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Showing 1 to 12 of 54 entries
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Germline modification of domestic animals.

Animal reproduction

Tang L, González R, Dobrinski I.
PMID: 27390591
Anim Reprod. 2015 Jan-Mar;12(1):93-104.

Genetically-modified domestic animal models are of increasing significance in biomedical research and agriculture. As authentic ES cells derived from domestic animals are not yet available, the prevailing approaches for engineering genetic modifications in those animals are pronuclear microinjection and...

Genomic amplification of an endogenous retrovirus in zebrafish T-cell malignancies.

Advances in hematology

Frazer JK, Batchelor LA, Bradley DF, Brown KH, Dobrinski KP, Lee C, Trede NS.
PMID: 22745640
Adv Hematol. 2012;2012:627920. doi: 10.1155/2012/627920. Epub 2012 Jun 13.

Genomic instability plays a crucial role in oncogenesis. Somatically acquired mutations can disable some genes and inappropriately activate others. In addition, chromosomal rearrangements can amplify, delete, or even fuse genes, altering their functions and contributing to malignant phenotypes. Using...

The TAM-TB Assay-A Promising TB Immune-Diagnostic Test With a Potential for Treatment Monitoring.

Frontiers in pediatrics

Ahmed MIM, Ziegler C, Held K, Dubinski I, Ley-Zaporozhan J, Geldmacher C, von Both U.
PMID: 30805325
Front Pediatr. 2019 Feb 11;7:27. doi: 10.3389/fped.2019.00027. eCollection 2019.

Tuberculosis (TB) epidemiology is changing in Western and Central Europe due to the rise in immigration and refugees fleeing high-TB-burden areas of war and devastation. The change in local demography and the lack of sensitive and specific TB diagnostic...

Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice.

Hepatology communications

Friedman JE, Dobrinskikh E, Alfonso-Garcia A, Fast A, Janssen RC, Soderborg TK, Anderson AL, Reisz JA, D'Alessandro A, Frank DN, Robertson CE, de la Houssaye BA, Johnson LK, Orlicky DJ, Wang XX, Levi M, Potma EO, El Kasmi KC, Jonscher KR.
PMID: 29507905
Hepatol Commun. 2018 Jan 22;2(3):313-328. doi: 10.1002/hep4.1139. eCollection 2018 Mar.

Increasingly, evidence suggests that exposure to maternal obesity creates an inflammatory environment

Forecasting physician workforce requirements.

JAMA

Hallock J, Kobrinski E, Mansfield C.
PMID: 7865005
JAMA. 1995 Jan 11;273(2):111; author reply 113. doi: 10.1001/jama.1995.03520260031015.

No abstract available.

Altered substrate metabolism in neurodegenerative disease: new insights from metabolic imaging.

Journal of neuroinflammation

Cleland NRW, Al-Juboori SI, Dobrinskikh E, Bruce KD.
PMID: 34711251
J Neuroinflammation. 2021 Oct 28;18(1):248. doi: 10.1186/s12974-021-02305-w.

Neurodegenerative diseases (NDs), such as Alzheimer's disease (AD), Parkinson's disease (PD) and multiple sclerosis (MS), are relatively common and devastating neurological disorders. For example, there are 6 million individuals living with AD in the United States, a number that...

The Proliferation of Pre-Pubertal Porcine Spermatogonia in Stirred Suspension Bioreactors Is Partially Mediated by the Wnt/β-Catenin Pathway.

International journal of molecular sciences

Sakib S, Voigt A, de Lima E Martins Lara N, Su L, Ungrin M, Rancourt D, Dobrinski I.
PMID: 34948348
Int J Mol Sci. 2021 Dec 17;22(24). doi: 10.3390/ijms222413549.

Male survivors of childhood cancer are at risk of suffering from infertility in adulthood because of gonadotoxic chemotherapies. For adult men, sperm collection and preservation are routine procedures prior to treatment; however, this is not an option for pre-pubertal...

Transcriptional Profiling of the Adult Hair Follicle Mesenchyme Reveals R-spondin as a Novel Regulator of Dermal Progenitor Function.

iScience

Hagner A, Shin W, Sinha S, Alpaugh W, Workentine M, Abbasi S, Rahmani W, Agabalyan N, Sharma N, Sparks H, Yoon J, Labit E, Cobb J, Dobrinski I, Biernaskie J.
PMID: 32289736
iScience. 2020 Apr 24;23(4):101019. doi: 10.1016/j.isci.2020.101019. Epub 2020 Apr 02.

The adult hair follicle (HF) undergoes successive regeneration driven by resident epithelial stem cells and neighboring mesenchyme. Recent work described the existence of HF dermal stem cells (hfDSCs), but the genetic regulation of hfDSCs and their daughter cell lineages...

The Proliferation of Pre-Pubertal Porcine Spermatogonia in Stirred Suspension Bioreactors Is Partially Mediated by the Wnt/β-Catenin Pathway.

International journal of molecular sciences

Sakib S, Voigt A, de Lima E Martins Lara N, Su L, Ungrin M, Rancourt D, Dobrinski I.
PMID: 34948348
Int J Mol Sci. 2021 Dec 17;22(24). doi: 10.3390/ijms222413549.

Male survivors of childhood cancer are at risk of suffering from infertility in adulthood because of gonadotoxic chemotherapies. For adult men, sperm collection and preservation are routine procedures prior to treatment; however, this is not an option for pre-pubertal...

An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation.

bioRxiv : the preprint server for biology

Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, Walter P, Manglik A.
PMID: 32817938
bioRxiv. 2020 Aug 17; doi: 10.1101/2020.08.08.238469.

Without an effective prophylactic solution, infections from SARS-CoV-2 continue to rise worldwide with devastating health and economic costs. SARS-CoV-2 gains entry into host cells via an interaction between its Spike protein and the host cell receptor angiotensin converting enzyme...

Correction: Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission.

Journal of immunology (Baltimore, Md. : 1950)

Giugliano S, Petroff MG, Warren BD, Jasti S, Linscheid C, Ward A, Kramer A, Dobrinskikh E, Sheiko MA, Gale M, Golden-Mason L, Winn VD, Rosen HR.
PMID: 28069758
J Immunol. 2017 Jan 15;198(2):972. doi: 10.4049/jimmunol.1601926.

No abstract available.

A study of the magnetic resonance in a single-crystal Ni(50.47)Mn(28.17)Ga(21.36) alloy.

Journal of physics. Condensed matter : an Institute of Physics journal

Gavriljuk VG, Dobrinsky A, Shanina BD, Kolesnik SP.
PMID: 21690874
J Phys Condens Matter. 2006 Aug 16;18(32):7613-27. doi: 10.1088/0953-8984/18/32/010. Epub 2006 Jul 31.

The single-crystal non-stoichiometric magnetic shape memory alloy Ni(1-x-y)Mn(x)Ga(y) with x = 0.2817, y = 0.2136 is studied using magnetic resonance spectroscopy: ferromagnetic resonance (FMR) and conduction electron spin resonance (CESR). The temperature dependence of the integral intensity, the resonance...

Showing 1 to 12 of 54 entries