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Showing 1 to 12 of 16 entries
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Phospholipid nanoparticles: Therapeutic potentials against atherosclerosis via reducing cholesterol crystals and inhibiting inflammation.

EBioMedicine

Luo Y, Guo Y, Wang H, Yu M, Hong K, Li D, Li R, Wen B, Hu D, Chang L, Zhang J, Yang B, Sun D, Schwendeman AS, Eugene Chen Y.
PMID: 34879325
EBioMedicine. 2021 Dec 05;74:103725. doi: 10.1016/j.ebiom.2021.103725. Epub 2021 Dec 05.

BACKGROUND: Atherosclerosis-related cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Cholesterol crystals (CCs) induce inflammation in atherosclerosis and are associated with unstable plaques and poor prognosis, but no drug can remove CCs in the clinic currently.METHODS: We...

Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation.

eLife

Lei I, Tian S, Gao W, Liu L, Guo Y, Tang P, Chen E, Wang Z.
PMID: 34939931
Elife. 2021 Dec 23;10. doi: 10.7554/eLife.60311.

Myocardial infarction (MI) is accompanied by severe energy deprivation and extensive epigenetic changes. However, how energy metabolism and chromatin modifications are interlinked during MI and heart repair has been poorly explored. Here, we examined the effect of different carbon...

Phospholipid nanoparticles: Therapeutic potentials against atherosclerosis via reducing cholesterol crystals and inhibiting inflammation.

EBioMedicine

Luo Y, Guo Y, Wang H, Yu M, Hong K, Li D, Li R, Wen B, Hu D, Chang L, Zhang J, Yang B, Sun D, Schwendeman AS, Eugene Chen Y.
PMID: 34879325
EBioMedicine. 2021 Dec 05;74:103725. doi: 10.1016/j.ebiom.2021.103725. Epub 2021 Dec 05.

BACKGROUND: Atherosclerosis-related cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Cholesterol crystals (CCs) induce inflammation in atherosclerosis and are associated with unstable plaques and poor prognosis, but no drug can remove CCs in the clinic currently.METHODS: We...

The histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRαβ.

Cell death and differentiation

Zhang H, Hu Y, Liu D, Liu Z, Xie N, Liu S, Zhang J, Jiang Y, Li C, Wang Q, Chen X, Ye D, Sun D, Zhai Y, Yan X, Liu Y, Chen CD, Huang X, Eugene Chin Y, Shi Y, Wu B, Zhang X.
PMID: 34999729
Cell Death Differ. 2022 Jan 09; doi: 10.1038/s41418-021-00921-w. Epub 2022 Jan 09.

Intestinal intraepithelial lymphocytes (IELs) are distributed along the length of the intestine and are considered the frontline of immune surveillance. The precise molecular mechanisms, especially epigenetic regulation, of their development and function are poorly understood. The trimethylation of histone...

Dental pulp testing: a review.

International journal of dentistry

Chen E, Abbott PV.
PMID: 20339575
Int J Dent. 2009;2009:365785. doi: 10.1155/2009/365785. Epub 2009 Nov 12.

Dental pulp testing is a useful and essential diagnostic aid in endodontics. Pulp sensibility tests include thermal and electric tests, which extrapolate pulp health from sensory response. Whilst pulp sensibility tests are the most commonly used in clinical practice,...

Phospholipid nanoparticles: Therapeutic potentials against atherosclerosis via reducing cholesterol crystals and inhibiting inflammation.

EBioMedicine

Luo Y, Guo Y, Wang H, Yu M, Hong K, Li D, Li R, Wen B, Hu D, Chang L, Zhang J, Yang B, Sun D, Schwendeman AS, Eugene Chen Y.
PMID: 34879325
EBioMedicine. 2021 Dec 05;74:103725. doi: 10.1016/j.ebiom.2021.103725. Epub 2021 Dec 05.

BACKGROUND: Atherosclerosis-related cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Cholesterol crystals (CCs) induce inflammation in atherosclerosis and are associated with unstable plaques and poor prognosis, but no drug can remove CCs in the clinic currently.METHODS: We...

Phospholipid nanoparticles: Therapeutic potentials against atherosclerosis via reducing cholesterol crystals and inhibiting inflammation.

EBioMedicine

Luo Y, Guo Y, Wang H, Yu M, Hong K, Li D, Li R, Wen B, Hu D, Chang L, Zhang J, Yang B, Sun D, Schwendeman AS, Eugene Chen Y.
PMID: 34879325
EBioMedicine. 2021 Dec;74:103725. doi: 10.1016/j.ebiom.2021.103725. Epub 2021 Dec 06.

BACKGROUND: Atherosclerosis-related cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Cholesterol crystals (CCs) induce inflammation in atherosclerosis and are associated with unstable plaques and poor prognosis, but no drug can remove CCs in the clinic currently.METHODS: We...

Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation.

eLife

Lei I, Tian S, Gao W, Liu L, Guo Y, Tang P, Chen E, Wang Z.
PMID: 34939931
Elife. 2021 Dec 23;10. doi: 10.7554/eLife.60311. Epub 2021 Dec 23.

Myocardial infarction (MI) is accompanied by severe energy deprivation and extensive epigenetic changes. However, how energy metabolism and chromatin modifications are interlinked during MI and heart repair has been poorly explored. Here, we examined the effect of different carbon...

Phospholipid nanoparticles: Therapeutic potentials against atherosclerosis via reducing cholesterol crystals and inhibiting inflammation.

EBioMedicine

Luo Y, Guo Y, Wang H, Yu M, Hong K, Li D, Li R, Wen B, Hu D, Chang L, Zhang J, Yang B, Sun D, Schwendeman AS, Eugene Chen Y.
PMID: 34879325
EBioMedicine. 2021 Dec 05;74:103725. doi: 10.1016/j.ebiom.2021.103725. Epub 2021 Dec 05.

BACKGROUND: Atherosclerosis-related cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Cholesterol crystals (CCs) induce inflammation in atherosclerosis and are associated with unstable plaques and poor prognosis, but no drug can remove CCs in the clinic currently.METHODS: We...

Phospholipid nanoparticles: Therapeutic potentials against atherosclerosis via reducing cholesterol crystals and inhibiting inflammation.

EBioMedicine

Luo Y, Guo Y, Wang H, Yu M, Hong K, Li D, Li R, Wen B, Hu D, Chang L, Zhang J, Yang B, Sun D, Schwendeman AS, Eugene Chen Y.
PMID: 34879325
EBioMedicine. 2021 Dec 05;74:103725. doi: 10.1016/j.ebiom.2021.103725. Epub 2021 Dec 05.

BACKGROUND: Atherosclerosis-related cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Cholesterol crystals (CCs) induce inflammation in atherosclerosis and are associated with unstable plaques and poor prognosis, but no drug can remove CCs in the clinic currently.METHODS: We...

Differential inflammatory responses of the native left and right ventricle associated with donor heart preservation.

Physiological reports

Lei I, Huang W, Ward PA, Pober JS, Tellides G, Ailawadi G, Pagani FD, Landstrom AP, Wang Z, Mortensen RM, Cascalho M, Platt J, Eugene Chen Y, Lam HYK, Tang PC.
PMID: 34435466
Physiol Rep. 2021 Sep;9(17):e15004. doi: 10.14814/phy2.15004.

BACKGROUND: Dysfunction and inflammation of hearts subjected to cold ischemic preservation may differ between left and right ventricles, suggesting distinct strategies for amelioration.METHODS AND RESULTS: Explanted murine hearts subjected to cold ischemia for 0, 4, or 8 h in...

Assessing risk post intervention for an acute coronary syndrome: a review of the risk assessment tools and their development.

Contemporary nurse

Scruth E, Worrall-Carter L, Cheng E, Rolley J, Page K.
PMID: 23343227
Contemp Nurse. 2012 Dec;43(1):2-12. doi: 10.5172/conu.2012.43.1.2.

Considerable variability in survival rate after an acute myocardial infarction exists and accurate risk stratification is of significant importance. The American College of Cardiology and the American Heart Association has recommended early risk stratification using several clinical risk scoring...

Showing 1 to 12 of 16 entries