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Showing 1 to 12 of 77 entries
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Docosahexaenoic Acid therapy of experimental ischemic stroke.

Translational stroke research

Belayev L, Khoutorova L, Atkins KD, Eady TN, Hong S, Lu Y, Obenaus A, Bazan NG.
PMID: 21423332
Transl Stroke Res. 2011 Mar;2(1):33-41. doi: 10.1007/s12975-010-0046-0. Epub 2010 Nov 04.

We examined the neuroprotective efficacy of docosahexaenoic acid (DHA), an omega-3 essential fatty acid family member, in acute ischemic stroke; studied the therapeutic window; and investigated whether DHA administration after an ischemic stroke is able to salvage the penumbra....

Formation of atmospheric molecular clusters consisting of sulfuric acid and C.

Physical chemistry chemical physics : PCCP

Elm J, Myllys N, Olenius T, Halonen R, Kurtén T, Vehkamäki H.
PMID: 28134369
Phys Chem Chem Phys. 2017 Feb 08;19(6):4877-4886. doi: 10.1039/c6cp08127d.

Using computational methods, we investigate the formation of atmospheric clusters consisting of sulfuric acid (SA) and 3-methyl-1,2,3-butanetricarboxylic acid (MBTCA), identified from α-pinene oxidation. The molecular structure of the clusters is obtained using three different DFT functionals (PW91, M06-2X and...

Editorial overview: Viral immunology before COVID-19.

Current opinion in virology

Oxenius A, Zajac AJ.
PMID: 34968790
Curr Opin Virol. 2021 Nov 24;52:217-219. doi: 10.1016/j.coviro.2021.11.010. Epub 2021 Nov 24.

No abstract available.

Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF.

The Journal of experimental medicine

Hausmann A, Felmy B, Kunz L, Kroon S, Berthold DL, Ganz G, Sandu I, Nakamura T, Zangger NS, Zhang Y, Dolowschiak T, Fattinger SA, Furter M, Müller-Hauser AA, Barthel M, Vlantis K, Wachsmuth L, Kisielow J, Tortola L, Heide D, Heikenwälder M, Oxenius A, Kopf M, Schroeder T, Pasparakis M, Sellin ME, Hardt WD.
PMID: 34529751
J Exp Med. 2021 Nov 01;218(11). doi: 10.1084/jem.20210862. Epub 2021 Sep 16.

Intestinal epithelial cell (IEC) NF-κB signaling regulates the balance between mucosal homeostasis and inflammation. It is not fully understood which signals tune this balance and how bacterial exposure elicits the process. Pure LPS induces epithelial NF-κB activation in vivo....

Aquimarins, Peptide Antibiotics with Amino-Modified C-Termini from a Sponge-Derived Aquimarina sp. Bacterium.

Angewandte Chemie (International ed. in English)

Dieterich CL, Probst SI, Ueoka R, Sandu I, Schäfle D, Dal Molin M, Minas HA, Costa R, Oxenius A, Sander P, Piel J.
PMID: 34918870
Angew Chem Int Ed Engl. 2021 Dec 17; doi: 10.1002/anie.202115802. Epub 2021 Dec 17.

Genome mining and bioactivity studies suggested the sponge-derived bacterium Aquimarina sp. Aq135 as a producer of new antibiotics. Activity-guided isolation identified antibacterial peptides, named aquimarins, featuring a new scaffold with an unusual C-terminal amino group and chlorine moieties. Responsible...

Right ventricular dilatation in patients with pulmonary regurgitation after repair of tetralogy of Fallot: How fast does it progress?.

Annals of pediatric cardiology

Hoelscher M, Bonassin F, Oxenius A, Seifert B, Leonardi B, Kellenberger CJ, Valsangiacomo Buechel ER.
PMID: 33311917
Ann Pediatr Cardiol. 2020 Oct-Dec;13(4):294-300. doi: 10.4103/apc.APC_140_19. Epub 2020 Jul 24.

OBJECTIVE: Pulmonary valve regurgitation (PR) and right ventricular (RV) dilatation are important residual findings after surgical repair of tetralogy of Fallot (TOF). We sought to describe the natural course of RV dilatation over time in patients with severe PR...

Fibronectin fibers are highly tensed in healthy organs in contrast to tumors and virus-infected lymph nodes.

Matrix biology plus

Fonta CM, Arnoldini S, Jaramillo D, Moscaroli A, Oxenius A, Behe M, Vogel V.
PMID: 33543039
Matrix Biol Plus. 2020 Jul 17;8:100046. doi: 10.1016/j.mbplus.2020.100046. eCollection 2020 Nov.

The extracellular matrix (ECM) acts as reservoir for a plethora of growth factors and cytokines some of which are hypothesized to be regulated by ECM fiber tension. Yet, ECM fiber tension has never been mapped in healthy versus diseased...

Editorial overview: Viral immunology before COVID-19.

Current opinion in virology

Oxenius A, Zajac AJ.
PMID: 34968790
Curr Opin Virol. 2021 Nov 24;52:217-219. doi: 10.1016/j.coviro.2021.11.010. Epub 2021 Nov 24.

No abstract available.

Viral mimetic triggers cerebral arteriopathy in juvenile brain via neutrophil elastase and NETosis.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Rayasam A, Jullienne A, Chumak T, Faustino J, Szu J, Hamer M, Ek CJ, Mallard C, Obenaus A, Vexler ZS.
PMID: 34293939
J Cereb Blood Flow Metab. 2021 Dec;41(12):3171-3186. doi: 10.1177/0271678X211032737. Epub 2021 Jul 22.

Stroke is among the top ten causes of death in children but has received disproportionally little attention. Cerebral arteriopathies account for up to 80% of childhood arterial ischemic stroke (CAIS) cases and are strongly predictive of CAIS recurrence and...

Guanidine: A Highly Efficient Stabilizer in Atmospheric New-Particle Formation.

The journal of physical chemistry. A

Myllys N, Ponkkonen T, Passananti M, Elm J, Vehkamäki H, Olenius T.
PMID: 29693391
J Phys Chem A. 2018 May 24;122(20):4717-4729. doi: 10.1021/acs.jpca.8b02507. Epub 2018 May 11.

The role of a strong organobase, guanidine, in sulfuric acid-driven new-particle formation is studied using state-of-the-art quantum chemical methods and molecular cluster formation simulations. Cluster formation mechanisms at the molecular level are resolved, and theoretical results on cluster stability...

Robust metric for quantifying the importance of stochastic effects on nanoparticle growth.

Scientific reports

Olenius T, Pichelstorfer L, Stolzenburg D, Winkler PM, Lehtinen KEJ, Riipinen I.
PMID: 30242199
Sci Rep. 2018 Sep 21;8(1):14160. doi: 10.1038/s41598-018-32610-z.

Comprehensive representation of nanoparticle dynamics is necessary for understanding nucleation and growth phenomena. This is critical in atmospheric physics, as airborne particles formed from vapors have significant but highly uncertain effects on climate. While the vapor-particle mass exchange driving...

Recognition and Regulation of T Cells by NK Cells.

Frontiers in immunology

Pallmer K, Oxenius A.
PMID: 27446081
Front Immunol. 2016 Jun 24;7:251. doi: 10.3389/fimmu.2016.00251. eCollection 2016.

Regulation of T cell responses by innate lymphoid cells (ILCs) is increasingly documented and studied. Direct or indirect crosstalk between ILCs and T cells early during and after T cell activation can affect their differentiation, polarization, and survival. Natural...

Showing 1 to 12 of 77 entries