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Synthetic approaches to the 2014 new drugs.

Bioorganic & medicinal chemistry

Flick AC, Ding HX, Leverett CA, Kyne RE, Liu KK, Fink SJ, O'Donnell CJ.
PMID: 27020685
Bioorg Med Chem. 2016 May 01;24(9):1937-80. doi: 10.1016/j.bmc.2016.03.004. Epub 2016 Mar 09.

New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide insight into molecular recognition and also serve as leads for designing future new drugs. This annual review covers...

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Flick AC, Ding HX, Leverett CA, et al. Synthetic approaches to the 2014 new drugs. Bioorg Med Chem. 2016;24(9):1937-80doi: 10.1016/j.bmc.2016.03.004.
Flick, A. C., Ding, H. X., Leverett, C. A., Kyne, R. E., Liu, K. K., Fink, S. J., & O'Donnell, C. J. (2016). Synthetic approaches to the 2014 new drugs. Bioorganic & medicinal chemistry, 24(9), 1937-80. https://doi.org/10.1016/j.bmc.2016.03.004
Flick, Andrew C, et al. "Synthetic approaches to the 2014 new drugs." Bioorganic & medicinal chemistry vol. 24,9 (2016): 1937-80. doi: https://doi.org/10.1016/j.bmc.2016.03.004
Flick AC, Ding HX, Leverett CA, Kyne RE, Liu KK, Fink SJ, O'Donnell CJ. Synthetic approaches to the 2014 new drugs. Bioorg Med Chem. 2016 May 01;24(9):1937-80. doi: 10.1016/j.bmc.2016.03.004. Epub 2016 Mar 09. PMID: 27020685.
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Hindered Energy Cascade in Highly Helical Isotropic Turbulence.

Physical review letters

Stepanov R, Golbraikh E, Frick P, Shestakov A.
PMID: 26684120
Phys Rev Lett. 2015 Dec 04;115(23):234501. doi: 10.1103/PhysRevLett.115.234501. Epub 2015 Dec 01.

The conventional approach to the turbulent energy cascade, based on Richardson-Kolmogorov phenomenology, ignores the topology of emerging vortices, which is related to the helicity of the turbulent flow. It is generally believed that helicity can play a significant role...

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Stepanov R, Golbraikh E, Frick P, et al. Hindered Energy Cascade in Highly Helical Isotropic Turbulence. Phys Rev Lett. 2015;115(23):234501doi: 10.1103/PhysRevLett.115.234501.
Stepanov, R., Golbraikh, E., Frick, P., & Shestakov, A. (2015). Hindered Energy Cascade in Highly Helical Isotropic Turbulence. Physical review letters, 115(23), 234501. https://doi.org/10.1103/PhysRevLett.115.234501
Stepanov, Rodion, et al. "Hindered Energy Cascade in Highly Helical Isotropic Turbulence." Physical review letters vol. 115,23 (2015): 234501. doi: https://doi.org/10.1103/PhysRevLett.115.234501
Stepanov R, Golbraikh E, Frick P, Shestakov A. Hindered Energy Cascade in Highly Helical Isotropic Turbulence. Phys Rev Lett. 2015 Dec 04;115(23):234501. doi: 10.1103/PhysRevLett.115.234501. Epub 2015 Dec 01. PMID: 26684120.
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Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase.

ACS infectious diseases

Sweeney NL, Hanson AM, Mukherjee S, Ndjomou J, Geiss BJ, Steel JJ, Frankowski KJ, Li K, Schoenen FJ, Frick DN.
PMID: 26029739
ACS Infect Dis. 2015 Mar 13;1(3):140-148. doi: 10.1021/id5000458.

The flavivirus nonstructural protein 3 (NS3) is a protease and helicase, and on the basis of its similarity to its homologue encoded by the hepatitis C virus (HCV), the flavivirus NS3 might be a promising drug target. Few flavivirus...

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Sweeney NL, Hanson AM, Mukherjee S, et al. Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase. ACS Infect Dis. 2015;1(3):140-148doi: 10.1021/id5000458.
Sweeney, N. L., Hanson, A. M., Mukherjee, S., Ndjomou, J., Geiss, B. J., Steel, J. J., Frankowski, K. J., Li, K., Schoenen, F. J., & Frick, D. N. (2015). Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase. ACS infectious diseases, 1(3), 140-148. https://doi.org/10.1021/id5000458
Sweeney, Noreena L, et al. "Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase." ACS infectious diseases vol. 1,3 (2015): 140-148. doi: https://doi.org/10.1021/id5000458
Sweeney NL, Hanson AM, Mukherjee S, Ndjomou J, Geiss BJ, Steel JJ, Frankowski KJ, Li K, Schoenen FJ, Frick DN. Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase. ACS Infect Dis. 2015 Mar 13;1(3):140-148. doi: 10.1021/id5000458. PMID: 26029739; PMCID: PMC4444071.
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Picturing perspectives: development of perspective-taking abilities in 4- to 8-year-olds.

Frontiers in psychology

Frick A, Möhring W, Newcombe NS.
PMID: 24817860
Front Psychol. 2014 Apr 30;5:386. doi: 10.3389/fpsyg.2014.00386. eCollection 2014.

Although the development of perspective taking has been well researched, there is no uniform methodology for assessing this ability across a wide age span when frames of reference conflict. To address this gap, we created scenes of toy photographers...

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Frick A, Möhring W, Newcombe NS. Picturing perspectives: development of perspective-taking abilities in 4- to 8-year-olds. Front Psychol. 2014;5:386doi: 10.3389/fpsyg.2014.00386.
Frick, A., Möhring, W., & Newcombe, N. S. (2014). Picturing perspectives: development of perspective-taking abilities in 4- to 8-year-olds. Frontiers in psychology, 5386. https://doi.org/10.3389/fpsyg.2014.00386
Frick, Andrea, et al. "Picturing perspectives: development of perspective-taking abilities in 4- to 8-year-olds." Frontiers in psychology vol. 5 (2014): 386. doi: https://doi.org/10.3389/fpsyg.2014.00386
Frick A, Möhring W, Newcombe NS. Picturing perspectives: development of perspective-taking abilities in 4- to 8-year-olds. Front Psychol. 2014 Apr 30;5:386. doi: 10.3389/fpsyg.2014.00386. eCollection 2014. PMID: 24817860; PMCID: PMC4012199.
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Erratum for Holm et al., Activation of the Contact System at the Surface of Fusobacterium necrophorum Represents a Possible Virulence Mechanism in Lemièrre's Syndrome.

Infection and immunity

Holm K, Frick IM, Björck L, Rasmussen M.
PMID: 26450975
Infect Immun. 2015 Nov;83(11):4451. doi: 10.1128/IAI.01123-15.

No abstract available.

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Holm K, Frick IM, Björck L, et al. Erratum for Holm et al., Activation of the Contact System at the Surface of Fusobacterium necrophorum Represents a Possible Virulence Mechanism in Lemièrre's Syndrome. Infect Immun. 2015;83(11):4451doi: 10.1128/IAI.01123-15.
Holm, K., Frick, I. M., Björck, L., & Rasmussen, M. (2015). Erratum for Holm et al., Activation of the Contact System at the Surface of Fusobacterium necrophorum Represents a Possible Virulence Mechanism in Lemièrre's Syndrome. Infection and immunity, 83(11), 4451. https://doi.org/10.1128/IAI.01123-15
Holm, Karin, et al. "Erratum for Holm et al., Activation of the Contact System at the Surface of Fusobacterium necrophorum Represents a Possible Virulence Mechanism in Lemièrre's Syndrome." Infection and immunity vol. 83,11 (2015): 4451. doi: https://doi.org/10.1128/IAI.01123-15
Holm K, Frick IM, Björck L, Rasmussen M. Erratum for Holm et al., Activation of the Contact System at the Surface of Fusobacterium necrophorum Represents a Possible Virulence Mechanism in Lemièrre's Syndrome. Infect Immun. 2015 Nov;83(11):4451. doi: 10.1128/IAI.01123-15. PMID: 26450975; PMCID: PMC4598390.
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Temperature-Induced Switchable Adhesion using Nickel-Titanium-Polydimethylsiloxane Hybrid Surfaces.

Advanced functional materials

Frensemeier M, Kaiser JS, Frick CP, Schneider AS, Arzt E, Fertig RS, Kroner E.
PMID: 26120295
Adv Funct Mater. 2015 May;25(20):3013-3021. doi: 10.1002/adfm.201500437. Epub 2015 Apr 08.

A switchable dry adhesive based on a nickel-titanium (NiTi) shape-memory alloy with an adhesive silicone rubber surface has been developed. Although several studies investigate micropatterned, bioinspired adhesive surfaces, very few focus on reversible adhesion. The system here is based...

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Frensemeier M, Kaiser JS, Frick CP, et al. Temperature-Induced Switchable Adhesion using Nickel-Titanium-Polydimethylsiloxane Hybrid Surfaces. Adv Funct Mater. 2015;25(20):3013-3021doi: 10.1002/adfm.201500437.
Frensemeier, M., Kaiser, J. S., Frick, C. P., Schneider, A. S., Arzt, E., Fertig, R. S., & Kroner, E. (2015). Temperature-Induced Switchable Adhesion using Nickel-Titanium-Polydimethylsiloxane Hybrid Surfaces. Advanced functional materials, 25(20), 3013-3021. https://doi.org/10.1002/adfm.201500437
Frensemeier, Mareike, et al. "Temperature-Induced Switchable Adhesion using Nickel-Titanium-Polydimethylsiloxane Hybrid Surfaces." Advanced functional materials vol. 25,20 (2015): 3013-3021. doi: https://doi.org/10.1002/adfm.201500437
Frensemeier M, Kaiser JS, Frick CP, Schneider AS, Arzt E, Fertig RS, Kroner E. Temperature-Induced Switchable Adhesion using Nickel-Titanium-Polydimethylsiloxane Hybrid Surfaces. Adv Funct Mater. 2015 May;25(20):3013-3021. doi: 10.1002/adfm.201500437. Epub 2015 Apr 08. PMID: 26120295; PMCID: PMC4478996.
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High-power laser system multiplexing for x-ray backlighting.

Applied optics

Manes KR, Phillion DW, Holzrichter JR, Hildum JS, Seppala LG, Frick FA, Kuizenga DJ.
PMID: 18224091
Appl Opt. 1985 Nov 01;24(21):3579. doi: 10.1364/ao.24.003579.

No abstract available.

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Manes KR, Phillion DW, Holzrichter JR, et al. High-power laser system multiplexing for x-ray backlighting. Appl Opt. 1985;24(21):3579doi: 10.1364/ao.24.003579.
Manes, K. R., Phillion, D. W., Holzrichter, J. R., Hildum, J. S., Seppala, L. G., Frick, F. A., & Kuizenga, D. J. (1985). High-power laser system multiplexing for x-ray backlighting. Applied optics, 24(21), 3579. https://doi.org/10.1364/ao.24.003579
Manes, K R, et al. "High-power laser system multiplexing for x-ray backlighting." Applied optics vol. 24,21 (1985): 3579. doi: https://doi.org/10.1364/ao.24.003579
Manes KR, Phillion DW, Holzrichter JR, Hildum JS, Seppala LG, Frick FA, Kuizenga DJ. High-power laser system multiplexing for x-ray backlighting. Appl Opt. 1985 Nov 01;24(21):3579. doi: 10.1364/ao.24.003579. PMID: 18224091.
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An analysis of an operant discrimination.

The Journal of psychology

FRICK FC.
PMID: 18865244
J Psychol. 1948 Jul;26:93-123. doi: 10.1080/00223980.1948.9917398.

No abstract available.

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FRICK FC. An analysis of an operant discrimination. J Psychol. 1948;26:93-123doi: 10.1080/00223980.1948.9917398.
FRICK, F. C. (1948). An analysis of an operant discrimination. The Journal of psychology, 2693-123. https://doi.org/10.1080/00223980.1948.9917398
FRICK, F C. "An analysis of an operant discrimination." The Journal of psychology vol. 26 (1948): 93-123. doi: https://doi.org/10.1080/00223980.1948.9917398
FRICK FC. An analysis of an operant discrimination. J Psychol. 1948 Jul;26:93-123. doi: 10.1080/00223980.1948.9917398. PMID: 18865244.
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Concerning Proposition 2 on November ballot.

California and western medicine

Briggs LH, Frick DJ, Moffitt HC, Peers RA, Toland CG, Smith RK.
PMID: 18743841
Cal West Med. 1936 Oct;45(4):374-5.

No abstract available.

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Briggs LH, Frick DJ, Moffitt HC, et al. Concerning Proposition 2 on November ballot. Cal West Med. 1936;45(4):374-5
Briggs, L. H., Frick, D. J., Moffitt, H. C., Peers, R. A., Toland, C. G., & Smith, R. K. (1936). Concerning Proposition 2 on November ballot. California and western medicine, 45(4), 374-5.
Briggs, L H, et al. "Concerning Proposition 2 on November ballot." California and western medicine vol. 45,4 (1936): 374-5.
Briggs LH, Frick DJ, Moffitt HC, Peers RA, Toland CG, Smith RK. Concerning Proposition 2 on November ballot. Cal West Med. 1936 Oct;45(4):374-5. PMID: 18743841; PMCID: PMC1761400.
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Assimilation of information from dot and matrix patterns.

Journal of experimental psychology

KLEMMER ET, FRICK FC.
PMID: 13034996
J Exp Psychol. 1953 Jan;45(1):15-9. doi: 10.1037/h0060868.

No abstract available.

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KLEMMER ET, FRICK FC. Assimilation of information from dot and matrix patterns. J Exp Psychol. 1953;45(1):15-9doi: 10.1037/h0060868.
KLEMMER, E. T., & FRICK, F. C. (1953). Assimilation of information from dot and matrix patterns. Journal of experimental psychology, 45(1), 15-9. https://doi.org/10.1037/h0060868
KLEMMER, E T, and FRICK, F C. "Assimilation of information from dot and matrix patterns." Journal of experimental psychology vol. 45,1 (1953): 15-9. doi: https://doi.org/10.1037/h0060868
KLEMMER ET, FRICK FC. Assimilation of information from dot and matrix patterns. J Exp Psychol. 1953 Jan;45(1):15-9. doi: 10.1037/h0060868. PMID: 13034996.
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Aqueous Nile blue: a simple, versatile and safe reagent for the detection of latent fingermarks.

Chemical communications (Cambridge, England)

Frick AA, Busetti F, Cross A, Lewis SW.
PMID: 24535380
Chem Commun (Camb). 2014 Mar 28;50(25):3341-3. doi: 10.1039/c3cc49577a. Epub 2014 Feb 18.

Nile blue A in aqueous solution undergoes spontaneous hydrolysis to the photoluminescent compound Nile red. This reagent provides a simple and safe approach to the detection of latent fingermarks on porous and non-porous surfaces.

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Frick AA, Busetti F, Cross A, et al. Aqueous Nile blue: a simple, versatile and safe reagent for the detection of latent fingermarks. Chem Commun (Camb). 2014;50(25):3341-3doi: 10.1039/c3cc49577a.
Frick, A. A., Busetti, F., Cross, A., & Lewis, S. W. (2014). Aqueous Nile blue: a simple, versatile and safe reagent for the detection of latent fingermarks. Chemical communications (Cambridge, England), 50(25), 3341-3. https://doi.org/10.1039/c3cc49577a
Frick, Amanda A, et al. "Aqueous Nile blue: a simple, versatile and safe reagent for the detection of latent fingermarks." Chemical communications (Cambridge, England) vol. 50,25 (2014): 3341-3. doi: https://doi.org/10.1039/c3cc49577a
Frick AA, Busetti F, Cross A, Lewis SW. Aqueous Nile blue: a simple, versatile and safe reagent for the detection of latent fingermarks. Chem Commun (Camb). 2014 Mar 28;50(25):3341-3. doi: 10.1039/c3cc49577a. Epub 2014 Feb 18. PMID: 24535380.
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2,3-Bis(phenylsulfonyl)-1,3-butadiene as a reagent for the synthesis of the azatricyclic core of (+/-)-halichlorine.

The Journal of organic chemistry

Flick AC, Caballero MJ, Lee HI, Padwa A.
PMID: 20151655
J Org Chem. 2010 Mar 19;75(6):1992-6. doi: 10.1021/jo100055u.

An efficient stereocontrolled route to the azatricyclic core of an advanced halichlorine intermediate is described. Reaction of the oxime derived from 2-(oxo-cyclopentyl)acetic acid ethyl ester with 2,3-bis(phenylsulfonyl)-1,3-butadiene gives rise to a 7-oxa-1-azanorbornane cycloadduct in high yield. The formation of...

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Flick AC, Caballero MJ, Lee HI, et al. 2,3-Bis(phenylsulfonyl)-1,3-butadiene as a reagent for the synthesis of the azatricyclic core of (+/-)-halichlorine. J Org Chem. 2010;75(6):1992-6doi: 10.1021/jo100055u.
Flick, A. C., Caballero, M. J., Lee, H. I., & Padwa, A. (2010). 2,3-Bis(phenylsulfonyl)-1,3-butadiene as a reagent for the synthesis of the azatricyclic core of (+/-)-halichlorine. The Journal of organic chemistry, 75(6), 1992-6. https://doi.org/10.1021/jo100055u
Flick, Andrew C, et al. "2,3-Bis(phenylsulfonyl)-1,3-butadiene as a reagent for the synthesis of the azatricyclic core of (+/-)-halichlorine." The Journal of organic chemistry vol. 75,6 (2010): 1992-6. doi: https://doi.org/10.1021/jo100055u
Flick AC, Caballero MJ, Lee HI, Padwa A. 2,3-Bis(phenylsulfonyl)-1,3-butadiene as a reagent for the synthesis of the azatricyclic core of (+/-)-halichlorine. J Org Chem. 2010 Mar 19;75(6):1992-6. doi: 10.1021/jo100055u. PMID: 20151655.
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Showing 1 to 12 of 161 entries