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Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle.

Fluids and barriers of the CNS

Engelhardt B, Coisne C.
PMID: 21349152
Fluids Barriers CNS. 2011 Jan 18;8(1):4. doi: 10.1186/2045-8118-8-4.

Neuronal activity within the central nervous system (CNS) strictly depends on homeostasis and therefore does not tolerate uncontrolled entry of blood components. It has been generally believed that under normal conditions, the endothelial blood-brain barrier (BBB) and the epithelial...

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Engelhardt B, Coisne C. Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle. Fluids Barriers CNS. 2011;8(1):4doi: 10.1186/2045-8118-8-4.
Engelhardt, B., & Coisne, C. (2011). Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle. Fluids and barriers of the CNS, 8(1), 4. https://doi.org/10.1186/2045-8118-8-4
Engelhardt, Britta, and Coisne, Caroline. "Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle." Fluids and barriers of the CNS vol. 8,1 (2011): 4. doi: https://doi.org/10.1186/2045-8118-8-4
Engelhardt B, Coisne C. Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle. Fluids Barriers CNS. 2011 Jan 18;8(1):4. doi: 10.1186/2045-8118-8-4. PMID: 21349152; PMCID: PMC3039833.
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New Area Law in General Relativity.

Physical review letters

Bousso R, Engelhardt N.
PMID: 26340179
Phys Rev Lett. 2015 Aug 21;115(8):081301. doi: 10.1103/PhysRevLett.115.081301. Epub 2015 Aug 18.

We report a new area law in general relativity. A future holographic screen is a hypersurface foliated by marginally trapped surfaces. We show that their area increases monotonically along the foliation. Future holographic screens can easily be found in...

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Bousso R, Engelhardt N. New Area Law in General Relativity. Phys Rev Lett. 2015;115(8):081301doi: 10.1103/PhysRevLett.115.081301.
Bousso, R., & Engelhardt, N. (2015). New Area Law in General Relativity. Physical review letters, 115(8), 081301. https://doi.org/10.1103/PhysRevLett.115.081301
Bousso, Raphael, and Engelhardt, Netta. "New Area Law in General Relativity." Physical review letters vol. 115,8 (2015): 081301. doi: https://doi.org/10.1103/PhysRevLett.115.081301
Bousso R, Engelhardt N. New Area Law in General Relativity. Phys Rev Lett. 2015 Aug 21;115(8):081301. doi: 10.1103/PhysRevLett.115.081301. Epub 2015 Aug 18. PMID: 26340179.
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Importance of biomarkers in glioblastomas patients receiving local BCNU wafer chemotherapy.

Molecular cytogenetics

Urbschat S, Sippl C, Engelhardt J, Kammers K, Oertel J, Ketter R.
PMID: 28484518
Mol Cytogenet. 2017 May 04;10:16. doi: 10.1186/s13039-017-0317-5. eCollection 2017.

BACKGROUND: To assess the influence of molecular markers with potential prognostic value to groups of patients with newly diagnosed glioblastoma patients were examined: group A with 36 patients (surgical resection plus standard combined chemoradiotherapy) and group B with 36...

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Urbschat S, Sippl C, Engelhardt J, et al. Importance of biomarkers in glioblastomas patients receiving local BCNU wafer chemotherapy. Mol Cytogenet. 2017;10:16doi: 10.1186/s13039-017-0317-5.
Urbschat, S., Sippl, C., Engelhardt, J., Kammers, K., Oertel, J., & Ketter, R. (2017). Importance of biomarkers in glioblastomas patients receiving local BCNU wafer chemotherapy. Molecular cytogenetics, 1016. https://doi.org/10.1186/s13039-017-0317-5
Urbschat, Steffi, et al. "Importance of biomarkers in glioblastomas patients receiving local BCNU wafer chemotherapy." Molecular cytogenetics vol. 10 (2017): 16. doi: https://doi.org/10.1186/s13039-017-0317-5
Urbschat S, Sippl C, Engelhardt J, Kammers K, Oertel J, Ketter R. Importance of biomarkers in glioblastomas patients receiving local BCNU wafer chemotherapy. Mol Cytogenet. 2017 May 04;10:16. doi: 10.1186/s13039-017-0317-5. eCollection 2017. PMID: 28484518; PMCID: PMC5418867.
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Intermediate uveitis, posterior uveitis, and panuveitis in the Mid-Atlantic USA.

Clinical ophthalmology (Auckland, N.Z.)

Engelhard SB, Patel V, Reddy AK.
PMID: 26345421
Clin Ophthalmol. 2015 Aug 25;9:1549-55. doi: 10.2147/OPTH.S89428. eCollection 2015.

BACKGROUND: The purpose of this study was to identify the causes, clinical features, and outcomes of intermediate uveitis, posterior uveitis, and panuveitis in patients managed in a mid-Atlantic tertiary care center.METHODS: This was a retrospective observational study of intermediate...

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Engelhard SB, Patel V, Reddy AK. Intermediate uveitis, posterior uveitis, and panuveitis in the Mid-Atlantic USA. Clin Ophthalmol. 2015;9:1549-55doi: 10.2147/OPTH.S89428.
Engelhard, S. B., Patel, V., & Reddy, A. K. (2015). Intermediate uveitis, posterior uveitis, and panuveitis in the Mid-Atlantic USA. Clinical ophthalmology (Auckland, N.Z.), 91549-55. https://doi.org/10.2147/OPTH.S89428
Engelhard, Stephanie B, et al. "Intermediate uveitis, posterior uveitis, and panuveitis in the Mid-Atlantic USA." Clinical ophthalmology (Auckland, N.Z.) vol. 9 (2015): 1549-55. doi: https://doi.org/10.2147/OPTH.S89428
Engelhard SB, Patel V, Reddy AK. Intermediate uveitis, posterior uveitis, and panuveitis in the Mid-Atlantic USA. Clin Ophthalmol. 2015 Aug 25;9:1549-55. doi: 10.2147/OPTH.S89428. eCollection 2015. PMID: 26345421; PMCID: PMC4556262.
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Effects of structured interview guides and rater monitoring in clinical trials.

Journal of psychiatric research

Lipsitz JD, Kobak K, Williams JB, Engelhardt N.
PMID: 25062754
J Psychiatr Res. 2014 Oct;57:178-9. doi: 10.1016/j.jpsychires.2014.06.014. Epub 2014 Jul 05.

No abstract available.

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Lipsitz JD, Kobak K, Williams JB, et al. Effects of structured interview guides and rater monitoring in clinical trials. J Psychiatr Res. 2014;57:178-9doi: 10.1016/j.jpsychires.2014.06.014.
Lipsitz, J. D., Kobak, K., Williams, J. B., & Engelhardt, N. (2014). Effects of structured interview guides and rater monitoring in clinical trials. Journal of psychiatric research, 57178-9. https://doi.org/10.1016/j.jpsychires.2014.06.014
Lipsitz, Joshua D, et al. "Effects of structured interview guides and rater monitoring in clinical trials." Journal of psychiatric research vol. 57 (2014): 178-9. doi: https://doi.org/10.1016/j.jpsychires.2014.06.014
Lipsitz JD, Kobak K, Williams JB, Engelhardt N. Effects of structured interview guides and rater monitoring in clinical trials. J Psychiatr Res. 2014 Oct;57:178-9. doi: 10.1016/j.jpsychires.2014.06.014. Epub 2014 Jul 05. PMID: 25062754.
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Familiar and unfamiliar face recognition in crested macaques (Macaca nigra).

Royal Society open science

Micheletta J, Whitehouse J, Parr LA, Marshman P, Engelhardt A, Waller BM.
PMID: 26064665
R Soc Open Sci. 2015 May 27;2(5):150109. doi: 10.1098/rsos.150109. eCollection 2015 May.

Many species use facial features to identify conspecifics, which is necessary to navigate a complex social environment. The fundamental mechanisms underlying face processing are starting to be well understood in a variety of primate species. However, most studies focus...

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Micheletta J, Whitehouse J, Parr LA, et al. Familiar and unfamiliar face recognition in crested macaques (Macaca nigra). R Soc Open Sci. 2015;2(5):150109doi: 10.1098/rsos.150109.
Micheletta, J., Whitehouse, J., Parr, L. A., Marshman, P., Engelhardt, A., & Waller, B. M. (2015). Familiar and unfamiliar face recognition in crested macaques (Macaca nigra). Royal Society open science, 2(5), 150109. https://doi.org/10.1098/rsos.150109
Micheletta, Jérôme, et al. "Familiar and unfamiliar face recognition in crested macaques (Macaca nigra)." Royal Society open science vol. 2,5 (2015): 150109. doi: https://doi.org/10.1098/rsos.150109
Micheletta J, Whitehouse J, Parr LA, Marshman P, Engelhardt A, Waller BM. Familiar and unfamiliar face recognition in crested macaques (Macaca nigra). R Soc Open Sci. 2015 May 27;2(5):150109. doi: 10.1098/rsos.150109. eCollection 2015 May. PMID: 26064665; PMCID: PMC4453246.
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Leptomeningeal contrast enhancement and blood-CSF barrier dysfunction in aseptic meningitis.

Neurology(R) neuroimmunology & neuroinflammation

Alonso A, Eisele P, Ebert AD, Griebe M, Engelhardt B, Szabo K, Hennerici MG, Gass A.
PMID: 26516629
Neurol Neuroimmunol Neuroinflamm. 2015 Oct 15;2(6):e164. doi: 10.1212/NXI.0000000000000164. eCollection 2015 Dec.

OBJECTIVE: To investigate the blood-CSF barrier (BCSFB) dysfunction in aseptic meningitis.METHODS: In our case series of 14 patients with acute aseptic meningitis, we compared MRI characteristics with CSF findings.RESULTS: Contrast enhancement in the sulcal space in a leptomeningeal pattern...

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Alonso A, Eisele P, Ebert AD, et al. Leptomeningeal contrast enhancement and blood-CSF barrier dysfunction in aseptic meningitis. Neurol Neuroimmunol Neuroinflamm. 2015;2(6):e164doi: 10.1212/NXI.0000000000000164.
Alonso, A., Eisele, P., Ebert, A. D., Griebe, M., Engelhardt, B., Szabo, K., Hennerici, M. G., & Gass, A. (2015). Leptomeningeal contrast enhancement and blood-CSF barrier dysfunction in aseptic meningitis. Neurology(R) neuroimmunology & neuroinflammation, 2(6), e164. https://doi.org/10.1212/NXI.0000000000000164
Alonso, Angelika, et al. "Leptomeningeal contrast enhancement and blood-CSF barrier dysfunction in aseptic meningitis." Neurology(R) neuroimmunology & neuroinflammation vol. 2,6 (2015): e164. doi: https://doi.org/10.1212/NXI.0000000000000164
Alonso A, Eisele P, Ebert AD, Griebe M, Engelhardt B, Szabo K, Hennerici MG, Gass A. Leptomeningeal contrast enhancement and blood-CSF barrier dysfunction in aseptic meningitis. Neurol Neuroimmunol Neuroinflamm. 2015 Oct 15;2(6):e164. doi: 10.1212/NXI.0000000000000164. eCollection 2015 Dec. PMID: 26516629; PMCID: PMC4608759.
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[Nephritis in a Staffordshire Terrier puppy caused by Encephalitozoon cuniculi genotype I].

Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere

Engelhardt S, Buder A, Pfeil K, Schwittlick U, Klas E, Hinney B, Aupperle-Lellbach H, Pfeil I.
PMID: 29099899
Tierarztl Prax Ausg K Kleintiere Heimtiere. 2017 Nov 03;45(6). doi: 10.15654/TPK-161123. Epub 2017 Nov 03.

An 8-week-old puppy was presented to the clinic because of anorexia, polyuria, polydipsia and azotemia. The urinary sediment displayed large amounts of protozoan-like organisms, which could be identified by PCR as Encephalitozoon cuniculi genotype I. In the immunofluorescence antibody...

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Engelhardt S, Buder A, Pfeil K, et al. Nephritis bei einem Staffordshire-Terrier-Welpen verursacht durch Encephalitozoon cuniculi Genotyp I. [Nephritis in a Staffordshire Terrier puppy caused by Encephalitozoon cuniculi genotype I]. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2017;45(6)doi: 10.15654/TPK-161123.
Engelhardt, S., Buder, A., Pfeil, K., Schwittlick, U., Klas, E., Hinney, B., Aupperle-Lellbach, H., & Pfeil, I. (2017). Nephritis bei einem Staffordshire-Terrier-Welpen verursacht durch Encephalitozoon cuniculi Genotyp I. [Nephritis in a Staffordshire Terrier puppy caused by Encephalitozoon cuniculi genotype I]. Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere, 45(6), . https://doi.org/10.15654/TPK-161123
Engelhardt, Stephan, et al. "Nephritis bei einem Staffordshire-Terrier-Welpen verursacht durch Encephalitozoon cuniculi Genotyp I." [Nephritis in a Staffordshire Terrier puppy caused by Encephalitozoon cuniculi genotype I]. Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere vol. 45,6 (2017). doi: https://doi.org/10.15654/TPK-161123
Engelhardt S, Buder A, Pfeil K, Schwittlick U, Klas E, Hinney B, Aupperle-Lellbach H, Pfeil I. Nephritis bei einem Staffordshire-Terrier-Welpen verursacht durch Encephalitozoon cuniculi Genotyp I. [Nephritis in a Staffordshire Terrier puppy caused by Encephalitozoon cuniculi genotype I]. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2017 Nov 03;45(6). doi: 10.15654/TPK-161123. Epub 2017 Nov 03. German. PMID: 29099899.
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2000-fold parallelized dual-color STED fluorescence nanoscopy.

Optics express

Bergermann F, Alber L, Sahl SJ, Engelhardt J, Hell SW.
PMID: 25835668
Opt Express. 2015 Jan 12;23(1):211-23. doi: 10.1364/OE.23.000211.

Stimulated Emission Depletion (STED) nanoscopy enables multi-color fluorescence imaging at the nanometer scale. Its typical single-point scanning implementation can lead to long acquisition times. In order to unleash the full spatiotemporal resolution potential of STED nanoscopy, parallelized scanning is...

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Bergermann F, Alber L, Sahl SJ, et al. 2000-fold parallelized dual-color STED fluorescence nanoscopy. Opt Express. 2015;23(1):211-23doi: 10.1364/OE.23.000211.
Bergermann, F., Alber, L., Sahl, S. J., Engelhardt, J., & Hell, S. W. (2015). 2000-fold parallelized dual-color STED fluorescence nanoscopy. Optics express, 23(1), 211-23. https://doi.org/10.1364/OE.23.000211
Bergermann, Fabian, et al. "2000-fold parallelized dual-color STED fluorescence nanoscopy." Optics express vol. 23,1 (2015): 211-23. doi: https://doi.org/10.1364/OE.23.000211
Bergermann F, Alber L, Sahl SJ, Engelhardt J, Hell SW. 2000-fold parallelized dual-color STED fluorescence nanoscopy. Opt Express. 2015 Jan 12;23(1):211-23. doi: 10.1364/OE.23.000211. PMID: 25835668.
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Hydroxylated Fluorescent Dyes for Live-Cell Labeling: Synthesis, Spectra and Super-Resolution STED.

Chemistry (Weinheim an der Bergstrasse, Germany)

Butkevich AN, Belov VN, Kolmakov K, Sokolov VV, Shojaei H, Sidenstein SC, Kamin D, Matthias J, Vlijm R, Engelhardt J, Hell SW.
PMID: 28370443
Chemistry. 2017 Sep 07;23(50):12114-12119. doi: 10.1002/chem.201701216. Epub 2017 May 02.

Hydroxylated rhodamines, carbopyronines, silico- and germanorhodamines with absorption maxima in the range of 530-640 nm were prepared and applied in specific labeling of living cells. The direct and high-yielding entry to germa- and silaxanthones tolerates the presence of protected...

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Butkevich AN, Belov VN, Kolmakov K, et al. Hydroxylated Fluorescent Dyes for Live-Cell Labeling: Synthesis, Spectra and Super-Resolution STED. Chemistry. 2017;23(50):12114-12119doi: 10.1002/chem.201701216.
Butkevich, A. N., Belov, V. N., Kolmakov, K., Sokolov, V. V., Shojaei, H., Sidenstein, S. C., Kamin, D., Matthias, J., Vlijm, R., Engelhardt, J., & Hell, S. W. (2017). Hydroxylated Fluorescent Dyes for Live-Cell Labeling: Synthesis, Spectra and Super-Resolution STED. Chemistry (Weinheim an der Bergstrasse, Germany), 23(50), 12114-12119. https://doi.org/10.1002/chem.201701216
Butkevich, Alexey N, et al. "Hydroxylated Fluorescent Dyes for Live-Cell Labeling: Synthesis, Spectra and Super-Resolution STED." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 23,50 (2017): 12114-12119. doi: https://doi.org/10.1002/chem.201701216
Butkevich AN, Belov VN, Kolmakov K, Sokolov VV, Shojaei H, Sidenstein SC, Kamin D, Matthias J, Vlijm R, Engelhardt J, Hell SW. Hydroxylated Fluorescent Dyes for Live-Cell Labeling: Synthesis, Spectra and Super-Resolution STED. Chemistry. 2017 Sep 07;23(50):12114-12119. doi: 10.1002/chem.201701216. Epub 2017 May 02. PMID: 28370443; PMCID: PMC5599963.
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Learning (from) the errors of a systems biology model.

Scientific reports

Engelhardt B, Frőhlich H, Kschischo M.
PMID: 26865316
Sci Rep. 2016 Feb 11;6:20772. doi: 10.1038/srep20772.

Mathematical modelling is a labour intensive process involving several iterations of testing on real data and manual model modifications. In biology, the domain knowledge guiding model development is in many cases itself incomplete and uncertain. A major problem in...

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Engelhardt B, Frőhlich H, Kschischo M. Learning (from) the errors of a systems biology model. Sci Rep. 2016;6:20772doi: 10.1038/srep20772.
Engelhardt, B., Frőhlich, H., & Kschischo, M. (2016). Learning (from) the errors of a systems biology model. Scientific reports, 620772. https://doi.org/10.1038/srep20772
Engelhardt, Benjamin, et al. "Learning (from) the errors of a systems biology model." Scientific reports vol. 6 (2016): 20772. doi: https://doi.org/10.1038/srep20772
Engelhardt B, Frőhlich H, Kschischo M. Learning (from) the errors of a systems biology model. Sci Rep. 2016 Feb 11;6:20772. doi: 10.1038/srep20772. PMID: 26865316; PMCID: PMC4749970.
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Data Quality Monitoring in Clinical Trials: Has It Been Worth It? An Evaluation and Prediction of the Future by All Stakeholders.

Innovations in clinical neuroscience

, Daniel D, Kalali A, West M, Walling D, Hilt D, Engelhardt N, Alphs L, Loebel A, Vanover K, Atkinson S, Opler M, Sachs G, Nations K, Brady C.
PMID: 27413584
Innov Clin Neurosci. 2016 Feb 01;13(1):27-33. eCollection 2016.

This paper summarizes the results of the CNS Summit Data Quality Monitoring Workgroup analysis of current data quality monitoring techniques used in central nervous system (CNS) clinical trials. Based on audience polls conducted at the CNS Summit 2014, the...

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, Daniel D, Kalali A, et al. Data Quality Monitoring in Clinical Trials: Has It Been Worth It? An Evaluation and Prediction of the Future by All Stakeholders. Innov Clin Neurosci. 2016;13(1):27-33
, Daniel, D., Kalali, A., West, M., Walling, D., Hilt, D., Engelhardt, N., Alphs, L., Loebel, A., Vanover, K., Atkinson, S., Opler, M., Sachs, G., Nations, K., & Brady, C. (2016). Data Quality Monitoring in Clinical Trials: Has It Been Worth It? An Evaluation and Prediction of the Future by All Stakeholders. Innovations in clinical neuroscience, 13(1), 27-33.
, et al. "Data Quality Monitoring in Clinical Trials: Has It Been Worth It? An Evaluation and Prediction of the Future by All Stakeholders." Innovations in clinical neuroscience vol. 13,1 (2016): 27-33.
, Daniel D, Kalali A, West M, Walling D, Hilt D, Engelhardt N, Alphs L, Loebel A, Vanover K, Atkinson S, Opler M, Sachs G, Nations K, Brady C. Data Quality Monitoring in Clinical Trials: Has It Been Worth It? An Evaluation and Prediction of the Future by All Stakeholders. Innov Clin Neurosci. 2016 Feb 01;13(1):27-33. eCollection 2016. PMID: 27413584; PMCID: PMC4896826.
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Showing 1 to 12 of 418 entries