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Cerebrospinal Fluid TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Patients with and without the C9ORF72 Hexanucleotide Expansion.

Dementia and geriatric cognitive disorders extra

Junttila A, Kuvaja M, Hartikainen P, Siloaho M, Helisalmi S, Moilanen V, Kiviharju A, Jansson L, Tienari PJ, Remes AM, Herukka SK.
PMID: 27195002
Dement Geriatr Cogn Dis Extra. 2016 Apr 16;6(1):142-9. doi: 10.1159/000444788. eCollection 2016.

BACKGROUND: TDP-43 is the main protein component of ubiquitinated inclusions in a subgroup of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) patients. The C9ORF72 hexanucleotide expansion is one of the main mutations associated with TDP-43 pathology in...

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Junttila A, Kuvaja M, Hartikainen P, et al. Cerebrospinal Fluid TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Patients with and without the C9ORF72 Hexanucleotide Expansion. Dement Geriatr Cogn Dis Extra. 2016;6(1):142-9doi: 10.1159/000444788.
Junttila, A., Kuvaja, M., Hartikainen, P., Siloaho, M., Helisalmi, S., Moilanen, V., Kiviharju, A., Jansson, L., Tienari, P. J., Remes, A. M., & Herukka, S. K. (2016). Cerebrospinal Fluid TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Patients with and without the C9ORF72 Hexanucleotide Expansion. Dementia and geriatric cognitive disorders extra, 6(1), 142-9. https://doi.org/10.1159/000444788
Junttila, Anna, et al. "Cerebrospinal Fluid TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Patients with and without the C9ORF72 Hexanucleotide Expansion." Dementia and geriatric cognitive disorders extra vol. 6,1 (2016): 142-9. doi: https://doi.org/10.1159/000444788
Junttila A, Kuvaja M, Hartikainen P, Siloaho M, Helisalmi S, Moilanen V, Kiviharju A, Jansson L, Tienari PJ, Remes AM, Herukka SK. Cerebrospinal Fluid TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Patients with and without the C9ORF72 Hexanucleotide Expansion. Dement Geriatr Cogn Dis Extra. 2016 Apr 16;6(1):142-9. doi: 10.1159/000444788. eCollection 2016. PMID: 27195002; PMCID: PMC4868946.
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The Nature of Transannular Interactions in E4N4 and E8(2+) (E = S, Se).

Journal of chemical theory and computation

Moilanen J, Karttunen AJ, Tuononen HM, Chivers T.
PMID: 26605588
J Chem Theory Comput. 2012 Nov 13;8(11):4249-58. doi: 10.1021/ct300627p. Epub 2012 Oct 05.

The electronic structures of tetrachalcogen tetranitrides, E4N4, and octachalcogen dications, E8(2+), and the nature of their intramolecular E···E interactions (E = S, Se) was studied with high-level theoretical methods. The results reveal that the singlet ground states of both...

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Moilanen J, Karttunen AJ, Tuononen HM, et al. The Nature of Transannular Interactions in E4N4 and E8(2+) (E = S, Se). J Chem Theory Comput. 2012;8(11):4249-58doi: 10.1021/ct300627p.
Moilanen, J., Karttunen, A. J., Tuononen, H. M., & Chivers, T. (2012). The Nature of Transannular Interactions in E4N4 and E8(2+) (E = S, Se). Journal of chemical theory and computation, 8(11), 4249-58. https://doi.org/10.1021/ct300627p
Moilanen, Jani, et al. "The Nature of Transannular Interactions in E4N4 and E8(2+) (E = S, Se)." Journal of chemical theory and computation vol. 8,11 (2012): 4249-58. doi: https://doi.org/10.1021/ct300627p
Moilanen J, Karttunen AJ, Tuononen HM, Chivers T. The Nature of Transannular Interactions in E4N4 and E8(2+) (E = S, Se). J Chem Theory Comput. 2012 Nov 13;8(11):4249-58. doi: 10.1021/ct300627p. Epub 2012 Oct 05. PMID: 26605588.
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Microsomal Prostaglandin E Synthase-1 Expression in Inflammatory Conditions Is Downregulated by Dexamethasone: Seminal Role of the Regulatory Phosphatase MKP-1.

Frontiers in pharmacology

Tuure L, Hämäläinen M, Whittle BJ, Moilanen E.
PMID: 28983247
Front Pharmacol. 2017 Sep 21;8:646. doi: 10.3389/fphar.2017.00646. eCollection 2017.

Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme situated downstream of cyclo-oxygenase-2, promoting the excessive PGE

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Tuure L, Hämäläinen M, Whittle BJ, et al. Microsomal Prostaglandin E Synthase-1 Expression in Inflammatory Conditions Is Downregulated by Dexamethasone: Seminal Role of the Regulatory Phosphatase MKP-1. Front Pharmacol. 2017;8:646doi: 10.3389/fphar.2017.00646.
Tuure, L., Hämäläinen, M., Whittle, B. J., & Moilanen, E. (2017). Microsomal Prostaglandin E Synthase-1 Expression in Inflammatory Conditions Is Downregulated by Dexamethasone: Seminal Role of the Regulatory Phosphatase MKP-1. Frontiers in pharmacology, 8646. https://doi.org/10.3389/fphar.2017.00646
Tuure, Lauri, et al. "Microsomal Prostaglandin E Synthase-1 Expression in Inflammatory Conditions Is Downregulated by Dexamethasone: Seminal Role of the Regulatory Phosphatase MKP-1." Frontiers in pharmacology vol. 8 (2017): 646. doi: https://doi.org/10.3389/fphar.2017.00646
Tuure L, Hämäläinen M, Whittle BJ, Moilanen E. Microsomal Prostaglandin E Synthase-1 Expression in Inflammatory Conditions Is Downregulated by Dexamethasone: Seminal Role of the Regulatory Phosphatase MKP-1. Front Pharmacol. 2017 Sep 21;8:646. doi: 10.3389/fphar.2017.00646. eCollection 2017. PMID: 28983247; PMCID: PMC5613146.
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Risk factors for schizophrenia. Follow-up data from the Northern Finland 1966 Birth Cohort Study.

World psychiatry : official journal of the World Psychiatric Association (WPA)

Isohanni M, Miettunen J, Mäki P, Murray GK, Ridler K, Lauronen E, Moilanen K, Alaräisänen A, Haapea M, Isohanni I, Ivleva E, Tamminga C, McGrath J, Koponen H.
PMID: 17139352
World Psychiatry. 2006 Oct;5(3):168-71.

This paper updates single risk factors identified by the Northern Finland 1966 Birth Cohort Study up to the end of year 2001 or age 34. Impaired performance (e.g., delayed motor or intellectual development) or adverse exposures (e.g., pregnancy and...

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Isohanni M, Miettunen J, Mäki P, et al. Risk factors for schizophrenia. Follow-up data from the Northern Finland 1966 Birth Cohort Study. World Psychiatry. 2006;5(3):168-71
Isohanni, M., Miettunen, J., Mäki, P., Murray, G. K., Ridler, K., Lauronen, E., Moilanen, K., Alaräisänen, A., Haapea, M., Isohanni, I., Ivleva, E., Tamminga, C., McGrath, J., & Koponen, H. (2006). Risk factors for schizophrenia. Follow-up data from the Northern Finland 1966 Birth Cohort Study. World psychiatry : official journal of the World Psychiatric Association (WPA), 5(3), 168-71.
Isohanni, Matti, et al. "Risk factors for schizophrenia. Follow-up data from the Northern Finland 1966 Birth Cohort Study." World psychiatry : official journal of the World Psychiatric Association (WPA) vol. 5,3 (2006): 168-71.
Isohanni M, Miettunen J, Mäki P, Murray GK, Ridler K, Lauronen E, Moilanen K, Alaräisänen A, Haapea M, Isohanni I, Ivleva E, Tamminga C, McGrath J, Koponen H. Risk factors for schizophrenia. Follow-up data from the Northern Finland 1966 Birth Cohort Study. World Psychiatry. 2006 Oct;5(3):168-71. PMID: 17139352; PMCID: PMC1636118.
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What nonlinear-IR experiments can tell you about water that the IR spectrum cannot.

Journal of the American Chemical Society

Piletic IR, Moilanen DE, Levinger NE, Fayer MD.
PMID: 16895392
J Am Chem Soc. 2006 Aug 16;128(32):10366-7. doi: 10.1021/ja062549p.

Frequently, the IR spectrum of water is used to characterize the structure and strength of the associated hydrogen bond network. Here, we use nonlinear-IR spectroscopy to investigate the dynamics of four aqueous systems that have very similar absorption spectra....

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Piletic IR, Moilanen DE, Levinger NE, et al. What nonlinear-IR experiments can tell you about water that the IR spectrum cannot. J Am Chem Soc. 2006;128(32):10366-7doi: 10.1021/ja062549p.
Piletic, I. R., Moilanen, D. E., Levinger, N. E., & Fayer, M. D. (2006). What nonlinear-IR experiments can tell you about water that the IR spectrum cannot. Journal of the American Chemical Society, 128(32), 10366-7. https://doi.org/10.1021/ja062549p
Piletic, Ivan R, et al. "What nonlinear-IR experiments can tell you about water that the IR spectrum cannot." Journal of the American Chemical Society vol. 128,32 (2006): 10366-7. doi: https://doi.org/10.1021/ja062549p
Piletic IR, Moilanen DE, Levinger NE, Fayer MD. What nonlinear-IR experiments can tell you about water that the IR spectrum cannot. J Am Chem Soc. 2006 Aug 16;128(32):10366-7. doi: 10.1021/ja062549p. PMID: 16895392.
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Tracking water's response to structural changes in Nafion membranes.

The journal of physical chemistry. A

Moilanen DE, Piletic IR, Fayer MD.
PMID: 16854019
J Phys Chem A. 2006 Jul 27;110(29):9084-8. doi: 10.1021/jp0623084.

As the water content of Nafion membranes increases, the local environments of water molecules change due to reorganization of the pendant side chains in the hydrophilic domains. Changes in local structure as a function of water content are studied...

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Moilanen DE, Piletic IR, Fayer MD. Tracking water's response to structural changes in Nafion membranes. J Phys Chem A. 2006;110(29):9084-8doi: 10.1021/jp0623084.
Moilanen, D. E., Piletic, I. R., & Fayer, M. D. (2006). Tracking water's response to structural changes in Nafion membranes. The journal of physical chemistry. A, 110(29), 9084-8. https://doi.org/10.1021/jp0623084
Moilanen, David E, et al. "Tracking water's response to structural changes in Nafion membranes." The journal of physical chemistry. A vol. 110,29 (2006): 9084-8. doi: https://doi.org/10.1021/jp0623084
Moilanen DE, Piletic IR, Fayer MD. Tracking water's response to structural changes in Nafion membranes. J Phys Chem A. 2006 Jul 27;110(29):9084-8. doi: 10.1021/jp0623084. PMID: 16854019.
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Halo arcs from airborne, pyramidal ice crystals falling with their C axes in vertical orientation.

Applied optics

Pekkola M, Riikonen M, Moilanen J, Ruoskanen J.
PMID: 18268733
Appl Opt. 1998 Mar 20;37(9):1435-40. doi: 10.1364/ao.37.001435.

Many halo arcs are caused by pyramidal crystals that have {1 0 -1 1} crystal faces. We treat halo arcs arising from pyramidal crystals that fall in the air with their c axes vertically oriented. To our knowledge only...

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Pekkola M, Riikonen M, Moilanen J, et al. Halo arcs from airborne, pyramidal ice crystals falling with their C axes in vertical orientation. Appl Opt. 1998;37(9):1435-40doi: 10.1364/ao.37.001435.
Pekkola, M., Riikonen, M., Moilanen, J., & Ruoskanen, J. (1998). Halo arcs from airborne, pyramidal ice crystals falling with their C axes in vertical orientation. Applied optics, 37(9), 1435-40. https://doi.org/10.1364/ao.37.001435
Pekkola, M, et al. "Halo arcs from airborne, pyramidal ice crystals falling with their C axes in vertical orientation." Applied optics vol. 37,9 (1998): 1435-40. doi: https://doi.org/10.1364/ao.37.001435
Pekkola M, Riikonen M, Moilanen J, Ruoskanen J. Halo arcs from airborne, pyramidal ice crystals falling with their C axes in vertical orientation. Appl Opt. 1998 Mar 20;37(9):1435-40. doi: 10.1364/ao.37.001435. PMID: 18268733.
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Predictors of Longitudinal Growth in Inhibitory Control in Early Childhood.

Social development (Oxford, England)

Moilanen KL, Shaw DS, Dishion TJ, Gardner F, Wilson M.
PMID: 20376201
Soc Dev. 2009 Feb 18;19(2):326-347. doi: 10.1111/j.1467-9507.2009.00536.x.

In the current study, we examined latent growth in 731 young children's inhibitory control from ages 2 to 4, and whether demographic characteristics or parenting behaviors were related to initial levels and growth in inhibitory control. As part of...

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Moilanen KL, Shaw DS, Dishion TJ, et al. Predictors of Longitudinal Growth in Inhibitory Control in Early Childhood. Soc Dev. 2009;19(2):326-347doi: 10.1111/j.1467-9507.2009.00536.x.
Moilanen, K. L., Shaw, D. S., Dishion, T. J., Gardner, F., & Wilson, M. (2009). Predictors of Longitudinal Growth in Inhibitory Control in Early Childhood. Social development (Oxford, England), 19(2), 326-347. https://doi.org/10.1111/j.1467-9507.2009.00536.x
Moilanen, Kristin L, et al. "Predictors of Longitudinal Growth in Inhibitory Control in Early Childhood." Social development (Oxford, England) vol. 19,2 (2009): 326-347. doi: https://doi.org/10.1111/j.1467-9507.2009.00536.x
Moilanen KL, Shaw DS, Dishion TJ, Gardner F, Wilson M. Predictors of Longitudinal Growth in Inhibitory Control in Early Childhood. Soc Dev. 2009 Feb 18;19(2):326-347. doi: 10.1111/j.1467-9507.2009.00536.x. PMID: 20376201; PMCID: PMC2850123.
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Weak interactions between trivalent pnictogen centers: computational analysis of bonding in dimers X3E...EX3 (E = pnictogen, X = halogen).

Inorganic chemistry

Moilanen J, Ganesamoorthy C, Balakrishna MS, Tuononen HM.
PMID: 19518113
Inorg Chem. 2009 Jul 20;48(14):6740-7. doi: 10.1021/ic900635f.

The nature of weak interactions in dimers X(3)E...EX(3) (E = N-Bi, X = F-I) was investigated by wave function and density functional theory (DFT)-based methods. Out of the 20 systems studied, 10 are found to be bound at the...

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Moilanen J, Ganesamoorthy C, Balakrishna MS, et al. Weak interactions between trivalent pnictogen centers: computational analysis of bonding in dimers X3E...EX3 (E = pnictogen, X = halogen). Inorg Chem. 2009;48(14):6740-7doi: 10.1021/ic900635f.
Moilanen, J., Ganesamoorthy, C., Balakrishna, M. S., & Tuononen, H. M. (2009). Weak interactions between trivalent pnictogen centers: computational analysis of bonding in dimers X3E...EX3 (E = pnictogen, X = halogen). Inorganic chemistry, 48(14), 6740-7. https://doi.org/10.1021/ic900635f
Moilanen, Jani, et al. "Weak interactions between trivalent pnictogen centers: computational analysis of bonding in dimers X3E...EX3 (E = pnictogen, X = halogen)." Inorganic chemistry vol. 48,14 (2009): 6740-7. doi: https://doi.org/10.1021/ic900635f
Moilanen J, Ganesamoorthy C, Balakrishna MS, Tuononen HM. Weak interactions between trivalent pnictogen centers: computational analysis of bonding in dimers X3E...EX3 (E = pnictogen, X = halogen). Inorg Chem. 2009 Jul 20;48(14):6740-7. doi: 10.1021/ic900635f. PMID: 19518113.
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Nature of bonding in group 13 dimetallenes: a delicate balance between singlet diradical character and closed shell interactions.

Inorganic chemistry

Moilanen J, Power PP, Tuononen HM.
PMID: 21049909
Inorg Chem. 2010 Dec 06;49(23):10992-1000. doi: 10.1021/ic101487g. Epub 2010 Nov 04.

The nature of metal-metal bonding in group 13 dimetallenes REER (E = Al, Ga, In, Tl; R = H, Me, (t)Bu, Ph) was investigated by use of quantum chemical methods that include HF, second order Møller-Plesset perturbation theory (MP2),...

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Moilanen J, Power PP, Tuononen HM. Nature of bonding in group 13 dimetallenes: a delicate balance between singlet diradical character and closed shell interactions. Inorg Chem. 2010;49(23):10992-1000doi: 10.1021/ic101487g.
Moilanen, J., Power, P. P., & Tuononen, H. M. (2010). Nature of bonding in group 13 dimetallenes: a delicate balance between singlet diradical character and closed shell interactions. Inorganic chemistry, 49(23), 10992-1000. https://doi.org/10.1021/ic101487g
Moilanen, Jani, et al. "Nature of bonding in group 13 dimetallenes: a delicate balance between singlet diradical character and closed shell interactions." Inorganic chemistry vol. 49,23 (2010): 10992-1000. doi: https://doi.org/10.1021/ic101487g
Moilanen J, Power PP, Tuononen HM. Nature of bonding in group 13 dimetallenes: a delicate balance between singlet diradical character and closed shell interactions. Inorg Chem. 2010 Dec 06;49(23):10992-1000. doi: 10.1021/ic101487g. Epub 2010 Nov 04. PMID: 21049909.
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GroupICA dual regression analysis of resting state networks in a behavioral variant of frontotemporal dementia.

Frontiers in human neuroscience

Rytty R, Nikkinen J, Paavola L, Abou Elseoud A, Moilanen V, Visuri A, Tervonen O, Renton AE, Traynor BJ, Kiviniemi V, Remes AM.
PMID: 23986673
Front Hum Neurosci. 2013 Aug 26;7:461. doi: 10.3389/fnhum.2013.00461. eCollection 2013.

Functional MRI studies have revealed changes in default-mode and salience networks in neurodegenerative dementias, especially in Alzheimer's disease (AD). The purpose of this study was to analyze the whole brain cortex resting state networks (RSNs) in patients with behavioral...

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Rytty R, Nikkinen J, Paavola L, et al. GroupICA dual regression analysis of resting state networks in a behavioral variant of frontotemporal dementia. Front Hum Neurosci. 2013;7:461doi: 10.3389/fnhum.2013.00461.
Rytty, R., Nikkinen, J., Paavola, L., Abou Elseoud, A., Moilanen, V., Visuri, A., Tervonen, O., Renton, A. E., Traynor, B. J., Kiviniemi, V., & Remes, A. M. (2013). GroupICA dual regression analysis of resting state networks in a behavioral variant of frontotemporal dementia. Frontiers in human neuroscience, 7461. https://doi.org/10.3389/fnhum.2013.00461
Rytty, Riikka, et al. "GroupICA dual regression analysis of resting state networks in a behavioral variant of frontotemporal dementia." Frontiers in human neuroscience vol. 7 (2013): 461. doi: https://doi.org/10.3389/fnhum.2013.00461
Rytty R, Nikkinen J, Paavola L, Abou Elseoud A, Moilanen V, Visuri A, Tervonen O, Renton AE, Traynor BJ, Kiviniemi V, Remes AM. GroupICA dual regression analysis of resting state networks in a behavioral variant of frontotemporal dementia. Front Hum Neurosci. 2013 Aug 26;7:461. doi: 10.3389/fnhum.2013.00461. eCollection 2013. PMID: 23986673; PMCID: PMC3752460.
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Increase in physical activity and cardiometabolic risk profile change during lifestyle intervention in primary healthcare: 1-year follow-up study among individuals at high risk for type 2 diabetes.

BMJ open

Kujala UM, Jokelainen J, Oksa H, Saaristo T, Rautio N, Moilanen L, Korpi-Hyövälti E, Saltevo J, Vanhala M, Niskanen L, Peltonen M, Tuomilehto J, Uusitupa M, Keinänen-Kiukaannemi S.
PMID: 22184585
BMJ Open. 2011 Dec 19;1(2):e000292. doi: 10.1136/bmjopen-2011-000292. Print 2011.

Objectives To investigate the association between increase in physical activity and changes in cardiometabolic risk factors during a lifestyle intervention programme in routine clinical settings. Design Prospective follow-up. Setting 400 primary healthcare centres and occupational healthcare outpatient clinics in...

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Kujala UM, Jokelainen J, Oksa H, et al. Increase in physical activity and cardiometabolic risk profile change during lifestyle intervention in primary healthcare: 1-year follow-up study among individuals at high risk for type 2 diabetes. BMJ Open. 2011;1(2):e000292doi: 10.1136/bmjopen-2011-000292.
Kujala, U. M., Jokelainen, J., Oksa, H., Saaristo, T., Rautio, N., Moilanen, L., Korpi-Hyövälti, E., Saltevo, J., Vanhala, M., Niskanen, L., Peltonen, M., Tuomilehto, J., Uusitupa, M., & Keinänen-Kiukaannemi, S. (2011). Increase in physical activity and cardiometabolic risk profile change during lifestyle intervention in primary healthcare: 1-year follow-up study among individuals at high risk for type 2 diabetes. BMJ open, 1(2), e000292. https://doi.org/10.1136/bmjopen-2011-000292
Kujala, Urho M, et al. "Increase in physical activity and cardiometabolic risk profile change during lifestyle intervention in primary healthcare: 1-year follow-up study among individuals at high risk for type 2 diabetes." BMJ open vol. 1,2 (2011): e000292. doi: https://doi.org/10.1136/bmjopen-2011-000292
Kujala UM, Jokelainen J, Oksa H, Saaristo T, Rautio N, Moilanen L, Korpi-Hyövälti E, Saltevo J, Vanhala M, Niskanen L, Peltonen M, Tuomilehto J, Uusitupa M, Keinänen-Kiukaannemi S. Increase in physical activity and cardiometabolic risk profile change during lifestyle intervention in primary healthcare: 1-year follow-up study among individuals at high risk for type 2 diabetes. BMJ Open. 2011 Dec 19;1(2):e000292. doi: 10.1136/bmjopen-2011-000292. Print 2011. PMID: 22184585; PMCID: PMC3244658.
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