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In support of regional teaching.

Medical & biological illustration

Coles CR.
PMID: 895220
Med Biol Illus. 1977 Feb;27(1):21-2.

No abstract available.

An Approach to the Core of Lactonamycin.

Organic letters

Parsons PJ, Jones DR, Walsh LJ, Allen LAT, Onwubiko A, Preece L, Board J, White AJP.
PMID: 28445072
Org Lett. 2017 May 19;19(10):2533-2535. doi: 10.1021/acs.orglett.7b00902. Epub 2017 Apr 26.

A cascade reaction has been developed for the synthesis of lactonamycin. In this paper, we demonstrate that a transition-metal-free thermal ene-diyne cyclization can be used for the construction of the entire core of the antibiotic lactonamycin and anticancer agent...

Analysis of Left Atrial Respiratory and Cardiac Motion for Cardiac Ablation Therapy.

Proceedings of SPIE--the International Society for Optical Engineering

Rettmann ME, Holmes DR, Johnson SB, Lehmann HI, Robb RA, Packer DL.
PMID: 26405370
Proc SPIE Int Soc Opt Eng. 2015 Feb 21;9415. doi: 10.1117/12.2081209.

Cardiac ablation therapy is often guided by models built from preoperative computed tomography (CT) or magnetic resonance imaging (MRI) scans. One of the challenges in guiding a procedure from a preoperative model is properly synching the preoperative models with...

Calibration and Evaluation of a Magnetically Tracked ICE Probe for Guidance of Left Atrial Ablation Therapy.

Proceedings of SPIE--the International Society for Optical Engineering

Linte CA, Rettmann ME, Dilger B, Gunawan MS, Arunachalam SP, Holmes DR, Packer DL, Robb RA.
PMID: 26401065
Proc SPIE Int Soc Opt Eng. 2012 Feb 04;8316. doi: 10.1117/12.912869.

The novel prototype system for advanced visualization for image-guided left atrial ablation therapy developed in our laboratory permits ready integration of multiple imaging modalities, surgical instrument tracking, interventional devices and electro-physiologic data. This technology allows subject-specific procedure planning and...

Toward Standardized Mapping for Left Atrial Analysis and Cardiac Ablation Guidance.

Proceedings of SPIE--the International Society for Optical Engineering

Rettmann ME, Holmes DR, Linte CA, Packer DL, Robb RA.
PMID: 26401067
Proc SPIE Int Soc Opt Eng. 2014 Feb 15;9036. doi: 10.1117/12.2043191.

In catheter-based cardiac ablation, the pulmonary vein ostia are important landmarks for guiding the ablation procedure, and for this reason, have been the focus of many studies quantifying their size, structure, and variability. Analysis of pulmonary vein structure, however,...

Student perceptions of a spiral curriculum.

European journal of dental education : official journal of the Association for Dental Education in Europe

Coelho CS, Moles DR.
PMID: 26096630
Eur J Dent Educ. 2016 Aug;20(3):161-6. doi: 10.1111/eje.12156. Epub 2015 Jun 22.

AIM: The aim of this study was evaluation of constructive alignment of student perceptions to a spiral curriculum, as a pre-requisite to successful learning.METHOD: A survey was undertaken to evaluate student thoughts and experiences of a spiral curriculum, by...

The Essential Role of Educator Development: 10 Years of the ACC Emerging Faculty Program.

Journal of the American College of Cardiology

Auseon AJ, O'Gara PT, Klodas E, Holmes DR, Jackson MJ, Green JS, Konstam MA, Nishimura RA.
PMID: 27151350
J Am Coll Cardiol. 2016 May 10;67(18):2177-2182. doi: 10.1016/j.jacc.2016.02.052.

The American College of Cardiology Emerging Faculty program was developed in 2005 to promote a systematic approach to "educate the educators" through training and mentorship. A primary focus of the program is the biennial Teaching Skills Workshop, which has...

Trophic niche divergence among colour morphs that exhibit alternative mating tactics.

Royal Society open science

Lattanzio MS, Miles DB.
PMID: 27152203
R Soc Open Sci. 2016 Apr 13;3(4):150531. doi: 10.1098/rsos.150531. eCollection 2016 Apr.

Discrete colour morphs associated with alternative mating tactics are assumed to be ecologically equivalent. Yet suites of behaviours linked with reproduction can also favour habitat segregation and exploitation of different prey among morphs. By contrast, trophic polymorphisms are usually...

Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression.

Cell reports

de Vries NA, Hulsman D, Akhtar W, de Jong J, Miles DC, Blom M, van Tellingen O, Jonkers J, van Lohuizen M.
PMID: 25600873
Cell Rep. 2015 Jan 20;10(3):383-397. doi: 10.1016/j.celrep.2014.12.028. Epub 2015 Jan 15.

EZH2 is frequently overexpressed in glioblastoma (GBM), suggesting an oncogenic function that could be a target for therapeutic intervention. However, reduced EZH2 activity can also promote tumorigenesis, leading to concerns about the use of EZH2 inhibitors. Here, we provide...

A comparison of clinical laboratory data for assigning a consensus value for manganese in a caprine blood reference material.

Journal of analytical atomic spectrometry

Praamsma ML, Jones DR, Jarrett JM, Dumas P, Cirtiu CM, Parsons PJ.
PMID: 26290619
J Anal At Spectrom. 2012 Oct;27(11):1975-1982. doi: 10.1039/C2JA30142C.

Biomonitoring for manganese (Mn) exposure is important due to its potential to cause adverse health effects. In this study, we investigate how different sample preparation methods (simple dilution, digestion, volumetric, gravimetric), calibration protocols (aqueous, blood-based, standard additions), and instrumental...

A Rapid, Semi-Quantitative Assay to Screen for Modulators of Alpha-Synuclein Oligomerization Ex vivo.

Frontiers in neuroscience

Delenclos M, Trendafilova T, Jones DR, Moussaud S, Baine AM, Yue M, Hirst WD, McLean PJ.
PMID: 26834539
Front Neurosci. 2016 Jan 19;9:511. doi: 10.3389/fnins.2015.00511. eCollection 2015.

Alpha synuclein (αsyn) aggregates are associated with the pathogenesis of Parkinson's disease and others related disorders. Although modulation of αsyn aggregation is an attractive therapeutic target, new powerful methodologies are desperately needed to facilitate in vivo screening of novel...

Analytical method for total chromium and nickel in urine using an inductively coupled plasma-universal cell technology-mass spectrometer (ICP-UCT-MS) in kinetic energy discrimination (KED) mode.

Journal of analytical atomic spectrometry

Quarles CD, Jones DR, Jarrett JM, Shakirova G, Pan Y, Caldwell KL, Jones RL.
PMID: 26229219
J Anal At Spectrom. 2014;2014(2):297-303. doi: 10.1039/C3JA50272D.

Biomonitoring and emergency response measurements are an important aspect of the Division of Laboratory Sciences of the National Center for Environmental Health, Centers for Disease Control and Prevention (CDC). The continuing advancement in instrumentation allows for enhancements to existing...

Showing 1 to 12 of 408 entries