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Showing 1 to 12 of 93 entries
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Effects of Benzo(e)pyrene on Reactive Oxygen/Nitrogen Species and Inflammatory Cytokines Induction in Human RPE Cells and Attenuation by Mitochondrial-involved Mechanism.

Journal of ophthalmic & vision research

Estrago-Franco MF, Moustafa MT, Riazi-Esfahani M, Sapkal AU, Piche-Lopez R, Patil AJ, Sharma A, Falatoonzadeh P, Chwa M, Luczy-Bachman G, Kuppermann BD, Kenney MC.
PMID: 27994808
J Ophthalmic Vis Res. 2016 Oct-Dec;11(4):385-393. doi: 10.4103/2008-322X.194091.

PURPOSE: To identify inhibitors that could effectively lower reactive oxygen/nitrogen species (ROS/RNS), complement and inflammatory cytokine levels induced by Benzo(e)pyrene [B(e)p], an element of cigarette smoke, in human retinal pigment epithelial cells (ARPE-19) METHODS: ARPE-19 cells were treated for...

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Estrago-Franco MF, Moustafa MT, Riazi-Esfahani M, et al. Effects of Benzo(e)pyrene on Reactive Oxygen/Nitrogen Species and Inflammatory Cytokines Induction in Human RPE Cells and Attenuation by Mitochondrial-involved Mechanism. J Ophthalmic Vis Res. 2016;11(4):385-393doi: 10.4103/2008-322X.194091.
Estrago-Franco, M. F., Moustafa, M. T., Riazi-Esfahani, M., Sapkal, A. U., Piche-Lopez, R., Patil, A. J., Sharma, A., Falatoonzadeh, P., Chwa, M., Luczy-Bachman, G., Kuppermann, B. D., & Kenney, M. C. (2016). Effects of Benzo(e)pyrene on Reactive Oxygen/Nitrogen Species and Inflammatory Cytokines Induction in Human RPE Cells and Attenuation by Mitochondrial-involved Mechanism. Journal of ophthalmic & vision research, 11(4), 385-393. https://doi.org/10.4103/2008-322X.194091
Estrago-Franco, M Fernanda, et al. "Effects of Benzo(e)pyrene on Reactive Oxygen/Nitrogen Species and Inflammatory Cytokines Induction in Human RPE Cells and Attenuation by Mitochondrial-involved Mechanism." Journal of ophthalmic & vision research vol. 11,4 (2016): 385-393. doi: https://doi.org/10.4103/2008-322X.194091
Estrago-Franco MF, Moustafa MT, Riazi-Esfahani M, Sapkal AU, Piche-Lopez R, Patil AJ, Sharma A, Falatoonzadeh P, Chwa M, Luczy-Bachman G, Kuppermann BD, Kenney MC. Effects of Benzo(e)pyrene on Reactive Oxygen/Nitrogen Species and Inflammatory Cytokines Induction in Human RPE Cells and Attenuation by Mitochondrial-involved Mechanism. J Ophthalmic Vis Res. 2016 Oct-Dec;11(4):385-393. doi: 10.4103/2008-322X.194091. PMID: 27994808; PMCID: PMC5139551.
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Photoacoustic clutter reduction by inversion of a linear scatter model using plane wave ultrasound measurements.

Biomedical optics express

Schwab HM, Beckmann MF, Schmitz G.
PMID: 27446669
Biomed Opt Express. 2016 Mar 24;7(4):1468-78. doi: 10.1364/BOE.7.001468. eCollection 2016 Apr 01.

Photoacoustic imaging aims to visualize light absorption properties of biological tissue by receiving a sound wave that is generated inside the observed object as a result of the photoacoustic effect. In clinical applications, the strong light absorption in human...

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Schwab HM, Beckmann MF, Schmitz G. Photoacoustic clutter reduction by inversion of a linear scatter model using plane wave ultrasound measurements. Biomed Opt Express. 2016;7(4):1468-78doi: 10.1364/BOE.7.001468.
Schwab, H. M., Beckmann, M. F., & Schmitz, G. (2016). Photoacoustic clutter reduction by inversion of a linear scatter model using plane wave ultrasound measurements. Biomedical optics express, 7(4), 1468-78. https://doi.org/10.1364/BOE.7.001468
Schwab, Hans-Martin, et al. "Photoacoustic clutter reduction by inversion of a linear scatter model using plane wave ultrasound measurements." Biomedical optics express vol. 7,4 (2016): 1468-78. doi: https://doi.org/10.1364/BOE.7.001468
Schwab HM, Beckmann MF, Schmitz G. Photoacoustic clutter reduction by inversion of a linear scatter model using plane wave ultrasound measurements. Biomed Opt Express. 2016 Mar 24;7(4):1468-78. doi: 10.1364/BOE.7.001468. eCollection 2016 Apr 01. PMID: 27446669; PMCID: PMC4929655.
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The effect of social stress on hippocampal gene expression.

Molecular and cellular neurosciences

Chao HM, Blanchard DC, Blanchard RJ, McEwen BS, Sakai RR.
PMID: 19912962
Mol Cell Neurosci. 1993 Dec;4(6):543-8. doi: 10.1006/mcne.1993.1067.

The housing of male and female rats in a visible burrow system in which a dominance hierarchy is established and interactions between animals can be monitored provides an effective method by which the behavioral and neuroendocrine effects of social...

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Chao HM, Blanchard DC, Blanchard RJ, et al. The effect of social stress on hippocampal gene expression. Mol Cell Neurosci. 1993;4(6):543-8doi: 10.1006/mcne.1993.1067.
Chao, H. M., Blanchard, D. C., Blanchard, R. J., McEwen, B. S., & Sakai, R. R. (1993). The effect of social stress on hippocampal gene expression. Molecular and cellular neurosciences, 4(6), 543-8. https://doi.org/10.1006/mcne.1993.1067
Chao, H M, et al. "The effect of social stress on hippocampal gene expression." Molecular and cellular neurosciences vol. 4,6 (1993): 543-8. doi: https://doi.org/10.1006/mcne.1993.1067
Chao HM, Blanchard DC, Blanchard RJ, McEwen BS, Sakai RR. The effect of social stress on hippocampal gene expression. Mol Cell Neurosci. 1993 Dec;4(6):543-8. doi: 10.1006/mcne.1993.1067. PMID: 19912962.
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Corneal Oxidative Damage in Keratoconus Cells due to Decreased Oxidant Elimination from Modified Expression Levels of SOD Enzymes, PRDX6, SCARA3, CPSF3, and FOXM1.

Journal of ophthalmic & vision research

Atilano SR, Lee DH, Fukuhara PS, Chwa M, Nesburn AB, Udar N, Kenney MC.
PMID: 30820289
J Ophthalmic Vis Res. 2019 Jan-Mar;14(1):62-70. doi: 10.4103/jovr.jovr_80_18.

PURPOSE: To compare the levels of gene expression for enzymes involved in production and elimination of reactive oxygen/nitrogen species (ROS/RNS) in normal human corneal cells (NL cells) with those in human corneal cells with keratoconus (KC cells) METHODS: Primary...

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Atilano SR, Lee DH, Fukuhara PS, et al. Corneal Oxidative Damage in Keratoconus Cells due to Decreased Oxidant Elimination from Modified Expression Levels of SOD Enzymes, PRDX6, SCARA3, CPSF3, and FOXM1. J Ophthalmic Vis Res. 2019;14(1):62-70doi: 10.4103/jovr.jovr_80_18.
Atilano, S. R., Lee, D. H., Fukuhara, P. S., Chwa, M., Nesburn, A. B., Udar, N., & Kenney, M. C. (2019). Corneal Oxidative Damage in Keratoconus Cells due to Decreased Oxidant Elimination from Modified Expression Levels of SOD Enzymes, PRDX6, SCARA3, CPSF3, and FOXM1. Journal of ophthalmic & vision research, 14(1), 62-70. https://doi.org/10.4103/jovr.jovr_80_18
Atilano, Shari R, et al. "Corneal Oxidative Damage in Keratoconus Cells due to Decreased Oxidant Elimination from Modified Expression Levels of SOD Enzymes, PRDX6, SCARA3, CPSF3, and FOXM1." Journal of ophthalmic & vision research vol. 14,1 (2019): 62-70. doi: https://doi.org/10.4103/jovr.jovr_80_18
Atilano SR, Lee DH, Fukuhara PS, Chwa M, Nesburn AB, Udar N, Kenney MC. Corneal Oxidative Damage in Keratoconus Cells due to Decreased Oxidant Elimination from Modified Expression Levels of SOD Enzymes, PRDX6, SCARA3, CPSF3, and FOXM1. J Ophthalmic Vis Res. 2019 Jan-Mar;14(1):62-70. doi: 10.4103/jovr.jovr_80_18. PMID: 30820289; PMCID: PMC6388514.
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Advances in Methylmercury Toxicology and Risk Assessment.

Toxics

Chan HM.
PMID: 30939776
Toxics. 2019 Apr 01;7(2). doi: 10.3390/toxics7020020.

Mercury (Hg) is a global pollutant that affects the health of both humans and ecosystems [...].

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Chan HM. Advances in Methylmercury Toxicology and Risk Assessment. Toxics. 2019;7(2)doi: 10.3390/toxics7020020.
Chan, H. M. (2019). Advances in Methylmercury Toxicology and Risk Assessment. Toxics, 7(2), . https://doi.org/10.3390/toxics7020020
Chan, Hing Man. "Advances in Methylmercury Toxicology and Risk Assessment." Toxics vol. 7,2 (2019). doi: https://doi.org/10.3390/toxics7020020
Chan HM. Advances in Methylmercury Toxicology and Risk Assessment. Toxics. 2019 Apr 01;7(2). doi: 10.3390/toxics7020020. PMID: 30939776; PMCID: PMC6631574.
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Development of Hydrophilic PVDF Membrane Using Vapour Induced Phase Separation Method for Produced Water Treatment.

Membranes

Mat Nawi NI, Chean HM, Shamsuddin N, Bilad MR, Narkkun T, Faungnawakij K, Khan AL.
PMID: 32560031
Membranes (Basel). 2020 Jun 16;10(6). doi: 10.3390/membranes10060121.

During the production of oil and gas, a large amount of oily wastewater is generated, which would pollute the environment if discharged without proper treatment. As one of the most promising treatment options, membrane material used for oily wastewater...

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Mat Nawi NI, Chean HM, Shamsuddin N, et al. Development of Hydrophilic PVDF Membrane Using Vapour Induced Phase Separation Method for Produced Water Treatment. Membranes (Basel). 2020;10(6)doi: 10.3390/membranes10060121.
Mat Nawi, N. I., Chean, H. M., Shamsuddin, N., Bilad, M. R., Narkkun, T., Faungnawakij, K., & Khan, A. L. (2020). Development of Hydrophilic PVDF Membrane Using Vapour Induced Phase Separation Method for Produced Water Treatment. Membranes, 10(6), . https://doi.org/10.3390/membranes10060121
Mat Nawi, Normi Izati, et al. "Development of Hydrophilic PVDF Membrane Using Vapour Induced Phase Separation Method for Produced Water Treatment." Membranes vol. 10,6 (2020). doi: https://doi.org/10.3390/membranes10060121
Mat Nawi NI, Chean HM, Shamsuddin N, Bilad MR, Narkkun T, Faungnawakij K, Khan AL. Development of Hydrophilic PVDF Membrane Using Vapour Induced Phase Separation Method for Produced Water Treatment. Membranes (Basel). 2020 Jun 16;10(6). doi: 10.3390/membranes10060121. PMID: 32560031; PMCID: PMC7345896.
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Effects of fluoroquinolones and tetracyclines on mitochondria of human retinal MIO-M1 cells.

Experimental eye research

Salimiaghdam N, Singh L, Schneider K, Chwa M, Atilano SR, Nalbandian A, Limb GA, Kenney MC.
PMID: 34856207
Exp Eye Res. 2021 Nov 29;214:108857. doi: 10.1016/j.exer.2021.108857. Epub 2021 Nov 29.

Our goal was to explore the detrimental impacts of ciprofloxacin (CPFX) and tetracycline (TETRA) on human retinal Müller (MIO-M1) cells in vitro. Cells were exposed to 30, 60 and 120 μg/ml of CPFX and TETRA. The cellular metabolism was...

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Salimiaghdam N, Singh L, Schneider K, et al. Effects of fluoroquinolones and tetracyclines on mitochondria of human retinal MIO-M1 cells. Exp Eye Res. 2021;214:108857doi: 10.1016/j.exer.2021.108857.
Salimiaghdam, N., Singh, L., Schneider, K., Chwa, M., Atilano, S. R., Nalbandian, A., Limb, G. A., & Kenney, M. C. (2021). Effects of fluoroquinolones and tetracyclines on mitochondria of human retinal MIO-M1 cells. Experimental eye research, 214108857. https://doi.org/10.1016/j.exer.2021.108857
Salimiaghdam, Nasim, et al. "Effects of fluoroquinolones and tetracyclines on mitochondria of human retinal MIO-M1 cells." Experimental eye research vol. 214 (2021): 108857. doi: https://doi.org/10.1016/j.exer.2021.108857
Salimiaghdam N, Singh L, Schneider K, Chwa M, Atilano SR, Nalbandian A, Limb GA, Kenney MC. Effects of fluoroquinolones and tetracyclines on mitochondria of human retinal MIO-M1 cells. Exp Eye Res. 2021 Nov 29;214:108857. doi: 10.1016/j.exer.2021.108857. Epub 2021 Nov 29. PMID: 34856207.
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Age-Related Macular Degeneration (AMD) Transmitochondrial Cybrids Protected from Cellular Damage and Death by Human Retinal Progenitor Cells (hRPCs).

Stem cells international

Yu JJ, Azzam DB, Chwa M, Schneider K, Cho JH, Hsiang C, Klassen H, Kenney MC, Yang J.
PMID: 33628267
Stem Cells Int. 2021 Feb 09;2021:6655372. doi: 10.1155/2021/6655372. eCollection 2021.

PURPOSE: One of the leading causes of irreversible blindness worldwide, age-related macular degeneration (AMD) is a progressive disorder leading to retinal degeneration. While several treatment options exist for the exudative form of AMD, there are currently no FDA-approved treatments...

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Yu JJ, Azzam DB, Chwa M, et al. Age-Related Macular Degeneration (AMD) Transmitochondrial Cybrids Protected from Cellular Damage and Death by Human Retinal Progenitor Cells (hRPCs). Stem Cells Int. 2021;2021:6655372doi: 10.1155/2021/6655372.
Yu, J. J., Azzam, D. B., Chwa, M., Schneider, K., Cho, J. H., Hsiang, C., Klassen, H., Kenney, M. C., & Yang, J. (2021). Age-Related Macular Degeneration (AMD) Transmitochondrial Cybrids Protected from Cellular Damage and Death by Human Retinal Progenitor Cells (hRPCs). Stem cells international, 20216655372. https://doi.org/10.1155/2021/6655372
Yu, Jeffrey J, et al. "Age-Related Macular Degeneration (AMD) Transmitochondrial Cybrids Protected from Cellular Damage and Death by Human Retinal Progenitor Cells (hRPCs)." Stem cells international vol. 2021 (2021): 6655372. doi: https://doi.org/10.1155/2021/6655372
Yu JJ, Azzam DB, Chwa M, Schneider K, Cho JH, Hsiang C, Klassen H, Kenney MC, Yang J. Age-Related Macular Degeneration (AMD) Transmitochondrial Cybrids Protected from Cellular Damage and Death by Human Retinal Progenitor Cells (hRPCs). Stem Cells Int. 2021 Feb 09;2021:6655372. doi: 10.1155/2021/6655372. eCollection 2021. PMID: 33628267; PMCID: PMC7886532.
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Systematic pan-cancer characterization of nuclear receptors identifies potential cancer biomarkers and therapeutic targets.

Cancer research

Jiang J, Yuan J, Hu Z, Xu M, Zhang Y, Long M, Fan Y, Montone K, Tanyi JL, Tavana O, Chan HM, Zhang L, Hu X.
PMID: 34750098
Cancer Res. 2021 Nov 08; doi: 10.1158/0008-5472.CAN-20-3458. Epub 2021 Nov 08.

The nuclear receptor (NR) superfamily is one of the major druggable gene families, representing targets of approximately 13.5% of approved drugs. Certain NRs, such as estrogen receptor and androgen receptor, have been well demonstrated to be functionally involved in...

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Jiang J, Yuan J, Hu Z, et al. Systematic pan-cancer characterization of nuclear receptors identifies potential cancer biomarkers and therapeutic targets. Cancer Res. 2021;doi: 10.1158/0008-5472.CAN-20-3458.
Jiang, J., Yuan, J., Hu, Z., Xu, M., Zhang, Y., Long, M., Fan, Y., Montone, K., Tanyi, J. L., Tavana, O., Chan, H. M., Zhang, L., & Hu, X. (2021). Systematic pan-cancer characterization of nuclear receptors identifies potential cancer biomarkers and therapeutic targets. Cancer research, . https://doi.org/10.1158/0008-5472.CAN-20-3458
Jiang, Junjie, et al. "Systematic pan-cancer characterization of nuclear receptors identifies potential cancer biomarkers and therapeutic targets." Cancer research vol. (2021). doi: https://doi.org/10.1158/0008-5472.CAN-20-3458
Jiang J, Yuan J, Hu Z, Xu M, Zhang Y, Long M, Fan Y, Montone K, Tanyi JL, Tavana O, Chan HM, Zhang L, Hu X. Systematic pan-cancer characterization of nuclear receptors identifies potential cancer biomarkers and therapeutic targets. Cancer Res. 2021 Nov 08; doi: 10.1158/0008-5472.CAN-20-3458. Epub 2021 Nov 08. PMID: 34750098.
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Protective Effects of 17β-Estradiol on Benzo(e) pyrene[B(e)P]-induced Toxicity in ARPE-19 cells.

Journal of ophthalmic & vision research

Sapkal AU, Nashine S, Mansoor S, Sharma VR, Ramirez CA, Migon RZ, Gupta NK, Chwa M, Kuppermann BD, Kenney MC.
PMID: 30479711
J Ophthalmic Vis Res. 2018 Oct-Dec;13(4):419-425. doi: 10.4103/jovr.jovr_16_18.

PURPOSE: The aim of this study was to examine the effect of 17β-estradiol on Benzo(e)pyrene [B(e)P]-induced toxicity in ARPE-19 cells.METHODS: We pretreated ARPE-19 cells with 20 nM and 40 nM 17β-estradiol for 6 hours, followed by addition of 300...

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Sapkal AU, Nashine S, Mansoor S, et al. Protective Effects of 17β-Estradiol on Benzo(e) pyrene[B(e)P]-induced Toxicity in ARPE-19 cells. J Ophthalmic Vis Res. 2018;13(4):419-425doi: 10.4103/jovr.jovr_16_18.
Sapkal, A. U., Nashine, S., Mansoor, S., Sharma, V. R., Ramirez, C. A., Migon, R. Z., Gupta, N. K., Chwa, M., Kuppermann, B. D., & Kenney, M. C. (2018). Protective Effects of 17β-Estradiol on Benzo(e) pyrene[B(e)P]-induced Toxicity in ARPE-19 cells. Journal of ophthalmic & vision research, 13(4), 419-425. https://doi.org/10.4103/jovr.jovr_16_18
Sapkal, Ashish U, et al. "Protective Effects of 17β-Estradiol on Benzo(e) pyrene[B(e)P]-induced Toxicity in ARPE-19 cells." Journal of ophthalmic & vision research vol. 13,4 (2018): 419-425. doi: https://doi.org/10.4103/jovr.jovr_16_18
Sapkal AU, Nashine S, Mansoor S, Sharma VR, Ramirez CA, Migon RZ, Gupta NK, Chwa M, Kuppermann BD, Kenney MC. Protective Effects of 17β-Estradiol on Benzo(e) pyrene[B(e)P]-induced Toxicity in ARPE-19 cells. J Ophthalmic Vis Res. 2018 Oct-Dec;13(4):419-425. doi: 10.4103/jovr.jovr_16_18. PMID: 30479711; PMCID: PMC6210882.
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Potential adverse effects of ciprofloxacin and tetracycline on ARPE-19 cell lines.

BMJ open ophthalmology

Salimiaghdam N, Singh L, Schneider K, Nalbandian A, Chwa M, Atilano SR, Bao A, Kenney MC.
PMID: 32724857
BMJ Open Ophthalmol. 2020 Jul 21;5(1):e000458. doi: 10.1136/bmjophth-2020-000458. eCollection 2020.

BACKGROUND: We aim to determine the possible adverse effects of ciprofloxacin (CPFX) and tetracycline (TETRA), as examples of bactericidal and bacteriostatic agents, respectively, on cultured human retinal pigment epithelial cells (ARPE-19).METHODS: Cells were treated with 30, 60 and 120...

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Salimiaghdam N, Singh L, Schneider K, et al. Potential adverse effects of ciprofloxacin and tetracycline on ARPE-19 cell lines. BMJ Open Ophthalmol. 2020;5(1):e000458doi: 10.1136/bmjophth-2020-000458.
Salimiaghdam, N., Singh, L., Schneider, K., Nalbandian, A., Chwa, M., Atilano, S. R., Bao, A., & Kenney, M. C. (2020). Potential adverse effects of ciprofloxacin and tetracycline on ARPE-19 cell lines. BMJ open ophthalmology, 5(1), e000458. https://doi.org/10.1136/bmjophth-2020-000458
Salimiaghdam, Nasim, et al. "Potential adverse effects of ciprofloxacin and tetracycline on ARPE-19 cell lines." BMJ open ophthalmology vol. 5,1 (2020): e000458. doi: https://doi.org/10.1136/bmjophth-2020-000458
Salimiaghdam N, Singh L, Schneider K, Nalbandian A, Chwa M, Atilano SR, Bao A, Kenney MC. Potential adverse effects of ciprofloxacin and tetracycline on ARPE-19 cell lines. BMJ Open Ophthalmol. 2020 Jul 21;5(1):e000458. doi: 10.1136/bmjophth-2020-000458. eCollection 2020. PMID: 32724857; PMCID: PMC7375423.
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N-Acetyl-l-cysteine capped quantum dots offer neuronal cell protection by inhibiting beta (1-40) amyloid fibrillation.

Biomaterials science

Ng OTW, Wong Y, Chan HM, Cheng J, Qi X, Chan WH, Yung KKL, Li HW.
PMID: 32481833
Biomater Sci. 2013 Jun 07;1(6):577-580. doi: 10.1039/c3bm60029g. Epub 2013 Apr 17.

This is the first work that revealed the neuro-protective effect of functionalized quantum dots against the cytotoxicity induced by beta-amyloid peptides. This study gives insight into the future treatment of Alzheimer's disease. It opens many avenues for the development...

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Ng OTW, Wong Y, Chan HM, et al. N-Acetyl-l-cysteine capped quantum dots offer neuronal cell protection by inhibiting beta (1-40) amyloid fibrillation. Biomater Sci. 2013;1(6):577-580doi: 10.1039/c3bm60029g.
Ng, O. T. W., Wong, Y., Chan, H. M., Cheng, J., Qi, X., Chan, W. H., Yung, K. K. L., & Li, H. W. (2013). N-Acetyl-l-cysteine capped quantum dots offer neuronal cell protection by inhibiting beta (1-40) amyloid fibrillation. Biomaterials science, 1(6), 577-580. https://doi.org/10.1039/c3bm60029g
Ng, Olivia T W, et al. "N-Acetyl-l-cysteine capped quantum dots offer neuronal cell protection by inhibiting beta (1-40) amyloid fibrillation." Biomaterials science vol. 1,6 (2013): 577-580. doi: https://doi.org/10.1039/c3bm60029g
Ng OTW, Wong Y, Chan HM, Cheng J, Qi X, Chan WH, Yung KKL, Li HW. N-Acetyl-l-cysteine capped quantum dots offer neuronal cell protection by inhibiting beta (1-40) amyloid fibrillation. Biomater Sci. 2013 Jun 07;1(6):577-580. doi: 10.1039/c3bm60029g. Epub 2013 Apr 17. PMID: 32481833.
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