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Showing 1 to 12 of 3807 entries
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The rapid synthesis and dynamic behaviour of an isophthalamide [2]catenane.

Organic & biomolecular chemistry

Marrs CN, Evans NH.
PMID: 26391526
Org Biomol Chem. 2015 Dec 07;13(45):11021-5. doi: 10.1039/c5ob01770j. Epub 2015 Sep 22.

A serendipitous [2]catenane has been prepared in three steps from commercially available starting materials. The interlocked topology of the catenane has been confirmed by single crystal X-ray structural determination. The rings of the catenane may rotate relative to one...

The PIN domain endonuclease Utp24 cleaves pre-ribosomal RNA at two coupled sites in yeast and humans.

Nucleic acids research

Wells GR, Weichmann F, Colvin D, Sloan KE, Kudla G, Tollervey D, Watkins NJ, Schneider C.
PMID: 27034467
Nucleic Acids Res. 2016 Jun 20;44(11):5399-409. doi: 10.1093/nar/gkw213. Epub 2016 Mar 31.

During ribosomal RNA (rRNA) maturation, cleavages at defined sites separate the mature rRNAs from spacer regions, but the identities of several enzymes required for 18S rRNA release remain unknown. PilT N-terminus (PIN) domain proteins are frequently endonucleases and the...

Septins Focus Cellular Growth for Host Infection by Pathogenic Fungi.

Frontiers in cell and developmental biology

Momany M, Talbot NJ.
PMID: 28424773
Front Cell Dev Biol. 2017 Apr 05;5:33. doi: 10.3389/fcell.2017.00033. eCollection 2017.

One of the key challenges faced by microbial pathogens is invasion of host tissue. Fungal pathogens adopt a number of distinct strategies to overcome host cell defenses, including the development of specialized infection structures, the secretion of proteins that...

Hill classification is superior to the axial length of a hiatal hernia for assessment of the mechanical anti-reflux barrier at the gastroesophageal junction.

Endoscopy international open

Hansdotter I, Björ O, Andreasson A, Agreus L, Hellström P, Forsberg A, Talley NJ, Vieth M, Wallner B.
PMID: 27004249
Endosc Int Open. 2016 Mar;4(3):E311-7. doi: 10.1055/s-0042-101021. Epub 2016 Feb 10.

BACKGROUND AND STUDY AIMS: The pathogenesis of gastroesophageal reflux disease (GERD) is multifactorial, including the mechanical anti-reflux barrier of the gastroesophageal junction. This barrier can be evaluated endoscopically in two ways: by measuring the axial length of any hiatal...

The threat of antimalarial drug resistance.

Tropical diseases, travel medicine and vaccines

Hanboonkunupakarn B, White NJ.
PMID: 28883954
Trop Dis Travel Med Vaccines. 2016 Jul 07;2:10. doi: 10.1186/s40794-016-0027-8. eCollection 2016.

The battle between man and malaria has continued for thousands of years. Antimalarial drugs are essential weapons to fight the disease, but their efficacy is threatened by drug resistance which continues to emerge creating a major obstacle to malaria...

The role of necroptosis in atherosclerotic disease.

JACC. Basic to translational science

Leeper NJ.
PMID: 28480338
JACC Basic Transl Sci. 2016 Oct;1(6):548-550. doi: 10.1016/j.jacbts.2016.08.002.

It is now known that cells don't always die by apoptosis, but can also undergo a process known as programmed cell necrosis, or necroptosis. In a study recently published in

Effector Diversification Contributes to Xanthomonas oryzae pv. oryzae Phenotypic Adaptation in a Semi-Isolated Environment.

Scientific reports

Quibod IL, Perez-Quintero A, Booher NJ, Dossa GS, Grande G, Szurek B, Vera Cruz C, Bogdanove AJ, Oliva R.
PMID: 27667260
Sci Rep. 2016 Sep 26;6:34137. doi: 10.1038/srep34137.

Understanding the processes that shaped contemporary pathogen populations in agricultural landscapes is quite important to define appropriate management strategies and to support crop improvement efforts. Here, we took advantage of an historical record to examine the adaptation pathway of...

Phylogenetic and chemical diversity of fungal endophytes isolated from .

Mycology

Raja HA, Kaur A, El-Elimat T, Figueroa M, Kumar R, Deep G, Agarwal R, Faeth SH, Cech NB, Oberlies NH.
PMID: 26000195
Mycology. 2015 Jan 02;6(1):8-27. doi: 10.1080/21501203.2015.1009186. Epub 2015 Feb 23.

Use of the herb milk thistle (

Far-field optical nanothermometry using individual sub-50 nm upconverting nanoparticles.

Nanoscale

Kilbane JD, Chan EM, Monachon C, Borys NJ, Levy ES, Pickel AD, Urban JJ, Schuck PJ, Dames C.
PMID: 27216164
Nanoscale. 2016 Jun 02;8(22):11611-6. doi: 10.1039/c6nr01479h.

We demonstrate far-field optical thermometry using individual NaYF4 nanoparticles doped with 2% Er(3+) and 20% Yb(3+). Isolated 20 × 20 × 40 nm(3) particles were identified using only far-field optical imaging, confirmed by subsequent scanning electron microscopy. The luminescence...

Key bacterial families (Clostridiaceae, Erysipelotrichaceae and Bacteroidaceae) are related to the digestion of protein and energy in dogs.

PeerJ

Bermingham EN, Maclean P, Thomas DG, Cave NJ, Young W.
PMID: 28265505
PeerJ. 2017 Mar 02;5:e3019. doi: 10.7717/peerj.3019. eCollection 2017.

BACKGROUND: Much of the recent research in companion animal nutrition has focussed on understanding the role of diet on faecal microbiota composition. To date, diet-induced changes in faecal microbiota observed in humans and rodents have been extrapolated to pets...

Concurrent chemoradiation for high-risk prostate cancer.

World journal of clinical oncology

Cooper BT, Sanfilippo NJ.
PMID: 26266099
World J Clin Oncol. 2015 Aug 10;6(4):35-42. doi: 10.5306/wjco.v6.i4.35.

There are estimated to be 220800 cases of prostate cancer diagnosed in 2015, making up 26% of all cancer diagnoses. Fortunately, adenocarcinoma of the prostate is often a highly treatable malignancy. Even though the majority of prostate cancer patients...

Belowground Response to Drought in a Tropical Forest Soil. I. Changes in Microbial Functional Potential and Metabolism.

Frontiers in microbiology

Bouskill NJ, Wood TE, Baran R, Ye Z, Bowen BP, Lim H, Zhou J, Nostrand JD, Nico P, Northen TR, Silver WL, Brodie EL.
PMID: 27148214
Front Microbiol. 2016 Apr 20;7:525. doi: 10.3389/fmicb.2016.00525. eCollection 2016.

Global climate models predict a future of increased severity of drought in many tropical forests. Soil microbes are central to the balance of these systems as sources or sinks of atmospheric carbon (C), yet how they respond metabolically to...

Showing 1 to 12 of 3807 entries