UI Index

HNSCC cells resistant to EGFR pathway inhibitors are hypermutated and sensitive to DNA damaging substances.

American journal of cancer research

Schulz D, Wirth M, Piontek G, Buchberger AM, Schlegel J, Reiter R, Multhoff G, Pickhard A.
PMID: 27725902
Am J Cancer Res. 2016 Sep 01;6(9):1963-1975. eCollection 2016.

Despite remarkable successes with targeted therapies in the treatment of cancer, resistance can occur which limits the clinical outcome. In this study, we generated and characterized resistant cell clones derived from two different head and neck squamous cell carcinoma...

Influence of tumors on protective anti-tumor immunity and the effects of irradiation.

Frontiers in oncology

Foulds GA, Radons J, Kreuzer M, Multhoff G, Pockley AG.
PMID: 23378947
Front Oncol. 2013 Feb 01;3:14. doi: 10.3389/fonc.2013.00014. eCollection 2013.

Innate and adaptive immunity plays important roles in the development and progression of cancer and it is becoming apparent that tumors can influence the induction of potentially protective responses in a number of ways. The prevalence of immunoregulatory T...

Radiation, inflammation, and immune responses in cancer.

Frontiers in oncology

Multhoff G, Radons J.
PMID: 22675673
Front Oncol. 2012 Jun 04;2:58. doi: 10.3389/fonc.2012.00058. eCollection 2012.

Chronic inflammation has emerged as one of the hallmarks of cancer. Inflammation also plays a pivotal role in modulating radiation responsiveness of tumors. As discussed in this review, ionizing radiation (IR) leads to activation of several transcription factors modulating...

Genetic mapping of semi-polar metabolites in pepper fruits (.

Molecular breeding : new strategies in plant improvement

Wahyuni Y, Stahl-Hermes V, Ballester AR, de Vos RC, Voorrips RE, Maharijaya A, Molthoff J, Zamora MV, Sudarmonowati E, Arisi AC, Bino RJ, Bovy AG.
PMID: 24532977
Mol Breed. 2014;33:503-518. doi: 10.1007/s11032-013-9967-0. Epub 2013 Oct 23.

Untargeted LCMS profiling of semi-polar metabolites followed by metabolite quantitative trait locus (mQTL) analysis was performed in ripe pepper fruits of 113 F2 plants derived from a cross between

Heat Shock Protein 70 (Hsp70) Peptide Activated Natural Killer (NK) Cells for the Treatment of Patients with Non-Small Cell Lung Cancer (NSCLC) after Radiochemotherapy (RCTx) - From Preclinical Studies to a Clinical Phase II Trial.

Frontiers in immunology

Specht HM, Ahrens N, Blankenstein C, Duell T, Fietkau R, Gaipl US, Günther C, Gunther S, Habl G, Hautmann H, Hautmann M, Huber RM, Molls M, Offner R, Rödel C, Rödel F, Schütz M, Combs SE, Multhoff G.
PMID: 25926832
Front Immunol. 2015 Apr 15;6:162. doi: 10.3389/fimmu.2015.00162. eCollection 2015.

Heat shock protein 70 (Hsp70) is frequently overexpressed in tumor cells. An unusual cell surface localization could be demonstrated on a large variety of solid tumors including lung, colorectal, breast, squamous cell carcinomas of the head and neck, prostate...

Novel Approaches to Improve the Efficacy of Immuno-Radiotherapy.

Frontiers in oncology

Shevtsov M, Sato H, Multhoff G, Shibata A.
PMID: 30941308
Front Oncol. 2019 Mar 19;9:156. doi: 10.3389/fonc.2019.00156. eCollection 2019.

Radiotherapy (RT) has been applied for decades as a treatment modality in the management of various types of cancer. Ionizing radiation induces tumor cell death, which in turn can either elicit protective anti-tumor immune responses or immunosuppression in the...

Radiation-induced changes in microcirculation and interstitial fluid pressure affecting the delivery of macromolecules and nanotherapeutics to tumors.

Frontiers in oncology

Multhoff G, Vaupel P.
PMID: 23162794
Front Oncol. 2012 Nov 15;2:165. doi: 10.3389/fonc.2012.00165. eCollection 2012.

The immature, chaotic microvasculature of most solid tumors can present a significant impediment to blood-borne delivery, uneven distribution, and compromised penetration of macromolecular anticancer drugs and diagnostic agents from tumor microvessels across the interstitial space to cancer cells. To...

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death.

Frontiers in immunology

Garg AD, Galluzzi L, Apetoh L, Baert T, Birge RB, Bravo-San Pedro JM, Breckpot K, Brough D, Chaurio R, Cirone M, Coosemans A, Coulie PG, De Ruysscher D, Dini L, de Witte P, Dudek-Peric AM, Faggioni A, Fucikova J, Gaipl US, Golab J, Gougeon ML, Hamblin MR, Hemminki A, Herrmann M, Hodge JW, Kepp O, Kroemer G, Krysko DV, Land WG, Madeo F, Manfredi AA, Mattarollo SR, Maueroder C, Merendino N, Multhoff G, Pabst T, Ricci JE, Riganti C, Romano E, Rufo N, Smyth MJ, Sonnemann J, Spisek R, Stagg J, Vacchelli E, Vandenabeele P, Vandenberk L, Van den Eynde BJ, Van Gool S, Velotti F, Zitvogel L, Agostinis P.
PMID: 26635802
Front Immunol. 2015 Nov 20;6:588. doi: 10.3389/fimmu.2015.00588. eCollection 2015.

The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, including dendritic cell-based vaccines, checkpoint-blocking therapies, and adoptive T-cell transfer, researchers have started to focus...

Pretargeted PET Imaging of .

ACS omega

Keinänen O, Mäkilä EM, Lindgren R, Virtanen H, Liljenbäck H, Oikonen V, Sarparanta M, Molthoff C, Windhorst AD, Roivainen A, Salonen JJ, Airaksinen AJ.
PMID: 28649670
ACS Omega. 2017 Jan 31;2(1):62-69. doi: 10.1021/acsomega.6b00269. Epub 2017 Jan 06.

Pretargeted positron emission tomography (PET) imaging based on bioorthogonal chemical reactions has proven its potential in immunoimaging. It may also have great potential in nanotheranostic applications. Here, we report the first successful pretargeted PET imaging of

Accomplices of the Hypoxic Tumor Microenvironment Compromising Antitumor Immunity: Adenosine, Lactate, Acidosis, Vascular Endothelial Growth Factor, Potassium Ions, and Phosphatidylserine.

Frontiers in immunology

Vaupel P, Multhoff G.
PMID: 29312351
Front Immunol. 2017 Dec 21;8:1887. doi: 10.3389/fimmu.2017.01887. eCollection 2017.

In this minireview, we aim to highlight key factors of the tumor microenvironment, including adenosine, lactate, acidosis, vascular endothelial growth factor, phosphatidylserine, high extracellular K

Hsp70 in Liquid Biopsies-A Tumor-Specific Biomarker for Detection and Response Monitoring in Cancer.

Cancers

Werner C, Stangl S, Salvermoser L, Schwab M, Shevtsov M, Xanthopoulos A, Wang F, Dezfouli AB, Thölke D, Ostheimer C, Medenwald D, Windberg M, Bache M, Schlapschy M, Skerra A, Multhoff G.
PMID: 34359606
Cancers (Basel). 2021 Jul 23;13(15). doi: 10.3390/cancers13153706.

In contrast to normal cells, tumor cells of multiple entities overexpress the Heat shock protein 70 (Hsp70) not only in the cytosol, but also present it on their plasma membrane in a tumor-specific manner. Furthermore, membrane Hsp70-positive tumor cells...

NK Cells Armed with Chimeric Antigen Receptors (CAR): Roadblocks to Successful Development.

Cells

Bashiri Dezfouli A, Yazdi M, Pockley AG, Khosravi M, Kobold S, Wagner E, Multhoff G.
PMID: 34943898
Cells. 2021 Dec 01;10(12). doi: 10.3390/cells10123390.

In recent years, cell-based immunotherapies have demonstrated promising results in the treatment of cancer. Chimeric antigen receptors (CARs) arm effector cells with a weapon for targeting tumor antigens, licensing engineered cells to recognize and kill cancer cells. The quality...