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Showing 1 to 12 of 18 entries
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Molecular Application of Aptamers in the Diagnosis and Treatment of Cancer and Communicable Diseases.

Pharmaceuticals (Basel, Switzerland)

Molefe PF, Masamba P, Oyinloye BE, Mbatha LS, Meyer M, Kappo AP.
PMID: 30274155
Pharmaceuticals (Basel). 2018 Sep 28;11(4). doi: 10.3390/ph11040093.

Cancer and infectious diseases such as Ebola, HIV, tuberculosis, Zika, hepatitis, measles and human schistosomiasis are serious global health hazards. The increasing annual morbidities and mortalities of these diseases have been blamed on drug resistance and the inefficacy of...

Microscale thermophoresis analysis of the molecular interaction between small nuclear ribonucleoprotein polypeptide G and the RING finger domain of RBBP6 towards anti-cancer drug discovery.

American journal of translational research

Mabonga L, Masamba P, Basson AK, Kappo AP.
PMID: 34956492
Am J Transl Res. 2021 Nov 15;13(11):12775-12785. eCollection 2021.

Regulatory core-splicing proteins are now becoming highly promising therapeutic targets for the development of anti-cancer drugs. SNRPG and RBBP6 are two good examples of regulatory core-splicing proteins involved in tumorigenesis and tumor development whose multi-functional role is primarily mediated...

Current Biochemical Applications and Future Prospects of Chlorotoxin in Cancer Diagnostics and Therapeutics.

Advanced pharmaceutical bulletin

Khanyile S, Masamba P, Oyinloye BE, Mbatha LS, Kappo AP.
PMID: 31857956
Adv Pharm Bull. 2019 Oct;9(4):510-520. doi: 10.15171/apb.2019.061. Epub 2019 Oct 24.

Chlorotoxin (CTX) is a minute 4 kDa protein made up of 36 amino acid residues, commonly known for its binding affinity to chloride channels and matrix metalloproteinase-2 (MMP-2) of glioma tumors of the spine and brain. This property and...

Use of Fundus Autofluorescence Combined with Optical Coherence Tomography for Diagnose of Geographic Atrophy in Age-Related Macular Degeneration.

Medical hypothesis, discovery & innovation ophthalmology journal

Massamba N, Sellam A, Butel N, Skondra D, Caillaux V, Bodaghi B.
PMID: 31788492
Med Hypothesis Discov Innov Ophthalmol. 2019;8(4):298-305. Epub 2019 Oct 01.

The aim of this study was to demonstrate the sensitivity of Optical coherence tomography (OCT) in detection of geographic atrophy (GA) secondary to exudative age related macular degeneration (AMD). In this retrospective case series study 77 patients (53% female,...

Structural Analysis and Epitope Prediction of MHC Class-1-Chain Related Protein-A for Cancer Vaccine Development.

Vaccines

Adekiya TA, Aruleba RT, Khanyile S, Masamba P, Oyinloye BE, Kappo AP.
PMID: 29295563
Vaccines (Basel). 2017 Dec 25;6(1). doi: 10.3390/vaccines6010001.

Major histocompatibility complex class 1 chain-related gene sequence A is a polymorphic gene found at about 46.6 kb centromeric to HLA-B. It encodes a transmembrane protein, which is a non-classical human leukocyte antigen whose expression is normally induced by...

Roles of Heat Shock Proteins in Apoptosis, Oxidative Stress, Human Inflammatory Diseases, and Cancer.

Pharmaceuticals (Basel, Switzerland)

Ikwegbue PC, Masamba P, Oyinloye BE, Kappo AP.
PMID: 29295496
Pharmaceuticals (Basel). 2017 Dec 23;11(1). doi: 10.3390/ph11010002.

Heat shock proteins (HSPs) play cytoprotective activities under pathological conditions through the initiation of protein folding, repair, refolding of misfolded peptides, and possible degradation of irreparable proteins. Excessive apoptosis, resulting from increased reactive oxygen species (ROS) cellular levels and...

Closing the Gap: An Atomistic Structural and Functional Perspective of S. mansoni Universal Stress G4LZI3 Protein in Complex with Phenolic Compounds.

Current drug discovery technologies

Masamba P, Munsamy G, Kappo AP.
PMID: 33001015
Curr Drug Discov Technol. 2021;18(5):e01102020186453. doi: 10.2174/1570163817666201001122436.

BACKGROUND: For decades, Praziquantel has been the undisputed drug of choice for all schistosome infections, but rising concerns due to the unelucidated mechanism of action of the drug and unavoidable reports of emerging drug resistant strains has necessitated the...

Evaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiography.

Scientific reports

Massamba N, Mackin AG, Chun LY, Rodriguez S, Dimitroyannis RC, Bodaghi B, Hariprasad SM, Skondra D.
PMID: 34750481
Sci Rep. 2021 Nov 08;11(1):21886. doi: 10.1038/s41598-021-01380-6.

This study compared macular capillary parameters between healthy black and white subjects using optical coherence tomography angiography (OCTA). We measured vessel density (VD) of superficial (SCP), intermediate (ICP), and deep (DCP) capillary plexuses and choriocapillaris blood flow area (BFA)...

Evaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiography.

Scientific reports

Massamba N, Mackin AG, Chun LY, Rodriguez S, Dimitroyannis RC, Bodaghi B, Hariprasad SM, Skondra D.
PMID: 34750481
Sci Rep. 2021 Nov 08;11(1):21886. doi: 10.1038/s41598-021-01380-6.

This study compared macular capillary parameters between healthy black and white subjects using optical coherence tomography angiography (OCTA). We measured vessel density (VD) of superficial (SCP), intermediate (ICP), and deep (DCP) capillary plexuses and choriocapillaris blood flow area (BFA)...

Sensitivity and specificity of the body mass index to assess low percent body fat in African women.

American journal of human biology : the official journal of the Human Biology Council

Gartner A, Maire B, Traissac P, Massamba JP, Kameli Y, Keraudren V, Delpeuch F.
PMID: 11534001
Am J Hum Biol. 2000 Jan;12(1):25-31. doi: 10.1002/(SICI)1520-6300(200001/02)12:1<25::AID-AJHB4>3.0.CO;2-9.

The objective of this study was to evaluate the ability of the body mass index (BMI, kg/m(2)) to reflect low percent body fat (%BF) in a population with a rather mild but widespread prevalence of low BMI. A sample...

The eye: a window on kidney diseases.

Clinical kidney journal

Bodaghi B, Massamba N, Izzedine H.
PMID: 25852906
Clin Kidney J. 2014 Aug;7(4):337-8. doi: 10.1093/ckj/sfu073.

No abstract available.

Present dynamics of the savanna-forest boundary in the Congolese Mayombe: a pedological, botanical and isotopic (.

Oecologia

Schwartz D, de Foresta H, Mariotti A, Balesdent J, Massimba JP, Girardin C.
PMID: 28307452
Oecologia. 1996 Jun;106(4):516-524. doi: 10.1007/BF00329710.

Isolated savannas enclosed by forest are especially abundant in the eastern part of the Congolese Mayombe. They are about 3000 years old, and were more extensive some centuries ago. The boundary between forest and savanna is very abrupt, as...

Showing 1 to 12 of 18 entries