems and integrative neuroscience

Blum K, Marcelo F, Dushaj K, Fried L, Badgaiyan RD.
PMID: 28491463
J Syst Integr Neurosci. 2016 Sep;2(3):162-165. doi: 10.15761/JSIN.1000129.

Since it is known that relapse, morality, and hospitalizations have been tied to the presence of the Dopamine D2 Receptor A1 allele, as one example, and carriers of this gene variant have a proclivity to favor amino-acid therapy, it...

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Blum K, Marcelo F, Dushaj K, et al. "Pro-dopamine regulation (KB220Z™)" as a long-term therapeutic modality to overcome reduced resting state dopamine tone in opiate/opioid epidemic in America. J Syst Integr Neurosci. 2016;2(3):162-165doi: 10.15761/JSIN.1000129.
Blum, K., Marcelo, F., Dushaj, K., Fried, L., & Badgaiyan, R. D. (2016). "Pro-dopamine regulation (KB220Z™)" as a long-term therapeutic modality to overcome reduced resting state dopamine tone in opiate/opioid epidemic in America. Journal of systems and integrative neuroscience, 2(3), 162-165. https://doi.org/10.15761/JSIN.1000129
Blum, K, et al. ""Pro-dopamine regulation (KB220Z™)" as a long-term therapeutic modality to overcome reduced resting state dopamine tone in opiate/opioid epidemic in America." Journal of systems and integrative neuroscience vol. 2,3 (2016): 162-165. doi: https://doi.org/10.15761/JSIN.1000129
Blum K, Marcelo F, Dushaj K, Fried L, Badgaiyan RD. "Pro-dopamine regulation (KB220Z™)" as a long-term therapeutic modality to overcome reduced resting state dopamine tone in opiate/opioid epidemic in America. J Syst Integr Neurosci. 2016 Sep;2(3):162-165. doi: 10.15761/JSIN.1000129. PMID: 28491463; PMCID: PMC5421552.
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Improvement of long-term memory access with a pro-dopamine regulator in an elderly male: Are we targeting dopamine tone?.

Journal of systems and integrative neuroscience

McLaughlin T, Han D, Nicholson J, Steinberg B, Blum K, Febo M, Braverman E, Li M, Fried L, Badgaiyan R.
PMID: 29423319
J Syst Integr Neurosci. 2017 May;3(3). doi: 10.15761/JSIN.1000165. Epub 2017 Jun 17.

With aging, there is decline in both short-term and long-term memory. This effect is magnified by epigenetic insults on specific, dopamine- related genes (e.g., DRD2, DAT1) as well as by impaired or reduced mRNA transcription. In addition, long-term memory...

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McLaughlin T, Han D, Nicholson J, et al. Improvement of long-term memory access with a pro-dopamine regulator in an elderly male: Are we targeting dopamine tone?. J Syst Integr Neurosci. 2017;3(3)doi: 10.15761/JSIN.1000165.
McLaughlin, T., Han, D., Nicholson, J., Steinberg, B., Blum, K., Febo, M., Braverman, E., Li, M., Fried, L., & Badgaiyan, R. (2017). Improvement of long-term memory access with a pro-dopamine regulator in an elderly male: Are we targeting dopamine tone?. Journal of systems and integrative neuroscience, 3(3), . https://doi.org/10.15761/JSIN.1000165
McLaughlin, Thomas, et al. "Improvement of long-term memory access with a pro-dopamine regulator in an elderly male: Are we targeting dopamine tone?." Journal of systems and integrative neuroscience vol. 3,3 (2017). doi: https://doi.org/10.15761/JSIN.1000165
McLaughlin T, Han D, Nicholson J, Steinberg B, Blum K, Febo M, Braverman E, Li M, Fried L, Badgaiyan R. Improvement of long-term memory access with a pro-dopamine regulator in an elderly male: Are we targeting dopamine tone?. J Syst Integr Neurosci. 2017 May;3(3). doi: 10.15761/JSIN.1000165. Epub 2017 Jun 17. PMID: 29423319; PMCID: PMC5800757.
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THE BENEFITS OF CUSTOMIZED DNA DIRECTED NUTRITION TO BALANCE THE BRAIN REWARD CIRCUITRY AND REDUCE ADDICTIVE BEHAVIORS.

Precision medicine

Blum K, Downs BW, Dushaj K, Li M, Braverman ER, Fried L, Waite R, Demotrovics Z, Badgaiyan RD.
PMID: 28066828
Precis Med (Bangalore). 2016;1(1):18-33. Epub 2016 Aug 01.

DNA Customization of nutraceutical products is here. In the truest sense, "Gene Guided Precision Nutrition

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Blum K, Downs BW, Dushaj K, et al. THE BENEFITS OF CUSTOMIZED DNA DIRECTED NUTRITION TO BALANCE THE BRAIN REWARD CIRCUITRY AND REDUCE ADDICTIVE BEHAVIORS. Precis Med (Bangalore). 2016;1(1):18-33
Blum, K., Downs, B. W., Dushaj, K., Li, M., Braverman, E. R., Fried, L., Waite, R., Demotrovics, Z., & Badgaiyan, R. D. (2016). THE BENEFITS OF CUSTOMIZED DNA DIRECTED NUTRITION TO BALANCE THE BRAIN REWARD CIRCUITRY AND REDUCE ADDICTIVE BEHAVIORS. Precision medicine, 1(1), 18-33.
Blum, Kenneth, et al. "THE BENEFITS OF CUSTOMIZED DNA DIRECTED NUTRITION TO BALANCE THE BRAIN REWARD CIRCUITRY AND REDUCE ADDICTIVE BEHAVIORS." Precision medicine vol. 1,1 (2016): 18-33.
Blum K, Downs BW, Dushaj K, Li M, Braverman ER, Fried L, Waite R, Demotrovics Z, Badgaiyan RD. THE BENEFITS OF CUSTOMIZED DNA DIRECTED NUTRITION TO BALANCE THE BRAIN REWARD CIRCUITRY AND REDUCE ADDICTIVE BEHAVIORS. Precis Med (Bangalore). 2016;1(1):18-33. Epub 2016 Aug 01. PMID: 28066828; PMCID: PMC5210211.
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GLOBAL OPIOID EPIDEMIC: DOOMED TO FAIL WITHOUT GENETICALLY BASED PRECISION ADDICTION MEDICINE (PAM.

Precision medicine

Blum K, Modestino EJ, Gondré-Lewis MC, Neary J, Siwicki D, Hauser M, Barh D, Steinberg B, Badgaiyan RD.
PMID: 29372187
Precis Med (Bangalore). 2017;2(1):17-22. Epub 2017 Nov 18.

It is a reality that globally opioid deaths have soared for men and women of all social, economic status and age from heroin and fentanyl overdoses. Specifically, in the United States, deaths from narcotic overdoses have reached alarming metrics...

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Blum K, Modestino EJ, Gondré-Lewis MC, et al. GLOBAL OPIOID EPIDEMIC: DOOMED TO FAIL WITHOUT GENETICALLY BASED PRECISION ADDICTION MEDICINE (PAM. Precis Med (Bangalore). 2017;2(1):17-22
Blum, K., Modestino, E. J., Gondré-Lewis, M. C., Neary, J., Siwicki, D., Hauser, M., Barh, D., Steinberg, B., & Badgaiyan, R. D. (2017). GLOBAL OPIOID EPIDEMIC: DOOMED TO FAIL WITHOUT GENETICALLY BASED PRECISION ADDICTION MEDICINE (PAM. Precision medicine, 2(1), 17-22.
Blum, Kenneth, et al. "GLOBAL OPIOID EPIDEMIC: DOOMED TO FAIL WITHOUT GENETICALLY BASED PRECISION ADDICTION MEDICINE (PAM." Precision medicine vol. 2,1 (2017): 17-22.
Blum K, Modestino EJ, Gondré-Lewis MC, Neary J, Siwicki D, Hauser M, Barh D, Steinberg B, Badgaiyan RD. GLOBAL OPIOID EPIDEMIC: DOOMED TO FAIL WITHOUT GENETICALLY BASED PRECISION ADDICTION MEDICINE (PAM. Precis Med (Bangalore). 2017;2(1):17-22. Epub 2017 Nov 18. PMID: 29372187; PMCID: PMC5778881.
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Introducing Precision Addiction Management of Reward Deficiency Syndrome, the Construct That Underpins All Addictive Behaviors.

Frontiers in psychiatry

Blum K, Gondré-Lewis MC, Baron D, Thanos PK, Braverman ER, Neary J, Elman I, Badgaiyan RD.
PMID: 30542299
Front Psychiatry. 2018 Nov 27;9:548. doi: 10.3389/fpsyt.2018.00548. eCollection 2018.

No abstract available.

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Blum K, Gondré-Lewis MC, Baron D, et al. Introducing Precision Addiction Management of Reward Deficiency Syndrome, the Construct That Underpins All Addictive Behaviors. Front Psychiatry. 2018;9:548doi: 10.3389/fpsyt.2018.00548.
Blum, K., Gondré-Lewis, M. C., Baron, D., Thanos, P. K., Braverman, E. R., Neary, J., Elman, I., & Badgaiyan, R. D. (2018). Introducing Precision Addiction Management of Reward Deficiency Syndrome, the Construct That Underpins All Addictive Behaviors. Frontiers in psychiatry, 9548. https://doi.org/10.3389/fpsyt.2018.00548
Blum, Kenneth, et al. "Introducing Precision Addiction Management of Reward Deficiency Syndrome, the Construct That Underpins All Addictive Behaviors." Frontiers in psychiatry vol. 9 (2018): 548. doi: https://doi.org/10.3389/fpsyt.2018.00548
Blum K, Gondré-Lewis MC, Baron D, Thanos PK, Braverman ER, Neary J, Elman I, Badgaiyan RD. Introducing Precision Addiction Management of Reward Deficiency Syndrome, the Construct That Underpins All Addictive Behaviors. Front Psychiatry. 2018 Nov 27;9:548. doi: 10.3389/fpsyt.2018.00548. eCollection 2018. PMID: 30542299; PMCID: PMC6277779.
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Our evolved unique pleasure circuit makes humans different from apes: Reconsideration of data derived from animal studies.

Journal of systems and integrative neuroscience

Blum K, Gondré-Lewis M, Steinberg B, Elman I, Baron D, Modestino EJ, Badgaiyan RD, Gold MS.
PMID: 30956812
J Syst Integr Neurosci. 2018 Jun;4(1). doi: 10.15761/JSIN.1000191. Epub 2018 Feb 28.

The brain regions tied to pleasure can be triggered by engaging in sex, eating tasty food, watching a movie, accomplishments at school and athletics, consuming drugs, and noble efforts to help the community, the country, and the world. It...

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Blum K, Gondré-Lewis M, Steinberg B, et al. Our evolved unique pleasure circuit makes humans different from apes: Reconsideration of data derived from animal studies. J Syst Integr Neurosci. 2018;4(1)doi: 10.15761/JSIN.1000191.
Blum, K., Gondré-Lewis, M., Steinberg, B., Elman, I., Baron, D., Modestino, E. J., Badgaiyan, R. D., & Gold, M. S. (2018). Our evolved unique pleasure circuit makes humans different from apes: Reconsideration of data derived from animal studies. Journal of systems and integrative neuroscience, 4(1), . https://doi.org/10.15761/JSIN.1000191
Blum, Kenneth, et al. "Our evolved unique pleasure circuit makes humans different from apes: Reconsideration of data derived from animal studies." Journal of systems and integrative neuroscience vol. 4,1 (2018). doi: https://doi.org/10.15761/JSIN.1000191
Blum K, Gondré-Lewis M, Steinberg B, Elman I, Baron D, Modestino EJ, Badgaiyan RD, Gold MS. Our evolved unique pleasure circuit makes humans different from apes: Reconsideration of data derived from animal studies. J Syst Integr Neurosci. 2018 Jun;4(1). doi: 10.15761/JSIN.1000191. Epub 2018 Feb 28. PMID: 30956812; PMCID: PMC6446569.
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The Benefits of Genetic Addiction Risk Score (GARS.

International journal of genomics and data mining

Blum K, Modestino EJ, Gondre-Lewis M, Chapman EJ, Neary J, Siwicki D, Baron D, Hauser M, Smith DE, Roy AK, Thanos PK, Steinberg B, McLaughlin T, Fried L, Barh D, Dunston GA, Badgaiyan RD.
PMID: 30198022
Int J Genom Data Min. 2018;2018(1). doi: 10.29014/IJGD-115.000015. Epub 2018 Jan 15.

Following 25 years of extensive research by many scientists worldwide, a panel of ten reward gene risk variants, called the Genetic Addiction Risk Score (GARS), has been developed. In unpublished work, when GARS was compared to the Addiction Severity...

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Blum K, Modestino EJ, Gondre-Lewis M, et al. The Benefits of Genetic Addiction Risk Score (GARS. Int J Genom Data Min. 2018;2018(1)doi: 10.29014/IJGD-115.000015.
Blum, K., Modestino, E. J., Gondre-Lewis, M., Chapman, E. J., Neary, J., Siwicki, D., Baron, D., Hauser, M., Smith, D. E., Roy, A. K., Thanos, P. K., Steinberg, B., McLaughlin, T., Fried, L., Barh, D., Dunston, G. A., & Badgaiyan, R. D. (2018). The Benefits of Genetic Addiction Risk Score (GARS. International journal of genomics and data mining, 2018(1), . https://doi.org/10.29014/IJGD-115.000015
Blum, Kenneth, et al. "The Benefits of Genetic Addiction Risk Score (GARS." International journal of genomics and data mining vol. 2018,1 (2018). doi: https://doi.org/10.29014/IJGD-115.000015
Blum K, Modestino EJ, Gondre-Lewis M, Chapman EJ, Neary J, Siwicki D, Baron D, Hauser M, Smith DE, Roy AK, Thanos PK, Steinberg B, McLaughlin T, Fried L, Barh D, Dunston GA, Badgaiyan RD. The Benefits of Genetic Addiction Risk Score (GARS. Int J Genom Data Min. 2018;2018(1). doi: 10.29014/IJGD-115.000015. Epub 2018 Jan 15. PMID: 30198022; PMCID: PMC6128289.
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The benefits of genetic addiction risk score (GARS™) and pro-dopamine regulation in combating suicide in the American Indian population.

Journal of systems and integrative neuroscience

Blum K, Siwicki D, Baron D, Modestino EJ, Badgaiyan RD.
PMID: 31660252
J Syst Integr Neurosci. 2018 Sep 14;4. doi: 10.15761/JSIN.1000195.

It is well-known that Native Americans (NA) clinically present with a very high rate of alcoholism and other drugs of abuse. It is also known that NA also display a very high rate of suicide compared to other ethnic...

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Blum K, Siwicki D, Baron D, et al. The benefits of genetic addiction risk score (GARS™) and pro-dopamine regulation in combating suicide in the American Indian population. J Syst Integr Neurosci. 2018;4doi: 10.15761/JSIN.1000195.
Blum, K., Siwicki, D., Baron, D., Modestino, E. J., & Badgaiyan, R. D. (2018). The benefits of genetic addiction risk score (GARS™) and pro-dopamine regulation in combating suicide in the American Indian population. Journal of systems and integrative neuroscience, 4. https://doi.org/10.15761/JSIN.1000195
Blum, Kenneth, et al. "The benefits of genetic addiction risk score (GARS™) and pro-dopamine regulation in combating suicide in the American Indian population." Journal of systems and integrative neuroscience vol. 4 (2018). doi: https://doi.org/10.15761/JSIN.1000195
Blum K, Siwicki D, Baron D, Modestino EJ, Badgaiyan RD. The benefits of genetic addiction risk score (GARS™) and pro-dopamine regulation in combating suicide in the American Indian population. J Syst Integr Neurosci. 2018 Sep 14;4. doi: 10.15761/JSIN.1000195. PMID: 31660252; PMCID: PMC6816273.
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Biotechnical development of genetic addiction risk score (GARS) and selective evidence for inclusion of polymorphic allelic risk in substance use disorder (SUD).

Journal of systems and integrative neuroscience

Blum K, Bowirrat A, Baron D, Lott L, Ponce JV, Brewer R, Siwicki D, Boyett B, Gondre-Lewis MC, Smith DE, Panayotis K T, Badgaiyan S, Hauser M, Fried L, A R, Downs BW, Badgaiyan RD.
PMID: 33614164
J Syst Integr Neurosci. 2020 Aug;6(2). doi: 10.15761/JSIN.1000221. Epub 2019 Dec 19.

Research into the neurogenetic basis of addiction identified and characterized by Reward Deficiency Syndrome (RDS) includes all drug and non-drug addictive, obsessive and compulsive behaviors. We are proposing herein that a new model for the prevention and treatment of...

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Blum K, Bowirrat A, Baron D, et al. Biotechnical development of genetic addiction risk score (GARS) and selective evidence for inclusion of polymorphic allelic risk in substance use disorder (SUD). J Syst Integr Neurosci. 2019;6(2)doi: 10.15761/JSIN.1000221.
Blum, K., Bowirrat, A., Baron, D., Lott, L., Ponce, J. V., Brewer, R., Siwicki, D., Boyett, B., Gondre-Lewis, M. C., Smith, D. E., Panayotis K, T., Badgaiyan, S., Hauser, M., Fried, L., A, R., Downs, B. W., & Badgaiyan, R. D. (2020). Biotechnical development of genetic addiction risk score (GARS) and selective evidence for inclusion of polymorphic allelic risk in substance use disorder (SUD). Journal of systems and integrative neuroscience, 6(2), . https://doi.org/10.15761/JSIN.1000221
Blum, K, et al. "Biotechnical development of genetic addiction risk score (GARS) and selective evidence for inclusion of polymorphic allelic risk in substance use disorder (SUD)." Journal of systems and integrative neuroscience vol. 6,2 (2020). doi: https://doi.org/10.15761/JSIN.1000221
Blum K, Bowirrat A, Baron D, Lott L, Ponce JV, Brewer R, Siwicki D, Boyett B, Gondre-Lewis MC, Smith DE, Panayotis K T, Badgaiyan S, Hauser M, Fried L, A R, Downs BW, Badgaiyan RD. Biotechnical development of genetic addiction risk score (GARS) and selective evidence for inclusion of polymorphic allelic risk in substance use disorder (SUD). J Syst Integr Neurosci. 2020 Aug;6(2). doi: 10.15761/JSIN.1000221. Epub 2019 Dec 19. PMID: 33614164; PMCID: PMC7891477.
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Hypothesizing in the Face of the Opioid Crisis Coupling Genetic Addiction Risk Severity (GARS) Testing with Electrotherapeutic Nonopioid Modalities Such as H-Wave Could Attenuate Both Pain and Hedonic Addictive Behaviors.

International journal of environmental research and public health

Gupta A, Bowirrat A, Gomez LL, Baron D, Elman I, Giordano J, Jalali R, Badgaiyan RD, Modestino EJ, Gold MS, Braverman ER, Bajaj A, Blum K.
PMID: 35010811
Int J Environ Res Public Health. 2022 Jan 04;19(1). doi: 10.3390/ijerph19010552.

In the United States, amid the opioid overdose epidemic, nonaddicting/nonpharmacological proven strategies are available to treat pain and manage chronic pain effectively without opioids. Evidence supporting the long-term use of opioids for pain is lacking, as is the will...

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Gupta A, Bowirrat A, Gomez LL, et al. Hypothesizing in the Face of the Opioid Crisis Coupling Genetic Addiction Risk Severity (GARS) Testing with Electrotherapeutic Nonopioid Modalities Such as H-Wave Could Attenuate Both Pain and Hedonic Addictive Behaviors. Int J Environ Res Public Health. 2022;19(1)doi: 10.3390/ijerph19010552.
Gupta, A., Bowirrat, A., Gomez, L. L., Baron, D., Elman, I., Giordano, J., Jalali, R., Badgaiyan, R. D., Modestino, E. J., Gold, M. S., Braverman, E. R., Bajaj, A., & Blum, K. (2022). Hypothesizing in the Face of the Opioid Crisis Coupling Genetic Addiction Risk Severity (GARS) Testing with Electrotherapeutic Nonopioid Modalities Such as H-Wave Could Attenuate Both Pain and Hedonic Addictive Behaviors. International journal of environmental research and public health, 19(1), . https://doi.org/10.3390/ijerph19010552
Gupta, Ashim, et al. "Hypothesizing in the Face of the Opioid Crisis Coupling Genetic Addiction Risk Severity (GARS) Testing with Electrotherapeutic Nonopioid Modalities Such as H-Wave Could Attenuate Both Pain and Hedonic Addictive Behaviors." International journal of environmental research and public health vol. 19,1 (2022). doi: https://doi.org/10.3390/ijerph19010552
Gupta A, Bowirrat A, Gomez LL, Baron D, Elman I, Giordano J, Jalali R, Badgaiyan RD, Modestino EJ, Gold MS, Braverman ER, Bajaj A, Blum K. Hypothesizing in the Face of the Opioid Crisis Coupling Genetic Addiction Risk Severity (GARS) Testing with Electrotherapeutic Nonopioid Modalities Such as H-Wave Could Attenuate Both Pain and Hedonic Addictive Behaviors. Int J Environ Res Public Health. 2022 Jan 04;19(1). doi: 10.3390/ijerph19010552. PMID: 35010811.
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