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Showing 1 to 12 of 23 entries
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A double-blind placebo-controlled trial of maca root as treatment for antidepressant-induced sexual dysfunction in women.

Evidence-based complementary and alternative medicine : eCAM

Dording CM, Schettler PJ, Dalton ED, Parkin SR, Walker RS, Fehling KB, Fava M, Mischoulon D.
PMID: 25954318
Evid Based Complement Alternat Med. 2015;2015:949036. doi: 10.1155/2015/949036. Epub 2015 Apr 14.

Objective. We sought to demonstrate that maca root may be an effective treatment for antidepressant-induced sexual dysfunction (AISD) in women. Method. We conducted a 12-week, double-blind, placebo-controlled trial of maca root (3.0 g/day) in 45 female outpatients (mean age...

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Dording CM, Schettler PJ, Dalton ED, et al. A double-blind placebo-controlled trial of maca root as treatment for antidepressant-induced sexual dysfunction in women. Evid Based Complement Alternat Med. 2015;2015:949036doi: 10.1155/2015/949036.
Dording, C. M., Schettler, P. J., Dalton, E. D., Parkin, S. R., Walker, R. S., Fehling, K. B., Fava, M., & Mischoulon, D. (2015). A double-blind placebo-controlled trial of maca root as treatment for antidepressant-induced sexual dysfunction in women. Evidence-based complementary and alternative medicine : eCAM, 2015949036. https://doi.org/10.1155/2015/949036
Dording, Christina M, et al. "A double-blind placebo-controlled trial of maca root as treatment for antidepressant-induced sexual dysfunction in women." Evidence-based complementary and alternative medicine : eCAM vol. 2015 (2015): 949036. doi: https://doi.org/10.1155/2015/949036
Dording CM, Schettler PJ, Dalton ED, Parkin SR, Walker RS, Fehling KB, Fava M, Mischoulon D. A double-blind placebo-controlled trial of maca root as treatment for antidepressant-induced sexual dysfunction in women. Evid Based Complement Alternat Med. 2015;2015:949036. doi: 10.1155/2015/949036. Epub 2015 Apr 14. PMID: 25954318; PMCID: PMC4411442.
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Extracellular matrix gene expression profiling using microfluidics for colorectal carcinoma stratification.

Biomicrofluidics

Hayes CJ, Dowling CM, Dwane S, McCumiskey ME, Tormey SM, Anne Merrigan B, Coffey JC, Kiely PA, Dalton TM.
PMID: 27822332
Biomicrofluidics. 2016 Oct 31;10(5):054124. doi: 10.1063/1.4966245. eCollection 2016 Sep.

In cancer, biomarkers have many potential applications including generation of a differential diagnosis, prediction of response to treatment, and monitoring disease progression. Many molecular biomarkers have been put forward for different diseases but most of them do not possess...

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Hayes CJ, Dowling CM, Dwane S, et al. Extracellular matrix gene expression profiling using microfluidics for colorectal carcinoma stratification. Biomicrofluidics. 2016;10(5):054124doi: 10.1063/1.4966245.
Hayes, C. J., Dowling, C. M., Dwane, S., McCumiskey, M. E., Tormey, S. M., Anne Merrigan, B., Coffey, J. C., Kiely, P. A., & Dalton, T. M. (2016). Extracellular matrix gene expression profiling using microfluidics for colorectal carcinoma stratification. Biomicrofluidics, 10(5), 054124. https://doi.org/10.1063/1.4966245
Hayes, Christopher J, et al. "Extracellular matrix gene expression profiling using microfluidics for colorectal carcinoma stratification." Biomicrofluidics vol. 10,5 (2016): 054124. doi: https://doi.org/10.1063/1.4966245
Hayes CJ, Dowling CM, Dwane S, McCumiskey ME, Tormey SM, Anne Merrigan B, Coffey JC, Kiely PA, Dalton TM. Extracellular matrix gene expression profiling using microfluidics for colorectal carcinoma stratification. Biomicrofluidics. 2016 Oct 31;10(5):054124. doi: 10.1063/1.4966245. eCollection 2016 Sep. PMID: 27822332; PMCID: PMC5097046.
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DYT6 mutated THAP1 is a cell type dependent regulator of the SP1 family.

Brain : a journal of neurology

Cheng F, Zheng W, Barbuti PA, Bonsi P, Liu C, Casadei N, Ponterio G, Meringolo M, Admard J, Dording CM, Yu-Taeger L, Nguyen HP, Grundmann-Hauser K, Ott T, Houlden H, Pisani A, Krüger R, Riess O.
PMID: 35015830
Brain. 2022 Jan 07; doi: 10.1093/brain/awac001. Epub 2022 Jan 07.

DYT6 dystonia is caused by mutations in the transcription factor THAP1. THAP1 knock-out or knock-in mouse models revealed complex gene expression changes which are potentially responsible for the pathogenesis of DYT6 dystonia. However, how THAP1 mutations lead to these...

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Cheng F, Zheng W, Barbuti PA, et al. DYT6 mutated THAP1 is a cell type dependent regulator of the SP1 family. Brain. 2022;doi: 10.1093/brain/awac001.
Cheng, F., Zheng, W., Barbuti, P. A., Bonsi, P., Liu, C., Casadei, N., Ponterio, G., Meringolo, M., Admard, J., Dording, C. M., Yu-Taeger, L., Nguyen, H. P., Grundmann-Hauser, K., Ott, T., Houlden, H., Pisani, A., Krüger, R., & Riess, O. (2022). DYT6 mutated THAP1 is a cell type dependent regulator of the SP1 family. Brain : a journal of neurology, . https://doi.org/10.1093/brain/awac001
Cheng, Fubo, et al. "DYT6 mutated THAP1 is a cell type dependent regulator of the SP1 family." Brain : a journal of neurology vol. (2022). doi: https://doi.org/10.1093/brain/awac001
Cheng F, Zheng W, Barbuti PA, Bonsi P, Liu C, Casadei N, Ponterio G, Meringolo M, Admard J, Dording CM, Yu-Taeger L, Nguyen HP, Grundmann-Hauser K, Ott T, Houlden H, Pisani A, Krüger R, Riess O. DYT6 mutated THAP1 is a cell type dependent regulator of the SP1 family. Brain. 2022 Jan 07; doi: 10.1093/brain/awac001. Epub 2022 Jan 07. PMID: 35015830.
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Primary paratesticular seminoma - A case report.

International journal of surgery case reports

Dowling CM, Manecksha RP, McGuire C, Swan N, Thornhill JA.
PMID: 22898258
Int J Surg Case Rep. 2012;3(11):526-8. doi: 10.1016/j.ijscr.2012.04.016. Epub 2012 May 03.

INTRODUCTION: Paratesticular tumours are rare. Rhabdomyosarcomas are the commonest malignant paratesticular tumours although tumours can arise from any paratesticular structure. Here we report a case of a primary paratesticular seminoma and a review of the literature.PRESENTATION OF CASE: A...

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Dowling CM, Manecksha RP, McGuire C, et al. Primary paratesticular seminoma - A case report. Int J Surg Case Rep. 2012;3(11):526-8doi: 10.1016/j.ijscr.2012.04.016.
Dowling, C. M., Manecksha, R. P., McGuire, C., Swan, N., & Thornhill, J. A. (2012). Primary paratesticular seminoma - A case report. International journal of surgery case reports, 3(11), 526-8. https://doi.org/10.1016/j.ijscr.2012.04.016
Dowling, C M, et al. "Primary paratesticular seminoma - A case report." International journal of surgery case reports vol. 3,11 (2012): 526-8. doi: https://doi.org/10.1016/j.ijscr.2012.04.016
Dowling CM, Manecksha RP, McGuire C, Swan N, Thornhill JA. Primary paratesticular seminoma - A case report. Int J Surg Case Rep. 2012;3(11):526-8. doi: 10.1016/j.ijscr.2012.04.016. Epub 2012 May 03. PMID: 22898258; PMCID: PMC3437387.
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Expression of protein kinase C gamma promotes cell migration in colon cancer.

Oncotarget

Dowling CM, Hayes SL, Phelan JJ, Cathcart MC, Finn SP, Mehigan B, McCormick P, Coffey JC, O'sullivan J, Kiely PA.
PMID: 29069771
Oncotarget. 2017 Jul 01;8(42):72096-72107. doi: 10.18632/oncotarget.18916. eCollection 2017 Sep 22.

Despite extensive efforts, Protein Kinase Cs (PKCs) have proven to be an intractable target in cancer therapies. Traditionally it was accepted that PKCs act as tumour promoters, however new research suggests that PKCs may play an important role in...

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Dowling CM, Hayes SL, Phelan JJ, et al. Expression of protein kinase C gamma promotes cell migration in colon cancer. Oncotarget. 2017;8(42):72096-72107doi: 10.18632/oncotarget.18916.
Dowling, C. M., Hayes, S. L., Phelan, J. J., Cathcart, M. C., Finn, S. P., Mehigan, B., McCormick, P., Coffey, J. C., O'sullivan, J., & Kiely, P. A. (2017). Expression of protein kinase C gamma promotes cell migration in colon cancer. Oncotarget, 8(42), 72096-72107. https://doi.org/10.18632/oncotarget.18916
Dowling, Catríona M, et al. "Expression of protein kinase C gamma promotes cell migration in colon cancer." Oncotarget vol. 8,42 (2017): 72096-72107. doi: https://doi.org/10.18632/oncotarget.18916
Dowling CM, Hayes SL, Phelan JJ, Cathcart MC, Finn SP, Mehigan B, McCormick P, Coffey JC, O'sullivan J, Kiely PA. Expression of protein kinase C gamma promotes cell migration in colon cancer. Oncotarget. 2017 Jul 01;8(42):72096-72107. doi: 10.18632/oncotarget.18916. eCollection 2017 Sep 22. PMID: 29069771; PMCID: PMC5641114.
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Gene-corrected p.A30P SNCA patient-derived isogenic neurons rescue neuronal branching and function.

Scientific reports

Barbuti PA, Ohnmacht J, Santos BFR, Antony PM, Massart F, Cruciani G, Dording CM, Pavelka L, Casadei N, Kwon YJ, Krüger R.
PMID: 34754035
Sci Rep. 2021 Nov 09;11(1):21946. doi: 10.1038/s41598-021-01505-x.

Parkinson's disease (PD) is characterised by the degeneration of A9 dopaminergic neurons and the pathological accumulation of alpha-synuclein. The p.A30P SNCA mutation generates the pathogenic form of the alpha-synuclein protein causing an autosomal-dominant form of PD. There are limited...

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Barbuti PA, Ohnmacht J, Santos BFR, et al. Gene-corrected p.A30P SNCA patient-derived isogenic neurons rescue neuronal branching and function. Sci Rep. 2021;11(1):21946doi: 10.1038/s41598-021-01505-x.
Barbuti, P. A., Ohnmacht, J., Santos, B. F. R., Antony, P. M., Massart, F., Cruciani, G., Dording, C. M., Pavelka, L., Casadei, N., Kwon, Y. J., & Krüger, R. (2021). Gene-corrected p.A30P SNCA patient-derived isogenic neurons rescue neuronal branching and function. Scientific reports, 11(1), 21946. https://doi.org/10.1038/s41598-021-01505-x
Barbuti, Peter A, et al. "Gene-corrected p.A30P SNCA patient-derived isogenic neurons rescue neuronal branching and function." Scientific reports vol. 11,1 (2021): 21946. doi: https://doi.org/10.1038/s41598-021-01505-x
Barbuti PA, Ohnmacht J, Santos BFR, Antony PM, Massart F, Cruciani G, Dording CM, Pavelka L, Casadei N, Kwon YJ, Krüger R. Gene-corrected p.A30P SNCA patient-derived isogenic neurons rescue neuronal branching and function. Sci Rep. 2021 Nov 09;11(1):21946. doi: 10.1038/s41598-021-01505-x. PMID: 34754035; PMCID: PMC8578337.
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Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer.

Science advances

Dowling CM, Hollinshead KER, Di Grande A, Pritchard J, Zhang H, Dillon ET, Haley K, Papadopoulos E, Mehta AK, Bleach R, Lindner AU, Mooney B, Düssmann H, O'Connor D, Prehn JHM, Wynne K, Hemann M, Bradner JE, Kimmelman AC, Guerriero JL, Cagney G, Wong KK, Letai AG, Chonghaile TN.
PMID: 33523897
Sci Adv. 2021 Jan 15;7(3). doi: 10.1126/sciadv.abc4897. Print 2021 Jan.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer without a targeted form of therapy. Unfortunately, up to 70% of patients with TNBC develop resistance to treatment. A known contributor to chemoresistance is dysfunctional mitochondrial apoptosis signaling. We...

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Dowling CM, Hollinshead KER, Di Grande A, et al. Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer. Sci Adv. 2021;7(3)doi: 10.1126/sciadv.abc4897.
Dowling, C. M., Hollinshead, K. E. R., Di Grande, A., Pritchard, J., Zhang, H., Dillon, E. T., Haley, K., Papadopoulos, E., Mehta, A. K., Bleach, R., Lindner, A. U., Mooney, B., Düssmann, H., O'Connor, D., Prehn, J. H. M., Wynne, K., Hemann, M., Bradner, J. E., Kimmelman, A. C., Guerriero, J. L., Cagney, G., Wong, K. K., Letai, A. G., & Chonghaile, T. N. (2021). Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer. Science advances, 7(3), . https://doi.org/10.1126/sciadv.abc4897
Dowling, Catríona M, et al. "Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer." Science advances vol. 7,3 (2021). doi: https://doi.org/10.1126/sciadv.abc4897
Dowling CM, Hollinshead KER, Di Grande A, Pritchard J, Zhang H, Dillon ET, Haley K, Papadopoulos E, Mehta AK, Bleach R, Lindner AU, Mooney B, Düssmann H, O'Connor D, Prehn JHM, Wynne K, Hemann M, Bradner JE, Kimmelman AC, Guerriero JL, Cagney G, Wong KK, Letai AG, Chonghaile TN. Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer. Sci Adv. 2021 Jan 15;7(3). doi: 10.1126/sciadv.abc4897. Print 2021 Jan. PMID: 33523897; PMCID: PMC7810372.
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Comparative study of the adhesion, friction, and mechanical properties of CF3- and CH3-terminated alkanethiol monolayers.

Langmuir : the ACS journal of surfaces and colloids

Houston JE, Doelling CM, Vanderlick TK, Hu Y, Scoles G, Wenzl I, Lee TR.
PMID: 15835957
Langmuir. 2005 Apr 26;21(9):3926-32. doi: 10.1021/la046901t.

We report the results of a direct comparison of the adhesion, friction, and mechanical properties between alkanethiol self-assembled monolayer films terminated by either CH(3) or CF(3) end groups using both interfacial force (IFM) and atomic force (AFM) microscopies. The...

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Houston JE, Doelling CM, Vanderlick TK, et al. Comparative study of the adhesion, friction, and mechanical properties of CF3- and CH3-terminated alkanethiol monolayers. Langmuir. 2005;21(9):3926-32doi: 10.1021/la046901t.
Houston, J. E., Doelling, C. M., Vanderlick, T. K., Hu, Y., Scoles, G., Wenzl, I., & Lee, T. R. (2005). Comparative study of the adhesion, friction, and mechanical properties of CF3- and CH3-terminated alkanethiol monolayers. Langmuir : the ACS journal of surfaces and colloids, 21(9), 3926-32. https://doi.org/10.1021/la046901t
Houston, Jack E, et al. "Comparative study of the adhesion, friction, and mechanical properties of CF3- and CH3-terminated alkanethiol monolayers." Langmuir : the ACS journal of surfaces and colloids vol. 21,9 (2005): 3926-32. doi: https://doi.org/10.1021/la046901t
Houston JE, Doelling CM, Vanderlick TK, Hu Y, Scoles G, Wenzl I, Lee TR. Comparative study of the adhesion, friction, and mechanical properties of CF3- and CH3-terminated alkanethiol monolayers. Langmuir. 2005 Apr 26;21(9):3926-32. doi: 10.1021/la046901t. PMID: 15835957.
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The importance of selecting the appropriate reference genes for quantitative real time PCR as illustrated using colon cancer cells and tissue.

F1000Research

Dowling CM, Walsh D, Coffey JC, Kiely PA.
PMID: 26962435
F1000Res. 2016 Jan 22;5:99. doi: 10.12688/f1000research.7656.2. eCollection 2016.

Quantitative real-time reverse-transcription polymerase chain reaction (RT-qPCR) remains the most sensitive technique for nucleic acid quantification. Its popularity is reflected in the remarkable number of publications reporting RT-qPCR data. Careful normalisation within RT-qPCR studies is imperative to ensure accurate...

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Dowling CM, Walsh D, Coffey JC, et al. The importance of selecting the appropriate reference genes for quantitative real time PCR as illustrated using colon cancer cells and tissue. F1000Res. 2016;5:99doi: 10.12688/f1000research.7656.2.
Dowling, C. M., Walsh, D., Coffey, J. C., & Kiely, P. A. (2016). The importance of selecting the appropriate reference genes for quantitative real time PCR as illustrated using colon cancer cells and tissue. F1000Research, 599. https://doi.org/10.12688/f1000research.7656.2
Dowling, Catríona M, et al. "The importance of selecting the appropriate reference genes for quantitative real time PCR as illustrated using colon cancer cells and tissue." F1000Research vol. 5 (2016): 99. doi: https://doi.org/10.12688/f1000research.7656.2
Dowling CM, Walsh D, Coffey JC, Kiely PA. The importance of selecting the appropriate reference genes for quantitative real time PCR as illustrated using colon cancer cells and tissue. F1000Res. 2016 Jan 22;5:99. doi: 10.12688/f1000research.7656.2. eCollection 2016. PMID: 26962435; PMCID: PMC4768652.
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A South African family with oculopharyngeal muscular dystrophy: Clinical and molecular genetic characteristics.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

Schutte CM, Dorfling CM, van Coller R, Honey EM, van Rensburg EJ.
PMID: 26428746
S Afr Med J. 2015 Sep 21;105(7):540-3. doi: 10.7196/SAMJnew.7880.

Autosomal dominantly inherited oculopharyngeal muscular dystrophy (OPMD) is caused by a trinucleotide repeat expansion in exon 1 of the polyadenylate binding protein nuclear 1 (PABPN1) gene on chromosome 14q. A large family with OPMD was recently identified in Pretoria,...

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Schutte CM, Dorfling CM, van Coller R, et al. A South African family with oculopharyngeal muscular dystrophy: Clinical and molecular genetic characteristics. S Afr Med J. 2015;105(7):540-3doi: 10.7196/SAMJnew.7880.
Schutte, C. M., Dorfling, C. M., van Coller, R., Honey, E. M., & van Rensburg, E. J. (2015). A South African family with oculopharyngeal muscular dystrophy: Clinical and molecular genetic characteristics. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 105(7), 540-3. https://doi.org/10.7196/SAMJnew.7880
Schutte, Clara Maria, et al. "A South African family with oculopharyngeal muscular dystrophy: Clinical and molecular genetic characteristics." South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde vol. 105,7 (2015): 540-3. doi: https://doi.org/10.7196/SAMJnew.7880
Schutte CM, Dorfling CM, van Coller R, Honey EM, van Rensburg EJ. A South African family with oculopharyngeal muscular dystrophy: Clinical and molecular genetic characteristics. S Afr Med J. 2015 Sep 21;105(7):540-3. doi: 10.7196/SAMJnew.7880. PMID: 26428746.
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Female Sexual Dysfunction: Natural and Complementary Treatments.

Focus (American Psychiatric Publishing)

Dording CM, Sangermano L.
PMID: 31975896
Focus (Am Psychiatr Publ). 2018 Jan;16(1):19-23. doi: 10.1176/appi.focus.20170049. Epub 2018 Jan 24.

Sexual dysfunction, which may affect any part of the sexual response cycle (e.g., libido, arousal, and orgasm), is a highly prevalent condition among women and is associated with significant negative consequences for quality of life. Unfortunately, few effective traditional...

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Dording CM, Sangermano L. Female Sexual Dysfunction: Natural and Complementary Treatments. Focus (Am Psychiatr Publ). 2018;16(1):19-23doi: 10.1176/appi.focus.20170049.
Dording, C. M., & Sangermano, L. (2018). Female Sexual Dysfunction: Natural and Complementary Treatments. Focus (American Psychiatric Publishing), 16(1), 19-23. https://doi.org/10.1176/appi.focus.20170049
Dording, Christina M, and Sangermano, Lisa. "Female Sexual Dysfunction: Natural and Complementary Treatments." Focus (American Psychiatric Publishing) vol. 16,1 (2018): 19-23. doi: https://doi.org/10.1176/appi.focus.20170049
Dording CM, Sangermano L. Female Sexual Dysfunction: Natural and Complementary Treatments. Focus (Am Psychiatr Publ). 2018 Jan;16(1):19-23. doi: 10.1176/appi.focus.20170049. Epub 2018 Jan 24. PMID: 31975896; PMCID: PMC6519565.
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Outcomes from the Introduction of a Combined Urology Outpatient Clinic.

Advances in urology

Browne C, Dowling CM, O'Malley P, Nusrat N, Walsh K, Jaffry S, Rogers E, Durkan GC, D'Arcy FT.
PMID: 30627154
Adv Urol. 2018 Nov 29;2018:9738548. doi: 10.1155/2018/9738548. eCollection 2018.

BACKGROUND: A combined urology clinic staffed by four consultants and four non-consultant hospital doctors (NCHDs) was introduced in our institution in October 2015. This clinic is supported by a pre-clinic radiology meeting and a synchronous urology clinical nurse specialist...

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Browne C, Dowling CM, O'Malley P, et al. Outcomes from the Introduction of a Combined Urology Outpatient Clinic. Adv Urol. 2018;2018:9738548doi: 10.1155/2018/9738548.
Browne, C., Dowling, C. M., O'Malley, P., Nusrat, N., Walsh, K., Jaffry, S., Rogers, E., Durkan, G. C., & D'Arcy, F. T. (2018). Outcomes from the Introduction of a Combined Urology Outpatient Clinic. Advances in urology, 20189738548. https://doi.org/10.1155/2018/9738548
Browne, Clíodhna, et al. "Outcomes from the Introduction of a Combined Urology Outpatient Clinic." Advances in urology vol. 2018 (2018): 9738548. doi: https://doi.org/10.1155/2018/9738548
Browne C, Dowling CM, O'Malley P, Nusrat N, Walsh K, Jaffry S, Rogers E, Durkan GC, D'Arcy FT. Outcomes from the Introduction of a Combined Urology Outpatient Clinic. Adv Urol. 2018 Nov 29;2018:9738548. doi: 10.1155/2018/9738548. eCollection 2018. PMID: 30627154; PMCID: PMC6305039.
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