UI Index

HNSCC cells resistant to EGFR pathway inhibitors are hypermutated and sensitive to DNA damaging substances.

American journal of cancer research

Schulz D, Wirth M, Piontek G, Buchberger AM, Schlegel J, Reiter R, Multhoff G, Pickhard A.
PMID: 27725902
Am J Cancer Res. 2016 Sep 01;6(9):1963-1975. eCollection 2016.

Despite remarkable successes with targeted therapies in the treatment of cancer, resistance can occur which limits the clinical outcome. In this study, we generated and characterized resistant cell clones derived from two different head and neck squamous cell carcinoma...

Segmented lateral dyke growth in a rifting event at Bárðarbunga volcanic system, Iceland.

Nature

Sigmundsson F, Hooper A, Hreinsdóttir S, Vogfjörd KS, Ófeigsson BG, Heimisson ER, Dumont S, Parks M, Spaans K, Gudmundsson GB, Drouin V, Árnadóttir T, Jónsdóttir K, Gudmundsson MT, Högnadóttir T, Fridriksdóttir HM, Hensch M, Einarsson P, Magnússon E, Samsonov S, Brandsdóttir B, White RS, Ágústsdóttir T, Greenfield T, Green RG, Hjartardóttir ÁR, Pedersen R, Bennett RA, Geirsson H, La Femina PC, Björnsson H, Pálsson F, Sturkell E, Bean CJ, Möllhoff M, Braiden AK, Eibl EP.
PMID: 25517098
Nature. 2015 Jan 08;517(7533):191-5. doi: 10.1038/nature14111. Epub 2014 Dec 15.

Crust at many divergent plate boundaries forms primarily by the injection of vertical sheet-like dykes, some tens of kilometres long. Previous models of rifting events indicate either lateral dyke growth away from a feeding source, with propagation rates decreasing...

Regional anaesthesia in patients at coronary risk for noncardiac and cardiac surgery.

Current opinion in anaesthesiology

Möllhoff T, Theilmeier G, Van Aken H.
PMID: 17016379
Curr Opin Anaesthesiol. 2001 Feb;14(1):17-25. doi: 10.1097/00001503-200102000-00004.

This review presents a brief overview about the role of regional anaesthesia in patients at risk for myocardial ischemia and/or infarction after cardiac and noncardiac surgical procedures. It includes pathophysiological insights in the problems of plaque rupture and the...

Influence of tumors on protective anti-tumor immunity and the effects of irradiation.

Frontiers in oncology

Foulds GA, Radons J, Kreuzer M, Multhoff G, Pockley AG.
PMID: 23378947
Front Oncol. 2013 Feb 01;3:14. doi: 10.3389/fonc.2013.00014. eCollection 2013.

Innate and adaptive immunity plays important roles in the development and progression of cancer and it is becoming apparent that tumors can influence the induction of potentially protective responses in a number of ways. The prevalence of immunoregulatory T...

Radiation, inflammation, and immune responses in cancer.

Frontiers in oncology

Multhoff G, Radons J.
PMID: 22675673
Front Oncol. 2012 Jun 04;2:58. doi: 10.3389/fonc.2012.00058. eCollection 2012.

Chronic inflammation has emerged as one of the hallmarks of cancer. Inflammation also plays a pivotal role in modulating radiation responsiveness of tumors. As discussed in this review, ionizing radiation (IR) leads to activation of several transcription factors modulating...

Heat Shock Protein 70 (Hsp70) Peptide Activated Natural Killer (NK) Cells for the Treatment of Patients with Non-Small Cell Lung Cancer (NSCLC) after Radiochemotherapy (RCTx) - From Preclinical Studies to a Clinical Phase II Trial.

Frontiers in immunology

Specht HM, Ahrens N, Blankenstein C, Duell T, Fietkau R, Gaipl US, Günther C, Gunther S, Habl G, Hautmann H, Hautmann M, Huber RM, Molls M, Offner R, Rödel C, Rödel F, Schütz M, Combs SE, Multhoff G.
PMID: 25926832
Front Immunol. 2015 Apr 15;6:162. doi: 10.3389/fimmu.2015.00162. eCollection 2015.

Heat shock protein 70 (Hsp70) is frequently overexpressed in tumor cells. An unusual cell surface localization could be demonstrated on a large variety of solid tumors including lung, colorectal, breast, squamous cell carcinomas of the head and neck, prostate...

Novel Approaches to Improve the Efficacy of Immuno-Radiotherapy.

Frontiers in oncology

Shevtsov M, Sato H, Multhoff G, Shibata A.
PMID: 30941308
Front Oncol. 2019 Mar 19;9:156. doi: 10.3389/fonc.2019.00156. eCollection 2019.

Radiotherapy (RT) has been applied for decades as a treatment modality in the management of various types of cancer. Ionizing radiation induces tumor cell death, which in turn can either elicit protective anti-tumor immune responses or immunosuppression in the...

Radiation-induced changes in microcirculation and interstitial fluid pressure affecting the delivery of macromolecules and nanotherapeutics to tumors.

Frontiers in oncology

Multhoff G, Vaupel P.
PMID: 23162794
Front Oncol. 2012 Nov 15;2:165. doi: 10.3389/fonc.2012.00165. eCollection 2012.

The immature, chaotic microvasculature of most solid tumors can present a significant impediment to blood-borne delivery, uneven distribution, and compromised penetration of macromolecular anticancer drugs and diagnostic agents from tumor microvessels across the interstitial space to cancer cells. To...

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death.

Frontiers in immunology

Garg AD, Galluzzi L, Apetoh L, Baert T, Birge RB, Bravo-San Pedro JM, Breckpot K, Brough D, Chaurio R, Cirone M, Coosemans A, Coulie PG, De Ruysscher D, Dini L, de Witte P, Dudek-Peric AM, Faggioni A, Fucikova J, Gaipl US, Golab J, Gougeon ML, Hamblin MR, Hemminki A, Herrmann M, Hodge JW, Kepp O, Kroemer G, Krysko DV, Land WG, Madeo F, Manfredi AA, Mattarollo SR, Maueroder C, Merendino N, Multhoff G, Pabst T, Ricci JE, Riganti C, Romano E, Rufo N, Smyth MJ, Sonnemann J, Spisek R, Stagg J, Vacchelli E, Vandenabeele P, Vandenberk L, Van den Eynde BJ, Van Gool S, Velotti F, Zitvogel L, Agostinis P.
PMID: 26635802
Front Immunol. 2015 Nov 20;6:588. doi: 10.3389/fimmu.2015.00588. eCollection 2015.

The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, including dendritic cell-based vaccines, checkpoint-blocking therapies, and adoptive T-cell transfer, researchers have started to focus...

Accomplices of the Hypoxic Tumor Microenvironment Compromising Antitumor Immunity: Adenosine, Lactate, Acidosis, Vascular Endothelial Growth Factor, Potassium Ions, and Phosphatidylserine.

Frontiers in immunology

Vaupel P, Multhoff G.
PMID: 29312351
Front Immunol. 2017 Dec 21;8:1887. doi: 10.3389/fimmu.2017.01887. eCollection 2017.

In this minireview, we aim to highlight key factors of the tumor microenvironment, including adenosine, lactate, acidosis, vascular endothelial growth factor, phosphatidylserine, high extracellular K

Hsp70 in Liquid Biopsies-A Tumor-Specific Biomarker for Detection and Response Monitoring in Cancer.

Cancers

Werner C, Stangl S, Salvermoser L, Schwab M, Shevtsov M, Xanthopoulos A, Wang F, Dezfouli AB, Thölke D, Ostheimer C, Medenwald D, Windberg M, Bache M, Schlapschy M, Skerra A, Multhoff G.
PMID: 34359606
Cancers (Basel). 2021 Jul 23;13(15). doi: 10.3390/cancers13153706.

In contrast to normal cells, tumor cells of multiple entities overexpress the Heat shock protein 70 (Hsp70) not only in the cytosol, but also present it on their plasma membrane in a tumor-specific manner. Furthermore, membrane Hsp70-positive tumor cells...

Caldera resurgence during the 2018 eruption of Sierra Negra volcano, Galápagos Islands.

Nature communications

Bell AF, La Femina PC, Ruiz M, Amelung F, Bagnardi M, Bean CJ, Bernard B, Ebinger C, Gleeson M, Grannell J, Hernandez S, Higgins M, Liorzou C, Lundgren P, Meier NJ, Möllhoff M, Oliva SJ, Ruiz AG, Stock MJ.
PMID: 33654084
Nat Commun. 2021 Mar 02;12(1):1397. doi: 10.1038/s41467-021-21596-4.

Recent large basaltic eruptions began after only minor surface uplift and seismicity, and resulted in caldera subsidence. In contrast, some eruptions at Galápagos Island volcanoes are preceded by prolonged, large amplitude uplift and elevated seismicity. These systems also display...