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Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome.

Annals of intensive care

Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, Thompson BT, Matthay MA.
PMID: 25593740
Ann Intensive Care. 2014 Jul 03;4:22. doi: 10.1186/s13613-014-0022-z. eCollection 2014.

CLINICAL TRIALS REGISTRATION: NCT01775774 and NCT02097641.

The authors reply.

Critical care medicine

Kangelaris KN, Ware LB, Matthay MA, Calfee CS.
PMID: 27428148
Crit Care Med. 2016 Aug;44(8):e769-70. doi: 10.1097/CCM.0000000000001910.

No abstract available.

Activation of Ligand Reactivity: Thiolate C-S and Dithiophosphate Ester C-O Heterolyses within a Dimolybdenum(V) System.

Inorganic chemistry

Koffi-Sokpa EI, Calfee DT, Allred BR, Davis JL, Haub EK, Rich AK, Porter RA, Mashuta MS, Richardson JF, Noble ME.
PMID: 11670847
Inorg Chem. 1999 Feb 22;38(4):802-813. doi: 10.1021/ic981303l.

Ligand reactivity was demonstrated for sulfide alkylation, thiolate dealkylation, and dithiophosphate de-esterification within molybdenum(V) dimers. The cationic complex [Mo(2)(NC(6)H(4)Me)(2)(S(2)P(OEt)(2))(2)(&mgr;-O(2)CMe)(&mgr;-SR)(2)](+) was inductively activated toward thiolate C-S and dithiophosphate C-O heterolyses. The dealkylations were studied using anionic nucleophiles, and various reactivity...

Can quality-adjusted life year avoidance help in oncology drug reimbursement decisions?.

Journal of oncology practice

Calfee JE.
PMID: 20859437
J Oncol Pract. 2008 Jan;4(1):8. doi: 10.1200/JOP.0711501.

No abstract available.

Anomalous dispersion calculated for atmospheric water vapor.

Applied optics

Calfee RF.
PMID: 20068860
Appl Opt. 1968 Aug 01;7(8):1652-4. doi: 10.1364/AO.7.001652.

No abstract available.

Comparison of thermodilution measured extravascular lung water with chest radiographic assessment of pulmonary oedema in patients with acute lung injury.

Annals of intensive care

Brown LM, Calfee CS, Howard JP, Craig TR, Matthay MA, McAuley DF.
PMID: 23937970
Ann Intensive Care. 2013 Aug 11;3(1):25. doi: 10.1186/2110-5820-3-25.

BACKGROUND: Acute lung injury and the acute respiratory distress syndrome (ALI/ARDS) are characterized by pulmonary oedema, measured as extravascular lung water (EVLW). The chest radiograph (CXR) can potentially estimate the quantity of lung oedema while the transpulmonary thermodilution method...

Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties".

American journal of physiology. Lung cellular and molecular physiology

Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE.
PMID: 29109110
Am J Physiol Lung Cell Mol Physiol. 2017 Nov 01;313(5):L966-L967. doi: 10.1152/ajplung.00428.2017.

No abstract available.

Epidemiology of Bloodstream Infections Caused by .

Open forum infectious diseases

Baker TM, Rogers W, Chavda KD, Westblade LF, Jenkins SG, Nicolau DP, Kreiswirth BN, Calfee DP, Satlin MJ.
PMID: 30568979
Open Forum Infect Dis. 2018 Nov 19;5(12):ofy300. doi: 10.1093/ofid/ofy300. eCollection 2018 Dec.

BACKGROUND: Piperacillin-tazobactam-nonsusceptible (TZP-NS) Enterobacteriaceae are typically also resistant to ceftriaxone. We recently encountered bacteremias due to METHODS: We reviewed all RESULTS: There were 1857 CONCLUSIONS: TZP-NS/CRO-S

Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care: NHLBI Working Group Report.

American journal of respiratory and critical care medicine

Semler MW, Bernard GR, Aaron SD, Angus DC, Biros MH, Brower RG, Calfee CS, Colantuoni EA, Ferguson ND, Gong MN, Hopkins RO, Hough CL, Iwashyna TJ, Levy BD, Martin TR, Matthay MA, Mizgerd JP, Moss M, Needham DM, Self WH, Seymour CW, Stapleton RD, Thompson BT, Wunderink RG, Aggarwal NR, Reineck LA.
PMID: 32150460
Am J Respir Crit Care Med. 2020 Mar 09; doi: 10.1164/rccm.201908-1595WS. Epub 2020 Mar 09.

Preventing, treating, and promoting recovery from critical illness due to pulmonary disease are foundational goals of the critical care community and the National Heart, Lung, and Blood Institute. Decades of clinical research in acute respiratory distress syndrome, acute respiratory...

Impaired antibacterial immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.

medRxiv : the preprint server for health sciences

Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Jones N, Wu B, Darmanis S, Matthay MA, Lynch SV, DeRisi JL, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Rosenberg O, Calfee CS, Langelier CR.
PMID: 33791731
medRxiv. 2021 Mar 26; doi: 10.1101/2021.03.23.21253487.

Secondary bacterial infections, including ventilator-associated pneumonia (VAP), lead to worse clinical outcomes and increased mortality following viral respiratory infections. Critically ill patients with coronavirus disease 2019 (COVID-19) face an elevated risk of VAP, although susceptibility varies widely. Because mechanisms...

Comparison of machine learning clustering algorithms for detecting heterogeneity of treatment effect in acute respiratory distress syndrome: A secondary analysis of three randomised controlled trials.

EBioMedicine

Sinha P, Spicer A, Delucchi KL, McAuley DF, Calfee CS, Churpek MM.
PMID: 34861492
EBioMedicine. 2021 Nov 30;74:103697. doi: 10.1016/j.ebiom.2021.103697. Epub 2021 Nov 30.

BACKGROUND: Heterogeneity in Acute Respiratory Distress Syndrome (ARDS), as a consequence of its non-specific definition, has led to a multitude of negative randomised controlled trials (RCTs). Investigators have sought to identify heterogeneity of treatment effect (HTE) in RCTs using...

Global Absence and Targeting of Protective Immune States in Severe COVID-19.

Research square

Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF.
PMID: 33140041
Res Sq. 2020 Oct 28; doi: 10.21203/rs.3.rs-97042/v1.

While SARS-CoV-2 infection has pleiotropic and systemic effects in some patients, many others experience milder symptoms. We sought a holistic understanding of the severe/mild distinction in COVID-19 pathology, and its origins. We performed a wholeblood preserving single-cell analysis protocol...

Showing 1 to 12 of 137 entries