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Showing 1 to 12 of 202 entries
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Gain-of-function defects of astrocytic Kir4.1 channels in children with autism spectrum disorders and epilepsy.

Scientific reports

Sicca F, Ambrosini E, Marchese M, Sforna L, Servettini I, Valvo G, Brignone MS, Lanciotti A, Moro F, Grottesi A, Catacuzzeno L, Baldini S, Hasan S, D'Adamo MC, Franciolini F, Molinari P, Santorelli FM, Pessia M.
PMID: 27677466
Sci Rep. 2016 Sep 28;6:34325. doi: 10.1038/srep34325.

Dysfunction of the inwardly-rectifying potassium channels Kir4.1 (KCNJ10) represents a pathogenic mechanism contributing to Autism-Epilepsy comorbidity. To define the role of Kir4.1 variants in the disorder, we sequenced KCNJ10 in a sample of affected individuals, and performed genotype-phenotype correlations....

Atherogenic dyslipidemia and cardiovascular risk factors in obese children.

International journal of endocrinology

D'Adamo E, Guardamagna O, Chiarelli F, Bartuli A, Liccardo D, Ferrari F, Nobili V.
PMID: 25663838
Int J Endocrinol. 2015;2015:912047. doi: 10.1155/2015/912047. Epub 2015 Jan 12.

Childhood obesity when associated with serum lipoprotein changes triggers atherosclerosis. Evidences suggest that the atherosclerotic process begins in childhood and that the extent of early atherosclerosis of the aorta and coronary arteries can be associated with lipoprotein levels and...

Brain-derived neurotrophic factor serum levels in genetically isolated populations: gender-specific association with anxiety disorder subtypes but not with anxiety levels or Val66Met polymorphism.

PeerJ

Carlino D, Francavilla R, Baj G, Kulak K, d'Adamo P, Ulivi S, Cappellani S, Gasparini P, Tongiorgi E.
PMID: 26539329
PeerJ. 2015 Oct 29;3:e1252. doi: 10.7717/peerj.1252. eCollection 2015.

Anxiety disorders (ADs) are disabling chronic disorders with exaggerated behavioral response to threats. This study was aimed at testing the hypothesis that ADs may be associated with reduced neurotrophic activity, particularly of Brain-derived neurotrophic factor (BDNF), and determining possible...

Phase II Trial of Gemcitabine and Docetaxel with Bevacizumab in Soft Tissue Sarcoma.

Sarcoma

Dickson MA, D'Adamo DR, Keohan ML, D'Angelo SP, Carvajal RD, Gounder MM, Maki RG, Qin LX, Lefkowitz RA, McKennon OR, Hirst CM, Schwartz GK, Tap WD.
PMID: 26074722
Sarcoma. 2015;2015:532478. doi: 10.1155/2015/532478. Epub 2015 May 14.

Gemcitabine (G) and docetaxel (D) are commonly used to treat recurrent/metastatic soft tissue sarcoma. This study tested the hypothesis that outcomes would be improved by addition of bevacizumab (B). The initial design was randomized double-blind trial of G +...

Piezoelectric bone surgery in the treatment of an osteoma associated with an impacted inferior third molar: a case report.

Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases

D'Amato S, Sgaramella N, Vanore L, Piombino P, Orabona GD, Santagata M.
PMID: 25002883
Clin Cases Miner Bone Metab. 2014 Jan;11(1):73-6.

Operative removal of impacted mandibular third molars is a common and not riskless surgical procedure. We present an emblematic case of an osteoma closely associated with an impacted third left mandibular molar treated by Mectron Piezosurgery medical ultrasonic device.

Serum Proinflammatory Chemokines in Healthy Elderly Taking or not Taking Simvastatin - Data from the Brisighella Heart Study.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

D'Addato S, Cicero AF, Rosticci M, Reggi A, Cristino S, Dormi A, Borghi C.
PMID: 25491685
Adv Clin Exp Med. 2014 Sep-Oct;23(5):723-8. doi: 10.17219/acem/37230.

BACKGROUND: Recent preclinical evidence and data from adult subjects suggests that statins could improve the proinflammatory profile of hypercholesterolemic subjects.OBJECTIVES: We aim to compare the serum levels of a set of proinflammatory chemokines in elderly statistical twins taking or...

Effect of a short-term dietary supplementation with phytosterols, red yeast rice or both on lipid pattern in moderately hypercholesterolemic subjects: a three-arm, double-blind, randomized clinical trial.

Nutrition & metabolism

Cicero AFG, Fogacci F, Rosticci M, Parini A, Giovannini M, Veronesi M, D'Addato S, Borghi C.
PMID: 29021813
Nutr Metab (Lond). 2017 Sep 25;14:61. doi: 10.1186/s12986-017-0214-2. eCollection 2017.

BACKGROUND: Phytosterols and red yeast rice are largely studied cholesterol-lowering nutraceuticals, respectively inhibiting the bowel absorption and liver synthesis of cholesterol. Our aim was to test the effect on lipid profile of phytosterols, red yeast rice and their association.METHODS:...

Reconciling the discrepancies on the involvement of large-conductance Ca(2+)-activated K channels in glioblastoma cell migration.

Frontiers in cellular neuroscience

Catacuzzeno L, Caramia M, Sforna L, Belia S, Guglielmi L, D'Adamo MC, Pessia M, Franciolini F.
PMID: 25941475
Front Cell Neurosci. 2015 Apr 20;9:152. doi: 10.3389/fncel.2015.00152. eCollection 2015.

Glioblastoma (GBM) is the most common and aggressive primary brain tumor, and is notable for spreading so effectively through the brain parenchyma to make complete surgical resection virtually impossible, and prospect of life dismal. Several ion channels have been...

Phenotypic and genetic characterization of a family carrying two Xq21.1-21.3 interstitial deletions associated with syndromic hearing loss.

Molecular cytogenetics

Iossa S, Costa V, Corvino V, Auletta G, Barruffo L, Cappellani S, Ceglia C, Cennamo G, D'Adamo AP, D'Amico A, Di Paolo N, Forte R, Gasparini P, Laria C, Lombardo B, Malesci R, Vitale A, Marciano E, Franzè A.
PMID: 25821518
Mol Cytogenet. 2015 Mar 20;8:18. doi: 10.1186/s13039-015-0120-0. eCollection 2015.

BACKGROUND: Sensorineural hearing impairment is a common pathological manifestation in patients affected by X-linked intellectual disability. A few cases of interstitial deletions at Xq21 with several different phenotypic characteristics have been described, but to date, a complete molecular characterization...

Influence of size, shape and core-shell interface on surface plasmon resonance in Ag and Ag@MgO nanoparticle films deposited on Si/SiO x.

Beilstein journal of nanotechnology

D'Addato S, Pinotti D, Spadaro MC, Paolicelli G, Grillo V, Valeri S, Pasquali L, Bergamini L, Corni S.
PMID: 25821680
Beilstein J Nanotechnol. 2015 Feb 09;6:404-13. doi: 10.3762/bjnano.6.40. eCollection 2015.

Ag and Ag@MgO core-shell nanoparticles (NPs) with a diameter of d = 3-10 nm were obtained by physical synthesis methods and deposited on Si with its native ultrathin oxide layer SiO x (Si/SiO x ). Scanning electron microscopy and...

Omental adipose tissue fibrosis and insulin resistance in severe obesity.

Nutrition & diabetes

Guglielmi V, Cardellini M, Cinti F, Corgosinho F, Cardolini I, D'Adamo M, Zingaretti MC, Bellia A, Lauro D, Gentileschi P, Federici M, Cinti S, Sbraccia P.
PMID: 26258766
Nutr Diabetes. 2015 Aug 10;5:e175. doi: 10.1038/nutd.2015.22.

BACKGROUND/OBJECTIVES: The unresolved chronic inflammation of white adipose tissue (WAT) in obesity leads to interstitial deposition of fibrogenic proteins as reparative process. The contribution of omental adipose tissue (oWAT) fibrosis to obesity-related complications remains controversial. The aim of our...

Update on the implication of potassium channels in autism: K(+) channelautism spectrum disorder.

Frontiers in cellular neuroscience

Guglielmi L, Servettini I, Caramia M, Catacuzzeno L, Franciolini F, D'Adamo MC, Pessia M.
PMID: 25784856
Front Cell Neurosci. 2015 Mar 02;9:34. doi: 10.3389/fncel.2015.00034. eCollection 2015.

Autism spectrum disorders (ASDs) are characterized by impaired ability to properly implement environmental stimuli that are essential to achieve a state of social and cultural exchange. Indeed, the main features of ASD are impairments of interpersonal relationships, verbal and...

Showing 1 to 12 of 202 entries