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Genetics patients' perspectives on clinical genomic testing.

Personalized medicine

McGowan ML, Glinka A, Highland J, Asaad G, Sharp RR.
PMID: 24955098
Per Med. 2013 Jun 01;10(4):339-347. doi: 10.2217/pme.13.32.

AIMS: Advances in next-generation sequencing technologies make it possible to envisage multiple contexts in which genomic tools might be used to enhance patient care. We describe how genetics patients and their caregivers view the promises and perils of clinical...

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McGowan ML, Glinka A, Highland J, et al. Genetics patients' perspectives on clinical genomic testing. Per Med. 2013;10(4):339-347doi: 10.2217/pme.13.32.
McGowan, M. L., Glinka, A., Highland, J., Asaad, G., & Sharp, R. R. (2013). Genetics patients' perspectives on clinical genomic testing. Personalized medicine, 10(4), 339-347. https://doi.org/10.2217/pme.13.32
McGowan, Michelle L, et al. "Genetics patients' perspectives on clinical genomic testing." Personalized medicine vol. 10,4 (2013): 339-347. doi: https://doi.org/10.2217/pme.13.32
McGowan ML, Glinka A, Highland J, Asaad G, Sharp RR. Genetics patients' perspectives on clinical genomic testing. Per Med. 2013 Jun 01;10(4):339-347. doi: 10.2217/pme.13.32. PMID: 24955098; PMCID: PMC4061708.
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Cytotoxic effects of benzene metabolites on human sperm function: an in vitro study.

ISRN toxicology

Mandani P, Desai K, Highland H.
PMID: 24416599
ISRN Toxicol. 2013 Dec 12;2013:397524. doi: 10.1155/2013/397524. eCollection 2013.

In recent years, individuals are rampantly exposed to vapours of benzene, through paint, plastic, petroleum industries, fuel exhaust, and tobacco smoke. Hence the present investigation was directed towards determining the effect of benzene metabolites, namely, phenol-hydroquinone and catechol, on...

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Mandani P, Desai K, Highland H. Cytotoxic effects of benzene metabolites on human sperm function: an in vitro study. ISRN Toxicol. 2013;2013:397524doi: 10.1155/2013/397524.
Mandani, P., Desai, K., & Highland, H. (2013). Cytotoxic effects of benzene metabolites on human sperm function: an in vitro study. ISRN toxicology, 2013397524. https://doi.org/10.1155/2013/397524
Mandani, Priyanka, et al. "Cytotoxic effects of benzene metabolites on human sperm function: an in vitro study." ISRN toxicology vol. 2013 (2013): 397524. doi: https://doi.org/10.1155/2013/397524
Mandani P, Desai K, Highland H. Cytotoxic effects of benzene metabolites on human sperm function: an in vitro study. ISRN Toxicol. 2013 Dec 12;2013:397524. doi: 10.1155/2013/397524. eCollection 2013. PMID: 24416599; PMCID: PMC3874944.
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An instrument for in situ coherent x-ray studies of metal-organic vapor phase epitaxy of III-nitrides.

The Review of scientific instruments

Ju G, Highland MJ, Yanguas-Gil A, Thompson C, Eastman JA, Zhou H, Brennan SM, Stephenson GB, Fuoss PH.
PMID: 28372371
Rev Sci Instrum. 2017 Mar;88(3):035113. doi: 10.1063/1.4978656.

We describe an instrument that exploits the ongoing revolution in synchrotron sources, optics, and detectors to enable in situ studies of metal-organic vapor phase epitaxy (MOVPE) growth of III-nitride materials using coherent x-ray methods. The system includes high-resolution positioning...

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Ju G, Highland MJ, Yanguas-Gil A, et al. An instrument for in situ coherent x-ray studies of metal-organic vapor phase epitaxy of III-nitrides. Rev Sci Instrum. 2017;88(3):035113doi: 10.1063/1.4978656.
Ju, G., Highland, M. J., Yanguas-Gil, A., Thompson, C., Eastman, J. A., Zhou, H., Brennan, S. M., Stephenson, G. B., & Fuoss, P. H. (2017). An instrument for in situ coherent x-ray studies of metal-organic vapor phase epitaxy of III-nitrides. The Review of scientific instruments, 88(3), 035113. https://doi.org/10.1063/1.4978656
Ju, Guangxu, et al. "An instrument for in situ coherent x-ray studies of metal-organic vapor phase epitaxy of III-nitrides." The Review of scientific instruments vol. 88,3 (2017): 035113. doi: https://doi.org/10.1063/1.4978656
Ju G, Highland MJ, Yanguas-Gil A, Thompson C, Eastman JA, Zhou H, Brennan SM, Stephenson GB, Fuoss PH. An instrument for in situ coherent x-ray studies of metal-organic vapor phase epitaxy of III-nitrides. Rev Sci Instrum. 2017 Mar;88(3):035113. doi: 10.1063/1.4978656. PMID: 28372371.
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Mesoscopic structural phase progression in photo-excited VO2 revealed by time-resolved x-ray diffraction microscopy.

Scientific reports

Zhu Y, Cai Z, Chen P, Zhang Q, Highland MJ, Jung IW, Walko DA, Dufresne EM, Jeong J, Samant MG, Parkin SS, Freeland JW, Evans PG, Wen H.
PMID: 26915398
Sci Rep. 2016 Feb 26;6:21999. doi: 10.1038/srep21999.

Dynamical phase separation during a solid-solid phase transition poses a challenge for understanding the fundamental processes in correlated materials. Critical information underlying a phase transition, such as localized phase competition, is difficult to reveal by measurements that are spatially...

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Zhu Y, Cai Z, Chen P, et al. Mesoscopic structural phase progression in photo-excited VO2 revealed by time-resolved x-ray diffraction microscopy. Sci Rep. 2016;6:21999doi: 10.1038/srep21999.
Zhu, Y., Cai, Z., Chen, P., Zhang, Q., Highland, M. J., Jung, I. W., Walko, D. A., Dufresne, E. M., Jeong, J., Samant, M. G., Parkin, S. S., Freeland, J. W., Evans, P. G., & Wen, H. (2016). Mesoscopic structural phase progression in photo-excited VO2 revealed by time-resolved x-ray diffraction microscopy. Scientific reports, 621999. https://doi.org/10.1038/srep21999
Zhu, Yi, et al. "Mesoscopic structural phase progression in photo-excited VO2 revealed by time-resolved x-ray diffraction microscopy." Scientific reports vol. 6 (2016): 21999. doi: https://doi.org/10.1038/srep21999
Zhu Y, Cai Z, Chen P, Zhang Q, Highland MJ, Jung IW, Walko DA, Dufresne EM, Jeong J, Samant MG, Parkin SS, Freeland JW, Evans PG, Wen H. Mesoscopic structural phase progression in photo-excited VO2 revealed by time-resolved x-ray diffraction microscopy. Sci Rep. 2016 Feb 26;6:21999. doi: 10.1038/srep21999. PMID: 26915398; PMCID: PMC4768076.
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Three-dimensional nanofabrication with elastomeric phase masks.

The journal of physical chemistry. B

Shir DJ, Jeon S, Liao H, Highland M, Cahill DG, Su MF, El-Kady IF, Christodoulou CG, Bogart GR, Hamza AV, Rogers JA.
PMID: 17941660
J Phys Chem B. 2007 Nov 15;111(45):12945-58. doi: 10.1021/jp074093j. Epub 2007 Oct 17.

This Feature Article reviews recent work on an optical technique for fabricating, in a single exposure step, three-dimensional (3D) nanostructures with diverse structural layouts. The approach, which we refer to as proximity field nanopatterning, uses conformable, elastomeric phase masks...

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Shir DJ, Jeon S, Liao H, et al. Three-dimensional nanofabrication with elastomeric phase masks. J Phys Chem B. 2007;111(45):12945-58doi: 10.1021/jp074093j.
Shir, D. J., Jeon, S., Liao, H., Highland, M., Cahill, D. G., Su, M. F., El-Kady, I. F., Christodoulou, C. G., Bogart, G. R., Hamza, A. V., & Rogers, J. A. (2007). Three-dimensional nanofabrication with elastomeric phase masks. The journal of physical chemistry. B, 111(45), 12945-58. https://doi.org/10.1021/jp074093j
Shir, Daniel J, et al. "Three-dimensional nanofabrication with elastomeric phase masks." The journal of physical chemistry. B vol. 111,45 (2007): 12945-58. doi: https://doi.org/10.1021/jp074093j
Shir DJ, Jeon S, Liao H, Highland M, Cahill DG, Su MF, El-Kady IF, Christodoulou CG, Bogart GR, Hamza AV, Rogers JA. Three-dimensional nanofabrication with elastomeric phase masks. J Phys Chem B. 2007 Nov 15;111(45):12945-58. doi: 10.1021/jp074093j. Epub 2007 Oct 17. PMID: 17941660.
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Coherent Bragg nanodiffraction at the hard X-ray Nanoprobe beamline.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

Hruszkewycz SO, Holt MV, Maser J, Murray CE, Highland MJ, Folkman CM, Fuoss PH.
PMID: 24470418
Philos Trans A Math Phys Eng Sci. 2014 Jan 27;372(2010):20130118. doi: 10.1098/rsta.2013.0118. Print 2014 Mar 06.

Bragg coherent diffraction with nanofocused hard X-ray beams provides unique opportunities for quantitative in situ studies of crystalline structure in nanoscale regions of complex materials and devices by a variety of diffraction-based techniques. In the case of coherent diffraction...

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Hruszkewycz SO, Holt MV, Maser J, et al. Coherent Bragg nanodiffraction at the hard X-ray Nanoprobe beamline. Philos Trans A Math Phys Eng Sci. 2014;372(2010):20130118doi: 10.1098/rsta.2013.0118.
Hruszkewycz, S. O., Holt, M. V., Maser, J., Murray, C. E., Highland, M. J., Folkman, C. M., & Fuoss, P. H. (2014). Coherent Bragg nanodiffraction at the hard X-ray Nanoprobe beamline. Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 372(2010), 20130118. https://doi.org/10.1098/rsta.2013.0118
Hruszkewycz, S O, et al. "Coherent Bragg nanodiffraction at the hard X-ray Nanoprobe beamline." Philosophical transactions. Series A, Mathematical, physical, and engineering sciences vol. 372,2010 (2014): 20130118. doi: https://doi.org/10.1098/rsta.2013.0118
Hruszkewycz SO, Holt MV, Maser J, Murray CE, Highland MJ, Folkman CM, Fuoss PH. Coherent Bragg nanodiffraction at the hard X-ray Nanoprobe beamline. Philos Trans A Math Phys Eng Sci. 2014 Jan 27;372(2010):20130118. doi: 10.1098/rsta.2013.0118. Print 2014 Mar 06. PMID: 24470418; PMCID: PMC3900036.
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Quantitative nanoscale imaging of lattice distortions in epitaxial semiconductor heterostructures using nanofocused X-ray Bragg projection ptychography.

Nano letters

Hruszkewycz SO, Holt MV, Murray CE, Bruley J, Holt J, Tripathi A, Shpyrko OG, McNulty I, Highland MJ, Fuoss PH.
PMID: 22998744
Nano Lett. 2012 Oct 10;12(10):5148-54. doi: 10.1021/nl303201w. Epub 2012 Sep 26.

We imaged nanoscale lattice strain in a multilayer semiconductor device prototype with a new X-ray technique, nanofocused Bragg projection ptychography. Applying this technique to the epitaxial stressor layer of a SiGe-on-SOI structure, we measured the internal lattice behavior in...

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Hruszkewycz SO, Holt MV, Murray CE, et al. Quantitative nanoscale imaging of lattice distortions in epitaxial semiconductor heterostructures using nanofocused X-ray Bragg projection ptychography. Nano Lett. 2012;12(10):5148-54doi: 10.1021/nl303201w.
Hruszkewycz, S. O., Holt, M. V., Murray, C. E., Bruley, J., Holt, J., Tripathi, A., Shpyrko, O. G., McNulty, I., Highland, M. J., & Fuoss, P. H. (2012). Quantitative nanoscale imaging of lattice distortions in epitaxial semiconductor heterostructures using nanofocused X-ray Bragg projection ptychography. Nano letters, 12(10), 5148-54. https://doi.org/10.1021/nl303201w
Hruszkewycz, S O, et al. "Quantitative nanoscale imaging of lattice distortions in epitaxial semiconductor heterostructures using nanofocused X-ray Bragg projection ptychography." Nano letters vol. 12,10 (2012): 5148-54. doi: https://doi.org/10.1021/nl303201w
Hruszkewycz SO, Holt MV, Murray CE, Bruley J, Holt J, Tripathi A, Shpyrko OG, McNulty I, Highland MJ, Fuoss PH. Quantitative nanoscale imaging of lattice distortions in epitaxial semiconductor heterostructures using nanofocused X-ray Bragg projection ptychography. Nano Lett. 2012 Oct 10;12(10):5148-54. doi: 10.1021/nl303201w. Epub 2012 Sep 26. PMID: 22998744.
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Unique determination of the form-factor ratio in radiative pion decay.

Physical review letters

Bolton RD, Cooper MD, Frank JS, Grosnick D, Hallin AL, Heusi P, Highland VL, Hoffman CM, Hogan GE, Mariam FG, McDonough J, Mischke RE, Piilonen LE, Ritter M, Sandberg VD, Williams RA, Wilson SL, Wright SC.
PMID: 10033440
Phys Rev Lett. 1986 Sep 22;57(12):1402-1405. doi: 10.1103/PhysRevLett.57.1402.

No abstract available.

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Bolton RD, Cooper MD, Frank JS, et al. Unique determination of the form-factor ratio in radiative pion decay. Phys Rev Lett. 1986;57(12):1402-1405doi: 10.1103/PhysRevLett.57.1402.
Bolton, R. D., Cooper, M. D., Frank, J. S., Grosnick, D., Hallin, A. L., Heusi, P., Highland, V. L., Hoffman, C. M., Hogan, G. E., Mariam, F. G., McDonough, J., Mischke, R. E., Piilonen, L. E., Ritter, M., Sandberg, V. D., Williams, R. A., Wilson, S. L., & Wright, S. C. (1986). Unique determination of the form-factor ratio in radiative pion decay. Physical review letters, 57(12), 1402-1405. https://doi.org/10.1103/PhysRevLett.57.1402
Bolton, et al. "Unique determination of the form-factor ratio in radiative pion decay." Physical review letters vol. 57,12 (1986): 1402-1405. doi: https://doi.org/10.1103/PhysRevLett.57.1402
Bolton RD, Cooper MD, Frank JS, Grosnick D, Hallin AL, Heusi P, Highland VL, Hoffman CM, Hogan GE, Mariam FG, McDonough J, Mischke RE, Piilonen LE, Ritter M, Sandberg VD, Williams RA, Wilson SL, Wright SC. Unique determination of the form-factor ratio in radiative pion decay. Phys Rev Lett. 1986 Sep 22;57(12):1402-1405. doi: 10.1103/PhysRevLett.57.1402. PMID: 10033440.
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New searches for the C-noninvariant decay pi 0-->3 gamma and the rare decay pi 0-->4 gamma.

Physical review. D, Particles and fields

Bolton RD, Cooper MD, Frank JS, Grosnick DP, Hallin AL, Heusi P, Highland VL, Hoffman CM, Hogan GE, Mariam FG, McDonough J, McFarlane WK, Mischke RE, Piilonen LE, Sandberg VD, Sennhauser U, Werbeck RD, Williams RA, Wilson SL, Wright SC.
PMID: 9959363
Phys Rev D Part Fields. 1988 Oct 01;38(7):2121-2128. doi: 10.1103/physrevd.38.2121.

No abstract available.

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Bolton RD, Cooper MD, Frank JS, et al. New searches for the C-noninvariant decay pi 0-->3 gamma and the rare decay pi 0-->4 gamma. Phys Rev D Part Fields. 1988;38(7):2121-2128doi: 10.1103/physrevd.38.2121.
Bolton, R. D., Cooper, M. D., Frank, J. S., Grosnick, D. P., Hallin, A. L., Heusi, P., Highland, V. L., Hoffman, C. M., Hogan, G. E., Mariam, F. G., McDonough, J., McFarlane, W. K., Mischke, R. E., Piilonen, L. E., Sandberg, V. D., Sennhauser, U., Werbeck, R. D., Williams, R. A., Wilson, S. L., & Wright, S. C. (1988). New searches for the C-noninvariant decay pi 0-->3 gamma and the rare decay pi 0-->4 gamma. Physical review. D, Particles and fields, 38(7), 2121-2128. https://doi.org/10.1103/physrevd.38.2121
Bolton, et al. "New searches for the C-noninvariant decay pi 0-->3 gamma and the rare decay pi 0-->4 gamma." Physical review. D, Particles and fields vol. 38,7 (1988): 2121-2128. doi: https://doi.org/10.1103/physrevd.38.2121
Bolton RD, Cooper MD, Frank JS, Grosnick DP, Hallin AL, Heusi P, Highland VL, Hoffman CM, Hogan GE, Mariam FG, McDonough J, McFarlane WK, Mischke RE, Piilonen LE, Sandberg VD, Sennhauser U, Werbeck RD, Williams RA, Wilson SL, Wright SC. New searches for the C-noninvariant decay pi 0-->3 gamma and the rare decay pi 0-->4 gamma. Phys Rev D Part Fields. 1988 Oct 01;38(7):2121-2128. doi: 10.1103/physrevd.38.2121. PMID: 9959363.
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Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology.

American journal of human genetics

Spracklen CN, Karaderi T, Yaghootkar H, Schurmann C, Fine RS, Kutalik Z, Preuss MH, Lu Y, Wittemans LBL, Adair LS, Allison M, Amin N, Auer PL, Bartz TM, Blüher M, Boehnke M, Borja JB, Bork-Jensen J, Broer L, Chasman DI, Chen YI, Chirstofidou P, Demirkan A, van Duijn CM, Feitosa MF, Garcia ME, Graff M, Grallert H, Grarup N, Guo X, Haesser J, Hansen T, Harris TB, Highland HM, Hong J, Ikram MA, Ingelsson E, Jackson R, Jousilahti P, Kähönen M, Kizer JR, Kovacs P, Kriebel J, Laakso M, Lange LA, Lehtimäki T, Li J, Li-Gao R, Lind L, Luan J, Lyytikäinen LP, MacGregor S, Mackey DA, Mahajan A, Mangino M, Männistö S, McCarthy MI, McKnight B, Medina-Gomez C, Meigs JB, Molnos S, Mook-Kanamori D, Morris AP, de Mutsert R, Nalls MA, Nedeljkovic I, North KE, Pennell CE, Pradhan AD, Province MA, Raitakari OT, Raulerson CK, Reiner AP, Ridker PM, Ripatti S, Roberston N, Rotter JI, Salomaa V, Sandoval-Zárate AA, Sitlani CM, Spector TD, Strauch K, Stumvoll M, Taylor KD, Thuesen B, Tönjes A, Uitterlinden AG, Venturini C, Walker M, Wang CA, Wang S, Wareham NJ, Willems SM, Willems van Dijk K, Wilson JG, Wu Y, Yao J, Young KL, Langenberg C, Frayling TM, Kilpeläinen TO, Lindgren CM, Loos RJF, Mohlke KL.
PMID: 31491410
Am J Hum Genet. 2019 Sep 05;105(3):670-671. doi: 10.1016/j.ajhg.2019.08.001.

No abstract available.

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Spracklen CN, Karaderi T, Yaghootkar H, et al. Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology. Am J Hum Genet. 2019;105(3):670-671doi: 10.1016/j.ajhg.2019.08.001.
Spracklen, C. N., Karaderi, T., Yaghootkar, H., Schurmann, C., Fine, R. S., Kutalik, Z., Preuss, M. H., Lu, Y., Wittemans, L. B. L., Adair, L. S., Allison, M., Amin, N., Auer, P. L., Bartz, T. M., Blüher, M., Boehnke, M., Borja, J. B., Bork-Jensen, J., Broer, L., Chasman, D. I., Chen, Y. I., Chirstofidou, P., Demirkan, A., van Duijn, C. M., Feitosa, M. F., Garcia, M. E., Graff, M., Grallert, H., Grarup, N., Guo, X., Haesser, J., Hansen, T., Harris, T. B., Highland, H. M., Hong, J., Ikram, M. A., Ingelsson, E., Jackson, R., Jousilahti, P., Kähönen, M., Kizer, J. R., Kovacs, P., Kriebel, J., Laakso, M., Lange, L. A., Lehtimäki, T., Li, J., Li-Gao, R., Lind, L., Luan, J., Lyytikäinen, L. P., MacGregor, S., Mackey, D. A., Mahajan, A., Mangino, M., Männistö, S., McCarthy, M. I., McKnight, B., Medina-Gomez, C., Meigs, J. B., Molnos, S., Mook-Kanamori, D., Morris, A. P., de Mutsert, R., Nalls, M. A., Nedeljkovic, I., North, K. E., Pennell, C. E., Pradhan, A. D., Province, M. A., Raitakari, O. T., Raulerson, C. K., Reiner, A. P., Ridker, P. M., Ripatti, S., Roberston, N., Rotter, J. I., Salomaa, V., Sandoval-Zárate, A. A., Sitlani, C. M., Spector, T. D., Strauch, K., Stumvoll, M., Taylor, K. D., Thuesen, B., Tönjes, A., Uitterlinden, A. G., Venturini, C., Walker, M., Wang, C. A., Wang, S., Wareham, N. J., Willems, S. M., Willems van Dijk, K., Wilson, J. G., Wu, Y., Yao, J., Young, K. L., Langenberg, C., Frayling, T. M., Kilpeläinen, T. O., Lindgren, C. M., Loos, R. J. F., & Mohlke, K. L. (2019). Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology. American journal of human genetics, 105(3), 670-671. https://doi.org/10.1016/j.ajhg.2019.08.001
Spracklen, Cassandra N, et al. "Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology." American journal of human genetics vol. 105,3 (2019): 670-671. doi: https://doi.org/10.1016/j.ajhg.2019.08.001
Spracklen CN, Karaderi T, Yaghootkar H, Schurmann C, Fine RS, Kutalik Z, Preuss MH, Lu Y, Wittemans LBL, Adair LS, Allison M, Amin N, Auer PL, Bartz TM, Blüher M, Boehnke M, Borja JB, Bork-Jensen J, Broer L, Chasman DI, Chen YI, Chirstofidou P, Demirkan A, van Duijn CM, Feitosa MF, Garcia ME, Graff M, Grallert H, Grarup N, Guo X, Haesser J, Hansen T, Harris TB, Highland HM, Hong J, Ikram MA, Ingelsson E, Jackson R, Jousilahti P, Kähönen M, Kizer JR, Kovacs P, Kriebel J, Laakso M, Lange LA, Lehtimäki T, Li J, Li-Gao R, Lind L, Luan J, Lyytikäinen LP, MacGregor S, Mackey DA, Mahajan A, Mangino M, Männistö S, McCarthy MI, McKnight B, Medina-Gomez C, Meigs JB, Molnos S, Mook-Kanamori D, Morris AP, de Mutsert R, Nalls MA, Nedeljkovic I, North KE, Pennell CE, Pradhan AD, Province MA, Raitakari OT, Raulerson CK, Reiner AP, Ridker PM, Ripatti S, Roberston N, Rotter JI, Salomaa V, Sandoval-Zárate AA, Sitlani CM, Spector TD, Strauch K, Stumvoll M, Taylor KD, Thuesen B, Tönjes A, Uitterlinden AG, Venturini C, Walker M, Wang CA, Wang S, Wareham NJ, Willems SM, Willems van Dijk K, Wilson JG, Wu Y, Yao J, Young KL, Langenberg C, Frayling TM, Kilpeläinen TO, Lindgren CM, Loos RJF, Mohlke KL. Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology. Am J Hum Genet. 2019 Sep 05;105(3):670-671. doi: 10.1016/j.ajhg.2019.08.001. PMID: 31491410; PMCID: PMC6732522.
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Pulmonary arterial hypertension treatment with carvedilol for heart failure: a randomized controlled trial.

JCI insight

Farha S, Saygin D, Park MM, Cheong HI, Asosingh K, Comhair SA, Stephens OR, Roach EC, Sharp J, Highland KB, DiFilippo FP, Neumann DR, Tang WHW, Erzurum SC.
PMID: 28814664
JCI Insight. 2017 Aug 17;2(16). doi: 10.1172/jci.insight.95240. eCollection 2017 Aug 17.

BACKGROUND: Right-sided heart failure is the leading cause of death in pulmonary arterial hypertension (PAH). Similar to left heart failure, sympathetic overactivation and β-adrenoreceptor (βAR) abnormalities are found in PAH. Based on successful therapy of left heart failure with...

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Farha S, Saygin D, Park MM, et al. Pulmonary arterial hypertension treatment with carvedilol for heart failure: a randomized controlled trial. JCI Insight. 2017;2(16)doi: 10.1172/jci.insight.95240.
Farha, S., Saygin, D., Park, M. M., Cheong, H. I., Asosingh, K., Comhair, S. A., Stephens, O. R., Roach, E. C., Sharp, J., Highland, K. B., DiFilippo, F. P., Neumann, D. R., Tang, W. H. W., & Erzurum, S. C. (2017). Pulmonary arterial hypertension treatment with carvedilol for heart failure: a randomized controlled trial. JCI insight, 2(16), . https://doi.org/10.1172/jci.insight.95240
Farha, Samar, et al. "Pulmonary arterial hypertension treatment with carvedilol for heart failure: a randomized controlled trial." JCI insight vol. 2,16 (2017). doi: https://doi.org/10.1172/jci.insight.95240
Farha S, Saygin D, Park MM, Cheong HI, Asosingh K, Comhair SA, Stephens OR, Roach EC, Sharp J, Highland KB, DiFilippo FP, Neumann DR, Tang WHW, Erzurum SC. Pulmonary arterial hypertension treatment with carvedilol for heart failure: a randomized controlled trial. JCI Insight. 2017 Aug 17;2(16). doi: 10.1172/jci.insight.95240. eCollection 2017 Aug 17. PMID: 28814664; PMCID: PMC5621927.
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The PPARγ Agonist Rosiglitazone Is Antifibrotic for Scleroderma Lung Fibroblasts: Mechanisms of Action and Differential Racial Effects.

Pulmonary medicine

Bogatkevich GS, Highland KB, Akter T, Silver RM.
PMID: 22135743
Pulm Med. 2012;2012:545172. doi: 10.1155/2012/545172. Epub 2011 Nov 01.

We present novel data demonstrating that the expression of PPARγ is reduced in lung fibroblasts from black SSc-ILD patients as compared to white patients. Activating PPARγ with the agonist rosiglitazone increased the expression of MMP-1 and inhibited collagen type...

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Bogatkevich GS, Highland KB, Akter T, et al. The PPARγ Agonist Rosiglitazone Is Antifibrotic for Scleroderma Lung Fibroblasts: Mechanisms of Action and Differential Racial Effects. Pulm Med. 2011;2012:545172doi: 10.1155/2012/545172.
Bogatkevich, G. S., Highland, K. B., Akter, T., & Silver, R. M. (2012). The PPARγ Agonist Rosiglitazone Is Antifibrotic for Scleroderma Lung Fibroblasts: Mechanisms of Action and Differential Racial Effects. Pulmonary medicine, 2012545172. https://doi.org/10.1155/2012/545172
Bogatkevich, Galina S, et al. "The PPARγ Agonist Rosiglitazone Is Antifibrotic for Scleroderma Lung Fibroblasts: Mechanisms of Action and Differential Racial Effects." Pulmonary medicine vol. 2012 (2012): 545172. doi: https://doi.org/10.1155/2012/545172
Bogatkevich GS, Highland KB, Akter T, Silver RM. The PPARγ Agonist Rosiglitazone Is Antifibrotic for Scleroderma Lung Fibroblasts: Mechanisms of Action and Differential Racial Effects. Pulm Med. 2012;2012:545172. doi: 10.1155/2012/545172. Epub 2011 Nov 01. PMID: 22135743; PMCID: PMC3206324.
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