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Showing 1 to 12 of 206 entries
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β-catenin and PI3Kδ inhibition expands precursor Th17 cells with heightened stemness and antitumor activity.

JCI insight

Majchrzak K, Nelson MH, Bowers JS, Bailey SR, Wyatt MM, Wrangle JM, Rubinstein MP, Varela JC, Li Z, Himes RA, Chan SS, Paulos CM.
PMID: 28422756
JCI Insight. 2017 Apr 20;2(8). doi: 10.1172/jci.insight.90547. eCollection 2017 Apr 20.

ICOS costimulation generates Th17 cells with durable memory responses to tumor. Herein, we found that ICOS induces PI3K/p110δ/Akt and Wnt/β-catenin pathways in Th17 cells. Coinhibiting PI3Kδ and β-catenin altered the biological fate of Th17 cells. Th17 cells inhibited of...

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Majchrzak K, Nelson MH, Bowers JS, et al. β-catenin and PI3Kδ inhibition expands precursor Th17 cells with heightened stemness and antitumor activity. JCI Insight. 2017;2(8)doi: 10.1172/jci.insight.90547.
Majchrzak, K., Nelson, M. H., Bowers, J. S., Bailey, S. R., Wyatt, M. M., Wrangle, J. M., Rubinstein, M. P., Varela, J. C., Li, Z., Himes, R. A., Chan, S. S., & Paulos, C. M. (2017). β-catenin and PI3Kδ inhibition expands precursor Th17 cells with heightened stemness and antitumor activity. JCI insight, 2(8), . https://doi.org/10.1172/jci.insight.90547
Majchrzak, Kinga, et al. "β-catenin and PI3Kδ inhibition expands precursor Th17 cells with heightened stemness and antitumor activity." JCI insight vol. 2,8 (2017). doi: https://doi.org/10.1172/jci.insight.90547
Majchrzak K, Nelson MH, Bowers JS, Bailey SR, Wyatt MM, Wrangle JM, Rubinstein MP, Varela JC, Li Z, Himes RA, Chan SS, Paulos CM. β-catenin and PI3Kδ inhibition expands precursor Th17 cells with heightened stemness and antitumor activity. JCI Insight. 2017 Apr 20;2(8). doi: 10.1172/jci.insight.90547. eCollection 2017 Apr 20. PMID: 28422756; PMCID: PMC5396523.
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CryoEM and computer simulations reveal a novel kinase conformational switch in bacterial chemotaxis signaling.

eLife

Cassidy CK, Himes BA, Alvarez FJ, Ma J, Zhao G, Perilla JR, Schulten K, Zhang P.
PMID: 26583751
Elife. 2015 Nov 19;4. doi: 10.7554/eLife.08419.

Chemotactic responses in bacteria require large, highly ordered arrays of sensory proteins to mediate the signal transduction that ultimately controls cell motility. A mechanistic understanding of the molecular events underlying signaling, however, has been hampered by the lack of...

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Cassidy CK, Himes BA, Alvarez FJ, et al. CryoEM and computer simulations reveal a novel kinase conformational switch in bacterial chemotaxis signaling. Elife. 2015;4doi: 10.7554/eLife.08419.
Cassidy, C. K., Himes, B. A., Alvarez, F. J., Ma, J., Zhao, G., Perilla, J. R., Schulten, K., & Zhang, P. (2015). CryoEM and computer simulations reveal a novel kinase conformational switch in bacterial chemotaxis signaling. eLife, 4. https://doi.org/10.7554/eLife.08419
Cassidy, C Keith, et al. "CryoEM and computer simulations reveal a novel kinase conformational switch in bacterial chemotaxis signaling." eLife vol. 4 (2015). doi: https://doi.org/10.7554/eLife.08419
Cassidy CK, Himes BA, Alvarez FJ, Ma J, Zhao G, Perilla JR, Schulten K, Zhang P. CryoEM and computer simulations reveal a novel kinase conformational switch in bacterial chemotaxis signaling. Elife. 2015 Nov 19;4. doi: 10.7554/eLife.08419. PMID: 26583751; PMCID: PMC6746300.
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Some Comments on Topological Approaches to the π-Electron Currents in Conjugated Systems.

Journal of chemical theory and computation

Dickens TK, Gomes JA, Mallion RB.
PMID: 26598261
J Chem Theory Comput. 2011 Nov 08;7(11):3661-74. doi: 10.1021/ct2002539. Epub 2011 Oct 05.

Within the past two years, three sets of independent authors (Mandado, Ciesielski et al., and Randić) have proposed methods in which π-electron currents in conjugated systems are estimated by invoking the concept of circuits of conjugation. These methods are...

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Dickens TK, Gomes JA, Mallion RB. Some Comments on Topological Approaches to the π-Electron Currents in Conjugated Systems. J Chem Theory Comput. 2011;7(11):3661-74doi: 10.1021/ct2002539.
Dickens, T. K., Gomes, J. A., & Mallion, R. B. (2011). Some Comments on Topological Approaches to the π-Electron Currents in Conjugated Systems. Journal of chemical theory and computation, 7(11), 3661-74. https://doi.org/10.1021/ct2002539
Dickens, Timothy K, et al. "Some Comments on Topological Approaches to the π-Electron Currents in Conjugated Systems." Journal of chemical theory and computation vol. 7,11 (2011): 3661-74. doi: https://doi.org/10.1021/ct2002539
Dickens TK, Gomes JA, Mallion RB. Some Comments on Topological Approaches to the π-Electron Currents in Conjugated Systems. J Chem Theory Comput. 2011 Nov 08;7(11):3661-74. doi: 10.1021/ct2002539. Epub 2011 Oct 05. PMID: 26598261.
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Measurement errors for a portable device measuring short-term growth.

American journal of human biology : the official journal of the Human Biology Council

Himes JH, Carson C, Pheley A.
PMID: 28520299
Am J Hum Biol. 1991;3(4):325-329. doi: 10.1002/ajhb.1310030403.

A field trial was conducted for a portable Knee Height Measuring Device (KHMD). Measurement errors for the machine, within and between observers (intraobserver and interobserver) and within subjects (intrasubject), were calculated from repeated observations of two anthropometrists on 40...

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Himes JH, Carson C, Pheley A. Measurement errors for a portable device measuring short-term growth. Am J Hum Biol. 1991;3(4):325-329doi: 10.1002/ajhb.1310030403.
Himes, J. H., Carson, C., & Pheley, A. (1991). Measurement errors for a portable device measuring short-term growth. American journal of human biology : the official journal of the Human Biology Council, 3(4), 325-329. https://doi.org/10.1002/ajhb.1310030403
Himes, John H, et al. "Measurement errors for a portable device measuring short-term growth." American journal of human biology : the official journal of the Human Biology Council vol. 3,4 (1991): 325-329. doi: https://doi.org/10.1002/ajhb.1310030403
Himes JH, Carson C, Pheley A. Measurement errors for a portable device measuring short-term growth. Am J Hum Biol. 1991;3(4):325-329. doi: 10.1002/ajhb.1310030403. PMID: 28520299.
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The Interactive Effects of the Capability for Suicide and Major Depressive Episodes on Suicidal Behavior in a Military Sample.

Cognitive therapy and research

Chu C, Podlogar M, Hagan CR, Buchman-Schmitt JM, Silva C, Chiurliza B, Hames JL, Stanley IH, Lim LI, Joiner TE.
PMID: 26834299
Cognit Ther Res. 2016 Feb;40(1):22-30. doi: 10.1007/s10608-015-9727-z. Epub 2015 Sep 29.

Major depressive symptoms represent a significant risk for suicidal ideation and behavior. Given that suicide is fearsome, the interpersonal theory of suicide proposes that individuals who engage in suicidal behavior possess not only the desire to die, but also...

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Chu C, Podlogar M, Hagan CR, et al. The Interactive Effects of the Capability for Suicide and Major Depressive Episodes on Suicidal Behavior in a Military Sample. Cognit Ther Res. 2015;40(1):22-30doi: 10.1007/s10608-015-9727-z.
Chu, C., Podlogar, M., Hagan, C. R., Buchman-Schmitt, J. M., Silva, C., Chiurliza, B., Hames, J. L., Stanley, I. H., Lim, L. I., & Joiner, T. E. (2016). The Interactive Effects of the Capability for Suicide and Major Depressive Episodes on Suicidal Behavior in a Military Sample. Cognitive therapy and research, 40(1), 22-30. https://doi.org/10.1007/s10608-015-9727-z
Chu, Carol, et al. "The Interactive Effects of the Capability for Suicide and Major Depressive Episodes on Suicidal Behavior in a Military Sample." Cognitive therapy and research vol. 40,1 (2016): 22-30. doi: https://doi.org/10.1007/s10608-015-9727-z
Chu C, Podlogar M, Hagan CR, Buchman-Schmitt JM, Silva C, Chiurliza B, Hames JL, Stanley IH, Lim LI, Joiner TE. The Interactive Effects of the Capability for Suicide and Major Depressive Episodes on Suicidal Behavior in a Military Sample. Cognit Ther Res. 2016 Feb;40(1):22-30. doi: 10.1007/s10608-015-9727-z. Epub 2015 Sep 29. PMID: 26834299; PMCID: PMC4731046.
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Age-related decreased inhibitory vs. excitatory gene expression in the adult autistic brain.

Frontiers in neuroscience

van de Lagemaat LN, Nijhof B, Bosch DG, Kohansal-Nodehi M, Keerthikumar S, Heimel JA.
PMID: 25538548
Front Neurosci. 2014 Dec 08;8:394. doi: 10.3389/fnins.2014.00394. eCollection 2014.

Autism spectrum disorders (ASDs) are neurodevelopmental disorders characterized by impaired social interaction and communication, and restricted behavior and interests. A disruption in the balance of excitatory and inhibitory neurotransmission has been hypothesized to underlie these disorders. Here we demonstrate...

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van de Lagemaat LN, Nijhof B, Bosch DG, et al. Age-related decreased inhibitory vs. excitatory gene expression in the adult autistic brain. Front Neurosci. 2014;8:394doi: 10.3389/fnins.2014.00394.
van de Lagemaat, L. N., Nijhof, B., Bosch, D. G., Kohansal-Nodehi, M., Keerthikumar, S., & Heimel, J. A. (2014). Age-related decreased inhibitory vs. excitatory gene expression in the adult autistic brain. Frontiers in neuroscience, 8394. https://doi.org/10.3389/fnins.2014.00394
van de Lagemaat, Louie N, et al. "Age-related decreased inhibitory vs. excitatory gene expression in the adult autistic brain." Frontiers in neuroscience vol. 8 (2014): 394. doi: https://doi.org/10.3389/fnins.2014.00394
van de Lagemaat LN, Nijhof B, Bosch DG, Kohansal-Nodehi M, Keerthikumar S, Heimel JA. Age-related decreased inhibitory vs. excitatory gene expression in the adult autistic brain. Front Neurosci. 2014 Dec 08;8:394. doi: 10.3389/fnins.2014.00394. eCollection 2014. PMID: 25538548; PMCID: PMC4259106.
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Improved survival in lupus nephritis in the modern era (1979 - 1989).

African journal of health sciences

Mc'Ligeyo SO, Cameron SJ, Williams GD, Ogg C, Hartley RB, Chantler C, Haycock GB, Sacks S, Rigden R, Hicks JA.
PMID: 12160446
Afr J Health Sci. 1995 Feb;2(1):211-219.

We analysed outcome retrospectively in relation to treatment and disease stage in patients with systemic lupus erythematosus and glomerulonephritis, and compared these with similar patients referred to us during 1969 - 78, and other published series from the same...

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Mc'Ligeyo SO, Cameron SJ, Williams GD, et al. Improved survival in lupus nephritis in the modern era (1979 - 1989). Afr J Health Sci. 1995;2(1):211-219
Mc'Ligeyo, S. O., Cameron, S. J., Williams, G. D., Ogg, C., Hartley, R. B., Chantler, C., Haycock, G. B., Sacks, S., Rigden, R., & Hicks, J. A. (1995). Improved survival in lupus nephritis in the modern era (1979 - 1989). African journal of health sciences, 2(1), 211-219.
Mc'Ligeyo, Seth O., et al. "Improved survival in lupus nephritis in the modern era (1979 - 1989)." African journal of health sciences vol. 2,1 (1995): 211-219.
Mc'Ligeyo SO, Cameron SJ, Williams GD, Ogg C, Hartley RB, Chantler C, Haycock GB, Sacks S, Rigden R, Hicks JA. Improved survival in lupus nephritis in the modern era (1979 - 1989). Afr J Health Sci. 1995 Feb;2(1):211-219. PMID: 12160446.
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Novel, stereoselective tricyclization of a dienyne by titanium aryloxide centers.

Chemical communications (Cambridge, England)

Himes RA, Fanwick PE, Rothwell IP.
PMID: 12610944
Chem Commun (Camb). 2003 Jan 07;(1):18-9. doi: 10.1039/b209889j.

Titanium centers supported by aryloxide ligation mediate the tricyclization of a dienyne via intramolecular insertion of an olefin into the titanium-vinyl bond of a titanacyclopent-2-ene.

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Himes RA, Fanwick PE, Rothwell IP. Novel, stereoselective tricyclization of a dienyne by titanium aryloxide centers. Chem Commun (Camb). 2003;(1):18-9doi: 10.1039/b209889j.
Himes, R. A., Fanwick, P. E., & Rothwell, I. P. (2003). Novel, stereoselective tricyclization of a dienyne by titanium aryloxide centers. Chemical communications (Cambridge, England), (1), 18-9. https://doi.org/10.1039/b209889j
Himes, Richard A, et al. "Novel, stereoselective tricyclization of a dienyne by titanium aryloxide centers." Chemical communications (Cambridge, England) vol. ,1 (2003): 18-9. doi: https://doi.org/10.1039/b209889j
Himes RA, Fanwick PE, Rothwell IP. Novel, stereoselective tricyclization of a dienyne by titanium aryloxide centers. Chem Commun (Camb). 2003 Jan 07;(1):18-9. doi: 10.1039/b209889j. PMID: 12610944.
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Maturation-related deviations and misclassification of stature and weight in adolescence.

American journal of human biology : the official journal of the Human Biology Council

Himes JH.
PMID: 11533969
Am J Hum Biol. 1999;11(4):499-504. doi: 10.1002/(SICI)1520-6300(1999)11:4<499::AID-AJHB9>3.0.CO;2-M.

The present research quantifies normal deviations in stature and weight associated with variation in maturational status and describes the associated misclassification that occurs when using reference data based on chronological age. Misclassification is the likelihood that incorrect judgments will...

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Himes JH. Maturation-related deviations and misclassification of stature and weight in adolescence. Am J Hum Biol. 1999;11(4):499-504doi: 10.1002/(SICI)1520-6300(1999)11:4<499::AID-AJHB9>3.0.CO;2-M.
Himes, J. H. (1999). Maturation-related deviations and misclassification of stature and weight in adolescence. American journal of human biology : the official journal of the Human Biology Council, 11(4), 499-504. https://doi.org/10.1002/(SICI)1520-6300(1999)11:4<499::AID-AJHB9>3.0.CO;2-M
Himes, John H.. "Maturation-related deviations and misclassification of stature and weight in adolescence." American journal of human biology : the official journal of the Human Biology Council vol. 11,4 (1999): 499-504. doi: https://doi.org/10.1002/(SICI)1520-6300(1999)11:4<499::AID-AJHB9>3.0.CO;2-M
Himes JH. Maturation-related deviations and misclassification of stature and weight in adolescence. Am J Hum Biol. 1999;11(4):499-504. doi: 10.1002/(SICI)1520-6300(1999)11:4<499::AID-AJHB9>3.0.CO;2-M. PMID: 11533969.
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The mediating role of cutaneous sensitivity within neonatal psychoneuroimmunology.

Neuro endocrinology letters

Hayes JA, Adamson-Macedo EN, Perera S.
PMID: 11455348
Neuro Endocrinol Lett. 2000;21(3):187-193.

Preliminary results of this study have been presented at the ICIS Conferences held in Atlanta, 1998; a Summary of results has been quoted in Adamson-Macedo (1997; 1998). OBJECTIVES: Despite knowledge that preterm infants in intensive care are in distress...

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Hayes JA, Adamson-Macedo EN, Perera S. The mediating role of cutaneous sensitivity within neonatal psychoneuroimmunology. Neuro Endocrinol Lett. 2000;21(3):187-193
Hayes, J. A., Adamson-Macedo, E. N., & Perera, S. (2000). The mediating role of cutaneous sensitivity within neonatal psychoneuroimmunology. Neuro endocrinology letters, 21(3), 187-193.
Hayes, J.A., et al. "The mediating role of cutaneous sensitivity within neonatal psychoneuroimmunology." Neuro endocrinology letters vol. 21,3 (2000): 187-193.
Hayes JA, Adamson-Macedo EN, Perera S. The mediating role of cutaneous sensitivity within neonatal psychoneuroimmunology. Neuro Endocrinol Lett. 2000;21(3):187-193. PMID: 11455348.
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Attention in multiple sclerosis: correlates of impairment on the WAIS-R Digit Span Test.

Applied neuropsychology

Beatty WW, Paul RH, Blanco CR, Hames KA, Wilbanks SL.
PMID: 16318517
Appl Neuropsychol. 1995 Aug-Nov;2(3):139-44. doi: 10.1080/09084282.1995.9645351.

To re-examine the status of attention in multiple sclerosis (MS) 109 patients with clinically definite MS were administered the WAIS-R Digit Span (DS) and a battery of other neuropsychological (NP) tests of problem solving, abstraction, short-term memory (STM), long-term...

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Beatty WW, Paul RH, Blanco CR, et al. Attention in multiple sclerosis: correlates of impairment on the WAIS-R Digit Span Test. Appl Neuropsychol. 1995;2(3):139-44doi: 10.1080/09084282.1995.9645351.
Beatty, W. W., Paul, R. H., Blanco, C. R., Hames, K. A., & Wilbanks, S. L. (1995). Attention in multiple sclerosis: correlates of impairment on the WAIS-R Digit Span Test. Applied neuropsychology, 2(3), 139-44. https://doi.org/10.1080/09084282.1995.9645351
Beatty, W W, et al. "Attention in multiple sclerosis: correlates of impairment on the WAIS-R Digit Span Test." Applied neuropsychology vol. 2,3 (1995): 139-44. doi: https://doi.org/10.1080/09084282.1995.9645351
Beatty WW, Paul RH, Blanco CR, Hames KA, Wilbanks SL. Attention in multiple sclerosis: correlates of impairment on the WAIS-R Digit Span Test. Appl Neuropsychol. 1995 Aug-Nov;2(3):139-44. doi: 10.1080/09084282.1995.9645351. PMID: 16318517.
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QM/QM study of the coverage effects on the adsorption of amino-cyclopentene at the Si(100) surface.

Journal of computational chemistry

Santos HR, Ujaque G, Ramos MJ, Gomes JA.
PMID: 16983672
J Comput Chem. 2006 Nov 30;27(15):1892-7. doi: 10.1002/jcc.20513.

In this work, we have tested 30 different adsorption situations in several coverage scenarios for the 1-amino-3-cyclopentene (ACP) molecule on the Si(100) surface. We have used a five-spot testing zone inserted in the high-level part of a quantum-mechanical/quantum-mechanical study...

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Santos HR, Ujaque G, Ramos MJ, et al. QM/QM study of the coverage effects on the adsorption of amino-cyclopentene at the Si(100) surface. J Comput Chem. 2006;27(15):1892-7doi: 10.1002/jcc.20513.
Santos, H. R., Ujaque, G., Ramos, M. J., & Gomes, J. A. (2006). QM/QM study of the coverage effects on the adsorption of amino-cyclopentene at the Si(100) surface. Journal of computational chemistry, 27(15), 1892-7. https://doi.org/10.1002/jcc.20513
Santos, Hugo R R, et al. "QM/QM study of the coverage effects on the adsorption of amino-cyclopentene at the Si(100) surface." Journal of computational chemistry vol. 27,15 (2006): 1892-7. doi: https://doi.org/10.1002/jcc.20513
Santos HR, Ujaque G, Ramos MJ, Gomes JA. QM/QM study of the coverage effects on the adsorption of amino-cyclopentene at the Si(100) surface. J Comput Chem. 2006 Nov 30;27(15):1892-7. doi: 10.1002/jcc.20513. PMID: 16983672.
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Showing 1 to 12 of 206 entries