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Showing 1 to 12 of 130 entries
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Organ assessment and repair centers: The future of transplantation is near.

World journal of transplantation

Whitson BA, Black SM.
PMID: 25032094
World J Transplant. 2014 Jun 24;4(2):40-2. doi: 10.5500/wjt.v4.i2.40.

Solid organ transplantation is limited by suitable donor organ availability and the geographic limitations that lead to prolonged ischemic times. Ex vivo organ perfusion is an evolving technology that enables assessment of organ function prior to transplantation. As a...

Preservation solutions used during abdominal transplantation: Current status and outcomes.

World journal of transplantation

Latchana N, Peck JR, Whitson BA, Henry ML, Elkhammas EA, Black SM.
PMID: 26722644
World J Transplant. 2015 Dec 24;5(4):154-64. doi: 10.5500/wjt.v5.i4.154.

Organ preservation remains an important contributing factor to graft and patient outcomes. During donor organ procurement and transportation, cellular injury is mitigated through the use of preservation solutions in conjunction with hypothermia. Various preservation solutions and protocols exist with...

Impact of transjugular intrahepatic porto-systemic shunt on post liver transplantation outcomes: Study based on the United Network for Organ Sharing database.

World journal of hepatology

Mumtaz K, Metwally S, Modi RM, Patel N, Tumin D, Michaels AJ, Hanje J, El-Hinnawi A, Hayes D, Black SM.
PMID: 28144391
World J Hepatol. 2017 Jan 18;9(2):99-105. doi: 10.4254/wjh.v9.i2.99.

AIM: To determine the impact of transjugular intrahepatic porto-systemic shunt (TIPS) on post liver transplantation (LT) outcomes.METHODS: Utilizing the United Network for Organ Sharing (UNOS) database, we compared patients who underwent LT from 2002 to 2013 who had underwent...

Nitroalkenes confer acute cardioprotection via adenine nucleotide translocase 1.

The Journal of biological chemistry

Nadtochiy SM, Zhu QM, Urciuoli W, Rafikov R, Black SM, Brookes PS.
PMID: 26684340
J Biol Chem. 2015 Dec 18;290(51):30267. doi: 10.1074/jbc.A111.298406.

No abstract available.

CARNITINE HOMEOSTASIS, MITOCHONDRIAL FUNCTION, AND CARDIOVASCULAR DISEASE.

Drug discovery today. Disease mechanisms

Sharma S, Black SM.
PMID: 20648231
Drug Discov Today Dis Mech. 2009;6(1):e31-e39. doi: 10.1016/j.ddmec.2009.02.001.

Carnitines are involved in mitochondrial transport of fatty acids and are of critical importance for maintaining normal mitochondrial function. This review summarizes recent experimental and clinical studies showing that mitochondrial dysfunction secondary to a disruption of carnitine homeostasis may...

Glutathione supplementation attenuates lipopolysaccharide-induced mitochondrial dysfunction and apoptosis in a mouse model of acute lung injury.

Frontiers in physiology

Aggarwal S, Dimitropoulou C, Lu Q, Black SM, Sharma S.
PMID: 22654772
Front Physiol. 2012 May 28;3:161. doi: 10.3389/fphys.2012.00161. eCollection 2012.

Acute lung injury (ALI) is a life threatening condition associated with hypoxemia, diffuse alveolar damage, inflammation, and loss of lung function. Lipopolysaccharide (LPS; endotoxin) from the outer membrane of Gram-negative bacteria is a major virulence factor involved in the...

Data on chow, liver tissue and mitochondrial fatty acid compositions as well as mitochondrial proteome changes after feeding mice a western diet for 6-24 weeks.

Data in brief

Einer C, Hohenester S, Wimmer R, Wottke L, Artmann R, Schulz S, Gosmann C, Simmons A, Leitzinger C, Eberhagen C, Borchard S, Schmitt S, Hauck SM, von Toerne C, Jastroch M, Walheim E, Rust C, Gerbes AL, Popper B, Mayr D, Schnurr M, Vollmar AM, Denk G, Zischka H.
PMID: 29034285
Data Brief. 2017 Sep 18;15:163-169. doi: 10.1016/j.dib.2017.09.019. eCollection 2017 Dec.

The data presented in this article describe the fatty acid composition of chow, liver tissue and isolated liver mitochondria from mice fed for 6-24 weeks with a high caloric western diet (WD) in comparison to control diet (normal diet,...

Endotoxin- and mechanical stress-induced epigenetic changes in the regulation of the nicotinamide phosphoribosyltransferase promoter.

Pulmonary circulation

Elangovan VR, Camp SM, Kelly GT, Desai AA, Adyshev D, Sun X, Black SM, Wang T, Garcia JG.
PMID: 28090296
Pulm Circ. 2016 Dec;6(4):539-544. doi: 10.1086/688761.

Mechanical ventilation, a lifesaving intervention for patients with acute respiratory distress syndrome (ARDS), also unfortunately contributes to excessive mechanical stress and impaired lung physiological and structural integrity. We have elsewhere established the pivotal role of increased nicotinamide phosphoribosyltransferase (NAMPT)...

Long-term consequences of in utero irradiated mice indicate proteomic changes in synaptic plasticity related signalling.

Proteome science

Kempf SJ, von Toerne C, Hauck SM, Atkinson MJ, Benotmane MA, Tapio S.
PMID: 26578848
Proteome Sci. 2015 Nov 16;13:26. doi: 10.1186/s12953-015-0083-4. eCollection 2015.

BACKGROUND: The harmful consequences of in utero irradiation on learning and memory have been recognised but the molecular mechanisms behind the damage are still unknown.RESULTS: Using a mass spectrometry-based approach, we investigated the long-term changes in the global cortical...

Case reports in infectious diseases

Akateh C, Arnold CA, Benissan-Messan D, Michaels A, Black SM.
PMID: 30057834
Case Rep Infect Dis. 2018 Jul 02;2018:3170238. doi: 10.1155/2018/3170238. eCollection 2018.

CASE: In this case, we report on an incidental finding of CONCLUSION: Despite advances in transplant protocols and screening, disease transmission from the donor to recipient still occurs in about 0.2% of all organ transplants. With the increased use...

Pulmonary Endothelial Mechanical Sensing and Signaling, a Story of Focal Adhesions and Integrins in Ventilator Induced Lung Injury.

Frontiers in physiology

Kelly GT, Faraj R, Zhang Y, Maltepe E, Fineman JR, Black SM, Wang T.
PMID: 31105595
Front Physiol. 2019 Apr 26;10:511. doi: 10.3389/fphys.2019.00511. eCollection 2019.

Patients with critical illness such as acute lung injury often undergo mechanical ventilation in the intensive care unit. Though lifesaving in many instances, mechanical ventilation often results in ventilator induced lung injury (VILI), characterized by overdistension of lung tissue...

A novel moniliformin derivative as pan-inhibitor of histone deacetylases triggering apoptosis of leukemia cells.

Biochemical pharmacology

Lu X, Yan G, Dawood M, Klauck SM, Sugimoto Y, Klinger A, Fleischer E, Shan L, Efferth T.
PMID: 34265280
Biochem Pharmacol. 2021 Dec;194:114677. doi: 10.1016/j.bcp.2021.114677. Epub 2021 Jul 13.

New and potent agents that evade multidrug resistance (MDR) and inhibit epigenetic modifications are of great interest in cancer drug development. Here, we describe that a moniliformin derivative (IUPAC name: 3-(naphthalen-2-ylsulfanyl)-4-{[(2Z)-1,3,3-trimethyl-2,3-dihydro-1H-indol-2-ylidene]methyl}cyclobut-3-ene-1,2-dione; code: MCC1381) bypasses P-gp-mediated MDR. Using transcriptomics, we...

Showing 1 to 12 of 130 entries