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Surgical Trainee Opinions in the United Kingdom Regarding a Three-Dimensional Virtual Mentoring Environment (MentorSL) in Second Life: Pilot Study.

JMIR serious games

Jaffer U, John NW, Standfield N.
PMID: 25658652
JMIR Serious Games. 2013 Sep 20;1(1):e2. doi: 10.2196/games.2822.

BACKGROUND: Medical mentoring is becoming increasingly complex with the evolving needs of trainees and the complexities of their personal and social lives. The Internet is an enabling technology, which increasingly facilitates interaction with multiple people at a distance. Web...

Emphysematous pyelonephritis leading to end-stage renal failure.

NDT plus

Simms R, Torpey N, Kanagasundaram NS, Baines L, Sayer JA.
PMID: 25983899
NDT Plus. 2008 Aug;1(4):264-5. doi: 10.1093/ndtplus/sfn002. Epub 2008 Feb 14.

No abstract available.

Light-driven biocatalytic reduction of α,β-unsaturated compounds by ene reductases employing transition metal complexes as photosensitizers.

Catalysis science & technology

Peers MK, Toogood HS, Heyes DJ, Mansell D, Coe BJ, Scrutton NS.
PMID: 27019691
Catal Sci Technol. 2016 Jan 07;6(1):169-177. doi: 10.1039/c5cy01642h. Epub 2015 Oct 26.

Efficient and cost effective nicotinamide cofactor regeneration is essential for industrial-scale bio-hydrogenations employing flavin-containing biocatalysts such as the Old Yellow Enzymes. A direct flavin regeneration system using visible light to initiate a photoredox cycle and drive biocatalysis is described,...

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

PLoS genetics

Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T, Fall T, Kilpeläinen TO, Lu Y, Mägi R, Mihailov E, Pers TH, Rüeger S, Teumer A, Ehret GB, Ferreira T, Heard-Costa NL, Karjalainen J, Lagou V, Mahajan A, Neinast MD, Prokopenko I, Simino J, Teslovich TM, Jansen R, Westra HJ, White CC, Absher D, Ahluwalia TS, Ahmad S, Albrecht E, Alves AC, Bragg-Gresham JL, de Craen AJ, Bis JC, Bonnefond A, Boucher G, Cadby G, Cheng YC, Chiang CW, Delgado G, Demirkan A, Dueker N, Eklund N, Eiriksdottir G, Eriksson J, Feenstra B, Fischer K, Frau F, Galesloot TE, Geller F, Goel A, Gorski M, Grammer TB, Gustafsson S, Haitjema S, Hottenga JJ, Huffman JE, Jackson AU, Jacobs KB, Johansson Å, Kaakinen M, Kleber ME, Lahti J, Mateo Leach I, Lehne B, Liu Y, Lo KS, Lorentzon M, Luan J, Madden PA, Mangino M, McKnight B, Medina-Gomez C, Monda KL, Montasser ME, Müller G, Müller-Nurasyid M, Nolte IM, Panoutsopoulou K, Pascoe L, Paternoster L, Rayner NW, Renström F, Rizzi F, Rose LM, Ryan KA, Salo P, Sanna S, Scharnagl H, Shi J, Smith AV, Southam L, Stančáková A, Steinthorsdottir V, Strawbridge RJ, Sung YJ, Tachmazidou I, Tanaka T, Thorleifsson G, Trompet S, Pervjakova N, Tyrer JP, Vandenput L, van der Laan SW, van der Velde N, van Setten J, van Vliet-Ostaptchouk JV, Verweij N, Vlachopoulou E, Waite LL, Wang SR, Wang Z, Wild SH, Willenborg C, Wilson JF, Wong A, Yang J, Yengo L, Yerges-Armstrong LM, Yu L, Zhang W, Zhao JH, Andersson EA, Bakker SJ, Baldassarre D, Banasik K, Barcella M, Barlassina C, Bellis C, Benaglio P, Blangero J, Blüher M, Bonnet F, Bonnycastle LL, Boyd HA, Bruinenberg M, Buchman AS, Campbell H, Chen YI, Chines PS, Claudi-Boehm S, Cole J, Collins FS, de Geus EJ, de Groot LC, Dimitriou M, Duan J, Enroth S, Eury E, Farmaki AE, Forouhi NG, Friedrich N, Gejman PV, Gigante B, Glorioso N, Go AS, Gottesman O, Gräßler J, Grallert H, Grarup N, Gu YM, Broer L, Ham AC, Hansen T, Harris TB, Hartman CA, Hassinen M, Hastie N, Hattersley AT, Heath AC, Henders AK, Hernandez D, Hillege H, Holmen O, Hovingh KG, Hui J, Husemoen LL, Hutri-Kähönen N, Hysi PG, Illig T, De Jager PL, Jalilzadeh S, Jørgensen T, Jukema JW, Juonala M, Kanoni S, Karaleftheri M, Khaw KT, Kinnunen L, Kittner SJ, Koenig W, Kolcic I, Kovacs P, Krarup NT, Kratzer W, Krüger J, Kuh D, Kumari M, Kyriakou T, Langenberg C, Lannfelt L, Lanzani C, Lotay V, Launer LJ, Leander K, Lindström J, Linneberg A, Liu YP, Lobbens S, Luben R, Lyssenko V, Männistö S, Magnusson PK, McArdle WL, Menni C, Merger S, Milani L, Montgomery GW, Morris AP, Narisu N, Nelis M, Ong KK, Palotie A, Pérusse L, Pichler I, Pilia MG, Pouta A, Rheinberger M, Ribel-Madsen R, Richards M, Rice KM, Rice TK, Rivolta C, Salomaa V, Sanders AR, Sarzynski MA, Scholtens S, Scott RA, Scott WR, Sebert S, Sengupta S, Sennblad B, Seufferlein T, Silveira A, Slagboom PE, Smit JH, Sparsø TH, Stirrups K, Stolk RP, Stringham HM, Swertz MA, Swift AJ, Syvänen AC, Tan ST, Thorand B, Tönjes A, Tremblay A, Tsafantakis E, van der Most PJ, Völker U, Vohl MC, Vonk JM, Waldenberger M, Walker RW, Wennauer R, Widén E, Willemsen G, Wilsgaard T, Wright AF, Zillikens MC, van Dijk SC, van Schoor NM, Asselbergs FW, de Bakker PI, Beckmann JS, Beilby J, Bennett DA, Bergman RN, Bergmann S, Böger CA, Boehm BO, Boerwinkle E, Boomsma DI, Bornstein SR, Bottinger EP, Bouchard C, Chambers JC, Chanock SJ, Chasman DI, Cucca F, Cusi D, Dedoussis G, Erdmann J, Eriksson JG, Evans DA, de Faire U, Farrall M, Ferrucci L, Ford I, Franke L, Franks PW, Froguel P, Gansevoort RT, Gieger C, Grönberg H, Gudnason V, Gyllensten U, Hall P, Hamsten A, van der Harst P, Hayward C, Heliövaara M, Hengstenberg C, Hicks AA, Hingorani A, Hofman A, Hu F, Huikuri HV, Hveem K, James AL, Jordan JM, Jula A, Kähönen M, Kajantie E, Kathiresan S, Kiemeney LA, Kivimaki M, Knekt PB, Koistinen HA, Kooner JS, Koskinen S, Kuusisto J, Maerz W, Martin NG, Laakso M, Lakka TA, Lehtimäki T, Lettre G, Levinson DF, Lind L, Lokki ML, Mäntyselkä P, Melbye M, Metspalu A, Mitchell BD, Moll FL, Murray JC, Musk AW, Nieminen MS, Njølstad I, Ohlsson C, Oldehinkel AJ, Oostra BA, Palmer LJ, Pankow JS, Pasterkamp G, Pedersen NL, Pedersen O, Penninx BW, Perola M, Peters A, Polašek O, Pramstaller PP, Psaty BM, Qi L, Quertermous T, Raitakari OT, Rankinen T, Rauramaa R, Ridker PM, Rioux JD, Rivadeneira F, Rotter JI, Rudan I, den Ruijter HM, Saltevo J, Sattar N, Schunkert H, Schwarz PE, Shuldiner AR, Sinisalo J, Snieder H, Sørensen TI, Spector TD, Staessen JA, Stefania B, Thorsteinsdottir U, Stumvoll M, Tardif JC, Tremoli E, Tuomilehto J, Uitterlinden AG, Uusitupa M, Verbeek AL, Vermeulen SH, Viikari JS, Vitart V, Völzke H, Vollenweider P, Waeber G, Walker M, Wallaschofski H, Wareham NJ, Watkins H, Zeggini E, Chakravarti A, Clegg DJ, Cupples LA, Gordon-Larsen P, Jaquish CE, Rao DC, Abecasis GR, Assimes TL, Barroso I, Berndt SI, Boehnke M, Deloukas P, Fox CS, Groop LC, Hunter DJ, Ingelsson E, Kaplan RC, McCarthy MI, Mohlke KL, O'Connell JR, Schlessinger D, Strachan DP, Stefansson K, van Duijn CM, Hirschhorn JN, Lindgren CM, Heid IM, North KE, Borecki IB, Kutalik Z, Loos RJ.
PMID: 27355579
PLoS Genet. 2016 Jun 29;12(6):e1006166. doi: 10.1371/journal.pgen.1006166. eCollection 2016 Jun.

[This corrects the article DOI: 10.1371/journal.pgen.1005378.].

Biased signaling of protease-activated receptors.

Frontiers in endocrinology

Zhao P, Metcalf M, Bunnett NW.
PMID: 24860547
Front Endocrinol (Lausanne). 2014 May 13;5:67. doi: 10.3389/fendo.2014.00067. eCollection 2014.

In addition to their role in protein degradation and digestion, proteases can also function as hormone-like signaling molecules that regulate vital patho-physiological processes, including inflammation, hemostasis, pain, and repair mechanisms. Certain proteases can signal to cells by cleaving protease-activated...

The Fermi Gamma-Ray Space Telescope discovers the pulsar in the young galactic supernova remnant CTA 1.

Science (New York, N.Y.)

Abdo AA, Ackermann M, Atwood WB, Baldini L, Ballet J, Barbiellini G, Baring MG, Bastieri D, Baughman BM, Bechtol K, Bellazzini R, Berenji B, Blandford RD, Bloom ED, Bogaert G, Bonamente E, Borgland AW, Bregeon J, Brez A, Brigida M, Bruel P, Burnett TH, Caliandro GA, Cameron RA, Caraveo PA, Carlson P, Casandjian JM, Cecchi C, Charles E, Chekhtman A, Cheung CC, Chiang J, Ciprini S, Claus R, Cohen-Tanugi J, Cominsky LR, Conrad J, Cutini S, Davis DS, Dermer CD, de Angelis A, de Palma F, Digel SW, Dormody M, do Couto E Silva E, Drell PS, Dubois R, Dumora D, Edmonds Y, Farnier C, Focke WB, Fukazawa Y, Funk S, Fusco P, Gargano F, Gasparrini D, Gehrels N, Germani S, Giebels B, Giglietto N, Giordano F, Glanzman T, Godfrey G, Grenier IA, Grondin MH, Grove JE, Guillemot L, Guiriec S, Harding AK, Hartman RC, Hays E, Hughes RE, Jóhannesson G, Johnson AS, Johnson RP, Johnson TJ, Johnson WN, Kamae T, Kanai Y, Kanbach G, Katagiri H, Kawai N, Kerr M, Kishishita T, Kiziltan B, Knödlseder J, Kocian ML, Komin N, Kuehn F, Kuss M, Latronico L, Lemoine-Goumard M, Longo F, Lonjou V, Loparco F, Lott B, Lovellette MN, Lubrano P, Makeev A, Marelli M, Mazziotta MN, McEnery JE, McGlynn S, Meurer C, Michelson PF, Mineo T, Mitthumsiri W, Mizuno T, Moiseev AA, Monte C, Monzani ME, Morselli A, Moskalenko IV, Murgia S, Nakamori T, Nolan PL, Nuss E, Ohno M, Ohsugi T, Okumura A, Omodei N, Orlando E, Ormes JF, Ozaki M, Paneque D, Panetta JH, Parent D, Pelassa V, Pepe M, Pesce-Rollins M, Piano G, Pieri L, Piron F, Porter TA, Rainò S, Rando R, Ray PS, Razzano M, Reimer A, Reimer O, Reposeur T, Ritz S, Rochester LS, Rodriguez AY, Romani RW, Roth M, Ryde F, Sadrozinski HF, Sanchez D, Sander A, Parkinson PM, Schalk TL, Sellerholm A, Sgrò C, Siskind EJ, Smith DA, Smith PD, Spandre G, Spinelli P, Starck JL, Strickman MS, Suson DJ, Tajima H, Takahashi H, Takahashi T, Tanaka T, Thayer JB, Thayer JG, Thompson DJ, Thorsett SE, Tibaldo L, Torres DF, Tosti G, Tramacere A, Usher TL, Van Etten A, Vilchez N, Vitale V, Wang P, Watters K, Winer BL, Wood KS, Yasuda H, Ylinen T, Ziegler M.
PMID: 18927355
Science. 2008 Nov 21;322(5905):1218-21. doi: 10.1126/science.1165572. Epub 2008 Oct 16.

Energetic young pulsars and expanding blast waves [supernova remnants (SNRs)] are the most visible remains after massive stars, ending their lives, explode in core-collapse supernovae. The Fermi Gamma-Ray Space Telescope has unveiled a radio quiet pulsar located near the...

Sacral neuromodulation: Therapy evolution.

Indian journal of urology : IJU : journal of the Urological Society of India

Thompson JH, Sutherland SE, Siegel SW.
PMID: 21116359
Indian J Urol. 2010 Jul;26(3):379-84. doi: 10.4103/0970-1591.70576.

OBJECTIVES: Sacral neuromodulation has gained increased worldwide acceptance as the standard of care in patients with refractory overactive bladder (OAB) and non-obstructive urinary retention (NOUR). This review will detail the evolution of the technology.MATERIALS AND METHODS: The mechanism of...

Spectrum of the isotropic diffuse gamma-ray emission derived from first-year Fermi Large Area Telescope data.

Physical review letters

Abdo AA, Ackermann M, Ajello M, Atwood WB, Baldini L, Ballet J, Barbiellini G, Bastieri D, Baughman BM, Bechtol K, Bellazzini R, Berenji B, Blandford RD, Bloom ED, Bonamente E, Borgland AW, Bregeon J, Brez A, Brigida M, Bruel P, Burnett TH, Buson S, Caliandro GA, Cameron RA, Caraveo PA, Casandjian JM, Cavazzuti E, Cecchi C, Celik O, Charles E, Chekhtman A, Cheung CC, Chiang J, Ciprini S, Claus R, Cohen-Tanugi J, Cominsky LR, Conrad J, Cutini S, Dermer CD, de Angelis A, de Palma F, Digel SW, Di Bernardo G, do Couto e Silva E, Drell PS, Drlica-Wagner A, Dubois R, Dumora D, Farnier C, Favuzzi C, Fegan SJ, Focke WB, Fortin P, Frailis M, Fukazawa Y, Funk S, Fusco P, Gaggero D, Gargano F, Gasparrini D, Gehrels N, Germani S, Giebels B, Giglietto N, Giommi P, Giordano F, Glanzman T, Godfrey G, Grenier IA, Grondin MH, Grove JE, Guillemot L, Guiriec S, Gustafsson M, Hanabata Y, Harding AK, Hayashida M, Hughes RE, Itoh R, Jackson MS, Jóhannesson G, Johnson AS, Johnson RP, Johnson TJ, Johnson WN, Kamae T, Katagiri H, Kataoka J, Kawai N, Kerr M, Knödlseder J, Kocian ML, Kuehn F, Kuss M, Lande J, Latronico L, Lemoine-Goumard M, Longo F, Loparco F, Lott B, Lovellette MN, Lubrano P, Madejski GM, Makeev A, Mazziotta MN, McConville W, McEnery JE, Meurer C, Michelson PF, Mitthumsiri W, Mizuno T, Moiseev AA, Monte C, Monzani ME, Morselli A, Moskalenko IV, Murgia S, Nolan PL, Norris JP, Nuss E, Ohsugi T, Omodei N, Orlando E, Ormes JF, Paneque D, Panetta JH, Parent D, Pelassa V, Pepe M, Pesce-Rollins M, Piron F, Porter TA, Rainò S, Rando R, Razzano M, Reimer A, Reimer O, Reposeur T, Ritz S, Rochester LS, Rodriguez AY, Roth M, Ryde F, Sadrozinski HF, Sanchez D, Sander A, Saz Parkinson PM, Scargle JD, Sellerholm A, Sgrò C, Shaw MS, Siskind EJ, Smith DA, Smith PD, Spandre G, Spinelli P, Starck JL, Strickman MS, Strong AW, Suson DJ, Tajima H, Takahashi H, Takahashi T, Tanaka T, Thayer JB, Thayer JG, Thompson DJ, Tibaldo L, Torres DF, Tosti G, Tramacere A, Uchiyama Y, Usher TL, Vasileiou V, Vilchez N, Vitale V, Waite AP, Wang P, Winer BL, Wood KS, Ylinen T, Ziegler M.
PMID: 20366411
Phys Rev Lett. 2010 Mar 12;104(10):101101. doi: 10.1103/PhysRevLett.104.101101. Epub 2010 Mar 08.

We report on the first Fermi Large Area Telescope (LAT) measurements of the so-called "extragalactic" diffuse gamma-ray emission (EGB). This component of the diffuse gamma-ray emission is generally considered to have an isotropic or nearly isotropic distribution on the...

Asymmetric Reduction of Activated Alkenes by Pentaerythritol Tetranitrate Reductase: Specificity and Control of Stereochemical Outcome by Reaction Optimisation.

Advanced synthesis & catalysis

Fryszkowska A, Toogood H, Sakuma M, Gardiner JM, Stephens GM, Scrutton NS.
PMID: 20396613
Adv Synth Catal. 2009 Nov;351(17):2976-2990. doi: 10.1002/adsc.200900603.

We show that pentaerythritol tetranitrate reductase (PETNR), a member of the 'ene' reductase old yellow enzyme family, catalyses the asymmetric reduction of a variety of industrially relevant activated alpha,beta-unsaturated alkenes including enones, enals, maleimides and nitroalkenes. We have rationalised...

Graphical tools for macromolecular crystallography in PHENIX.

Journal of applied crystallography

Echols N, Grosse-Kunstleve RW, Afonine PV, Bunkóczi G, Chen VB, Headd JJ, McCoy AJ, Moriarty NW, Read RJ, Richardson DC, Richardson JS, Terwilliger TC, Adams PD.
PMID: 22675231
J Appl Crystallogr. 2012 Jun 01;45:581-586. doi: 10.1107/S0021889812017293. Epub 2012 May 16.

A new Python-based graphical user interface for the PHENIX suite of crystallography software is described. This interface unifies the command-line programs and their graphical displays, simplifying the development of new interfaces and avoiding duplication of function. With careful design,...

Chiral bases as useful probes of lithium amide reactivity.

Angewandte Chemie (International ed. in English)

Prestly MR, Simpkins NS.
PMID: 23097322
Angew Chem Int Ed Engl. 2012 Nov 26;51(48):12068-71. doi: 10.1002/anie.201206558. Epub 2012 Oct 24.

No abstract available.

Molecular processes in biological thermosensation.

Journal of biophysics (Hindawi Publishing Corporation : Online)

Digel I, Kayser P, Artmann GM.
PMID: 20130806
J Biophys. 2008;2008:602870. doi: 10.1155/2008/602870. Epub 2008 May 12.

Since thermal gradients are almost everywhere, thermosensation could represent one of the oldest sensory transduction processes that evolved in organisms. There are many examples of temperature changes affecting the physiology of living cells. Almost all classes of biological macromolecules...

Showing 1 to 12 of 264 entries